The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Abstract
One method of evaluating the degree of neurologic impairment in MS has been the combination of grades (0 = normal to 5 or 6 = maximal impairment) within 8 Functional Systems (FS) and an overall Disability Status Scale (DSS) that had steps from 0 (normal) to 10 (death due to MS). A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 . . . 9) now divided into two (1.0, 1.5, 2.0 . . . 9.5). The lower portion is obligatorily defined by Functional System grades. The FS are Pyramidal, Cerebellar, Brain Stem, Sensory, Bowel & Bladder, Visual, Cerebral, and Other; the Sensory and Bowel & Bladder Systems have been revised. Patterns of FS and relations of FS by type and grade to the DSS are demonstrated.
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“The Expanded Disability Status Scale (EDSS [26]) was administered by an experienced neurologist (M.C.) to investigate physical disability.”
From Coping strategies and their impact on quality of life and physical disability of people with multiple sclerosis (2021) · cites this paper as [26]
Citations
Cites
On the evaluation of disability in multiple sclerosis
Kurtzke, J. F. (1961) · Neurology · doi:10.1212/wnl.11.8.686 · Cited by 330
Further notes on disability evaluation in multiple sclerosis, with scale modifications
Kurtzke, J. F. (1965) · Neurology · doi:10.1212/wnl.15.7.654 · Cited by 309
A New Scale for Evaluating Disability in Multiple Sclerosis
Kurtzke, J. F. (1955) · Neurology · doi:10.1212/wnl.5.8.580 · Cited by 305
Wood, P. (1980) · PubMed · Cited by 247
NEUROLOGIC IMPAIRMENT IN MULTIPLE SCLEROSIS AND THE DISABILITY STATUS SCALE
Kurtzke, J. F. (1970) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1970.tb05808.x · Cited by 156
A PROPOSAL FOR A UNIFORM MINIMAL RECORD OF DISABILITY IN MULTIPLE SCLEROSIS
Kurtzke, J. F. (1981) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1981.tb05548.x · Cited by 127
Kurtzke, J. F., Beebe, G. W., Nagler, B., Auth, T. L., Kurland, L. T., & Nefzger, M. D. (1972) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1972.tb07525.x · Cited by 68
Mellerup, E., Fog, T., Raun, N. E., Colville, P., de Rham, B., Hannah, B., & Kurtzke, J. F. (1981) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1981.tb05549.x · Cited by 53
The effects of isoniazid on patients with multiple sclerosis; preliminary report.
Kurtzke, J. F., & Berlin, L. (1954) · PubMed · doi:10.1164/art.1954.70.4.577 · Cited by 23
ACUTE RESPIRATORY FAILURE IN MULTIPLE SCLEROSIS AND ITS MANAGEMENT
Guthrie, T. C., Kurtzke, J. F., & BERLIN, L. (1952) · Annals of Internal Medicine · doi:10.7326/0003-4819-37-6-1197 · Cited by 20
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The initial course of daily functioning in multiple sclerosis: a three-year follow-up study
de Groot, V, Beckerman, H., Lankhorst, G. J., Polman, C. H., & Bouter, L. M. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1238oa · Cited by 23
Sesel, A.-L., Sharpe, L., Beadnall, H. N., Barnett, M. H., Szabo, M., & Naismith, S. L. (2022) · Multiple Sclerosis Journal · doi:10.1177/13524585211068002 · Cited by 22
LaRocca, N. G., Ritvo, P. G., Miller, D. M., Fischer, J. S., Andrews, H., & Paty, D. W. (1996) · Multiple Sclerosis · doi:10.1007/978-1-4471-1271-6_7 · Cited by 21
Santangelo, G., Corte, M. D., Sparaco, M., Miele, G., Garramone, F., Cropano, M., Esposito, S., Lavorgna, L., Gallo, A., Tedeschi, G., et al. (2021) · Acta Neurologica Belgica · doi:10.1007/s13760-019-01212-5 · Cited by 20
Future‐directed thinking and depression in relapsing‐remitting multiple sclerosis
Moore, A. C., MacLeod, A. K., Barnes, D., & Langdon, D. W. (2006) · British Journal of Health Psychology · doi:10.1348/135910705x85781 · Cited by 20
Sheikhi, K., Ghaderi, S., Firouzi, H., Rahimibarghani, S., Shabani, E., Afkhami, H., & Yarahmadi, A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1517369 · Cited by 20
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Cadden, M. H., Guty, E. T., & Arnett, P. A. (2019) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acy067 · Cited by 19
Lowe, R., Barlow, C., Lloyd, B., Latchem-Hastings, J., Poile, V., Scoble, C., Dean-Young, A., Button, K., Playle, R., & Busse, M. (2021) · Trials · doi:10.1186/s13063-021-05245-1 · Cited by 19
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Francalancia, J., Mavrogiorgou, P., Juckel, G., Mitrovic, T., Kuhle, J., Naegelin, Y., Kappos, L., & Calabrese, P. (2021) · Brain Sciences · doi:10.3390/brainsci11080964 · Cited by 19
“Disability was also obtained from the patient’s medical records, since the examinations were done by a clinician during medical visits, employing the Expanded Disability Status Scale (EDSS) [16].”
