Cited by 81Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactPeroxisome Proliferator-Activated Receptors

Tissue Distribution and Hepatic Subcellular Distribution of Perfluorooctanoic Acid at Low Dose Are Different from Those at High Dose in Rats

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Kudo, Naomi, Sakai, Ayako, Mitsumoto, Atsushi, Hibino, Yasuhide, Tsuda, Tadashi, Kawashima, Yoichi·2007·Biological and Pharmaceutical Bulletin

Abstract

Fate of perfluorooctanoic acid (PFOA) after an intravenous injection to male rats at the dose of 0.041 mg/kg body weight was compared with that at the dose of 16.56 mg/kg body weight. In the liver, 52% and 27% of PFOA dosed was recovered 2 h after an intravenous injection at the low and the high doses, respectively. By contrast, larger proportion of PFOA dosed was distributed to serum, other tissues and carcass at the high dose compared with the low dose. Subcellular distribution of PFOA was determined in the liver. At the dose of 0.041 mg/kg, 45%, 34%, 18% and 3% were distributed to 8000 g pellet, 18000g pellet, 105000g pellet and 105000g supernatant fraction, respectively; 28%, 17%, 13% and 43% of PFOA were distributed to these fractions, respectively, at the dose of 16.56 mg/kg. The higher the concentration of hepatic PFOA was, the more the PFOA was distributed to 105000g supernatant fraction. Biliary excretion index increased as PFOA concentration raised in the liver. These results suggest that PFOA is preferentially taken-up by the liver, and distributed to membrane fractions, especially 18000g pellet, and hardly excreted into bile when exposed at very low dose.

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Crossref · 10.1248/bpb.30.1535

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  1. Ophaug R. H., Singer L., Proc. Soc. Exp. Biol. Med., 163, 19-23 (1980).

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Authors
Kudo, N., Sakai, A., Mitsumoto, A., Hibino, Y., Tsuda, T., & Kawashima, Y.
Affiliations
  • Josai University (JP)
  • Josai International University (JP)
Venue
Biological and Pharmaceutical Bulletin
Published
2007
Volume
30
Issue
8
Pages
1535-1540
ISSN
  • 0918-6158 (ISSN-L)
  • 1347-5215
OpenAlex
W2035672210
Cited by
81
References
28
Citations by year
2026: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
4.75
Type
journal article
Language
en
Open access
Locations
  • Biological and Pharmaceutical Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
perfluorooctanoic acid, tissue distribution, dose-dependent effects, low-dose exposure, hepatic uptake, biliary excretion, membrane fraction, intravenous injection, perfluorinated compounds
MeSH terms
Animals, Bile, Caprylates, Dose-Response Relationship, Drug, Fluorocarbons, Injections, Intravenous, Kidney, Liver, Male, Pharmacokinetics, Subcellular Fractions, Tissue Distribution, Rats, Wistar, Rats

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