Tissue Distribution and Hepatic Subcellular Distribution of Perfluorooctanoic Acid at Low Dose Are Different from Those at High Dose in Rats
Open accessAbstract
Fate of perfluorooctanoic acid (PFOA) after an intravenous injection to male rats at the dose of 0.041 mg/kg body weight was compared with that at the dose of 16.56 mg/kg body weight. In the liver, 52% and 27% of PFOA dosed was recovered 2 h after an intravenous injection at the low and the high doses, respectively. By contrast, larger proportion of PFOA dosed was distributed to serum, other tissues and carcass at the high dose compared with the low dose. Subcellular distribution of PFOA was determined in the liver. At the dose of 0.041 mg/kg, 45%, 34%, 18% and 3% were distributed to 8000 g pellet, 18000g pellet, 105000g pellet and 105000g supernatant fraction, respectively; 28%, 17%, 13% and 43% of PFOA were distributed to these fractions, respectively, at the dose of 16.56 mg/kg. The higher the concentration of hepatic PFOA was, the more the PFOA was distributed to 105000g supernatant fraction. Biliary excretion index increased as PFOA concentration raised in the liver. These results suggest that PFOA is preferentially taken-up by the liver, and distributed to membrane fractions, especially 18000g pellet, and hardly excreted into bile when exposed at very low dose.
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Cites
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750 · see citing works
Sources, fate and transport of perfluorocarboxylates
Prevedouros, K., Cousins, I. T., Buck, R. C., & Korzeniowski, S. H. (2006) · Environmental Science & Technology · doi:10.1021/es0512475 · Cited by 2,594 · see citing works
Biological Monitoring of Polyfluoroalkyl Substances: A Review
Houde, M., Martin, J. W., Letcher, R. J., Solomon, K. R., & Muir, D. C. G. (2006) · Environmental Science & Technology · doi:10.1021/es052580b · Cited by 1,259 · see citing works
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742 · see citing works
A global survey of perfluorinated acids in oceans
Yamashita, N., Kannan, K., Taniyasu, S., Horii, Y., Petrick, G., & Gamo, T. (2005) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2005.04.026 · Cited by 639 · see citing works
Quantitative determination of perfluorochemicals in sediments and domestic sludge.
Higgins, C., Field, J., Criddle, C., & Luthy, R. (2005) · Environmental Science and Technology · doi:10.1021/es048245p · Cited by 585 · see citing works
Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
Lau, C., Thibodeaux, J. R., Hanson, R., Narotsky, M., Rogers, J. M., Lindstrom, A., & Strynar, M. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj105 · Cited by 547 · see citing works
Taniyasu, S., Kannan, K., Horii, Y., Hanari, N., & Yamashita, N. (2003) · Environmental Science & Technology · doi:10.1021/es0303440 · Cited by 509 · see citing works
Perfluorinated Compounds in Coastal Waters of Hong Kong, South China, and Korea
So, M. K., Taniyasu, S., Yamashita, N., Giesy, J. P., Zheng, J., Fang, Z., Im, S., & Lam, P. K. S. (2004) · Environmental Science & Technology · doi:10.1021/es049441z · Cited by 402 · see citing works
Ehresman, D. J., Froehlich, J. W., Olsen, G. W., Chang, S., & Butenhoff, J. L. (2006) · Environmental Research · doi:10.1016/j.envres.2006.06.008 · Cited by 344 · see citing works
Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from China
Yeung, L. W. Y., So, M. K., Jiang, G., Taniyasu, S., Yamashita, N., Song, M., Wu, Y., Li, J., Giesy, J. P., Guruge, K. S., et al. (2005) · Environmental Science & Technology · doi:10.1021/es052067y · Cited by 341 · see citing works
