The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study
Abstract
We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends. Of 1,709 men enrolled in 1987-1989, 1,156 were followed up 7-10 yr afterward. By repeated-measures statistical analysis, we estimated simultaneously the cross-sectional age trend of each hormone between subjects within the baseline data, the cross-sectional trend between subjects within the follow-up data, and the longitudinal trend within subjects between baseline and follow-up. Total T declined cross-sectionally at 0.8%/yr of age within the follow-up data, whereas both free and albumin-bound T declined at about 2%/yr, all significantly more steeply than within the baseline data. Sex hormone-binding globulin increased cross-sectionally at 1.6%/yr in the follow-up data, similarly to baseline. The longitudinal decline within subjects between baseline and follow-up was considerably steeper than the cross-sectional trend within measurement times for total T (1.6%/yr) and bioavailable T (2-3%/yr). Dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, and estrone showed significant longitudinal declines, whereas dihydrotestosterone, pituitary gonadotropins, and PRL rose longitudinally. Apparent good health, defined as absence of chronic illness, prescription medication, obesity, or excessive drinking, added 10-15% to the level of several androgens and attenuated the cross-sectional trends in T and LH but did not otherwise affect longitudinal or cross-sectional trends. The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is because declines in testosterone per year of age is 2–threefold greater with longitudinal compared with cross-sectional analysis of the same cohort [35, 36].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [35]
In the citing paper
“About 2% of circulating T is free (unbound), 44% is bound to sex hormone-binding globulin (SHBG), and 54% is bound to albumin and other proteins (98).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [98]
In the citing paper
“We speculate that this phenomenon may be attributed to the gradual decline in serum testosterone levels with age, commencing in men in their mid-30s and decreasing at an average annual rate of 1.6%38–43.”
From Association between serum cotinine and total testosterone in adult males based on NHANES 2011–2016 (2024) · cites this paper as [39]
In the citing paper
“Age, 11,14-17 body mass index (BMI), 12 fasting blood glucose, 1,35 triglycerides, 36 alcohol consumption 13,14 and estradiol levels, 13 which have all been reported to be associated with alteration in hormone levels, were chosen as potential confounding factors in this study.”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [16]
In the citing paper
“Probable and possible associations of several factors, including age, cigarette smoking, body mass index (BMI), alcohol consumption and physical activity with hormone levels have been reported. 11-17”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [16]
7 more claims about this paper
Create a free account to see every claim other papers make about this one.
Citations
Cites
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,341
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Self-citationLinear Mixed Models for Longitudinal Data
Verbeke, G. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2294-1_3 · Cited by 3,506
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
GRAY, A., FELDMAN, H. A., MCKINLAY, J. B., & LONGCOPE, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,118
Self-citationPrinciples of Geriatric Medicine and Gerontology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-817_6 · Cited by 1,064
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Self-citationProspective Study of Sex Hormone Levels and Risk of Prostate Cancer
Gann, P. H., Hennekens, C. H., Ma, J., Longcope, C., & Stampfer, M. J. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.16.1118 · Cited by 782
Self-citation
Cited by
Items 101–200 of 1,007
Sex Differences in Alzheimer’s Disease
Aggarwal, N. T., & Mielke, M. M. (2023) · Neurologic Clinics · doi:10.1016/j.ncl.2023.01.001 · Cited by 185
Comparison of screening questionnaires for the diagnosis of hypogonadism
Morley, J. E., Perry, H. M., Kevorkian, R. T., & Patrick, P. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.07.004 · Cited by 168
Aging of the human ovary and testis
Perheentupa, A. H., & Huhtaniemi, I. T. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.004 · Cited by 172
Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample
Hall, S. A., Esche, G. R., Araujo, A. B., Travison, T. G., Clark, R. V., Williams, R. E., & McKinlay, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0021 · Cited by 167
Self-citationPrognostic factors in paediatric anaplastic large cell lymphoma role of ALK
Woessmann, W. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/434 · Cited by 167
Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures
