Cited by 1,861Hormonal and reproductive studiesSperm and Testicular FunctionHypothalamic control of reproductive hormones

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Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

Feldman, Henry A., Longcope, Christopher, Derby, Carol A., Johannes, Catherine B., Araujo, Andre B., Coviello, Andrea D., Bremner, William J., McKinlay, John B.·2002·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.87.2.8201

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Abstract

We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends. Of 1,709 men enrolled in 1987-1989, 1,156 were followed up 7-10 yr afterward. By repeated-measures statistical analysis, we estimated simultaneously the cross-sectional age trend of each hormone between subjects within the baseline data, the cross-sectional trend between subjects within the follow-up data, and the longitudinal trend within subjects between baseline and follow-up. Total T declined cross-sectionally at 0.8%/yr of age within the follow-up data, whereas both free and albumin-bound T declined at about 2%/yr, all significantly more steeply than within the baseline data. Sex hormone-binding globulin increased cross-sectionally at 1.6%/yr in the follow-up data, similarly to baseline. The longitudinal decline within subjects between baseline and follow-up was considerably steeper than the cross-sectional trend within measurement times for total T (1.6%/yr) and bioavailable T (2-3%/yr). Dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, and estrone showed significant longitudinal declines, whereas dihydrotestosterone, pituitary gonadotropins, and PRL rose longitudinally. Apparent good health, defined as absence of chronic illness, prescription medication, obesity, or excessive drinking, added 10-15% to the level of several androgens and attenuated the cross-sectional trends in T and LH but did not otherwise affect longitudinal or cross-sectional trends. The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.

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Authors: Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B.
Affiliations: New England Research Institutes (US)
University of Massachusetts Chan Medical School (US)
University of Washington (US)
Corresponding author: McKinlay, John B.
ORCID: Feldman, Henry A.
Derby, Carol A.
Johannes, Catherine B.
Coviello, Andrea D.
Bremner, William J.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2002-02
Volume: 87
Issue: 2
Pages: 589-598
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.87.2.8201
OpenAlex: W2161057551
Semantic Scholar: c34a4f1c4913ce7de26805a673886cab9c442eb2
Cited by: 1,861
References: 55
Citations by year: 2026: 34 · 2025: 68 · 2024: 80 · 2023: 69 · 2022: 90 · 2021: 91 · 2020: 107 · 2019: 82 · 2018: 76 · 2017: 77 · 2016: 113 · 2015: 90 · 2014: 110 · 2013: 90 · 2012: 94
FWCI: 27.91
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: serum testosterone, age-related decline, middle-aged men, sex hormone-binding globulin, free testosterone, bioavailable testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, estrone, dihydrotestosterone, gonadotropins, prolactin, health status, androgens, Massachusetts Male Aging Study
MeSH terms: Adult, Aged, Aging, Cross-Sectional Studies, Hormones, Humans, Longitudinal Studies, Male, Middle Aged, Random Allocation, Reference Values, Testosterone, Cohort Studies

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Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

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