MethodWicki, C. A., Hanson, J. V. M., & Schippling, S. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000604 · Cited by 16
Department of Psychology, F. O. L. A. H., Davoodi, M., Shameli, L., Department of Psychology, F. O. L. A. H., Hadianfard, H., & Department of Clinical Psychology, F. O. E. &. P. (2019) · Iranian Journal of Psychiatry and Clinical Psychology · doi:10.32598/ijpcp.25.3.250 · Cited by 16
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Fragoso, Y. D., Silva, É. O. D., & Finkelsztejn, A. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000500007 · Cited by 16
Biochemical Studies in Fibroblasts to Interpret Variants of Unknown Significance in the ABCD1 Gene
van de Stadt, S. I. W., Mooyer, P. A. W., Dijkstra, I. M. E., Dekker, C. J. M., Vats, D., Vera, M., Ruzhnikov, M. R. Z., van Haren, K., Tang, N., Koop, K., et al. (2021) · Genes · doi:10.3390/genes12121930 · Cited by 14
Miró, J., Amado, J. A., Pesquera, C., López-Cordovilla, J. J., & Berciano, J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1990.tb01013.x · Cited by 13
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Berg-Hansen, P., Moen, S. M., Klyve, T. D., Gonzalez, V., Seeberg, T. M., Celius, E. G., Austeng, A., & Meyer, F. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1227374 · Cited by 12
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Giovannetti, A. M., Pakenham, K. I., Presti, G., Quartuccio, M. E., Confalonieri, P., Bergamaschi, R., Grobberio, M., Di Filippo, M., Micheli, M., Brichetto, G., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267245 · Cited by 11
Meek, C., das Nair, R., Evangelou, N., Middleton, R., Tuite-Dalton, K., & Moghaddam, N. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104154 · Cited by 12
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“…of the McDonald criteria [19], men or non-menopausal women aged 18 to 50 years old, a score of ≤ 4.5 in the Expanded Disability Status Scale [20], no MS relapse or corticosteroid therapy for the past 3 months, no changes in the type or dose of MS medications for the past 6 months, and the…”
BackgroundInfluentialKhedr, E. M., El-Deen, H. B., El-Mokhtar, M. A., & Mahmoud, D. M. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106540 · Cited by 11
GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35
De Masi, R., & Orlando, S. (2021) · Pharmaceuticals · doi:10.3390/ph14111195 · Cited by 10
Saul, A., Taylor, B., Simpson, S., Ponsonby, A.-L., Blizzard, L., Dwyer, T., McMorran, B., Wood, B., & van der Mei, I. A. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458518770021 · Cited by 9
Papageorgiou, C. C., Sfagos, C., Kosma, K. K., Kontoangelos, K. A., Triantafyllou, N., Vassilopoulos, D., Rabavilas, A. D., & Soldatos, C. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.005 · Cited by 8
Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.
van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7
Angelova, G., Skodova, T., Prokopiusova, T., Markova, M., Hruskova, N., Prochazkova, M., Pavlikova, M., Spanhelova, S., Stetkarova, I., Bicikova, M., et al. (2020) · Life · doi:10.3390/life10110267 · Cited by 6
Bogosian, A., Day, F., Norton, S., Silber, E., Sakel, M., Sharrack, B., & Moss-Morris, R. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.966133 · Cited by 5
Helmlinger, B., Seebacher, B., Ropele, S., Hechenberger, S., Heschl, B., Reishofer, G., Jordan, S., Tinauer, C., Wurth, S., Valsasina, P., et al. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123426 · Cited by 4
Deparment of Psychology and Education of Exceptional Children, F. O. L., Shahriari, Y., Ghasemzadeh, S., Deparment of Psychology and Education of Exceptional Children, F. O. P. A. E. S., Vakili, S., & Deparment of Psychology and Education of Exceptional Children, F. O. L. (2019) · Iranian Journal of Psychiatry and Clinical Psychology · doi:10.32598/ijpcp.25.3.236 · Cited by 4
Giovannetti, A. M., Quintas, R., Maggiolo, S., & Quartuccio, M. E. (2024) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2290690 · Cited by 2
Link of the mechanisms of action of glatiramer acetate to its long-term clinical data.
Moreau, T. (2009) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(09)70005-x · Cited by 2
Goldsmith, K., Hudson, J. L., Chalder, T., Dennison, L., & Moss-Morris, R. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103594 · Cited by 2
Kordower (1999) · doi:10.1002/1531-8249(199909)46:3
Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199908)46:2
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2
Metadata
- Authors
- Kurtzke, J. F.
- Affiliations
- Georgetown University (US)
- Corresponding author
- Kurtzke, John F.
- Venue
- Neurology
- Published
- 1983-11
- Volume
- 33
- Issue
- 11
- Pages
- 1444-1444
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2112165124
- Cited by
- 15,011
- References
- 13
- Citations by year
- 2026: 474 · 2025: 622 · 2024: 692 · 2023: 648 · 2022: 722 · 2021: 781 · 2020: 764 · 2019: 648 · 2018: 603 · 2017: 592 · 2016: 657 · 2015: 634 · 2014: 632 · 2013: 586 · 2012: 581
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Speech and Hearing › Voice and Speech Disorders
- Keywords
- multiple sclerosis, Expanded Disability Status Scale, disability assessment, neurological deficit, functional systems, pyramidal system, cerebellar function, brainstem, sensory impairment, bowel and bladder dysfunction, visual impairment
- MeSH terms
- Humans, Multiple Sclerosis, Nervous System Diseases, Neurologic Examination
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