Structural brain abnormalities in multiple sclerosis patients with major depression
Abstract
Objective To assess the association between major depression and structural brain abnormalities in patients with multiple sclerosis (MS). Methods Two groups of patients with clinically definite MS were studied: 21 with Diagnostic and Statistical Manual of Mental Disorders (4th ed.)-defined major depression and 19 without. The groups did not differ on demographic, disease, or cognitive measures. All subjects underwent brain MRI. Tissue segmentation and regional brain masking were applied to the MRI data. Results Compared with the euthymic subjects, those with major depression had a greater T2-weighted lesion volume (p = 0.003) and more extensive T1-weighted lesion volume in the left medial inferior prefrontal cortex (p = 0.01) and less gray matter volume (p = 0.01) and more CSF volume in the left anterior temporal region (p = 0.005). A logistic regression analysis identified two independent predictors of depression: left medial inferior prefrontal cortex T2 lesion volume and left anterior temporal CSF volume. These variables accounted for 42% of the depression variance score. Conclusion Whereas both lesion burden and atrophy are important in the pathogenesis of depression in MS, psychosocial influences should also be considered.
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In one study, positive effects of therapy are maintained at least 6 months after the intervention; in another, therapy affects not only mood but also treatment adherence.
“Dans l'une de ces études [39], les effets positifs de la thérapie sont maintenus au moins 6 mois après l'intervention tandis que dans une autre la thérapie se répercute non seulement sur l'humeur mais aussi sur l'adhérence au traitement [41].”
From Prise en charge des troubles anxieux dans le cadre d'atteintes neurologiques (2004) · cites this paper as [39]
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Feinstein, A., DeLuca, J., Baune, B., Filippi, M., & Lassman, H. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2012.08.001 · Cited by 68 · see citing works
“The presence and extent of T2 lesion in selected WM regions (prefrontal cortex, temporal lobe, arcuate fasciculus) have been associated with depression (Feinstein et al., 2004; Pujol et al., 1997; Berg et al., 2000).”
BackgroundSelf-citationCarone, D., Benedict, R., Dwyer, M., Cookfair, D., Srinivasaraghavan, B., Tjoa, C., & Zivadinov, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.053 · Cited by 67 · see citing works
Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis
Gobbi, C., Rocca, M. A., Pagani, E., Riccitelli, G. C., Pravatà, E., Radaelli, M., Boneschi, F. M., Falini, A., Copetti, M., Comı, G., et al. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514530022 · Cited by 66 · see citing works
The risk of Bipolar Disorders in Multiple Sclerosis.
Carta, M., Moro, M., Lorefice, L., Trincas, G., Cocco, E., del Giudice, E., Fenu, G., Colom, F., & Marrosu, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.008 · Cited by 66 · see citing works
“Neuroimaging data have revealed an association between depressive symptoms and structural and functional brain abnormalities, suggesting that the demyelination process may have a causal role in depression (Bakshi et al., 2000; Feinstein et al., 2004).”
BackgroundGold, S. M., O'Connor, M., Gill, R., Kern, K. C., Shi, Y.-G., Henry, R. G., Pelletier, D., Mohr, D. C., & Sicotte, N. (2012) · Human Brain Mapping · doi:10.1002/hbm.22154 · Cited by 66 · see citing works
“Several papers have reported associations between MS-associated depression and decreased regional gray matter volumes, in particular in the temporal lobe [Feinstein et al., 2004; Zorzon et al., 2001, 2002].”
