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Cited by 391

The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.

Steroid regulated programmed cell death during Drosophila metamorphosis

Jiang, Changan, Baehrecke, Eric H., Thummel, Carl S.·1997·Development
DOI 10.1242/dev.124.22.4673
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Abstract

During insect metamorphosis, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) direct the destruction of obsolete larval tissues and their replacement by tissues and structures that form the adult fly. We show here that larval midgut and salivary gland histolysis are stage-specific steroid-triggered programmed cell death responses. Dying larval midgut and salivary gland cell nuclei become permeable to the vital dye acridine orange and their DNA undergoes fragmentation, indicative of apoptosis. Furthermore, the histolysis of these tissues can be inhibited by ectopic expression of the baculovirus antiapoptotic protein p35, implicating a role for caspases in the death response. Coordinate stage-specific induction of the Drosophila death genes reaper (rpr) and head involution defective (hid) immediately precedes the destruction of the larval midgut and salivary gland. In addition, the diap2 anti-cell death gene is repressed in larval salivary glands as rpr and hid are induced, suggesting that the death of this tissue is under both positive and negative regulation. Finally, diap2 is repressed by ecdysone in cultured salivary glands under the same conditions that induce rpr expression and trigger programmed cell death. These studies indicate that ecdysone directs the death of larval tissues via the precise stage- and tissue-specific regulation of key death effector genes.

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Metadata

Authors
Jiang, C., Baehrecke, E. H., & Thummel, C. S.
Venue
Development
Publisher
The Company of Biologists
Published
1997-11-15
Volume
124
Issue
22
Pages
4673-4683
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.124.22.4673
OpenAlex
W2171784464
Cited by
391
References
83
FWCI
5.63
Type
journal article
Language
en
Open access
closed

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