Detection of perfluorooctane surfactants in Great Lakes water
Boulanger, B., Vargo, J., Schnoor, J. L., & Hornbuckle, K. C. (2004) · Environmental Science & Technology · doi:10.1021/es0496975 · Cited by 299 · see citing works
Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats
Heuvel, J. P. V., Kuslikis, B. I., Rafelghem, M. J. V., & Peterson, R. E. (1991) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.2570060202 · Cited by 289 · see citing works
Ohmori, K., Kudo, N., Katayama, K., & Kawashima, Y. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00573-5 · Cited by 251 · see citing works
Self-citationHuman Donor Liver and Serum Concentrations of Perfluorooctanesulfonate and Other Perfluorochemicals
Olsen, G. W., Hansen, K. J., Stevenson, L. A., Burris, J. M., & Mandel, J. H. (2003) · Environmental Science & Technology · doi:10.1021/es020955c · Cited by 242 · see citing works
Perfluorochemicals in Pooled Serum Samples from United States Residents in 2001 and 2002
Calafat, A. M., Kuklenyik, Z., Caudill, S. P., Reidy, J. A., & Needham, L. L. (2006) · Environmental Science & Technology · doi:10.1021/es0517973 · Cited by 216 · see citing works
Kudo, N., Suzuki, É., Katakura, M., Ohmori, K., Noshiro, R., & Kawashima, Y. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00155-7 · Cited by 205 · see citing works
Self-citationKärrman, A., Mueller, J. F., van Bavel, B., Harden, F. A., Toms, L.-M. L., & Lindström, G. (2006) · Environmental Science & Technology · doi:10.1021/es060301u · Cited by 188 · see citing works
Hundley, S. G., Sarrif, A. M., & Kennedy, G. L. (2006) · Drug and Chemical Toxicology · doi:10.1080/01480540600561361 · Cited by 148 · see citing works
Chlorinated, Brominated, and Perfluorinated Contaminants in Livers of Polar Bears from Alaska
Kannan, K., Yun, S. H., & Evans, T. J. (2005) · Environmental Science & Technology · doi:10.1021/es051850n · Cited by 127 · see citing works
Biochemistry Involving Carbon-Fluorine Bonds
Filler1, R. (1976) · ACS symposium series · doi:10.1021/bk-1976-0028 · Cited by 102 · see citing works
Organic Fluorocompounds in Human Plasma: Prevalence and Characterization
GUY, W. S., Taves, D. R., & Brey, W. S. (1976) · ACS symposium series · doi:10.1021/bk-1976-0028.ch007 · Cited by 95 · see citing works
Metabolic Handling of Perfluorooctanoic Acid in Rats
Ophaug, R. H., & Singer, L. (1980) · Experimental Biology and Medicine · doi:10.3181/00379727-163-40715 · Cited by 72 · see citing works
Disposition of perfluorooctanoic acid in the rat after single and subchronic administration
Ylinen, M., Kojo, A., Hanhijärvi, H., & Peura, P. (1990) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01702360 · Cited by 68 · see citing works
Ohya, T., Kudo, N., Suzuki, É., & Kawashima, Y. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00448-4 · Cited by 67 · see citing works
Self-citationKatakura, M., Kudo, N., Tsuda, T., Hibino, Y., Mitsumoto, A., & Kawashima, Y. (2007) · Eisei kagaku · doi:10.1248/jhs.53.77 · Cited by 64 · see citing works
Self-citationSubcellular Distribution and Protein Binding of Perfluorooctanoic Acid in Rat Liver and Kidney
Han, X., Kemper, R. A., & Jepson, G. W. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-52547 · Cited by 47 · see citing works
Hanhijärvi, H., Ylinen, M., Kojo, A., & Kosma, V. (1987) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1987.tb01775.x · Cited by 34 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Ophaug R. H., Singer L., Proc. Soc. Exp. Biol. Med., 163, 19-23 (1980).
