Cited by 184Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

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Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

Domecq, Juan Pablo, Prutsky, Gabriela, Mullan, Rebecca J., Hazem, Ahmad, Sundaresh, Vishnu, Elamin, Mohammed B., Phung, Olivia J., Wang, Amy, Hoeger, Kathleen, Pasquali, Renato, Erwin, Patricia, Bodde, Amy, Montori, Victor M., Murad, M. Hassan·2013·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2013-2385

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Abstract

Context: Polycystic ovary syndrome (PCOS) is a prevalent disorder that affects women of childbearing age and may be related to obesity and insulin resistance. Objective: The purpose of this systematic review was to appraise the evidence of the impact of lifestyle modification (LSM) interventions on outcomes of women with PCOS. Data Sources: Sources included Ovid Medline, OVID Embase, OVID Cochrane Library, Web of Science, Scopus, PsycINFO, and CINAHL (up to January 2011). Study Selection: We included randomized controlled trials that enrolled woman of any age with PCOS who received LSM and compared them against women who received no intervention, minimal intervention, or metformin. Data Extraction: Two authors performed the data extraction independently. Data Synthesis: We included 9 trials enrolling 583 women with a high loss to follow-up rate, lack of blinding, and short follow-up. Compared with minimal intervention, LSM significantly reduced fasting blood glucose (weighted mean difference, −2.3 mg/dL; 95% confidence interval, −4.5 to −0.1, I2 = 72%, P = .04) and fasting blood insulin (weighted mean difference, −2.1 μU/mL, 95% confidence interval, −3.3 to −1.0, I2 = 0%, P < .001). Changes in body mass index were associated with changes in fasting blood glucose (P < .001). Metformin was not significantly better than LSM in improving blood glucose or insulin levels. We found no significant effect of LSM on pregnancy rate, and the effect on hirsutism was unclear. Conclusions: The available evidence suggests that LSM reduces fasting blood glucose and insulin levels in women with PCOS. Metformin has similar effects. Translation of these short-term effects to patient-important outcomes, beyond diabetes prevention, remains uncertain.

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Authors: Domecq, J. P., Prutsky, G., Mullan, R. J., Hazem, A., Sundaresh, V., Elamin, M. B., Phung, O. J., Wang, A., Hoeger, K., Pasquali, R., Erwin, P., Bodde, A., Montori, V. M., & Murad, M. H.
Affiliations: Henry Ford Hospital (US)
Wayne State University (US)
University of Minnesota (US)
University of North Dakota (US)
Louisiana State University Health Sciences Center Shreveport (US)
Texas Tech University (US)
Western University of Health Sciences (US)
Mayo Clinic (US)
University of Rochester Medicine (US)
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Knowledge and Evaluation Research Unit (J.P.D., G.P., R.J.M., A.W., P.E., A.B., V.M.M., M.H.M.), Rochester, Minnesota 55905
Corresponding author: Murad, M. Hassan
ORCID: Domecq, Juan Pablo
Sundaresh, Vishnu
Wang, Amy
Hoeger, Kathleen
Bodde, Amy
Murad, M. Hassan
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2013-12-01
Volume: 98
Issue: 12
Pages: 4655-4663
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2013-2385
OpenAlex: W2153353583
Cited by: 184
References: 59
Citations by year: 2026: 4 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 14 · 2020: 19 · 2019: 22 · 2018: 13 · 2017: 18 · 2016: 11 · 2015: 23 · 2014: 12 · 2013: 1
FWCI: 2.53
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords: polycystic ovary syndrome, lifestyle modification, metformin, fasting blood glucose, insulin levels, body mass index, obesity, insulin resistance, hirsutism, pregnancy rate, diabetes prevention
MeSH terms: Combined Modality Therapy, Diet, Reducing, Female, Humans, Hyperglycemia, Hyperinsulinism, Life Style, Patient Compliance, Polycystic Ovary Syndrome, Pregnancy, Exercise, Randomized Controlled Trials as Topic, Pregnancy Rate, Evidence-Based Medicine, Overweight, Lost to Follow-Up

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Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

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