Rubio-Ruiz, M. E., Guarner‐Lans, V., Pérez-Torres, I., & Soto, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030647 · Cited by 176
Endocrinology of the Aging Prostate: Current Concepts
Cannarella, R., Condorelli, R. A., Barbagallo, F., Vignera, S. L., & Calogero, A. E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.554078 · Cited by 176
Anorexia and Weight Loss in Older Persons
Morley, J. E. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.2.m131 · Cited by 167
Longitudinal changes in testosterone over five years in community-dwelling men
Shi, Z., Araujo, A. B., Martin, S., O'Loughlin, P., & Wittert, G. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3842 · Cited by 165
Lateef, O. M., & Akintubosun, M. O. (2020) · Journal of Circadian Rhythms · doi:10.5334/jcr.190 · Cited by 179
FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca 2+ /CREB pathway
Liu, X., Chan, H. C., Ding, G., Cai, J., Song, Y., Wang, T., Zhang, D., Chen, H., Yu, M. K., Wu, Y., et al. (2015) · Aging Cell · doi:10.1111/acel.12331 · Cited by 164
Mohr, B. A., Bhasin, S., Link, C. L., O’Donnell, A. B., & McKinlay, J. B. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02241 · Cited by 163
Self-citationTestosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels
Cunningham, G. R., Stephens-Shields, A. J., Rosen, R. C., Wang, C., Bhasin, S., Matsumoto, A. M., Parsons, J. K., Gill, T. M., Molitch, M. E., Farrar, J. T., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1645 · Cited by 162
The European Male Ageing Study (EMAS): design, methods and recruitment
Lee, D. M., O’Neill, T. W., Pye, S. R., Silman, A. J., Finn, J. D., Pendleton, N., Tajar, A., Bártfai, G., Casanueva, F. F., Forti, G., et al. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00879.x · Cited by 163
Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.19 · Cited by 160
Barrett-Connor, E., Dam, T.-T., Stone, K., Harrison, S. L., Redline, S., Orwoll, E., & for the Osteoporotic Fractures in Men Study Group (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2622 · Cited by 158
Almeida, O. P., Yeap, B. B., Hankey, G. J., Jamrozik, K., & Flicker, L. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.33 · Cited by 158
The association of testosterone, sleep, and sexual function in men and women
Andersen, M. L., Alvarenga, T. A., Mazaro‐Costa, R., Hachul, H., & Tufik, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.060 · Cited by 162
Yeap, B. B., Alfonso, H., Chubb, S. A. P., Handelsman, D. J., Hankey, G. J., Norman, P. E., & Flicker, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2265 · Cited by 155
Bowen, R. L., & Atwood, C. (2004) · Gerontology · doi:10.1159/000079125 · Cited by 164
Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154
Sex differences in sleep, circadian rhythms, and metabolism: Implications for precision medicine
Lok, R., Qian, J., & Chellappa, S. L. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.101926 · Cited by 175
Krasnoff, J. B., Basaria, S., Pencina, M. J., Jasuja, G. K., Vasan, R. S., Ulloor, J., Zhang, A., Coviello, A., Kelly-Hayes, M., D'Agostino, R. B., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2680 · Cited by 152
Self-citationPhysical Exercise in the Oldest Old
Valenzuela, P. L., Castillo‐García, A., Morales, J. S., Izquierdo, M., Serra‐Rexach, J. A., Santos‐Lozano, A., & Lucia, A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c190002 · Cited by 152
Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.001 · Cited by 166
Ding, J., & Sullivan, D. A. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.020 · Cited by 157
Testosterone and Bone Health in Men: A Narrative Review
Shigehara, K., Izumi, K., Kadono, Y., & Mizokami, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030530 · Cited by 161
Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels
Leder, B. Z., Rohrer, J. L., Rubin, S. D., Gallo, J., & Longcope, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031467 · Cited by 149
Self-citationImpact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring
Kaltsas, A., Moustakli, E., Zikopoulos, A., Georgiou, I. A., Dimitriadis, F., Symeonidis, E. N., Markou, E., Michaelidis, T. M., Tien, D. M. B., Giannakis, I., et al. (2023) · Genes · doi:10.3390/genes14020486 · Cited by 163
Kelsey, T., Li, L. Q., Mitchell, R. T., Whelan, A. D., Anderson, R. A., & Wallace, W. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109346 · Cited by 149
Dekkers, T. J., van Rentergem, J. A. A., Meijer, B., Popma, A., Wagemaker, E., & Huizenga, H. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.004 · Cited by 153
Aging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 152
Liu, P. Y., Swerdloff, R. S., & Veldhuis, J. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0807 · Cited by 143
(2008) · PubMed · Cited by 142
Aging and sex hormones in males
Decaroli, M. C., & Rochira, V. (2016) · Virulence · doi:10.1080/21505594.2016.1259053 · Cited by 151
