The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Conservation of the Notch signalling pathway in mammalian neurogenesis
Abstract
The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.
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Cites
The development of Drosophila melanogaster
Ingham, P. (1994) · Trends in Genetics · doi:10.1016/0168-9525(90)90017-z · Cited by 3,149
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696
Signalling downstream of activated mammalian Notch
Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., & Israel, A. (1995) · Nature · doi:10.1038/377355a0 · Cited by 1,390
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Wharton, K. A., Johansen, K. M., Xu, T., & Artavanis-Tsakonas, S. (1985) · Cell · doi:10.1016/0092-8674(85)90229-6 · Cited by 1,060
Guillemot, F., Lo, L.-C., Johnson, J. E., Auerbach, A., Anderson, D. J., & Joyner, A. L. (1993) · Cell · doi:10.1016/0092-8674(93)90381-y · Cited by 1,033
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Notch1 is required for the coordinate segmentation of somites
Conlon, R. A., Reaume, A. G., & Rossant, J. (1995) · Development · doi:10.1242/dev.121.5.1533 · Cited by 852
Self-citationIdentification of neurogenin, a Vertebrate Neuronal Determination Gene
Ma, Q., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 828
Cited by
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., & Kageyama, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2196 · Cited by 852
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624
When NRF2 Talks, Who's Listening?
Wakabayashi, N., Slocum, S. L., Skoko, J. J., Shin, S., & Kensler, T. W. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3216 · Cited by 595
Notch signaling in the mammalian central nervous system: insights from mouse mutants
Yoon, K., & Gaiano, N. (2005) · Nature Neuroscience · doi:10.1038/nn1475 · Cited by 587
Notch signalling pathway mediates hair cell development in mammalian cochlea
Lanford, P. J., Lan, Y., Jiang, R., Lindsell, C., Weinmaster, G., Gridley, T., & Kelley, M. W. (1999) · Nature Genetics · doi:10.1038/6804 · Cited by 485
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Self-citationFode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C., & Guillemot, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80989-7 · Cited by 444
Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development
Morin, X., & Bellaïche, Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.012 · Cited by 423
Neural stem cells: balancing self-renewal with differentiation
Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381
Ayyanan, A., Civenni, G., Ciarloni, L., Morel, C., Mueller, N., Lefort, K., Mandinova, A., Raffoul, W., Fiche, M., Dotto, G. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600065103 · Cited by 294
Stem cells, signals and vertebrate body axis extension
Wilson, V., Olivera-Martinez, I., & Storey, K. G. (2009) · Development · doi:10.1242/dev.021246 · Cited by 290
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
Hojo, M., Ohtsuka, T., Hashimoto, N., Gradwohl, G., Guillemot, F., & Kageyama, R. (2000) · Development · doi:10.1242/dev.127.12.2515 · Cited by 278
Notch1 is required for neuronal and glial differentiation in the cerebellum
Lütolf, S., Radtke, F., Aguet, M., Suter, U., & Taylor, V. (2002) · Development · doi:10.1242/dev.129.2.373 · Cited by 264
Presenilin-1 regulates neuronal differentiation during neurogenesis
Handler, M., Yang, X., & Shent, J. (2000) · Development · doi:10.1242/dev.127.12.2593 · Cited by 225
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis
Kawaguchi, A., Ikawa, T., Kasukawa, T., Ueda, H. R., Kurimoto, K., Saitou, M., & Matsuzaki, F. (2008) · Development · doi:10.1242/dev.022616 · Cited by 193
The Rb pathway in neurogenesis
Ferguson, K. L., & Slack, R. S. (2001) · Neuroreport · doi:10.1097/00001756-200107030-00001 · Cited by 57
Lee, C. T., Ma, Y. L., & Lee, E. H. Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04284.x · Cited by 32
Metadata
- Authors
- Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., & Conlon, R. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-03-15
- Volume
- 124
- Issue
- 6
- Pages
- 1139-1148
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2118589362
- Cited by
- 624
- References
- 68
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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