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Cited by 184Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

Domecq, Juan Pablo, Prutsky, Gabriela, Mullan, Rebecca J., Hazem, Ahmad, Sundaresh, Vishnu, Elamin, Mohammed B., Phung, Olivia J., Wang, Amy, Hoeger, Kathleen, Pasquali, Renato, Erwin, Patricia, Bodde, Amy, Montori, Victor M., Murad, M. Hassan·2013·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2013-2385
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Abstract

Context: Polycystic ovary syndrome (PCOS) is a prevalent disorder that affects women of childbearing age and may be related to obesity and insulin resistance. Objective: The purpose of this systematic review was to appraise the evidence of the impact of lifestyle modification (LSM) interventions on outcomes of women with PCOS. Data Sources: Sources included Ovid Medline, OVID Embase, OVID Cochrane Library, Web of Science, Scopus, PsycINFO, and CINAHL (up to January 2011). Study Selection: We included randomized controlled trials that enrolled woman of any age with PCOS who received LSM and compared them against women who received no intervention, minimal intervention, or metformin. Data Extraction: Two authors performed the data extraction independently. Data Synthesis: We included 9 trials enrolling 583 women with a high loss to follow-up rate, lack of blinding, and short follow-up. Compared with minimal intervention, LSM significantly reduced fasting blood glucose (weighted mean difference, −2.3 mg/dL; 95% confidence interval, −4.5 to −0.1, I2 = 72%, P = .04) and fasting blood insulin (weighted mean difference, −2.1 μU/mL, 95% confidence interval, −3.3 to −1.0, I2 = 0%, P < .001). Changes in body mass index were associated with changes in fasting blood glucose (P < .001). Metformin was not significantly better than LSM in improving blood glucose or insulin levels. We found no significant effect of LSM on pregnancy rate, and the effect on hirsutism was unclear. Conclusions: The available evidence suggests that LSM reduces fasting blood glucose and insulin levels in women with PCOS. Metformin has similar effects. Translation of these short-term effects to patient-important outcomes, beyond diabetes prevention, remains uncertain.

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Metadata

Authors
Domecq, J. P., Prutsky, G., Mullan, R. J., Hazem, A., Sundaresh, V., Elamin, M. B., Phung, O. J., Wang, A., Hoeger, K., Pasquali, R., Erwin, P., Bodde, A., Montori, V. M., & Murad, M. H.
Affiliations
  • Henry Ford Hospital (US)
  • Wayne State University (US)
  • University of Minnesota (US)
  • University of North Dakota (US)
  • Louisiana State University Health Sciences Center Shreveport (US)
  • Texas Tech University (US)
  • Western University of Health Sciences (US)
  • Mayo Clinic (US)
  • University of Rochester Medicine (US)
  • IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
  • Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905
Corresponding author
Murad, M. Hassan
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2013-12-01
Volume
98
Issue
12
Pages
4655-4663
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2013-2385
OpenAlex
W2153353583
Cited by
184
References
59
Citations by year
2026: 4 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 14 · 2020: 19 · 2019: 22 · 2018: 13 · 2017: 18 · 2016: 11 · 2015: 23 · 2014: 12 · 2013: 1
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, lifestyle modification, metformin, fasting blood glucose, insulin levels, body mass index, obesity, insulin resistance, hirsutism, pregnancy rate, diabetes prevention
MeSH terms
Combined Modality Therapy, Diet, Reducing, Female, Humans, Hyperglycemia, Hyperinsulinism, Life Style, Patient Compliance, Polycystic Ovary Syndrome, Pregnancy, Exercise, Randomized Controlled Trials as Topic, Pregnancy Rate, Evidence-Based Medicine, Overweight, Lost to Follow-Up

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