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Cited by 51Mitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research

The role of mitochondrial dynamics in mtDNA maintenance

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Sabouny, Rasha, Shutt, Timothy E.·2021·Journal of Cell Science
DOI 10.1242/jcs.258944
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Abstract

The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell, allows these critical organelles to adapt their function in response to cellular demands, and is also important for regulating mitochondrial DNA (mtDNA). While it is established that impairments in mitochondrial fusion and fission impact the mitochondrial genome and can lead to mtDNA depletion, abnormal nucleoid organization or accumulation of deletions, it is not entirely clear how or why remodeling mitochondrial network morphology affects mtDNA. Here, we focus on recent advances in our understanding of how mitochondrial dynamics contribute to the regulation of mtDNA and discuss links to human disease.

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  • Excessive mitochondrial fission without timely mitophagy-mediated clearance compromises mitochondrial genome integrity and nucleoid organization, leading to mtDNA loss and overall mitochondrial dysfunction.

    “Other reports have corroborated that excessive mitochondrial fission without timely mitophagy-mediated clearance compromises mitochondrial genome integrity, and nucleoid organization, leading to mtDNA loss, and overall mitochondrial dysfunction (Sabouny and Shutt, 2021).”

    From The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer’s disease (2024) · cites this paper as Sabouny and Shutt, 2021

    The “Mitophagy and mtDNA” section says fission enables mitophagy to remove damaged or mutant mtDNA, and “Nucleoid distribution” links disturbed fission–fusion balance to altered nucleoids. But the paper does not establish that excessive fission without timely mitophagy causes the claimed chain of mtDNA loss and mitochondrial dysfunction; “Fission and mtDNA replication” instead reports mtDNA depletion when fission is blocked. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Sabouny, R., & Shutt, T. E.
Affiliations
University of Calgary (CA)
Corresponding author
Sabouny, Rasha
ORCID
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2021-12-15
Volume
134
Issue
24
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.258944
OpenAlex
W4200049810
Cited by
51
References
0
Citations by year
2026: 13 · 2025: 17 · 2024: 12 · 2023: 5 · 2022: 4
FWCI
1.65
Type
journal article
Language
en
Open access
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords
mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial DNA maintenance, mtDNA depletion, mitochondrial genome, mitochondrial DNA deletions, mitochondrial network morphology, human disease
MeSH terms
DNA, Mitochondrial, Humans, Mitochondria, Genome, Mitochondrial, Mitochondrial Dynamics

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