Notch signaling: control of cell communication and cell fate

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624

Signalling downstream of activated mammalian Notch

Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., & Israel, A. (1995) · Nature · doi:10.1038/377355a0 · Cited by 1,390

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,284

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

Oda, T., Elkahloun, A. G., Pike, B. L., Okajima, K., Krantz, I. D., Genin, A., Piccoli, D. A., Meltzer, P. S., Spinner, N. B., Collins, F. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-235 · Cited by 1,158

Notch1 functions as a tumor suppressor in mouse skin

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C.-C., Clevers, H., Dotto, G. P., & Radtke, F. (2003) · Nature Genetics · doi:10.1038/ng1099 · Cited by 971

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

De Strooper, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00205-8 · Cited by 965

Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis

Palmeirim, I., Henrique, D., Ish-Horowicz, D., & Pourquié, O. (1997) · Cell · doi:10.1016/s0092-8674(00)80451-1 · Cited by 948

Notch1 is required for the coordinate segmentation of somites

Conlon, R. A., Reaume, A. G., & Rossant, J. (1995) · Development · doi:10.1242/dev.121.5.1533 · Cited by 852

γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, M. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824

Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

Itoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G. J., Ariza-McNaughton, L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00409-4 · Cited by 779

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

Rebay, I., Fleming, R. J., Fehon, R. G., Cherbas, L., Cherbas, P., & Artavanis-Tsakonas, S. (1991) · Cell · doi:10.1016/0092-8674(91)90064-6 · Cited by 772

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

Rhyu, M. S., Jan, L. Y., & Jan, Y. N. (1994) · Cell · doi:10.1016/0092-8674(94)90112-0 · Cited by 767

The choice of cell fate in the epidermis of Drosophila

Heitzler, P., & Simpson, P. (1991) · Cell · doi:10.1016/0092-8674(91)90263-x · Cited by 743

Nuclear Access and Action of Notch In Vivo

Struhl, G., & Adachi, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81193-9 · Cited by 733

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D., & Kintner, C. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675

Fringe modulates Notch–ligand interactions

Panin, V. M., Papayannopoulos, V., Wilson, R., & Irvine, K. D. (1997) · Nature · doi:10.1038/43191 · Cited by 586

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

Bailey, A. M., & Posakony, J. W. (1995) · Genes & Development · doi:10.1101/gad.9.21.2609 · Cited by 585

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

Kao, H.-Y., Ordentlich, P., Koyano-Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579

The suppressor of hairless protein participates in notch receptor signaling

Fortini, M. (1994) · Cell · doi:10.1016/0092-8674(94)90196-1 · Cited by 536

LIN-12/Notch signaling: lessons from worms and flies

Greenwald, I. (1998) · Genes & Development · doi:10.1101/gad.12.12.1751 · Cited by 535

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

Lehmann, R., Jim�nez, F., Dietrich, U., & Campos-Ortega, J. A. (1983) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848482 · Cited by 494

Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J., & Carroll, S. B. (1996) · Nature · doi:10.1038/382133a0 · Cited by 485

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

Kopan, R., Schroeter, E. H., Weintraub, H., & Nye, J. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1683 · Cited by 470

Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling

Barolo, S., & Posakony, J. W. (2002) · Genes & Development · doi:10.1101/gad.976502 · Cited by 468

Regulation of Notch Signaling Activity

Schweisguth, F. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.023 · Cited by 467

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

Struhl, G., Fitzgerald, K., & Greenwald, I. (1993) · Cell · doi:10.1016/0092-8674(93)90424-o · Cited by 462

Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J κ

Henkel, T., Ling, P. D., Hayward, S. D., & Peterson, M. G. (1994) · Science · doi:10.1126/science.8016657 · Cited by 455

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

Hsieh, J. J.-D., Henkel, T., Salmon, P., Robey, E., Peterson, M. G., & Hayward, S. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.952 · Cited by 451

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

Lecourtois, M., & Schweisguth, F. (1995) · Genes & Development · doi:10.1101/gad.9.21.2598 · Cited by 426

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

Lieber, T., Kidd, S., Alcamo, E., Corbin, V, & Young, M. W. (1993) · Genes & Development · doi:10.1101/gad.7.10.1949 · Cited by 421

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S., & Perrimon, N. (1996) · Science · doi:10.1126/science.271.5257.1826 · Cited by 418

Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

Bulman, M. P., Kusumi, K., Frayling, T. M., McKeown, C., Garrett, C., Lander, E. S., Krumlauf, R., Hattersley, A. T., Ellard, S., & Turnpenny, P. D. (2000) · Nature Genetics · doi:10.1038/74307 · Cited by 392

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

Henderson, S. T., Gao, D., Lambie, E. J., & Kimble, J. (1994) · Development · doi:10.1242/dev.120.10.2913 · Cited by 388

F3/Contactin Acts as a Functional Ligand for Notch during Oligodendrocyte Maturation

