The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
Abstract
The first cells generated during development of the vertebrate retina are the ganglion cells, the projection neurons of the retina. Although they are one of the most intensively studied cell types within the central nervous system, little is known of the mechanisms that determine ganglion cell fate. We demonstrate that ganglion cells are selected from a large group of competent progenitors that comprise the majority of the early embryonic retina and that differentiation within this group is regulated by Notch. Notch activity in vivo was diminished using antisense oligonucleotides or augmented using a retrovirally transduced constitutively active allele of Notch. The number of ganglion cells produced was inversely related to the level of Notch activity. In addition, the Notch ligand Delta inhibited retinal progenitors from differentiating as ganglion cells to the same degree as did activated Notch in an in vitro assay. These results suggest a conserved strategy for neurogenesis in the retina and describe a versatile in vitro and in vivo system with which to examine the action of the Notch pathway in a specific cell fate decision in a vertebrate.
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Cites
DISCHARGE PATTERNS AND FUNCTIONAL ORGANIZATION OF MAMMALIAN RETINA
Kuffler, S. W. (1953) · Journal of Neurophysiology · doi:10.1152/jn.1953.16.1.37 · Cited by 2,609
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Conservation of the Notch signalling pathway in mammalian neurogenesis
Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624
The Developmental Biology of Brain Tumors
Wechsler-Reya, R., & Scott, M. P. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.385 · Cited by 462
The Genetic Sequence of Retinal Development in the Ciliary Margin of theXenopusEye
Perron, M., Kanekar, S., Vetter, M. L., & Harris, W. A. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8939 · Cited by 317
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The Expression and Function of Notch Pathway Genes in the Developing Rat Eye
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Self-citationNotch1 is required for neuronal and glial differentiation in the cerebellum
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Notch signaling influences neuroprotective and proliferative properties of mature Müller glia
Ghai, K., Zelinka, C., & Fischer, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4919-09.2010 · Cited by 111
Nelson, B. R., Hartman, B. H., Ray, C. A., Hayashi, T., Bermingham‐McDonogh, O., & Reh, T. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21848 · Cited by 94
Cell birth and death in the mouse retinal ganglion cell layer
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MAPK signaling during Müller glial cell development in retina explant cultures
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Metadata
- Authors
- Austin, C. P., Feldman, D. E., Ida, J. A., & Cepko, C. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-11-01
- Volume
- 121
- Issue
- 11
- Pages
- 3637-3650
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1835721351
- Cited by
- 406
- References
- 1
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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