The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study
Abstract
We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends. Of 1,709 men enrolled in 1987-1989, 1,156 were followed up 7-10 yr afterward. By repeated-measures statistical analysis, we estimated simultaneously the cross-sectional age trend of each hormone between subjects within the baseline data, the cross-sectional trend between subjects within the follow-up data, and the longitudinal trend within subjects between baseline and follow-up. Total T declined cross-sectionally at 0.8%/yr of age within the follow-up data, whereas both free and albumin-bound T declined at about 2%/yr, all significantly more steeply than within the baseline data. Sex hormone-binding globulin increased cross-sectionally at 1.6%/yr in the follow-up data, similarly to baseline. The longitudinal decline within subjects between baseline and follow-up was considerably steeper than the cross-sectional trend within measurement times for total T (1.6%/yr) and bioavailable T (2-3%/yr). Dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, and estrone showed significant longitudinal declines, whereas dihydrotestosterone, pituitary gonadotropins, and PRL rose longitudinally. Apparent good health, defined as absence of chronic illness, prescription medication, obesity, or excessive drinking, added 10-15% to the level of several androgens and attenuated the cross-sectional trends in T and LH but did not otherwise affect longitudinal or cross-sectional trends. The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is because declines in testosterone per year of age is 2–threefold greater with longitudinal compared with cross-sectional analysis of the same cohort [35, 36].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [35]
In the citing paper
“About 2% of circulating T is free (unbound), 44% is bound to sex hormone-binding globulin (SHBG), and 54% is bound to albumin and other proteins (98).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [98]
In the citing paper
“We speculate that this phenomenon may be attributed to the gradual decline in serum testosterone levels with age, commencing in men in their mid-30s and decreasing at an average annual rate of 1.6%38–43.”
From Association between serum cotinine and total testosterone in adult males based on NHANES 2011–2016 (2024) · cites this paper as [39]
In the citing paper
“Age, 11,14-17 body mass index (BMI), 12 fasting blood glucose, 1,35 triglycerides, 36 alcohol consumption 13,14 and estradiol levels, 13 which have all been reported to be associated with alteration in hormone levels, were chosen as potential confounding factors in this study.”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [16]
In the citing paper
“Probable and possible associations of several factors, including age, cigarette smoking, body mass index (BMI), alcohol consumption and physical activity with hormone levels have been reported. 11-17”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [16]
7 more claims about this paper
Create a free account to see every claim other papers make about this one.
Citations
Cites
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,341
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Self-citationLinear Mixed Models for Longitudinal Data
Verbeke, G. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2294-1_3 · Cited by 3,506
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
GRAY, A., FELDMAN, H. A., MCKINLAY, J. B., & LONGCOPE, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,118
Self-citationPrinciples of Geriatric Medicine and Gerontology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-817_6 · Cited by 1,064
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Self-citationProspective Study of Sex Hormone Levels and Risk of Prostate Cancer
Gann, P. H., Hennekens, C. H., Ma, J., Longcope, C., & Stampfer, M. J. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.16.1118 · Cited by 782
Self-citation
Cited by
Items 901–1,000 of 1,007
Dote‐Montero, M., De‐la‐O, A., Jurado‐Fasoli, L., Ruiz, J. R., Castillo, M. J., & Amaro‐Gahete, F. J. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04692-7 · Cited by 18
Chu, L., Liu, W., Deng, J. H., Wu, Y., Yang, H., Wang, W., Hussain, A., Li, N., Zhou, D., & Deng, H. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113651 · Cited by 18
Yao, M., Rosario, E. R., Soper, J. C., & Pike, C. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.034 · Cited by 20