BackgroundMorris, G., Reiche, E. M. V., Murru, A., Carvalho, A. F., Maes, M. H. J., Berk, M., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0843-5 · Cited by 74 · see citing works
Fox, R., Coffey, C., Cudkowicz, M., Gleason, T. L., Goodman, A., Klawiter, E., Matsuda, K., McGovern, M. M., Conwit, R., Naismith, R., et al. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.08.009 · Cited by 64 · see citing works
Depressive syndromes in neurological disorders
Hellmann‐Regen, J., Piber, D., Hinkelmann, K., Gold, S. M., Heesen, C., Spitzer, C., Endres, M., & Otte, C. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0448-6 · Cited by 64 · see citing works
“While the location of lesions in depressed MS patients did not reveal any consistent topological patterns with an effect on mood [12, 13, 46, 163, 164], there appears to be a more robust association of MSrelated depression with regional cortical atrophy in the frontal and temporal lobe [46, 163, 164].”
Depression in neurological disorders: an update
Rickards, H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218601.17722.5b · Cited by 62 · see citing works
Nigro, S. L., Passamonti, L., Riccelli, R., Toschi, N., Rocca, F., Valentino, P., Nisticò, R., Fera, F. S., & Quattrone, A. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514558474 · Cited by 61 · see citing works
Shifting imaging targets in multiple sclerosis: From inflammation to neurodegeneration
Vigeveno, R. M., Wiebenga, O. T., Wattjes, M. P., Geurts, J. J. G., & Barkhof, F. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23578 · Cited by 55 · see citing works
Pathogenic mechanisms of depression in multiple sclerosis.
Vattakatuchery, J. J., Rickards, H., & Cavanna, A. (2011) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.23.3.261 · Cited by 59
Kiy, G., Lehmann, P., Hahn, H., Eling, P., Kastrup, A., & Hildebrandt, H. (2011) · Multiple Sclerosis · doi:10.1177/1352458511403530 · Cited by 57 · see citing works
“Similarly, Feinstein et al.17 found high lesion volume in the frontal lobe and the left anterior temporal lobe in depressed MS patients, compared with non-depressed patients.”
ResultMemory performance in multiple sclerosis patients correlates with central brain atrophy
Hildebrandt, H., Hahn, H. K., Kraus, J., Schulte-Herbrüggen, A., Schwarze, B., & Schwendemann, G. (2006) · Multiple Sclerosis · doi:10.1191/1352458506ms1286oa · Cited by 57 · see citing works
“As for cognitive functions, it may be possible that the investigation between regional brain atrophy and mood would yield more promising results [1,61].”
BackgroundDepressive Symptoms in Machado-Joseph Disease (SCA3) Patients and Their Relatives
Cecchin, C. R., Pires, A. P., Rieder, C., Monte, T., Silveira, I., Carvalho, T., Saraiva-Pereira, M., Sequeiros, J., & Jardim, L. (2006) · Public Health Genomics · doi:10.1159/000096276 · Cited by 56 · see citing works
Cortical atrophy and personality in multiple sclerosis.
Benedict, R., Hussein, S., Englert, J., Dwyer, M., Abdelrahman, N., Cox, J., Munschauer, F., Weinstock-Guttman, B., & Zivadinov, R. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.4.432 · Cited by 55 · see citing works
Lebedev, A. V., Beyer, M., Fritze, F., Westman, E., Ballard, C., & Aarsland, D. (2014) · The American journal of geriatric psychiatry · doi:10.1016/j.jagp.2013.02.004 · Cited by 54 · see citing works
Fatigue, Depression, and Anxiety Among Ambulating Multiple Sclerosis Patients
AlSaeed, S., Aljouee, T., Alkhawajah, N. M., Alarieh, R., AlGarni, H., Aljarallah, S., Ayyash, M., & Abu-Shaheen, A. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844461 · Cited by 53 · see citing works
Psychiatric disorders in multiple sclerosis
Sparaco, M., Lavorgna, L., & Bonavita, S. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09426-6 · Cited by 79 · see citing works
Relationships Between Multiple Sclerosis and Depression
Byatt, N., Rothschild, A. J., Riskind, P., Ionete, C., & Hunt, A. T. (2011) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.23.2.jnp198 · Cited by 51 · see citing works
