Cited by 624

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Conservation of the Notch signalling pathway in mammalian neurogenesis

Luis de la Pompa, José, Wakeham, Andrew, Correia, Kristen M., Samper, Enrique, Brown, Stephen, Aguilera, Renato J., Nakano, Toru, Honjo, Tasuku, Mak, Tak W., Rossant, Janet, Conlon, Ronald A.·1997·Development

DOI 10.1242/dev.124.6.1139

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Abstract

The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.

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See all 624

Authors: Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., & Conlon, R. A.
Venue: Development
Publisher: The Company of Biologists
Published: 1997-03-15
Volume: 124
Issue: 6
Pages: 1139-1148
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.124.6.1139
OpenAlex: W2118589362
Cited by: 624
References: 68
FWCI: 11.59
Type: journal article
Language: en
Open access: closed

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Conservation of the Notch signalling pathway in mammalian neurogenesis

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