Recent trends in the treatment of testosterone deficiency syndrome
Hong, B. S., & Ahn, T. Y. (2007) · International Journal of Urology · doi:10.1111/j.1442-2042.2007.01882.x · Cited by 17
Cachexia in chronic heart failure: endocrine determinants and treatment perspectives
Mangner, N., Matsuo, Y., Schuler, G. C., & Adams, V. (2012) · Endocrine · doi:10.1007/s12020-012-9767-z · Cited by 17
Testosterone Replacement with 1% Testosterone Gel and Priapism: No Definite Risk Relationship
Burnett, A. L. “., Kan‐Dobrosky, N., & Miller, M. G. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12059 · Cited by 17
Reproductive Endocrinology and Related Disorders
Isbell, T. S., Jungheim, E. S., & Gronowski, A. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6164-9.00056-1 · Cited by 17
Young, formidable men show greater sensitivity to facial cues of dominance
Richardson, T., Waddington, M., & Gilman, R. T. (2020) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2020.07.004 · Cited by 17
Impact of Acute Biochemical Castration on Insulin Sensitivity in Healthy Adult Men
Rabiee, A., Dwyer, A. A., Caronia, L. M., Hayes, F. J., Yialamas, M. A., Andersen, D. K., Thomas, B. J., Torriani, M., & Elahi, D. (2010) · Endocrine Research · doi:10.3109/07435801003705601 · Cited by 17
Brisson, D., Houde, G., St‐Pierre, J., Vohl, M., Mathieu, J., & Gaudet, D. (2002) · The Aging Male · doi:10.1080/tam.5.4.223.232 · Cited by 17
Testosterone and Alzheimer disease
Henderson, V. W., & Hogervorst, E. (2004) · Neurology · doi:10.1212/wnl.62.2.170 · Cited by 17
Moran, J. M., Martin, R. R., Pedrera-Canal, M., Alonso-Terron, J., Rodriguez-Velasco, F. J., & Pedrera-Zamorano, J. D. (2015) · Biological Research For Nursing · doi:10.1177/1099800414532710 · Cited by 16
Follicle-stimulating hormone: More than a marker for menopause
Spicer, J., Malaspina, D., Blank, S. V., & Goosens, K. A. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116239 · Cited by 16
Logue, D. M., Madigan, S. M., Melin, A., McDonnell, S., Delahunt, E., Heinen, M. M., & Corish, C. A. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1748116 · Cited by 18
Carto, C., Gurayah, A. A., Arbeláez, M. C. S., Grewal, M. R., Kohn, T. P., & Ramasamy, R. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad025 · Cited by 16
The Plateau in Muscle Growth with Resistance Training: An Exploration of Possible Mechanisms
Kataoka, R., Hammert, W. B., Yamada, Y., Song, J. S., Seffrin, A., Kang, A., Spitz, R. W., Wong, V. H. Y., & Loenneke, J. P. (2023) · Sports Medicine · doi:10.1007/s40279-023-01932-y · Cited by 17
Rabijewski, M., Papierska, L., Kuczerowski, R., & Piątkiewicz, P. (2015) · The Aging Male · doi:10.3109/13685538.2015.1083972 · Cited by 16
Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria
Abudu, E. K., Akanmu, S. A., Soriyan, O. O., Akinbami, A. A., Adediran, A., Adeyemo, T. A., & Okany, C. C. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-298 · Cited by 16
Total testosterone may not decline with ageing in K orean men aged 40 years or older
Kim, Y., Hong, D., Lee, D., Joo, N., & Kim, K. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04375.x · Cited by 16
Panizzon, M. S., Hauger, R. L., Eaves, L. J., Chen, C., Dale, A. M., Eyler, L. T., Fischl, B. R., Fennema‐Notestine, C., Franz, C. E., Grant, M. D., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.044 · Cited by 16
Testosterone Deficiency in Older Men: A Problem Worth Treating
Martin, C. M. (2012) · The Consultant Pharmacist · doi:10.4140/tcp.n.2012.152 · Cited by 16
DeFina, L. F., Radford, N. B., Leonard, D. S., Wilson, R. K., Cooper, T. C., Clark, S. M., Willis, B. L., Vega, G. L., Barlow, C. E., Farrell, S. W., et al. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.09.004 · Cited by 16
Nutritional Considerations in Preventing Muscle Atrophy
Creţoiu, S. M., & Zugravu, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_23 · Cited by 17
Low testosterone is associated with dysregulated eating symptoms in young adult men
Culbert, K. M., Shope, M. M., Sisk, C. L., & Klump, K. L. (2020) · International Journal of Eating Disorders · doi:10.1002/eat.23320 · Cited by 16
Njoroge, J. N., Tressel, W., Biggs, M. L., Matsumoto, A. M., Smith, N. L., Rosenberg, E. A., Hirsch, C. H., Gottdiener, J. S., Mukamal, K. J., & Kizer, J. R. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026953 · Cited by 19
Androgens and atrial fibrillation: Friends or foes?
