Polycystic Ovarian Syndrome: Evidence that Flutamide Restores Sensitivity of the Gonadotropin-Releasing Hormone Pulse Generator to Inhibition by Estradiol and Progesterone

The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited

Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603

Polycystic ovary syndrome: etiology, pathogenesis and diagnosis

Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.217 · Cited by 1,488

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome

Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020

Update on PCOS: consequences, challenges, and guiding treatment

Hoeger, K. M., Dokras, A., & Piltonen, T. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa839 · Cited by 610

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Hayes, M. G., Urbanek, M., Ehrmann, D. A., Armstrong, L. L., Lee, J. Y., Sisk, R., Karaderi, T., Barber, T. M., McCarthy, M. I., Franks, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8502 · Cited by 478

Treatment with Flutamide, Metformin, and Their Combination Added to a Hypocaloric Diet in Overweight-Obese Women with Polycystic Ovary Syndrome: A Randomized, 12-Month, Placebo-Controlled Study

Gambineri, A., Patton, L., Vaccina, A., Cacciari, M., Morselli-Labate, A. M., Cavazza, C., Pagotto, U., & Pasquali, R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2250 · Cited by 221

Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome

Gambineri, A., Pelusi, C., Genghini, S., Morselli‐Labate, A. M., Cacciari, M., Pagotto, U., & Pasquali, R. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01973.x · Cited by 216

The management of patients with polycystic ovary syndrome

Jayasena, C. N., & Franks, S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.102 · Cited by 196

New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins

Walters, K. A., Gilchrist, R. B., Ledger, W. L., Teede, H. J., Handelsman, D. J., & Campbell, R. E. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.08.005 · Cited by 186

Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models

Walters, K. A., Simanainen, U., & Handelsman, D. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq003 · Cited by 183

Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys

Abbott, D. H., Tarantal, A. F., & Dumesic, D. A. (2009) · American Journal of Primatology · doi:10.1002/ajp.20679 · Cited by 177

Neuroendocrine dysfunction in polycystic ovary syndrome

Burt Solorzano, C. M., Beller, J. P., Abshire, M. Y., Collins, J. S., McCartney, C. R., & Marshall, J. C. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.007 · Cited by 173

An update of genetic basis of PCOS pathogenesis

Crespo, R. P., Bachega, T. A. S. S., Mendonça, B. B., & Gomes, L. G. (2018) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000049 · Cited by 138

Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial

Banaszewska, B., Pawelczyk, L., Spaczynski, R. Z., Dziura, J., & Duleba, A. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1988 · Cited by 143

Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls

McCartney, C. R., Prendergast, K. A., Blank, S. K., Helm, K. D., Chhabra, S., & Marshall, J. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1252 · Cited by 116

Estrogenic Regulation of the GnRH Neuron

Radovick, S., Levine, J. E., & Wolfe, A. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00052 · Cited by 102

Polycystic Ovary Syndrome in Adolescence

Blank, S. K., Helm, K. D., McCartney, C. R., & Marshall, J. C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.005 · Cited by 97

Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome

Kawwass, J. F., Sanders, K. M., Loucks, T. L., Rohan, L. C., & Berga, S. L. (2017) · Human Reproduction · doi:10.1093/humrep/dex086 · Cited by 79

Current concepts of polycystic ovary syndrome pathogenesis

Rosenfield, R. L. (2020) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000945 · Cited by 77

Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys

Abbott, D. H., Rayome, B. H., Dumesic, D. A., Lewis, K. C., Edwards, A. K., Wallen, K., Wilson, M. E., Appt, S. E., & Levine, J. E. (2017) · Human Reproduction · doi:10.1093/humrep/dex036 · Cited by 66

Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: Insight from animal models

Roland, A. V., & Moenter, S. M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.002 · Cited by 57

Retention of Estradiol Negative Feedback Relationship to LH Predicts Ovulation in Response to Caloric Restriction and Weight Loss in Obese Patients with Polycystic Ovary Syndrome

van Dam, E. W. C. M., Roelfsema, F., Veldhuis, J. D., Hogendoorn, S., Westenberg, J., Helmerhorst, F. M., Frölich, M., Krans, H. M. J., Meinders, A. E., & Pijl, H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00377.2003 · Cited by 51

Luteinizing Hormone Secretion Is Not Influenced by Insulin Infusion in Women with Polycystic Ovary Syndrome Despite Improved Insulin Sensitivity during Pioglitazone Treatment

Mehta, R. V., Patel, K. S., Coffler, M. S., Dahan, M. H., Yoo, R. Y., Archer, J. S., Malcom, P. J., & Chang, R. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1040 · Cited by 47

Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome

Puttabyatappa, M., & Padmanabhan, V. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0079 · Cited by 43

What causes anovulation in polycystic ovary syndrome?

Franks, S., & Hardy, K. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.03.001 · Cited by 40

Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome

Doi, S. A. R., Al-Zaid, M., Towers, P. A., Scott, C. J., & Al-Shoumer, K. A. S. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345319 · Cited by 26

Animal models for PCOS — not the real thing

Azziz, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.57 · Cited by 21