Cited by
Sorted by citations
(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.653 · Cited by 529 · see citing works
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 519 · see citing works
Toxicology of perfluorinated compounds
Stahl, T., Mattern, D., & Brunn, H. (2011) · Environmental Sciences Europe · doi:10.1186/2190-4715-23-38 · Cited by 432 · see citing works
Pan, Y., Zhang, H., Cui, Q., Sheng, N., Yeung, L. W. Y., Guo, Y., Sun, Y., & Dai, J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02259 · Cited by 355 · see citing works
Perfluoroalkyl Acids and Related Chemistries—Toxicokinetics and Modes of Action
Andersen, M. E., Butenhoff, J. L., Chang, S., Farrar, D. G., Kennedy, G. L., Lau, C. S., Olsen, G. W., Seed, J. G., & Wallace, K. B. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm270 · Cited by 322 · see citing works
Benford, D., de Boer, J., Carere, A., Domenico, A. D., Johansson, N., Schrenk, D., Schoeters, G. E. R., de Voogt, P., & Dellatte, E. (2008) · UvA-DARE (University of Amsterdam) · Cited by 320 · see citing works
Shi, Y., Vestergren, R., Zhou, Z., Song, X., Xu, L., Liang, Y., & Cai, Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b04299 · Cited by 258 · see citing works
Renal elimination of perfluorocarboxylates (PFCAs)
Han, X., Nabb, D. L., Russell, M. H., Kennedy, G. L., & Rickard, R. W. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200363w · Cited by 250 · see citing works
Shi, Y., Vestergren, R., Nost, T. H., Zhou, Z., & Cai, Y. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b06128 · Cited by 216 · see citing works
Neurotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action and Environmental Relevance
Mariussen, E. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0822-6 · Cited by 204 · see citing works
Pizzurro, D. M., Seeley, M., Kerper, L. E., & Beck, B. D. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.05.008 · Cited by 206 · see citing works
Fragki, S., Dirven, H. A. A. M., Fletcher, T., Grasl‐Kraupp, B., Gützkow, K. B., Hoogenboom, L. A. P., Kersten, S., Lindeman, B., Louisse, J., Peijnenburg, A., et al. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1888073 · Cited by 189 · see citing works
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166 · see citing works
Loccisano, A. E., Campbell, J. L., Andersen, M. E., & M.A., H. J. C. I. (2010) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2010.12.004 · Cited by 141 · see citing works
Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages
Loccisano, A. E., Longnecker, M. P., Campbell, J. L., Andersen, M. E., & Clewell, H. J. (2013) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287394.2012.722523 · Cited by 141 · see citing works
Zhao, W. M., Zitzow, J. D., Weaver, Y. M., Ehresman, D. J., Chang, S., Butenhoff, J. L., & Hagenbuch, B. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw236 · Cited by 120 · see citing works
Cui, Q., Pan, Y., Wang, J., Liu, H., Yao, B., & Dai, J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115330 · Cited by 118 · see citing works
Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice
Lou, I., Wambaugh, J. F., Lau, C. S., Hanson, R. G., Lindstrom, A. B., Strynar, M. J., ZEHR, R. D. J., Setzer, R. W., & Barton, H. A. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn234 · Cited by 115 · see citing works
Curran, I. H., Hierlihy, S. L., Liston, V., Pantazopoulos, P., Nunnikhoven, A., Tittlemier, S. A., Barker, M., Trick, K. D., & Bondy, G. S. (2008) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802361763 · Cited by 110 · see citing works
Wolf, D. C., Moore, T., Abbott, B. D., Rosen, M. B., Das, K. P., ZEHR, R. D. J., Lindstrom, A. B., Strynar, M. J., & Lau, C. S. (2008) · Toxicologic Pathology · doi:10.1177/0192623308318216 · Cited by 111 · see citing works
Macon, M. B., Villanueva, L. R., Tatum-Gibbs, K. R., ZEHR, R. D. J., Strynar, M. J., Stanko, J. P., White, S. S., Helfant, L., & Fenton, S. E. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr076 · Cited by 110 · see citing works
Bogdanska, J., Borg, D., Sundström, M., Bergström, U., Halldin, K., Abedi-Valugerdi, M., Bergman, Å., Nelson, B., DePierre, J., & Nobel, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.014 · Cited by 109 · see citing works