Liu, T., Shehata, M. M., Li, G., & Wang, X. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.02.039 · Cited by 16
Zang, Z. J., Ji, S. Y., Wang, D., Zhang, Y. N., Zhang, E. H., & Zhang, B. (2014) · The Aging Male · doi:10.3109/13685538.2014.963042 · Cited by 17
The “Aging Males’ Symptoms” Scale (AMS): predictive value for lowered circulating androgens
Zengerling, F., Schrader, A. J., Cronauer, M. V., Stemann, H., Schrader, M. G., & Rinnab, L. J. (2012) · The Aging Male · doi:10.3109/13685538.2012.729232 · Cited by 16
Male menopause-time for a decent burial?
McKinlay, J. B., Travison, T. G., de Araújo, A. B., & Kupelian, V. A. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31815708ee · Cited by 16
Self-citationAlamir, M. A., Ellenberg, S. S., Swerdloff, R. S., WENGER, N. K., Mohler, E. R., Lewis, C. E., Barrett-Connor, E. L., Nakanishi, R., Darabian, S., Alani, A., et al. (2015) · Coronary Artery Disease · doi:10.1097/mca.0000000000000321 · Cited by 16
Lee, T., Pierrillas, P. B., Lin, Y., de Greef, R., Zandvliet, A. S., Schindler, E., & Migoya, E. M. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2743 · Cited by 16
Marriott, R. J., Murray, K., Budgeon, C. A., Codd, V., Hui, J., Arscott, G. M., Beilby, J. P., Hankey, G. J., Wittert, G., Wu, F. C. W., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad015 · Cited by 16
Stoodley, I. L., Berthon, B. S., Scott, H. A., Williams, E. J., Baines, P. J., Knox, H., Wood, S., Paradzayi, B., Cameron‐Smith, D., & Wood, L. G. (2024) · Nutrients · doi:10.3390/nu16091380 · Cited by 15
The influence of menopause on multiple sclerosis
Simonsen, C. S., Flemmen, H. Ø., Broch, L., Myklebust, H., Berg‐Hansen, P., Brunborg, C., & Celius, E. G. (2024) · European Journal of Neurology · doi:10.1111/ene.16566 · Cited by 15
Gonadal Hormone Changes with Aging and Their Impact on Chronic Pain
Athnaiel, O., Davidson, N., Mangat, J. S., Nasr, N. F., & Knežević, N. N. (2025) · Cells · doi:10.3390/cells14020123 · Cited by 16
The prevalence of Hypogonadism among diabetic and non-diabetic men in Jordan
Hayek, A. A., Khawaja, N. M., Khader, Y. S., Jafal, S., & Ajlouni, K. M. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.11.004 · Cited by 15
Testosterone therapy improves well being and psychological health
Akerman, J., Kovac, J. R., & Lipshultz, L. I. (2017) · Current Opinion in Urology · doi:10.1097/mou.0000000000000440 · Cited by 16
Blood Volume, Hemoglobin Mass, and Peak Oxygen Uptake in Older Adults: The Generation 100 Study
Lundgren, K. M., Aspvik, N. P., Langlo, K. A. R., Braaten, T. B., Wisløff, U., Stensvold, D., & Karlsen, T. (2021) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2021.638139 · Cited by 16
Natural Flavonoids in StAR Gene Expression and Testosterone Biosynthesis in Leydig Cell Aging
Jia, X. (2011) · InTech eBooks · doi:10.5772/16574 · Cited by 15
Halmenschlager, G., Rhoden, E. L., & Riedner, C. E. (2011) · World Journal of Urology · doi:10.1007/s00345-011-0724-x · Cited by 15
Pereira, C., Severo, M., Rafael, L., Martins, M. J., & Neves, D. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122869 · Cited by 15
Hipogonadismo masculino tardio ou andropausa
Martits, A. M., & Costa, E. M. F. (2004) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302004000400018 · Cited by 15
Dedov, I. I., Mel'nichenko, G. A., Rozhivanov, R. V., & Курбатов, Д. Г. (2015) · Problems of Endocrinology · doi:10.14341/probl201561560-71 · Cited by 16
