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Cited by 242Dementia and Cognitive Impairment ResearchSleep and Wakefulness ResearchSleep and related disorders

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index; none of the 31 sources its claims cite is checked for support yet.

Sleep architecture and the risk of incident dementia in the community

Open access
Pase, Matthew P., Himali, Jayandra J., Grima, Natalie A., Beiser, Alexa S., Satizabal, Claudia L., Aparicio, Hugo J., Thomas, Robert J., Gottlieb, Daniel J., Auerbach, Sandford H., Seshadri, Sudha·2017·Neurology
DOI 10.1212/wnl.0000000000004373PMC PMC5606917
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Abstract

OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male). Stages of sleep were quantified using home-based polysomnography. Participants were followed for a maximum of 19 years for incident dementia (mean follow-up 12 ± 5 years). RESULTS: We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia. After adjustments for age and sex, lower REM sleep percentage and longer REM sleep latency were both associated with a higher risk of incident dementia. Each percentage reduction in REM sleep was associated with approximately a 9% increase in the risk of incident dementia (hazard ratio 0.91; 95% confidence interval 0.86, 0.97). The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use, following exclusions for persons with mild cognitive impairment at baseline and following exclusions for early converters to dementia. Stages of non-REM sleep were not associated with dementia risk. CONCLUSIONS: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

In community-dwelling Framingham Heart Study Offspring participants older than 60, lower REM sleep percentage and longer REM sleep latency were prospectively associated with higher incident dementia risk over a mean 12 years. Non-REM sleep stages were not associated with dementia risk, implicating REM sleep mechanisms rather than slow-wave sleep.

Key findings

  • Among 321 participants (mean age 67 ± 5 years, 50% male; mean follow-up 12 ± 5 years, maximum 19 years), there were 32 incident all-cause dementia cases, including 24 Alzheimer disease (AD) dementia cases.
  • Each 1% lower REM sleep percentage was associated with approximately a 9% higher risk of incident all-cause dementia: age/sex-adjusted HR 0.91 (95% CI 0.86–0.97, p = 0.004); fully adjusted HR 0.91 (95% CI 0.85–0.98, p = 0.01). AD dementia results were similar (age/sex-adjusted HR 0.92, 95% CI 0.86–0.99, p = 0.02).
  • The lowest vs highest tertile of REM sleep latency was associated with lower all-cause dementia risk in model 1 (HR 0.37, 95% CI 0.14–0.97) and model 2 (HR 0.26, 95% CI 0.08–0.85). Higher wake after sleep onset was associated with increased risk only in model 2 (HR 2.08, 95% CI 1.02–4.23). Stages 1, 2, and slow-wave sleep were not significantly associated with dementia risk.
  • Sensitivity analyses excluding MCI at baseline or early converters did not materially change the REM sleep association. Excluding persons with high REM arousals due to hypopnea attenuated the association (all-cause dementia HR 0.94, 95% CI 0.88–1.01, p = 0.09). An APOE ε4 by REM sleep percentage interaction was found for AD dementia (p = 0.05), with lower REM sleep associated in ε4 noncarriers (HR 0.88, 95% CI 0.80–0.96) but not carriers (HR 0.99, 95% CI 0.90–1.08), though the authors caution interpretation.

Methods

  • Prospective cohort study using a subset of 321 Framingham Heart Study Offspring participants aged over 60 at the time of home-based polysomnography in the Sleep Heart Health Study (1995–1998); exclusions from 699 Offspring participants included age <60, prevalent dementia, no dementia follow-up, and missing PSG data.
  • Sleep stages were scored in 30-second epochs using Rechtschaffen and Kales criteria; primary exposures were percentage of time in stage 1, stage 2, slow-wave sleep (stages 3 and 4 combined), and REM sleep, with secondary measures of sleep continuity, fragmentation, and sleep-disordered breathing.
  • Incident dementia was ascertained through Framingham Heart Study surveillance, MMSE screening, neuropsychological/neurologic evaluations, and dementia review committee adjudication using DSM-IV; AD dementia used NINCDS-ADRDA criteria. Cox proportional hazards models were used: model 1 adjusted for age and sex; model 2 additionally adjusted for BMI, education, APOE ε4, systolic blood pressure, smoking, diabetes, heart disease, depressive symptoms, and medication use.

Limitations

  • The paper states small sample size and small number of incident events, limiting power to detect weaker associations with other sleep exposures, including the AHI ≥15 threshold; the sample was of Caucasian descent, so generalizability to other ethnic groups is unclear.
  • The paper states no information on shift work, preventing ascertainment of circadian rhythm sleep disorders.
  • Evident from the text: the APOE ε4 interaction for AD dementia was based on small event counts and overlapping confidence intervals; the single baseline PSG cannot capture changes in sleep architecture over follow-up, and observational design leaves potential residual confounding.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1212/wnl.0000000000004373

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

0 of 31 cited sources checked · 0 supported · 0 flagged

  • Findingown data
    § Sensitivity analysis.