Kim, S., Heo, S.-H., Lee, D., Hwang, I., Lee, Y., & Cho, H. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.09.017 · Cited by 106 · see citing works
Goeritz, I., Falk, S. R. N., Stahl, T., Schäfers, C., & Schlechtriem, C. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2279 · Cited by 103 · see citing works
Wang, Y., Vestergren, R., Shi, Y., Cao, D., Xu, L., Cai, Y., Zhao, X., & Wu, F. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b01980 · Cited by 84 · see citing works
Garcia, D. S., Sjödin, M. O. D., Hellstrandh, M., Norinder, U., Nikiforova, V., Lindberg, J., Wincent, E., Bergman, Å., Cotgreave, I. A., & Kos, V. M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.12.021 · Cited by 83 · see citing works
Loccisano, A. E., Campbell, J. L., Butenhoff, J. L., Andersen, M. E., & M.A., H. J. C. I. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.04.006 · Cited by 83 · see citing works
Cheng, W., & Ng, C. A. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02602 · Cited by 83 · see citing works
Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse
Tatum-Gibbs, K. R., Wambaugh, J. F., Das, K. P., ZEHR, R. D. J., Strynar, M. J., Lindstrom, A. B., Delinsky, A. D., & Lau, C. S. (2011) · Toxicology · doi:10.1016/j.tox.2011.01.003 · Cited by 81 · see citing works
Worley, R. R., & Fisher, J. W. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.10.017 · Cited by 76 · see citing works
Draft toxicological profile for perfluoroalkyls
Cadore, A., Chou, C.-Y., Jones, D. G., Llados, F., & Pohl, H. R. (2009) · Cited by 75 · see citing works
Loccisano, A. E., Campbell, J. L., Butenhoff, J. L., Andersen, M. E., & M.A., H. J. C. I. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.07.003 · Cited by 70 · see citing works
Lee, J. J., & Schultz, I. R. (2009) · Environmental Science & Technology · doi:10.1021/es901838y · Cited by 60 · see citing works
Toxicokinetics of perfluorocarboxylate isomers in rainbow trout
Silva, A. O. D., Tseng, P. J., & Mabury, S. A. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-088.1 · Cited by 60 · see citing works
Calvert, L., Green, M. P., Iuliis, G. D., Dun, M. D., Turner, B. D., Clarke, B., Eamens, A., Roman, S., & Nixon, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.799043 · Cited by 57 · see citing works
Worley, R., Yang, X.-X., & Fisher, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.07.001 · Cited by 51 · see citing works
Han, J., Gu, W., Barrett, H., Yang, D., Tang, S., Sun, J., Liu, J., Krause, H. M., Houck, K. A., & Peng, H. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7169 · Cited by 57 · see citing works
Wu, H., Yoon, M., Verner, M.-A., Xue, J., Luo, M., Andersen, M. E., Longnecker, M. P., & M.A., H. J. C. I. (2015) · Environment International · doi:10.1016/j.envint.2015.05.006 · Cited by 55 · see citing works
Zhang, H., He, J., Li, N., Gao, N., Du, Q., Chen, B., Chen, F., Shan, X., Ding, Y., Zhu, W., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.09.120 · Cited by 52 · see citing works
Shan, G., Ye, M., Zhu, B., & Zhu, L. Y. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.07.054 · Cited by 45 · see citing works
Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats
HAN, X., YANG, C., Snajdr, S. I., Nabb, D. L., & Mingoia, R. T. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.07.002 · Cited by 43 · see citing works
O'Brien, J., Crump, D., Mundy, L. J., Chu, S.-G., McLaren, K., Vongphachan, V., Letcher, R., & Kennedy, S. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.07.004 · Cited by 43 · see citing works
Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats
Kawabata, K., Matsuzaki, H., Nukui, S., Okazaki, M., Sakai, A., Kawashima, Y., & Kudo, N. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx058 · Cited by 37 · see citing works
Self-citationBogdanska, J., Borg, D., Bergström, U., Mellring, M., Bergman, Å., DePierre, J. W., & Nobel, S. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124755 · Cited by 37 · see citing works