Jastrzębska, S., Walczak-Jędrzejowska, R., Kramek, E., Marchlewska, K., Oszukowska, E., Filipiak, E., Kula, K., & Słowikowska‐Hilczer, J. (2014) · Endokrynologia Polska · doi:10.5603/ep.2014.0028 · Cited by 15
Shim, J. S., Kim, J. H., YOON, Y. S., Choi, H., Park, J. Y., & Bae, J. H. (2016) · LUTS Lower Urinary Tract Symptoms · doi:10.1111/luts.12150 · Cited by 15
Matsumoto, A. M. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.04.004 · Cited by 16
Krysiak, R. G., Gilowski, W., & Okopień, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.06.003 · Cited by 15
Akinloye, O., Popoola, B. B., Ajadi, M. B., Uchechukwu, J. G., & Oparinde, D. P. (2014) · Intern J Endocrinol Metab · doi:10.5812/ijem.10749 · Cited by 16
Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men
Yeap, B. B., Marriott, R. J., Manning, L. A., Dwivedi, G., Hankey, G. J., Wu, F. C. W., Nicholson, J. K., & Murray, K. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0104 · Cited by 16
Relationship between Serum Testosterone and Fracture Risk in Men: A Comparison of RIA and LC-MS/MS
Tran, T. S., Seibel, M. J., Eisman, J. A., Kushnir, M. M., Rockwood, A. L., & Nguyen, T. V. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.242339 · Cited by 14
Liu, P. Y., Takahashi, P. Y., Roebuck, P. D., Iranmanesh, A., & Veldhuis, J. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00138.2005 · Cited by 14
Asmail, A., Kesler, A., Kolb, H., Drory, V. E., & Karni, A. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1529669 · Cited by 14
Low Testosterone in Male Cancer Patients and Survivors
Xu, P. J., Choi, E. J., White, K. M., & Yafi, F. A. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.03.004 · Cited by 15
“Midlife crisis” on the road to successful workforce aging
Burke, V., & Grandey, A. A. (2020) · Industrial and Organizational Psychology · doi:10.1017/iop.2020.62 · Cited by 14
Aging and sex hormones in males
Decaroli, M. C., Vincentis, S. D., & Rochira, V. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.014 · Cited by 15
Silva, A. F., Carral, J. M. C., Mollinedo-Cardalda, I., Camões, M., & Bezerra, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18084053 · Cited by 14
Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
Kumari, N., Khan, A., Shaikh, U. H., Lobes, K., Kumar, D., Suman, F., Bhutto, N. S., Anees, F., Shahid, S., & Rizwan, A. (2021) · Cureus · doi:10.7759/cureus.16288 · Cited by 14
Singh, R., Nasci, V. L., Guthrie, G., Ertuğlu, L. A., Butt, M. K., Kirabo, A., & Gohar, E. Y. (2022) · Biomolecules · doi:10.3390/biom12030412 · Cited by 16
Testosterone: therapeutic or toxic for the cardiovascular health of men?
Michos, E. D., & Budoff, M. J. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00115-5 · Cited by 15
Late-onset hypogonadism among old and middle-aged males with prediabetes in Polish population
Rabijewski, M., Papierska, L., & Piątkiewicz, P. (2015) · The Aging Male · doi:10.3109/13685538.2015.1004048 · Cited by 14
The moderating impact of lifestyle factors on sex steroids, sexual activities and aging in Asian men
Goh, V. H. H., & Tong, T. Y. Y. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.121 · Cited by 14
Martin, S., Appleton, S., Adams, R., Taylor, A. W., Vincent, A. D., Brook, N. R., CATCHESIDE, P. G., Vakulin, A., McEvoy, R. D., Antic, N. A., et al. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.04.006 · Cited by 14
Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?
