Cited by 182Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

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Liu, Bingqian, Rasool, Suhail, Yang, Zhikuan, Glabe, Charles G., Schreiber, Steven S., Ge, Jian, Tan, Zhiqun·2009·The American Journal of Pathology

Abstract

Alzheimer's disease (AD) is pathologically characterized by accumulation of beta-amyloid (Abeta) protein deposits and/or neurofibrillary tangles in association with progressive cognitive deficits. Although numerous studies have demonstrated a relationship between brain pathology and AD progression, the Alzheimer's pathological hallmarks have not been found in the AD retina. A recent report showed Abeta plaques in the retinas of APPswe/PS1DeltaE9 transgenic mice. We now report the detection of Abeta plaques with increased retinal microvascular deposition of Abeta and neuroinflammation in Tg2576 mouse retinas. The majority of Abeta-immunoreactive plaques were detected from the ganglion cell layer to the inner plexiform layer, and some plaques were observed in the outer nuclear layer, photoreceptor outer segment, and optic nerve. Hyperphosphorylated tau was labeled in the corresponding areas of the Abeta plaques in adjacent sections. Although Abeta vaccinations reduced retinal Abeta deposits, there was a marked increase in retinal microvascular Abeta deposition as well as local neuroinflammation manifested by microglial infiltration and astrogliosis linked with disruption of the retinal organization. These results provide evidence to support further investigation of the use of retinal imaging to diagnose AD and to monitor disease activity.

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Authors
Liu, B., Rasool, S., Yang, Z., Glabe, C. G., Schreiber, S. S., Ge, J., & Tan, Z.
Affiliations
  • Sun Yat-sen University (CN)
  • University of California, Irvine (US)
Corresponding author
  • Ge, Jian
  • Tan, Zhiqun
Venue
The American Journal of Pathology
Publisher
Elsevier BV
Published
2009-11
Volume
175
Issue
5
Pages
2099-2110
ISSN
0002-9440 (ISSN-L)
OpenAlex
W2095555365
Cited by
182
References
71
Citations by year
2026: 3 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 15 · 2020: 21 · 2019: 16 · 2018: 17 · 2017: 11 · 2016: 15 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 8
FWCI
5.32
Type
journal article
Language
en
Open access
Locations
  • American Journal Of Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Larry L. Hillblom Foundation
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid plaques, retinal neuroinflammation, microglial infiltration, astrocyte activation, hyperphosphorylated tau, retinal microvasculature, Tg2576 mice, APPswe/PS1ΔE9 mice, ganglion cell layer
MeSH terms
Alzheimer Disease, Animals, Brain, Humans, Inflammation, Mice, Transgenic, Peptide Fragments, Retinal Vessels, Vaccination, Amyloid beta-Peptides, Neurofibrillary Tangles, Mice

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