Pfeifer, N. D., Harris, K. B., Yan, G. Z., & Brouwer, K. L. R. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.052134 · Cited by 36 · see citing works
Wen, Y., Kong, Y., Peng, Y. H., & Cui, X. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158372 · Cited by 32 · see citing works
Human Health Risk Assessment of Perfluoroalkyl Acids
Butenhoff, J. L., & Rodricks, J. V. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_15 · Cited by 31 · see citing works
Poteser, M., Hutter, H., Moshammer, H. M., & Weitensfelder, L. (2020) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2020.113566 · Cited by 31 · see citing works
Yamada, A., Bemrah, N., Veyrand, B., Pollono, C., Merlo, M., Desvignes, V., Sirot, V., Oseredczuk, M., Marchand, P., Cariou, R., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501113j · Cited by 29 · see citing works
Bian, Y., He, M., Ling, Y., Wang, X., Zhang, F., Feng, X., Zhang, Y., Xing, S., Li, J., Qiu, X., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118505 · Cited by 28 · see citing works
Metabolism and Pharmacokinetics
Kudo, N. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_6 · Cited by 25 · see citing works
Self-citationBioavailability of inhaled or ingested PFOA adsorbed to house dust
Gustafsson, Å., Wang, B., Gerde, P., Bergman, Å., & Yeung, L. W. Y. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20829-3 · Cited by 25 · see citing works
Modeling single and repeated dose pharmacokinetics of PFOA in mice
Wambaugh, J. F., Lou, I., Lau, C. S., Hanson, R. G., Lindstrom, A. B., Strynar, M. J., ZEHR, R. D. J., Setzer, R. W., & Barton, H. A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.11.083 · Cited by 23 · see citing works
Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body
Fàbrega, F., Kumar, V., Benfenati, E., Schuhmacher, M., Domingo, J. L., & Nadal, M. (2015) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248.2015.1060976 · Cited by 22 · see citing works
Zhao, S., Yang, Q. Y., Wang, B., Peng, Y., Zhan, J., & Liu, L. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2951-9 · Cited by 22 · see citing works
Persistent Organic Pollutants: An Overview
Wikoff, D. S., Fitzgerald, L., & Birnbaum, L. S. (2012) · doi:10.1002/9781118184141.ch1 · Cited by 22 · see citing works
Kudo, N., Yamazaki, T., Sakamoto, T., Sunaga, K., Tsuda, T., Mitsumoto, A., & Kawashima, Y. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.856 · Cited by 21 · see citing works
Self-citationPharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse
Rodriguez, C. E., Setzer, R. W., & Barton, H. A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.009 · Cited by 21 · see citing works
Iulini, M., Russo, G. L., Crispino, E., Paini, A., Fragki, S., Corsini, E., & Pappalardo, F. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.06.036 · Cited by 18 · see citing works
Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis
Wambaugh, J. F., Barton, H. A., & Setzer, R. W. (2008) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-008-9108-2 · Cited by 17 · see citing works
Bernstein, A. S., Kapraun, D. F., & Schlosser, P. M. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab063 · Cited by 16 · see citing works
EFSA Project on the use of NAMs to explore the immunotoxicity of PFAS
Corsini, E., Iulini, M., Galbiati, V., Maddalon, A., Pappalardo, F., Russo, G. L., Hoogenboom, L. A. P., Beekmann, K., Janssen, A. W. F., Louisse, J., et al. (2024) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2024.en-8926 · Cited by 16 · see citing works
Tissue toxicokinetics of perfluoro compounds with single and chronic low doses in male rats
Iwabuchi, K., Senzaki, N., Mazawa, D., Sato, I., Hara, M., Ueda, F., Liu, W., & Tsuda, S. (2017) · The Journal of Toxicological Sciences · doi:10.2131/jts.42.301 · Cited by 12 · see citing works
Brake, H. D., Wilkins, M. J., & Kaneene, J. B. (2023) · American Journal of Veterinary Research · doi:10.2460/ajvr.22.12.0221 · Cited by 10 · see citing works
IWASAKI, R., UCHIDA, J., Yamana, Y., Nakamura, Y., Maeda, K., Sotoma, S., & Yoshida, Y. (2023) · Electrochemistry · doi:10.5796/electrochemistry.23-00066 · Cited by 9 · see citing works
Dendritic cell vaccines in metastasized malignant melanoma.
