Innovative diagnostic tools for early detection of Alzheimer's disease
Open accessAbstract
Current state‐of‐the‐art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time‐consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost‐effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests.
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Flagged first, then by citations
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“Furthermore, current diagnostic measures can be invasive (CSF analyses), expensive (neuroimaging), time-consuming (neuropsychological assessment), and are often available only in specialized clinics, which lead to reduced accessibility as frontline screening tool for AD and related disorders (Laske et al., 2014).”
BackgroundSpeech evaluation of patients with alzheimer’s disease using an automatic interviewer
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- Authors
- Laske, C., Sohrabi, H. R., Frost, S. M., López-de-Ipiña, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S. R., Mueller, S., Linnemann, C., Bridenbaugh, S. A., Kanagasingam, Y., Martins, R. N., & O'Bryant, S. E.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Systems Engineering and Automation Department University of the Basque Country UPV/EHU Donostia Spain
- St George's, University of London (GB)
- Semeion Centro Ricerche di Scienze della Comunicazione (IT)
- Nanyang Technological University (SG)
- University of Tübingen (DE)
- Felix Platter-Hospital (CH)
- Department of Internal Medicine & Institute for Aging and Alzheimer's Disease Research University of North Texas Health Science Center Fort Worth TX USA
- Corresponding author
- Laske, Christoph
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-11-15
- Volume
- 11
- Issue
- 5
- Pages
- 561-578
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W1965462372
- Cited by
- 316
- References
- 200
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 35 · 2023: 33 · 2022: 29 · 2021: 34 · 2020: 21 · 2019: 24 · 2018: 33 · 2017: 19 · 2016: 30 · 2015: 13
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by)
- Murdoch University Research Portal (submittedVersion)
- Edith Cowan University Research Online (Edith Cowan University) (submittedVersion)
- DZNE Pub (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (DFG SO932-2)
- European Commission (FP7-ICT-2011-288551)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- Alzheimer's disease, early detection
- MeSH terms
- Alzheimer Disease, Depression, Diagnostic Tests, Routine, Electrophysiology, Eye, Gait, Humans, Memory Disorders, Early Diagnosis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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