A Role for GLP-1 in Treating Hyperphagia and Obesity
Open accessAbstract
Obesity is a chronic recurring disease whose prevalence has almost tripled over the past 40 years. In individuals with obesity, there is significant increased risk of morbidity and mortality, along with decreased quality of life. Increased obesity prevalence results, at least partly, from the increased global food supply that provides ubiquitous access to tasty, energy-dense foods. These hedonic foods and the nonfood cues that through association become reward predictive cues activate brain appetitive control circuits that drive hyperphagia and weight gain by enhancing food-seeking, motivation, and reward. Behavioral therapy (diet and lifestyle modifications) is the recommended initial treatment for obesity, yet it often fails to achieve meaningful weight loss. Furthermore, those who lose weight regain it over time through biological regulation. The need to effectively treat the pathophysiology of obesity thus centers on biologically based approaches such as bariatric surgery and more recently developed drug therapies. This review highlights neurobiological aspects relevant to obesity causation and treatment by emphasizing the common aspects of the feeding-inhibitory effects of multiple signals. We focus on glucagon like peptide-1 receptor (GLP-1R) signaling as a promising obesity treatment target by discussing the activation of intestinal- and brain-derived GLP-1 and GLP-1R expressing central nervous system circuits resulting from normal eating, bariatric surgery, and GLP-1R agonist drug therapy. Given the increased availability of energy-dense foods and frequent encounters with cues that drive hyperphagia, this review also describes how bariatric surgery and GLP-1R agonist therapies influence food reward and the motivational drive to overeat.
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Appetitive brain areas such as the striatum, insula, and orbitofrontal cortex that are commonly activated by viewing rewarding and energy-dense food pictures are significantly reduced by GLP-1 RA.
“Appetitive brain areas such as the striatum, insula, and orbitofrontal cortex that are commonly activated by viewing rewarding and energy-dense food pictures (13) are also significantly reduced by GLP-1 RA (14).”
From New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics (2023) · cites this paper as [14]
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GLP-1 and Its Role in Glycogen Production: A Narrative Review
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The Intricate Relationship between Circadian Rhythms and Gastrointestinal Peptides in Obesity
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Physiologic effects of the maqui berry ( Aristotelia chilensis ): a focus on metabolic homeostasis
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Post-oral sensing of fat increases food intake and attenuates body weight defense
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Pharmacological Aspects in the Management of Children and Adolescents with Prader–Willi Syndrome
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Hope in Hopeless Times: Gearing Up to Fight the Obesity Pandemic
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GLP-1 RECEPTORIŲ AGONISTŲ REIKŠMĖ 2 TIPO CUKRINIU DIABETU SERGANČIŲ PACIENČIŲ SVORIO MAŽINIMUI
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Glucagon-like peptide-1 receptor agonists and derivatives in the treatment of obesity - review
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Food Reinforcement Architecture
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Sonchus asper and Its Potential in Cosmetics—A Review
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- Authors
- Grill, H. J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Grill, Harvey J
- ORCID
- Grill, Harvey J
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2020-06-09
- Volume
- 161
- Issue
- 8
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC7899438
- OpenAlex
- W3033972450
- Cited by
- 101
- References
- 145
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 22 · 2023: 18 · 2022: 23 · 2021: 16 · 2020: 2
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucagon-like peptide-1, GLP-1 receptor, obesity, hyperphagia, food reward, appetite regulation, bariatric surgery, GLP-1 receptor agonists, energy-dense foods, food cues, weight regain
- MeSH terms
- Glucagon-Like Peptide-1 Receptor Agonists, Animals, Behavior Therapy, Eating, Humans, Hyperphagia, Obesity, Weight Loss, Receptors, Glucagon, Bariatric Surgery, Glucagon-Like Peptide 1
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