The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
Abstract
Dorsal and ventral pancreatic bud development from the endoderm requires inductive interactions with diverse mesodermal cell types and the action of transcription factors expressed within the endoderm. Presently it is unclear which mesodermal interactions activate which pancreatic transcription factors,and whether such inductions are common for initiating dorsal and ventral pancreas development. Previous studies of Lammert et al. (Lammert, E.,Cleaver, O. and Melton, D. (2001) Science 294, 564-567) showed that signaling from embryonic blood vessel cells, derived from the mesoderm,promotes pancreatic bud development. Using a combination of mouse Flk1-/- embryos lacking endothelial cells and tissue recombination experiments, we discovered that the initial induction of dorsal endoderm cells positive for the pancreatic and duodenal transcription factor Pdx1 does not require aorta or endothelial cell interactions, but dorsal pancreatic bud emergence and the maintenance of Pdx1 expression does. Aortal endothelial cells induce the crucial pancreatic transcription factor Ptf1a in the dorsal pancreatic endoderm; whereas the vitelline veins, which are normally adjacent to the emerging ventral pancreatic bud, are unnecessary for ventral Ptf1a induction or for ventral pancreatic bud initiation. We find that the aorta cells themselves, apart from the blood supply, cause the induction of Ptf1a in dorsal endoderm explants. Thus, endothelial cell interactions specifically promote early dorsal pancreatic development, at least in part, by inducing Ptf1a+ pancreatic progenitors. Additionally, we find that endothelial cells are necessary for the induction of both the insulin and glucagon genes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Millauer, B., Wizigmann-Voos, S., Schnürch, H., Martinez, R., Møller, N. P. H., Risau, W., & Ullrich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90573-9 · Cited by 1,927
Insulin-promoter-factor 1 is required for pancreas development in mice
Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,785
Gu, G., Dubauskaite, J., & Melton, D. A. (2002) · Development · doi:10.1242/dev.129.10.2447 · Cited by 1,518
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,513
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
Gradwohl, G., Dierich, A., LeMeur, M., & Guillemot, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1607 · Cited by 1,439
The mouse; its reproduction and development
Rugh, R. (1968) · Medical Entomology and Zoology · Cited by 1,251
Induction of Pancreatic Differentiation by Signals from Blood Vessels
Lammert, E., Cleaver, O., & Melton, D. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,050
Naya, F. J., Huang, H.-P., Qiu, Y., Mutoh, H., DeMayo, F. J., Leiter, A. B., & Tsai, M.-J. (1997) · Genes & Development · doi:10.1101/gad.11.18.2323 · Cited by 1,021
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 6×
“Genetic lineage tracing studies have shown that early endoderm cells expressing Ptf1a contribute to all pancreatic cell lineages and thereby constitute the definitive pancreatic progenitor population (Krapp et al., 1998; Kawaguchi et al., 2002).”
InfluentialIPF1, a homeodomain-containing transactivator of the insulin gene.
Ohlsson, H., Karlsson, K., & Edlund, T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06109.x · Cited by 888
Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function
Matsumoto, K., Yoshitomi, H., Rossant, J., & Zaret, K. S. (2001) · Science · doi:10.1126/science.1063889 · Cited by 875
Self-citationQuinn, T. P., Peters, K. G., De Vries, C., Ferrara, N., & Williams, L. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7533 · Cited by 754
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721
Self-citationflk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L., & Rossant, J. (1993) · Development · doi:10.1242/dev.118.2.489 · Cited by 695
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, T., & Edlund, H. (1997) · Nature · doi:10.1038/385257a0 · Cited by 688
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
Schwitzgebel, V. M., Scheel, D. W., Conners, J. R., Kalamaras, J., Lee, J. E., Anderson, D. J., Sussel, L., Johnson, J. D., & German, M. S. (2000) · Development · doi:10.1242/dev.127.16.3533 · Cited by 678
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
Herrera, P. L. (2000) · Development · doi:10.1242/dev.127.11.2317 · Cited by 672
Rossi, J. M., Dunn, N. R., Hogan, B. L. M., & Zaret, K. S. (2001) · Genes & Development · doi:10.1101/gad.904601 · Cited by 644
Self-citationNotochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · cited 1×
“In situ hybridization was performed as described previously (Ang et al., 1993; Jung et al., 1999) with Foxa2, Hnf6 and Shh riboprobes reported previously (Ang et al., 1993; Echelard et al., 1993; Rausa et al., 1997); then embryos were sectioned.”