Kupelian, V. A., Hayes, F. J., Link, C. L., Rosen, R. C., & McKinlay, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0054 · Cited by 140
Self-citationPosition Stand on Androgen and Human Growth Hormone Use
Hoffman, J. R., Kraemer, W. J., Bhasin, S., Storer, T. W., Ratamess, N. A., Haff, G. G., Willoughby, D. S., & Rogol, A. D. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31819df2e6 · Cited by 143
Evidence-Based Guideline for the management of osteoporosis in men
Fuggle, N. R., Beaudart, C., Bruyère, O., Abrahamsen, B., Al‐Daghri, N. M., Burlet, N., Chandran, M., Rosa, M. M., Cortet, B., Demonceau, C., et al. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01094-9 · Cited by 151
Yeap, B. B., Grossmann, M., McLachlan, R. I., Handelsman, D. J., Wittert, G. A., Conway, A. J., Stuckey, B. G., Lording, D. W., Allan, C. A., Zajac, J. D., et al. (2016) · Medical Journal of Australia · doi:10.5694/mja16.00393 · Cited by 135
The Influence of Sex Hormones in Liver Function and Disease
Kasarinaite, A., Sinton, M. C., Saunders, P. T. K., & Hay, D. C. (2023) · Cells · doi:10.3390/cells12121604 · Cited by 145
Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk
Joseph, C., Kenny, R. A., Taxel, P., Lorenzo, J., Duque, G., & Kuchel, G. A. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.01.004 · Cited by 137
Szulc, P., Claustrat, B., Marchand, F., & Delmas, P. D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030200 · Cited by 136
Erectile Dysfunction and Hypogonadism among Men with HIV
Crum‐Cianflone, N. F., Bavaro, M. F., Hale, B., Amling, C. L., Truett, A. A., Brandt, C., Pope, B., Furtek, K. J., Medina, S., & Wallace, M. R. (2007) · AIDS Patient Care and STDs · doi:10.1089/apc.2006.0071 · Cited by 136
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
van Anders, S. M., & Goldey, K. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.08.005 · Cited by 132
Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Park, M., & Choi, K. M. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155577 · Cited by 145
Androgen cell signaling pathways involved in neuroprotective actions
Pike, C. J., Nguyen, T. V., Ramsden, M., Yao, M., Murphy, M. P., & Rosario, E. R. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.006 · Cited by 132
Ostrowski, J., Kuhns, J. E., Lupisella, J. A., Manfredi, M. C., Beehler, B. C., Krystek, S. R., Bi, Y., Sun, C., Seethala, R., Golla, R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0843 · Cited by 133
The Encultured Brain: An Introduction to Neuroanthropology
Lende, D. H., & Downey, G. (2012) · Project Muse (Johns Hopkins University) · Cited by 130
Sex differences in age-related changes in the sleep-wake cycle
Carrier, J., Semba, K., Deurveilher, S., Drogos, L. L., Cyr-Cronier, J., Lord, C., & Sekerovick, Z. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.004 · Cited by 139
Fonda, S. J., Bertrand, R., O'Donnell, A., Longcope, C., & McKinlay, J. B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.385 · Cited by 129
Self-citationYeap, B. B., Chubb, S. A. P., Hyde, Z., Jamrozik, K., Hankey, G. J., Flicker, L., & Norman, P. E. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0348 · Cited by 128
Testosterone for the aging male; current evidence and recommended practice
Jones, H. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s190 · Cited by 204
Age‐related changes in testosterone and the role of replacement therapy in older men
Allan, C. A., & McLachlan, R. I. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02002.x · Cited by 129
Serum androgen levels in black, Hispanic, and white men
Litman, H. J., Bhasin, S., Link, C. L., Araujo, A. B., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0037 · Cited by 127
Self-citationTranslocator protein-mediated pharmacology of cholesterol transport and steroidogenesis
Papadopoulos, V., Aghazadeh, Y., Fan, J., Campioli, E., Zirkin, B. R., & Midzak, A. S. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.03.014 · Cited by 142
The relationship between sarcopenia and fragility fracture—a systematic review
Wong, R. M. Y., Wong, H., Zhang, N., Chow, S. K., Chau, W., Wang, J., Chim, Y. N., Leung, K., & Cheung, W. (2019) · Osteoporosis International · doi:10.1007/s00198-018-04828-0 · Cited by 132
Yeap, B. B., Almeida, O. P., Hyde, Z., Norman, P. E., Chubb, S. A. P., Jamrozik, K. D., & Flicker, L. A. (2007) · European Journal of Endocrinology · doi:10.1530/eje-06-0714 · Cited by 129
Mortality Risk in Older Men Associated with Changes in Weight, Lean Mass, and Fat Mass
Lee, C. G., Boyko, E. J., Nielson, C. M., Stefanick, M. L., Bauer, D. C., Hoffman, A. R., Dam, T.-T. L., Lapidus, J., Cawthon, P. M., Ensrud, K. E., et al. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03245.x · Cited by 127
Luboshitzky, R., Lavie, L., Shen‐Orr, Z., & Herer, P. (2005) · Obesity Research · doi:10.1038/oby.2005.88 · Cited by 126
Age-specific population centiles for androgen status in men