Erdmann, M., & Schuler‐Thurner, B. (2008) · PubMed · Cited by 9 · see citing works
Cheng, W., & Ng, C. A. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00193 · Cited by 8 · see citing works
Gao, Y., Guo, X., Wang, S., Chen, F., Ren, X., Xiao, H., & Wang, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114571 · Cited by 8 · see citing works
Role of magnetic resonance imaging in managing selected women with newly diagnosed breast cancer
Scomersi, S., Urbani, M., Tonutti, M., Zanconati, F., & Bortul, M. (2010) · The Breast · doi:10.1016/j.breast.2009.12.005 · Cited by 7 · see citing works
Luo, Y., Ma, S., Sui, B., Zhang, L., Yu, A., Zhang, J., Zhang, Y., Zhao, W., & Ouyang, G. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.112108 · Cited by 6 · see citing works
Disposition of perfluorododecanoic acid in male rats after oral administration
Kawabata, K., Tamaki, S., Kokubo, E., Kobayashi, Y., Shinohara, T., Sakai, A., Kawai, H. F., Mitsumoto, A., Kawashima, Y., & Kudo, N. (2017) · Fundamental Toxicological Sciences · doi:10.2131/fts.4.179 · Cited by 4 · see citing works
Self-citationTsiros, P., Minadakis, V., Li, D., & Sarimveis, H. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae051 · Cited by 4 · see citing works
Starnes, H. M., & Belcher, S. M. (2026) · Journal of Xenobiotics · doi:10.3390/jox16020054 · Cited by 2 · see citing works
Abudayyak, M., Karaman, E. F., Guler, Z. R., & Özden, S. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104083 · Cited by 2 · see citing works
Rice, P. A., Cooper, J. R., Pfeil, M., & Swain, M. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.21396-6 · Cited by 1 · see citing works
O’Brien, J. M. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4542 · Cited by 1 · see citing works
Dosimetric Anchoring of Toxicological Studies
Wambaugh, J. F. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_14
Atasever, A., Yaman, D., & Temel, A. (2014) · DergiPark (Istanbul University) · doi:10.16988/iuvfd.45208
Ray, J. N. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
Pannala, V. R., Hari, A., Auerbach, S. S., & Wallqvist, A. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1866643
- Authors
- Kudo, N., Sakai, A., Mitsumoto, A., Hibino, Y., Tsuda, T., & Kawashima, Y.
- Affiliations
- Josai University (JP)
- Josai International University (JP)
- ORCID
- Kudo, Naomi
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2007
- Volume
- 30
- Issue
- 8
- Pages
- 1535-1540
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2035672210
- Cited by
- 81
- References
- 28
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- perfluorooctanoic acid, tissue distribution, dose-dependent effects, low-dose exposure, hepatic uptake, biliary excretion, membrane fraction, intravenous injection, perfluorinated compounds
- MeSH terms
- Animals, Bile, Caprylates, Dose-Response Relationship, Drug, Fluorocarbons, Injections, Intravenous, Kidney, Liver, Male, Pharmacokinetics, Subcellular Fractions, Tissue Distribution, Rats, Wistar, Rats
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