    Exclusion of persons with a high number of arousals from REM sleep attenuated the HR linking REM sleep percentage to incident dementia.

    “The exclusion of persons with a high number of arousals from REM sleep attenuated the HR linking REM sleep percentage to incident dementia”
    Quote in the paperNot a substantial claim
  • Findingown data
    § Abstract

    The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use.

    “The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use”
    Quote in the paperSubstantial claim
  • Findingown data
    § Sensitivity analysis.

    No APOE e4 by REM sleep percentage interaction was identified when predicting all-cause dementia.

    “no such APOE e4 by REM sleep percentage interaction was identified when predicting all-cause dementia.”
    Quote in the paperNot a substantial claim
  • Findingown data
    § Sensitivity analysis.

    The attenuation of the association between REM sleep percentage and incident dementia after excluding high REM arousals appeared to be due to arousals resulting from hypopnea rather than obstructive apnea.

    “this attenuation appeared to be due to arousals resulting from hypopnea rather than obstructive apnea.”
    Quote in the paperNot a substantial claim
  • Findingown data
    § Abstract

    The magnitude of association between REM sleep percentage and dementia was similar following exclusions for persons with mild cognitive impairment at baseline.

    “following exclusions for persons with mild cognitive impairment at baseline”
    Quote in the paperNot a substantial claim
  • It may state two separate claims as one. 17
  • The quote only partly states this claim. 1
  • Probably not a substantial claim. 16

  • It may state two separate claims as one.

    Findingown data
    § Sensitivity analysis.

    After stratifying, lower REM sleep percentage was associated with a higher risk of incident AD dementia in e4 noncarriers (HR 0.88, 95% CI 0.80-0.96, p=0.006, events/n=14/245) but not carriers (HR 0.99, 95% CI 0.90-1.08, p=0.75, events/n=10/71).

    “After stratifying the results, lower REM sleep percentage was associated with a higher risk of incident AD dementia in e4 noncarriers (HR 0.88, 95% CI 0.80-0.96,p 5 0.006, events/n 5 14/245) but not carriers (HR 0.99, 95% CI 0.90-1.08,p 5 0.75, events/n 5 10/71).”
    Quote in the paperNot a substantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sample overview.

    Sleep onset latency, sleep efficiency, and the AHI were not related to dementia incidence in the sample.

    “Sleep onset latency, sleep efficiency, and the AHI were not related to dementia incidence in our sample (table e-1 at Neurology.org).”
    Quote in the paperSubstantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sample overview.

    Higher total sleep time was associated with a lower risk of all-cause dementia (HR 0.994; 95% CI 0.989-0.999) and AD dementia (HR 0.993; 95% CI 0.987-0.999) in model 1, but the effect sizes were small.

    “Although higher total sleep time was associated with a lower risk of all-cause dementia (HR 0.994; 95% CI 0.989-0.999)and AD dementia (HR 0.993; 95% CI 0.987-0.999) in model 1, the effect sizes were small.”
    Quote in the paperSubstantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sample overview.

    Higher wake after sleep onset was associated with an increased risk of incident all-cause dementia in model 2 (HR 2.08; 95% CI 1.02-4.23) but not model 1 (HR 1.58; 95% CI 0.88-2.83).

    “Higher wake after sleep onset was associated with an increased risk of incident allcause dementia in model 2 (HR 2.08; 95% CI 1.02-4.23)but not model 1 (HR 1.58; 95% CI 0.88-2.83).”
    Quote in the paperSubstantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sensitivity analysis.

    Cases of dementia due to synucleinopathies did not drive the results, given that effect sizes were similar when examining incident all-cause dementia (which included 6 cases of dementia with Lewy bodies) and AD dementia (no cases of mixed AD with Lewy bodies, Parkinson disease, or multiple system atrophy).

    “Cases of dementia due to the synucleinopathies did not drive our results given that effect sizes were similar when examining incident all-cause dementia (which included 6 cases of dementia with Lewy bodies) and AD dementia (no cases of mixed AD with Lewy bodies, Parkinson disease, or multiple system atrophy).”
    Quote in the paperSubstantial claim

  • The quote only partly states this claim.

    Findingown data
    § Sample overview.

    The effect sizes for REM sleep percentage and dementia were similar for AD dementia.

    “The effect sizes were similar for AD dementia.”
    Quote in the paperNot a substantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sensitivity analysis.

    Results for absolute time in each sleep stage were consistent with the primary models, although effect sizes for time in REM sleep and dementia were less marked.

    “Results for absolute time in each sleep stage were consistent with our primary models, although effect sizes for time in REM sleep and dementia were less marked (table e-2).”
    Quote in the paperNot a substantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sample overview.