Handelsman, D. J., Yeap, B. B., Flicker, L. A., Martin, S., Wittert, G., & Ly, L. P. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0380 · Cited by 127
Rovira‐Llopis, S., Bañuls, C., Marañón, A., Díaz‐Morales, N., Jover, A., Garzón, S., Rocha, M., Víctor, V. M., & Hernández‐Mijares, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.029 · Cited by 123
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 130
The health of normally aging men: The Massachusetts Male Aging Study (1987–2004)
O’Donnell, A. B., de Araújo, A. B., & McKinlay, J. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.03.023 · Cited by 124
Self-citationSex-Steroid Imbalance in Females and Dry Eye
Versura, P., Giannaccare, G., & Campos, E. C. (2014) · Current Eye Research · doi:10.3109/02713683.2014.966847 · Cited by 125
The Role of Testosterone in the Elderly: What Do We Know?
Barone, B., Napolitano, L., Abate, M., Cirillo, L., Reccia, P., Passaro, F., Turco, C., Morra, S., Mastrangelo, F., Scarpato, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073535 · Cited by 131
Hypogonadism in Hereditary Hemochromatosis
McDermott, J. H., & Walsh, C. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0980 · Cited by 119
Androgen Replacement Therapy: Present and Future
Gooren, L. J., & Bunck, M. C. M. (2004) · Drugs · doi:10.2165/00003495-200464170-00002 · Cited by 119
Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117
Ng, K., Donat, R., Chan, L., Lalak, A., Pierro, I. D., & Handelsman, D. J. (2004) · Human Reproduction · doi:10.1093/humrep/deh315 · Cited by 117
Exercise and the Aging Brain: Considerations for Sex Differences
Barha, C. K., & Liu-Ambrose, T. Y. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180067 · Cited by 129
Vagnerova, K., Koerner, I. P., & Hurn, P. D. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31817326a5 · Cited by 120
Testosterone Supplementation for Aging-Associated Sarcopenia
Bhasin, S. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.11.m1002 · Cited by 115
Sleep regulation and sex hormones exposure in men and women across adulthood
Lord, C., Sekerovic, Z., & Carrier, J. (2014) · Pathologie Biologie · doi:10.1016/j.patbio.2014.07.005 · Cited by 115
Testosterone and ill-health in aging men
Yeap, B. B. (2009) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1050 · Cited by 112
Why Is Androgen Replacement in Males Controversial?
Cunningham, G. R., & Toma, S. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0266 · Cited by 111
Corrales, J. J., Almeida, M., Burgo, R., Mories, M. T., Miralles, J. M., & Orfao, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06779 · Cited by 110
Lopresti, A. L., Drummond, P. D., & Smith, S. J. (2019) · American Journal of Men s Health · doi:10.1177/1557988319835985 · Cited by 118
Henriques, T. A., Zhang, X., Yiannikouris, F. B., Daugherty, A., & Cassis, L. A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160382 · Cited by 110
Leung, L., Andrews-Zwilling, Y., Yoon, S. Y., Jain, S., Ring, K., Dai, J., Wang, M. M., Tong, L., Walker, D., & Huang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053569 · Cited by 109
Chubb, S. A. P., Hyde, Z., Almeida, O. P., Flicker, L. A., Norman, P. E., Jamrozik, K. D., Hankey, G. J., & Yeap, B. B. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0893 · Cited by 110
Aging and pathogenesis of erectile dysfunction
Corona, G., Mannucci, E., Mansani, R., Petrone, L., Bartolini, M., Giommi, R., Mancini, M., Forti, G., & Maggi, M. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901225 · Cited by 109
Lunenfeld, B., Saad, F., & Hoesl, C. E. (2005) · The Aging Male · doi:10.1080/13685530500163416 · Cited by 109
Predictors of anterior pituitary insufficiency after traumatic brain injury
Schneider, M., Schneider, H. J., Yassouridis, A., Saller, B., Von Rosen, F., & Stalla, G. K. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03020.x · Cited by 107
Alzheimer, mitochondria and gender
Grimm, A., Mensah‐Nyagan, A. G., & Eckert, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.012 · Cited by 112
Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology
Rochira, V., Balestrieri, A., Madeo, B., Zirilli, L., Granata, A. R. M., & Carani, C. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02088 · Cited by 107
Sex hormones and skeletal muscle weakness
Sipilä, S., Narici, M., Kjaer, M., Pöllänen, E., Atkinson, R. A., Hansen, M., & Kovanen, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9425-8 · Cited by 106
Lehert, P., Villaseca, P., Hogervorst, E., Maki, P. M., & Henderson, V. W. (2015) · Climacteric · doi:10.3109/13697137.2015.1078106 · Cited by 114
Aging of the endocrine system and its potential impact on sarcopenia
Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 111
Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review
Shabsigh, R., Crawford, E. D., Nehra, A. X., & Slawin, K. M. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.31 · Cited by 107
Andropause: is androgen replacement therapy indicated for the aging male?
