Cited by 316Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

Innovative diagnostic tools for early detection of Alzheimer's disease

Open access
Laske, Christoph, Sohrabi, Hamid R., Frost, Shaun M., López-de-Ipiña, Karmele, Garrard, Peter, Buscema, Massimo, Dauwels, Justin, Soekadar, Surjo R. +6 more·2015·Alzheimer's & Dementia

Abstract

Current state‐of‐the‐art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time‐consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost‐effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests.

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Crossref · 10.1016/j.jalz.2014.06.004

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Authors
Laske, C., Sohrabi, H. R., Frost, S. M., López-de-Ipiña, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S. R., Mueller, S., Linnemann, C., Bridenbaugh, S. A., Kanagasingam, Y., Martins, R. N., & O'Bryant, S. E.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • Edith Cowan University (AU)
  • Commonwealth Scientific and Industrial Research Organisation (AU)
  • Systems Engineering and Automation Department University of the Basque Country UPV/EHU Donostia Spain
  • St George's, University of London (GB)
  • Semeion Centro Ricerche di Scienze della Comunicazione (IT)
  • Nanyang Technological University (SG)
  • University of Tübingen (DE)
  • Felix Platter-Hospital (CH)
  • Department of Internal Medicine & Institute for Aging and Alzheimer's Disease Research University of North Texas Health Science Center Fort Worth TX USA
Corresponding author
Laske, Christoph
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2014-11-15
Volume
11
Issue
5
Pages
561-578
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W1965462372
Cited by
316
References
200
Citations by year
2026: 18 · 2025: 27 · 2024: 35 · 2023: 33 · 2022: 29 · 2021: 34 · 2020: 21 · 2019: 24 · 2018: 33 · 2017: 19 · 2016: 30 · 2015: 13
FWCI
2.86
Type
journal article
Language
en
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by)
  • Murdoch University Research Portal (submittedVersion)
  • Edith Cowan University Research Online (Edith Cowan University) (submittedVersion)
  • DZNE Pub (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (DFG SO932-2)
  • European Commission (FP7-ICT-2011-288551)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords
Alzheimer's disease, early detection
MeSH terms
Alzheimer Disease, Depression, Diagnostic Tests, Routine, Electrophysiology, Eye, Gait, Humans, Memory Disorders, Early Diagnosis

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