    Over a mean of 12 (SD 5) years of follow-up, the study observed 32 cases of incident dementia, 24 of which were due to AD dementia.

    “Over a mean of 12 (SD 5) years of follow-up, we observed 32 cases of incident dementia, 24 of which were due to AD dementia.”
    • Also stated in: § Abstract · plain
      “We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia.”
    Quote in the paperNot a substantial claim

  • It may state two separate claims as one.

    Findingown data
    § Sensitivity analysis.

    Even after excluding persons with a high number of arousals from REM sleep, each percentage reduction in REM sleep percentage was associated with a nonstatistically significant 6% increase in all-cause dementia risk, suggesting contributions from other unmeasured factors.

    “However, even after excluding persons with a high number of arousals from REM sleep, each percentage reduction in REM sleep percentage was associated a nonstatistically significant 6% increase in all-cause dementia risk, suggesting contributions from other unmeasured factors.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.

    Premisecitation
    § Sensitivity analysis.

    A population-based study using PSG recently demonstrated that time in REM sleep is reduced in those with as compared to without cognitive impairment, perhaps as a result of sleep-disordered breathing.

    “A populationbased study using PSG recently demonstrated that time in REM sleep is reduced in those with as compared to without cognitive impairment, perhaps as a result of sleep-disordered breathing.21”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [21]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Interpretationcitation
    § Sensitivity analysis.

    Loss of cholinergic function may underpin the association between reduced REM sleep and dementia risk.

    “Thus, loss of cholinergic function may underpin the association between reduced REM sleep and dementia risk, i.e., a healthy cholinergic system maintains REM sleep metrics better than a slowly degenerating cholinergic system.”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [25]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [26]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [27]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.

    Premisecitation
    § Sensitivity analysis.

    REM sleep is thought to promote synaptic consolidation and to upregulate the activity of immediate early genes implicated in synaptic plasticity.

    “On the other hand, REM sleep is thought to promote synaptic consolidation and to upregulate the activity of immediate early genes implicated in synaptic plasticity.27,32”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [27]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [32]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Study design and conductown data
    § Statistical analysis.

    Model 1 analyses were adjusted for age and sex.

    “Model 1 included adjustments for age and sex.”
    Quote in the paperNot a substantial claim

  • It may state two separate claims as one.

    Study design and conductreasoning
    § Sensitivity analysis.

    Limitations of the current study include the small sample size and a small number of incident events, resulting in limited power to detect weaker but potentially important associations with other sleep-related exposures and dementia.

    “Limitations of the current study include the small sample size and a small number of incident events.Consequently, we had limited power to detect weaker but potentially important associations with other sleep-related exposures and dementia.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim.

    Study design and conductnone given
    § Statistical analysis.

    The proportionality of hazards assumption was confirmed before using Cox proportional hazards regression models.

    “After confirming the proportionality of hazards assumption, we used SAS software V9.4 (SAS Institute, Cary, NC) to estimate Cox proportional hazards regression models.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim.

    Premisecitation
    § Sensitivity analysis.

    AD is associated with loss of cholinergic function, from the degeneration of cholinergic projections in the basal forebrain and changes in acetylcholine release, high-affinity choline uptake, and acetylcholine receptor expression.

    “AD is well-known to be associated with loss of cholinergic function, from the degeneration of cholinergic projections in the basal forebrain and changes in acetylcholine release, high-affinity choline uptake, and acetylcholine receptor expression.28,29”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites [28]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [29]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Interpretationown data
    § Sensitivity analysis.

    As the sample was of Caucasian descent, it is unclear how the results generalize to other ethnic groups.

    “Second, as our sample was of Caucasian decent, it is unclear how our results generalize to other ethnic groups.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Premisecitation
    § Sensitivity analysis.

    Current research on sleep and AD is mostly focused on SWS.

    “Current research on sleep and AD is mostly focused on SWS.4,19,20”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [4]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [19]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [20]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • It may state two separate claims as one.

    Interpretationown data
    § Sensitivity analysis.

    The effect between REM sleep percentage and dementia was attenuated after excluding persons with a high number of arousals from REM sleep due to hypopneas, suggesting a possible contributing role of sleep-disordered breathing.

    “The effect between REM sleep percentage and dementia was attenuated after excluding persons with a high number of arousals from REM sleep due to hypopneas, suggesting a possible contributing role of sleep-disordered breathing.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.

    Premisecitation
    § Sensitivity analysis.

    REM sleep behavior disorder has been associated with dementia and is clinically diagnostic of dementia due to the synucleinopathies.

    “REM sleep behavior disorder has been associated with dementia and is clinically diagnostic of dementia due to the synucleinopathies.24”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [24]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • It may state two separate claims as one.

    Premisecitation
    § Sensitivity analysis.