Self-citationA bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Self-citationThe expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo
Armstrong, J. F., Pritchard-Jones, K., Bickmore, W. A., Hastie, N. D., & Bard, J. B. L. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90090-k · Cited by 589
Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.
Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., & Zaret, K. S. (1996) · Genes & Development · doi:10.1101/gad.10.13.1670 · Cited by 588
Self-citationAhlgren, U., Jonsson, J., & Edlund, H. (1996) · Development · doi:10.1242/dev.122.5.1409 · Cited by 547
Krapp, A., Knöfler, M., Ledermann, B., Bürki, K., Berney, C., Zoerkler, N., Hagenbüchle, O., & Wellauer, P. K. (1998) · Genes & Development · doi:10.1101/gad.12.23.3752 · Cited by 530
Pancreatic organogenesis — developmental mechanisms and implications for therapy
Edlund, H. (2002) · Nature Reviews Genetics · doi:10.1038/nrg841 · Cited by 523
Vertebrate Endoderm Development
Wells, J. M., & Melton, D. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.393 · Cited by 522
Endothelial signaling during development
Cleaver, O., & Melton, D. A. (2003) · Nature Medicine · doi:10.1038/nm0603-661 · Cited by 517
An ultrastructural analysis of the developing embryonic pancreas
Pictet, R. L., Clark, W. R., Williams, R. H., & Rutter, W. J. (1972) · Developmental Biology · doi:10.1016/0012-1606(72)90083-8 · Cited by 509
Barbera, J. P. M., Clements, M., Thomas, P., Rodriguez, T., Meloy, D., Kioussis, D., & Beddington, R. S. P. (2000) · Development · doi:10.1242/dev.127.11.2433 · Cited by 474
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
Apelqvist, Å., Ahlgren, U., & Edlund, H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00340-x · Cited by 444
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Notochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405
Epitheliomesenchymal interaction in pancreatic morphogenesis
Golosow, N., & Grobstein, C. (1962) · Developmental Biology · doi:10.1016/0012-1606(62)90042-8 · Cited by 398
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
Li, H., Arber, S., Jessell, T. M., & Edlund, H. (1999) · Nature Genetics · doi:10.1038/12669 · Cited by 378
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
Harrison, K. A., Thaler, J., Pfaff, S. L., Gu, H., & Kehrl, J. H. (1999) · Nature Genetics · doi:10.1038/12674 · Cited by 359
Gene expression cascades in pancreatic development
Wilson, M. E., Scheel, D., & German, M. S. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00333-7 · Cited by 354
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
Visvader, J. E., Fujiwara, Y., & Orkin, S. H. (1998) · Genes & Development · doi:10.1101/gad.12.4.473 · Cited by 328
Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects
Wessells, N. K., & Cohen, J. H. (1967) · Developmental Biology · doi:10.1016/0012-1606(67)90042-5 · Cited by 318
Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors
Gittes, G. K., Galante, P. E., Hanahan, D., Rutter, W. J., & Debas, H. T. (1996) · Development · doi:10.1242/dev.122.2.439 · Cited by 316
Vecchi, A., Garlanda, C., Lampugnani, M. G., Resnati, M., Matteucci, C., Stoppacciaro, A., Schnürch, H., Risau, W., Ruco, L., & Mantovani, A. (1994) · PubMed · Cited by 301
Formation of the digestive system in zebrafish. ii. pancreas morphogenesis☆
Field, H. A., Dong, P. D. S., Beis, D., & Stainier, D. Y. R. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00308-7 · Cited by 279
Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
Herrera, P.-L., Huarte, J., Sanvito, F., Meda, P., Orci, L., & Vassalli, J.-D. (1991) · Development · doi:10.1242/dev.113.4.1257 · Cited by 269
An experimental analysis of liver development.
Douarin, N. M. L. (1975) · PubMed · Cited by 268
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
Bort, R., Martinez-Barbera, J. P., Beddington, R. S. P., & Zaret, K. S. (2004) · Development · doi:10.1242/dev.00965 · Cited by 267 · cited 1×
“6F), as Hexmarks both hepatic and ventral pancreatic progenitor cells and not the dorsal pancreatic progenitors (Martinez-Barbera et al., 2000; Bort et al., 2004).”