Jarecki, P., Herman, W. A., Pawliczak, E., & Łącka, K. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s218545 · Cited by 14
Gleicher, S., Daugherty, M., Ferry, E., & Byler, T. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02557-0 · Cited by 14
Artz, A. S., Stephens‐Shields, A. J., Bhasin, S., Ellenberg, S. S., Cohen, H. J., & Snyder, P. J. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa521 · Cited by 14
Yamaguchi, K., Ishikawa, T., Chiba, K., & Fujisawa, M. (2010) · Andrologia · doi:10.1111/j.1439-0272.2009.01015.x · Cited by 15
Dehydroepiandrosterone Treatment in the Aging Male – What Should the Urologist Know?
Saad, F., Hoesl, C. E., Oettel, M., Fauteck, J., & Römmler, A. (2005) · European Urology · doi:10.1016/j.eururo.2005.06.020 · Cited by 14
Seidl, J. N. T., & Massman, P. J. (2014) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988714541872 · Cited by 14
Male hypogonadism in the primary care clinic
Grant, N. N., & Anawalt, B. D. (2003) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(03)00091-5 · Cited by 14
Hormonal Replacement Therapy for Aging Men?The Debate Goes On
Hargreave, T. B. (2004) · European Urology · doi:10.1016/j.eururo.2004.04.003 · Cited by 14
Hormones and Cardiovascular Disease in Older Men
Yeap, B. B., & Flicker, L. A. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.12.004 · Cited by 15
Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men
Déchaud, H., Denuzière, A., Rinaldi, S., Bocquet, J., Lejeune, H., & PUGEAT, M. M. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.077362 · Cited by 14
Hypotestosteronaemia in the aging male: should we treat it?
Christe, N., & Meier, C. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14216 · Cited by 14
Demystifying the Risk Factors and Preventive Measures for Osteoporosis
Vaishya, R., Iyengar, K. P., Jain, V. K., & Vaish, A. (2023) · Indian Journal of Orthopaedics · doi:10.1007/s43465-023-00998-0 · Cited by 14
Anis, A., El-Nady, S., Amer, H. A., Elbaz, H. T., Elweza, A. E., El-Borai, N. B., & El-Ballal, S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02874-y · Cited by 13
Testosterone Deficiency Syndrome: An overview with emphasis on the diagnostic conundrum
Morales, Á. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.11.024 · Cited by 13
Men's Attraction to Women's Bodies Changes Seasonally
Pawłowski, B., & Sorokowski, P. (2008) · Perception · doi:10.1068/p5715 · Cited by 13
Liao, P.-W., Wu, C., Chen, K., Jaw, F.-S., Yu, H., Liu, S., & Ho, C. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.10.002 · Cited by 15
Low levels of serum testosterone in middle-aged men impact pathological features of prostate cancer
Llukani, E., Katz, B., Agalliu, I., Lightfoot, A. J., Yu, S.-J. S., Kathrins, M. N., Lee, Z., Su, Y.-K., Agnew, K. M., McGill, A., et al. (2017) · Prostate International · doi:10.1016/j.prnil.2016.12.003 · Cited by 13
Peng, R., & Li, Y. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s298270 · Cited by 13
The Relationship Between PSA and Total Testosterone Levels in Men with Prostate Cancer
Flores, J. M., Bernie, H. L., Miranda, E., Nascimento, B., Schofield, E., Benfante, N. E., Carlsson, S., & Mulhall, J. P. (2022) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2022.01.003 · Cited by 13
Xu, L., Zhao, Q., Li, K., Zhang, Y., Wang, C., Hind, K., Wang, L., Liu, Y., & Cheng, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.817418 · Cited by 16
Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care
Shawky, N. M., Reckelhoff, J. F., Alexander, B. T., & Cardozo, L. L. Y. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.19501 · Cited by 13
Krysiak, R. G., Gilowski, W., & Okopień, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.08.009 · Cited by 13
Wagner, M., Moritz, A., & Volk, T. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02303.x · Cited by 15
Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities
Sun, K., Liang, G.-Q., Chen, X.-F., Ping, P., Yao, W., Zhang, S., Wang, B., Sun, Y., & Li, Z. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2011.171 · Cited by 13
Testosterone is not associated with mortality in older African-American males
Cummings‐Vaughn, L. A., Malmstrom, T. K., Morley, J. E., & Miller, D. K. (2010) · The Aging Male · doi:10.3109/13685538.2010.502269 · Cited by 13
Jankowska, E. A., Tkaczyszyn, M., Kalicińska, E., Banasiak, W., & Ponikowski, P. P. (2014) · Kardiologia Polska · doi:10.5603/kp.a2014.0025 · Cited by 13
Testosterone Therapy and Prostate Cancer
Davidson, E., & Morgentaler, A. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.007 · Cited by 14
Is it andropause? Recognizing androgen deficiency in aging men
Tan, R. S., & Pu, S. (2004) · Postgraduate Medicine · doi:10.3810/pgm.2004.01.1419 · Cited by 13
Tuin, J., Sanders, J., Buhl, B. M., van Beek, A. P., & Stegeman, C. A. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4297 · Cited by 14
Rabijewski, M., Papierska, L., Kozakowski, J., & Zgliczyński, W. (2012) · The Aging Male · doi:10.3109/13685538.2012.729233 · Cited by 13
Criminal energetics: A theory of antisocial enhancement and criminal attenuation
Vaughn, M. G., & DeLisi, M. (2017) · Aggression and Violent Behavior · doi:10.1016/j.avb.2017.11.002 · Cited by 13
Gore, J. L., & Rajfer, J. (2004) · Europe PMC (PubMed Central) · Cited by 13
Experiences and treatment patterns of hypogonadal men in a U.S. health system
Shortridge, E. F., Polzer, P. K., Donga, P. Z., Blanchette, C. M., Fang, Y. H., Burudpakdee, C., & Carswell, B. M. (2014) · International Journal of Clinical Practice · doi:10.1111/ijcp.12418 · Cited by 12
Figueiredo, M. G., Gagliano‐Jucá, T., & Basaria, S. S. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.12.002 · Cited by 12
Böker, K. O., Komrakova, M., Fahrendorff, L., Spelsberg, B. R., Hoffmann, D. B., Schilling, A. F., Lehmann, W., Taudien, S., & Sehmisch, S. (2023) · Endocrine · doi:10.1007/s12020-023-03422-7 · Cited by 12
Mardomingo, C. D., Utrera, L., Baliyan, S., García‐Herranz, S., Suárez-Falcón, J. C., Rodríguez‐Fernández, R., Sampedro‐Piquero, P., Valencia, A., & Venero, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1199405 · Cited by 17
Kim, H. J., Koo, H. S., Kim, Y., Kim, M. J., Kim, K., Joo, N., & Haam, J.-H. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-016-0803-6 · Cited by 13
Eissa, M. M., Ahmed, M. M., Eldaim, M. A. A., Orabi, S. H., Elbaz, H. T., Mohamed, M. A. E.-G., Elweza, A. E., & Mousa, A. (2020) · Andrologia · doi:10.1111/and.13811 · Cited by 12
Metadata
- Authors
- Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B.
- Affiliations
- New England Research Institutes (US)
- University of Massachusetts Chan Medical School (US)
- University of Washington (US)
- Corresponding author
- McKinlay, John B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-02
- Volume
- 87
- Issue
- 2
- Pages
- 589-598
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2161057551
- Semantic Scholar
- c34a4f1c4913ce7de26805a673886cab9c442eb2
- Cited by
- 1,861
- References
- 55
- Citations by year
- 2026: 34 · 2025: 68 · 2024: 80 · 2023: 69 · 2022: 90 · 2021: 91 · 2020: 107 · 2019: 82 · 2018: 76 · 2017: 77 · 2016: 113 · 2015: 90 · 2014: 110 · 2013: 90 · 2012: 94
- FWCI
- 27.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- serum testosterone, age-related decline, middle-aged men, sex hormone-binding globulin, free testosterone, bioavailable testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, estrone, dihydrotestosterone, gonadotropins, prolactin, health status, androgens, Massachusetts Male Aging Study
- MeSH terms
- Adult, Aged, Aging, Cross-Sectional Studies, Hormones, Humans, Longitudinal Studies, Male, Middle Aged, Random Allocation, Reference Values, Testosterone, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