“Our study also replicates the association between depression and cerebral atrophy in MS patients noted by previous authors.(10)”
BackgroundResultMental Health Comorbidity in MS: Depression, Anxiety, and Bipolar Disorder
Turner, A., Alschuler, K., Hughes, A., Beier, M., Haselkorn, J., Sloan, A., & Ehde, D. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0706-x · Cited by 49 · see citing works
Factors associated with emotional and behavioral outcomes in adolescents with multiple sclerosis
Till, C., Udler, E., Ghassemi, R., Narayanan, S., Arnold, D., & Banwell, B. L. (2012) · Multiple Sclerosis · doi:10.1177/1352458511433918 · Cited by 49 · see citing works
Psychotic features associated with multiple sclerosis
Kosmidis, M., Giannakou, M., Messinis, L., & Papathanasopoulos, P. (2010) · International Review of Psychiatry · doi:10.3109/09540261003589612 · Cited by 48 · see citing works
Fronto-limbic disconnection in patients with multiple sclerosis and depression
van Geest, Q., Boeschoten, R., Keijzer, M. J., Steenwijk, M., Pouwels, P., Twisk, J., Smit, J., Uitdehaag, B., Geurts, J., van Oppen, P., et al. (2018) · Multiple Sclerosis · doi:10.1177/1352458518767051 · Cited by 46 · see citing works
In multiple sclerosis anxiety, not depression, is related to gender
Théaudin, M., Romero, K., & Feinstein, A. (2016) · Multiple Sclerosis · doi:10.1177/1352458515588582 · Cited by 46 · see citing works
Self-citationMarkianos, M., Koutsis, G., Evangelopoulos, M., Mandellos, D., Karahalios, G., & Sfagos, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05750.x · Cited by 46 · see citing works
“1996), while lesion volume in specific areas seems to be connected with depressive symptomatology (Feinstein et al. 2004).”
BackgroundReview: Brain—immune communication psychoneuroimmunology of multiple sclerosis
Kern, S., & Ziemssen, T. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458507079657 · Cited by 45 · see citing works
“An alternative explanation comes from neuroimaging data showing that brain lesions in frontal regions and reduced temporal lobe volume have been positively associated with depressive symptoms [197,198].”
BackgroundBakshi, R., Hutton, G. J., Miller, J. R., & Radue, E. (2004) · Neurology · doi:10.1212/wnl.63.11_suppl_5.s3 · Cited by 44 · see citing works
Socioeconomic Trends in Hospitalization for Multiple Sclerosis
Lad, S., Chapman, C. H., Vaninetti, M., Steinman, L., Green, A., & Boakye, M. (2010) · Neuroepidemiology · doi:10.1159/000310301 · Cited by 42
Monté, G. C., Falcón, C., Pomarol‐Clotet, E., & Ashburner, J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.065 · Cited by 43 · see citing works
“A number of authors have suggested that pattern recognition could aid in clinical decision-making and treat-ment development (Feinstein et al., 2004; Frisoni et al., 2010; Ho et al., 2003).”
Background
- Authors
- Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., & Black, S.
- Affiliations
- St. Michael's Hospital (CA)
- From the University of Toronto (Drs. Feinstein, Lobaugh, O’Connor, and Black), Sunnybrook and Women’s College Health Sciences Centre (Drs. Feinstein, Lobaugh, and Black, P. Roy), and St. Michael’s Hospital (Dr. O’Connor, K. Feinstein), Toronto, Ontario, Canada.
- Venue
- Neurology
- Published
- 2004-02-24
- Volume
- 62
- Issue
- 4
- Pages
- 586-590
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2149802110
- Cited by
- 294
- References
- 34
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 15
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- multiple sclerosis, major depressive disorder, structural brain abnormalities, gray matter atrophy, cerebrospinal fluid volume, anterior temporal lobe, brain MRI, lesion burden, depression pathogenesis
- MeSH terms
- Adult, Atrophy, Brain, Cognition Disorders, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis
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