Self-citationPancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
Kim, S. K., & Melton, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13036 · Cited by 265
Wu, K.-L., Gannon, M., Peshavaria, M., Offield, M. F., Henderson, E., Ray, M., Marks, A., Gamer, L. W., Wright, C. V. E., & Stein, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6002 · Cited by 252
Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
Kumar, M., Jordan, N., Melton, D., & Grapin-Botton, A. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00183-0 · Cited by 250
Signaling and transcriptional control of pancreatic organogenesis
Kim, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00338-6 · Cited by 240
Single-Cell Transcript Analysis of Pancreas Development
Chiang, M.-K., & Melton, D. A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00035-2 · Cited by 235
Krapp, A., Knöfler, M., Frutiger, S., Hughes, G. J., Hagenbüchle, O., & Wellauer, P. K. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00806.x · Cited by 234
Houssaint, E. (1980) · Cell Differentiation · doi:10.1016/0045-6039(80)90026-3 · Cited by 209
Jacquemin, P., Lemaigre, F. P., & Rousseau, G. G. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00115-5 · Cited by 179
Burke, Z., & Oliver, G. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00240-x · Cited by 177
Rausa, F., Samadani, U., Ye, H., Lim, L., Fletcher, C. F., Jenkins, N. A., Copeland, N. G., & Costa, R. H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8744 · Cited by 169
XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm
Wright, C. V. E., Schnegelsberg, P., & Robertis, E. M. D. (1989) · Development · doi:10.1242/dev.105.4.787 · Cited by 162
Pancreatic β Cell-specific Transcription of thepdx-1 Gene
Gerrish, K., GANNON, M. A., Shih, D. Q., Henderson, E., Stoffel, M., Wright, C. V. E., & Stein, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3485 · Cited by 155
Landry, C., Clotman, F., Hioki, T., Oda, H., Picard, J. J., Lemaigre, F. P., & Rousseau, G. G. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8757 · Cited by 148
THE DEVELOPMENT OF THE DORSAL AND VENTRAL MAMMALIAN PANCREAS IN VIVO AND IN VITRO
Spooner, B. S., Walther, B. T., & Rutter, W. J. (1970) · The Journal of Cell Biology · doi:10.1083/jcb.47.1.235 · Cited by 127
The Role of PTF1-P48 in Pancreatic Acinar Gene Expression
Rose, S. D., Swift, G. H., Peyton, M. J., Hammer, R. E., & MacDonald, R. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106264200 · Cited by 117
Polyclonal origin of pancreatic islets in aggregation mouse chimaeras
Deltour, L., Leduque, P., Páldi, A., et al. (1991) · Development · doi:10.1242/dev.112.4.1115 · Cited by 103
Analysis of Pancreatic Development Using a Cell Lineage Label
Percival, A. C., & Slack, J. M. W. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4322 · Cited by 91
Oelrichs, R. B., Hh, R., Bernard, O., Ziemiecki, A., & Wilks, A. F. (1993) · PubMed · Cited by 85
Dorsal Pancreas Agenesis in N-Cadherin- Deficient Mice
Esni, F., Johansson, B. R., Radice, G. L., & Semb, H. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0405 · Cited by 78
Fate mapping study of the endoderm of the 1.5-day-old chick embryo
Matsushita, S. (1996) · Development Genes and Evolution · doi:10.1007/bf00365800 · Cited by 37
Endodermal Patterning and Organogenesis
GANNON, M. A., & Wright, C. V. E. (1999) · Elsevier eBooks · doi:10.1016/b978-012505255-9/50041-9 · Cited by 35
Development of the Endoderm and Its Tissue Derivatives
Hogan, B. L. M., & Zaret, K. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012597951-1/50019-6 · Cited by 23
Self-citationA culture system for the study of pancreatic organogenesis
Gittes, G. K., & Galante, P. E. (1993) · Methods in Cell Science · doi:10.1007/bf02387286 · Cited by 17
Cited by
Endothelial cells and VEGF in vascular development
Coultas, L., Chawengsaksophak, K., & Rossant, J. (2005) · Nature · doi:10.1038/nature04479 · Cited by 1,016
Pancreas organogenesis: From bud to plexus to gland
Pan, F. C., & Wright, C. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22584 · Cited by 614
Butler, J. M., Kobayashi, H., & Rafii, S. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2791 · Cited by 578
The Vascular Basement Membrane: A Niche for Insulin Gene Expression and β Cell Proliferation
Nikolova, G., Jabs, N., Konstantinova, I., Domogatskaya, A., Tryggvason, K., Sorokin, L., Fässler, R., Gu, G., Gerber, H.-P., Ferrara, N., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.015 · Cited by 511
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Metadata
- Authors
- Yoshitomi, H., & Zaret, K. S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-02-15
- Volume
- 131
- Issue
- 4
- Pages
- 807-817
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2070884732
- Cited by
- 260
- References
- 70
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
