Cited by 164Dementia and Cognitive Impairment ResearchGlaucoma and retinal disordersRetinal Imaging and Analysis

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Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging

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Danesh-Meyer, H. V., Birch, H., Ku, J. Y.-F., Carroll, S., Gamble, G.·2006·Neurology

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Abstract

In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.

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Authors: Danesh-Meyer, H. V., Birch, H., Ku, J. Y.-F., Carroll, S., & Gamble, G.
Affiliations: University of Auckland (NZ)
ORCID: Danesh-Meyer, H. V.
Gamble, G.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-11-28
Volume: 67
Issue: 10
Pages: 1852-1854
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000244490.07925.8b
OpenAlex: W2047691268
Cited by: 164
References: 9
Citations by year: 2026: 3 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 19 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 12
FWCI: 2.55
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: Alzheimer's disease, optic nerve fibers, optic nerve head, scanning laser ophthalmoscopy, cup-to-disc ratio, neurodegeneration, retinal imaging biomarkers
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Female, Humans, Male, Optic Nerve, Optic Nerve Diseases, Predictive Value of Tests, Retinal Ganglion Cells, Wallerian Degeneration, Case-Control Studies, Microscopy, Confocal, Ophthalmoscopes

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Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging

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