Hijazi, R. A., & Cunningham, G. R. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104518 · Cited by 105
Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
Reckelhoff, J. F., Yanes, L. L., Iliescu, R., Fortepiani, L. A., & Granger, J. P. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00034.2005 · Cited by 107
The Effects of Pharmacologically Induced Hypogonadism on Mood in HealthyMen
Schmidt, P. J., Berlin, K., Danaceau, M. A., Neeren, A. M., Haq, N., Roca, C. A., & Rubinow, D. R. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.997 · Cited by 108
Amanatkar, H. R., Chibnall, J. T., Seo, B.-W., Manepalli, J. N., & Grossberg, G. T. (2014) · Annals of Clinical Psychiatry · doi:10.1177/104012371402600103 · Cited by 107
Grimm, A., Biliouris, E. E., Lang, U. E., Götz, J., Mensah‐Nyagan, A. G., & Eckert, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1988-x · Cited by 110
Cheung, K. K. T., Luk, A. O. Y., So, W. Y., Ronald, C. W., Kong, A. P. S., Chow, F. C. C., & Chan, J. C. N. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12288 · Cited by 106
A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men
Park, S., Ham, J.-O., & Lee, B.-K. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.09.016 · Cited by 104
Nilsson, M. I., Mikhail, A., Lan, L., Di Carlo, A., Hamilton, B., Barnard, K., Hettinga, B. P., Hatcher, E., Tarnopolsky, M. G., Nederveen, J. P., et al. (2020) · Nutrients · doi:10.3390/nu12082391 · Cited by 94
Risk of Nonspine Fractures in Older Adults with Sarcopenia, Low Bone Mass, or Both
Chalhoub, D., Cawthon, P. M., Ensrud, K. E., Stefanick, M. L., Kado, D. M., Boudreau, R. M., Greenspan, S. L., Newman, A. B., Zmuda, J. M., ORWOLL, E. S., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13605 · Cited by 104
Life history context of reproductive aging in a wild primate model
Jeanne Altmann, A., Gesquiere, L. R., Galbany, J., Onyango, P. O., & Alberts, S. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05531.x · Cited by 106
Metadata
- Authors
- Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B.
- Affiliations
- New England Research Institutes (US)
- University of Massachusetts Chan Medical School (US)
- University of Washington (US)
- Corresponding author
- McKinlay, John B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-02
- Volume
- 87
- Issue
- 2
- Pages
- 589-598
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2161057551
- Semantic Scholar
- c34a4f1c4913ce7de26805a673886cab9c442eb2
- Cited by
- 1,861
- References
- 55
- Citations by year
- 2026: 34 · 2025: 68 · 2024: 80 · 2023: 69 · 2022: 90 · 2021: 91 · 2020: 107 · 2019: 82 · 2018: 76 · 2017: 77 · 2016: 113 · 2015: 90 · 2014: 110 · 2013: 90 · 2012: 94
- FWCI
- 27.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- serum testosterone, age-related decline, middle-aged men, sex hormone-binding globulin, free testosterone, bioavailable testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, estrone, dihydrotestosterone, gonadotropins, prolactin, health status, androgens, Massachusetts Male Aging Study
- MeSH terms
- Adult, Aged, Aging, Cross-Sectional Studies, Hormones, Humans, Longitudinal Studies, Male, Middle Aged, Random Allocation, Reference Values, Testosterone, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