    REM sleep latency is longer in patients with AD dementia as compared to controls, with latency appearing to increase across categories of AD severity.

    “REM sleep latency is also longer in patients with AD dementia as compared to controls with latency appearing to increase across categories of AD severity.3”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [3]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • It may state two separate claims as one.

    Interpretationown data
    § Sensitivity analysis.

    The findings implicate less REM sleep, and not SWS, with the risk of dementia.

    “However, our findings implicate less REM sleep, and not SWS, with the risk of dementia.”
    • Also stated in: § Abstract · plain
      “our findings implicate REM sleep mechanisms as predictors of clinical dementia.”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.

    Study design and conductnone given
    § Sensitivity analysis.

    Strengths of the current study include the population-based sample, rigorous surveillance for incident dementia, long duration of follow-up, and use of PSG to measure sleep architecture.

    “Strengths of the current study include the population-based sample, rigorous surveillance for incident dementia, long duration of follow-up, and use of PSG to measure sleep architecture.”
    Quote in the paperNot a substantial claim

  • Probably not a substantial claim. It may state two separate claims as one.

    Premisecitation
    § Sensitivity analysis.

    Cholinergic neurons are important determinants of REM sleep, with cholinergic activity low during SWS and high during REM sleep.

    “Cholinergic neurons are important determinants of REM sleep, 25,26 with cholinergic activity low during SWS and high during REM sleep.27”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites [25]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [26]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [27]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Study design and conductcitation
    § Assessment of PSG.

    Sleep stages were scored in 30-second epochs by the criteria outlined by Rechtschaffen and Kales.

    “Briefly, sleep stages were scored in 30-second epochs by the criteria outlined by Rechtschaffen and Kales.11”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [11]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Interpretationcitation
    § Sensitivity analysis.

    REM sleep may buffer against synaptic loss and cognitive decline by assisting in the production of new connections and networks.

    “Thus, REM sleep may also buffer against synaptic loss and cognitive decline by assisting in the production of new connections and networks.”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [27]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [32]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Study design and conductcitation
    § Assessment of PSG.

    The methods for polysomnography, including scoring guidelines and reliability, have been published previously.

    “The methods, including scoring guidelines and reliability, have been published previously.[8][9][10]”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites [8]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [9]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [10]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim.

    Study design and conductown data
    § Statistical analysis.

    Model 2 analyses included additional adjustments for body mass index, education, APOE e4, systolic blood pressure, current smoking, prevalent diabetes, prevalent heart disease, and depressive symptoms.

    “Model 2 included additional adjustments for body mass index, education (dichotomized at the level of college degree attainment), positivity for an APOE e4 allele, systolic blood pressure, current smoking, prevalent diabetes, prevalent heart disease, depressive symptoms”
    Quote in the paperSubstantial claim

  • Probably not a substantial claim. The paper’s conclusions may not depend on it.

    Premisecitation
    § Sensitivity analysis.

    In the same study, REM sleep percentage was positively correlated with CSF levels of Ab1-42 in 48 patients with AD.

    “In the same study, REM sleep percentage was positively correlated with CSF levels of Ab1-42 in 48 patients with AD.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [3]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

29 of 29

  • The paper relies on this without support.

    Sleep disturbance is common in dementia.

    “Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset.”

  • The paper relies on this without support.

    It is unclear whether differences in sleep architecture precede dementia onset.

    “Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset.”
2 of 2

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Metadata

Authors
Pase, M. P., Himali, J. J., Grima, N. A., Beiser, A. S., Satizabal, C. L., Aparicio, H. J., Thomas, R. J., Gottlieb, D. J., Auerbach, S. H., & Seshadri, S.
Affiliations
  • Boston University (US)
  • From the Department of Neurology (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health; Cognitive Neurology Unit (N.A.G.) and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-09-19
Volume
89
Issue
12
Pages
1244-1250
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000004373
PMC
PMC5606917
OpenAlex
W2747891109
Cited by
241
References
39
Citations by year
2026: 33 · 2025: 32 · 2024: 25 · 2023: 31 · 2022: 21 · 2021: 27 · 2020: 26 · 2019: 23 · 2018: 17 · 2017: 5
FWCI
14.65
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Funders
  • National Institute on Aging (P30AG010129, U01AG049505, U01AG052409, R01AG054076, R01AG049607, R01AG033193, T32AG036697)
  • National Institute of Neurological Disorders and Stroke (UH2NS100605, L30 NS093634, R01NS017950)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep architecture, incident dementia, REM sleep, REM latency, Alzheimer's disease, dementia risk, NREM sleep, slow-wave sleep, sleep disorders, Sleep Heart Health Study
MeSH terms
Aged, Dementia, Female, Follow-Up Studies, Humans, Male, Massachusetts, Middle Aged, Risk, Sleep Wake Disorders, Sleep, REM, Polysomnography

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