Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta-analysis
Abstract
Resistance training (RT) is a powerful first-line intervention for the management of type 2 diabetes mellitus (T2DM). Nonetheless, the effects of the most frequent RT (hypertrophy training [HT] and muscular endurance training [MERT]) employed for the management of T2DM, and which type of RT might exert superior effects, remain elusive. Thus, this review aims to assess the effects of HT and MERT on glycaemic control, physical fitness, body composition, lipid profile, blood pressure, C-reactive protein, and quality of life in patients with T2DM; to analyse which particular RT is more effective; to assess the effects of general RT; and to identify RT components, characteristics of patients, and medications that could mediate the effects of RT. Randomized controlled trials (RCT) and non-RCT (RT≥ 4 weeks) in adults with T2DM were selected. Both HT and MERT improved HbA1c, insulin levels and sensitivity, muscle strength, body mass index, waist circumference, and fat mass. Additionally, HT improved glucose, cardiorespiratory fitness, fat percentage, lean body mass, lipid profile, systolic blood pressure, and C-reactive protein, and MERT improved weight. Overall, HT and MERT exert beneficial effects well comparable with aerobic training. Both types of RT can be used as potent therapeutic interventions for the management of T2DM depending on patients' limitations/preferences.
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In subjects with diabetes or obesity, exercise increases insulin sensitivity independently of changes in body fat with nutritional interventions.
“In subjects with diabetes or obesity, exercise is the cornerstone of therapeutic interventions. It increases insulin sensitivity independently of changes in body fat with nutritional interventions”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [239]
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“• This is the first meta-analytic evidence regarding the effectiveness of the most frequent RT (hypertrophic [HT] and muscular endurance training [MERT]) employed for the management of T2DM.”
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- Authors
- Acosta‐Manzano, P., Rodriguez‐Ayllon, M., Acosta, F. M., Niederseer, D., & Niebauer, J.
- Affiliations
- Universidad de Granada (ES)
- Sport and Health University Research Institute (IMUDS) University of Granada Granada Spain
- University Hospital Zurich (CH)
- Paracelsus Medical University (AT)
- Corresponding author
- Acosta‐Manzano, Pedro
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2020-02-17
- Volume
- 21
- Issue
- 6
- Pages
- e13007-e13007
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W3005932906
- Cited by
- 59
- References
- 108
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Universidad de Granada (International mobility program for PhD candidates)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- resistance training, type 2 diabetes, hypertrophy training, muscular endurance training, glycemic control, HbA1c, insulin sensitivity, muscle strength, body composition, cardiorespiratory fitness, lipid profile, blood pressure, C-reactive protein, quality of life
- MeSH terms
- Endurance Training, Adult, Diabetes Mellitus, Type 2, Humans, Hypertrophy, Treatment Outcome, Resistance Training
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