Cited by 158Neuroendocrine regulation and behaviorMaternal and Perinatal Health InterventionsPregnancy-related medical research

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Plasma Oxytocin Concentrations in Men, Nonpregnant Women, and Pregnant Women before and during Spontaneous Labor*

LEAKE, ROSEMARY D., WEITZMAN, RICHARD E., GLATZ, THEODORE H., FISHER, DELBERT A.·1981·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-53-4-730

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Abstract

Baseline plasma oxytocin (OT) concentrations were measured in 25 healthy men, 102 nonpregnant women, and 59 pregnant women from 15-42 weeks gestation. In addition, plasma OT levels were measured at the onset, peak, and immediately after a single uterine contraction in 6 women in the latent phase and 14 women in the active phases of labor, as well as in 19 women at initial presentation of the fetal head on the perineum (+3 station) and 11 women at the time of delivery of the head during a normal vaginal delivery. Baseline plasma OT concentrations did not vary significantly among men (1.5 +/- 0.2 microunits/ml), nonpregnant women (1.4 +/- 0.2 microunits/ml), or pregnant women before labor (1.3 +/- 0.1 microunits/ml) and did not differ in an additional subgroup of 20 women receiving oral contraceptive medication (1.8 +/- 0.7 microunits/ml). In studies conducted during labor, plasma OT concentrations did not correlate with uterine pressure measurements and did not increase significantly over baseline pregnancy concentrations during the latent (1.3 +/- 0.2 microunits/ml) or active (1.6 +/- 0.2 microunits/ml) phases of labor. There was a significant increase in plasma OT levels from the time of initial visualization of the fetal head to the time of delivery of the head (1.1 +/- 0.1 to 4.2 +/- 1.1 microunits/ml, respectively; P less than 0.05). These data support the view that maternal plasma OT levels remain low during pregnancy until late in the second stage of labor.

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Authors: LEAKE, R. D., WEITZMAN, R. E., GLATZ, T. H., & FISHER, D. A.
Affiliations: University of California, Los Angeles (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1981-10
Volume: 53
Issue: 4
Pages: 730-733
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-53-4-730
OpenAlex: W1964255419
Cited by: 158
References: 22
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 5 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 1
FWCI: 8.77
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
Keywords: plasma oxytocin, labor, pregnancy, uterine contraction, second stage of labor, latent phase of labor, active phase of labor, oral contraceptives, uterine pressure, vaginal delivery, oxytocin secretion
MeSH terms: Female, Humans, Labor, Obstetric, Male, Neurophysins, Oxytocin, Pregnancy, Radioimmunoassay

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Plasma Oxytocin Concentrations in Men, Nonpregnant Women, and Pregnant Women before and during Spontaneous Labor*

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