Hu, Q.-D., Ang, B.-T., Karsak, M., Hu, W.-P., Cui, X.-Y., Duka, T., Takeda, Y., Chia, W., Sankar, N., Ng, Y.-K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00810-9 · Cited by 366

Notch Signaling in Cancer

Allenspach, E. J., Maillard, I., Aster, J. C., & Pear, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.5.159 · Cited by 344

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

Heitzler, P., Bourouis, M., Ruel, L., Carteret, C., & Simpson, P. (1996) · Development · doi:10.1242/dev.122.1.161 · Cited by 334

Masking of the CBF1/RBPJ κ Transcriptional Repression Domain by Epstein-Barr Virus EBNA2

Hsieh, J. J.-D., & Hayward, S. D. (1995) · Science · doi:10.1126/science.7725102 · Cited by 293

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors

Berry, L. W., Westlund, B., & Schedl, T. (1997) · Development · doi:10.1242/dev.124.4.925 · Cited by 270

Combinatorial Signaling in the Specification of Unique Cell Fates

Flores, G. V., Duan, H., Yan, H., Nagaraj, R., Fu, W., Zou, Y., Noll, M., & Banerjee, U. (2000) · Cell · doi:10.1016/s0092-8674(00)00106-9 · Cited by 261

The function of the neurogenic genes during epithelial development in the Drosophila embryo

Hartenstein, A. Y., Rugendorff, A., Tepass, U., & Hartenstein, V. (1992) · Development · doi:10.1242/dev.116.4.1203 · Cited by 258

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions

Lambie, E. J., & Kimble, J. (1991) · Development · doi:10.1242/dev.112.1.231 · Cited by 253

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

Wilkinson, H. A., Fitzgerald, K., & Greenwald, I. (1994) · Cell · doi:10.1016/0092-8674(94)90010-8 · Cited by 252

Unequal Segregation of Neuralized Biases Notch Activation during Asymmetric Cell Division

Le Borgne, R., & Schweisguth, F. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00187-4 · Cited by 243

The Theory of the Gene

Morgan, T. H. (1917) · The American Naturalist · doi:10.1086/279629 · Cited by 236

Learning and Memory Deficits in Notch Mutant Mice

Costa, R. M., Honjo, T., & Silva, A. J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00492-5 · Cited by 210

Fringe, Notch, and making developmental boundaries

Irvine, K. D. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80066-5 · Cited by 190

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate

Ramain, P., Khechumian, K., Seugnet, L., Arbogast, N., Ackermann, C., & Heitzler, P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00562-0 · Cited by 178

Notch pathway: Making sense of Suppressor of Hairless

Bray, S., & Furriols, M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00109-9 · Cited by 176

The Recombination Signal Sequence-Binding Protein RBP-2N Functions as a Transcriptional Repressor

Dou, S., Zeng, X., Cortés, P., Erdjument‐Bromage, H., Tempst, P., Honjo, T., & Vales, L. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.5.3310 · Cited by 168

A Role for Abl in Notch Signaling

Giniger, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81007-7 · Cited by 161

Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development

Posakony, J. W. (1994) · Cell · doi:10.1016/0092-8674(94)90105-8 · Cited by 151

A Notch-Independent Activity of Suppressor of Hairless Is Required for Normal Mechanoreceptor Physiology

Barolo, S., Walker, R. G., Polyanovsky, A. D., Freschi, G., Keil, T. A., & Posakony, J. W. (2000) · Cell · doi:10.1016/s0092-8674(00)00198-7 · Cited by 144

Persistent Expression of Genes of the Enhancer of Split Complex Suppresses Neural Development in Drosophila

Nakao, K., & Campos‐Ortega, J. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80046-x · Cited by 129

The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster

Parks, A. L., Huppert, S. S., & Muskavitch, M. A. T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00675-8 · Cited by 87

RBP-Jkrepression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2

Waltzer, L., Bourillot, P.-Y., Sergeant, A., et al. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.4939 · Cited by 87

Oscillations, clocks and segmentation

Bessho, Y., & Kageyama, R. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00083-2 · Cited by 84

Transactivation of Repair Genes by BRCA1

El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.5.162 · Cited by 63

MicroRNA functions in animal development and human disease

Alvarez-Garcia, I., & Miska, E. A. (2005) · Development · doi:10.1242/dev.02073 · Cited by 1,104

Cardiac Stem Cells and Mechanisms of Myocardial Regeneration

Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

Rodilla, V., Villanueva, A., Obrador-Hevia, A., Robert-Moreno, À., Fernández-Majada, V., Grilli, A., López-Bigas, N., Bellora, N., Albà, M. M., Torres, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813221106 · Cited by 384

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Pan, H., Haltiwanger, R. S., & Bellen, H. J. (2008) · Cell · doi:10.1016/j.cell.2007.12.016 · Cited by 306