Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats
Open accessAbstract
The brain level of perfluorododecanoic acid (PFDoA) was compared with those of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in rats 9 days after a single oral dose (50 mg/kg). The PFDoA level in the brain was 44.0 ± 2.0 µg/g, which was higher than that in the serum (24.4 ± 1.0 µg/ml). In contrast, the concentrations of PFOA and PFDA in the brain were low (<0.8 and 4.7 ± 0.4 µg/g, respectively), and less than one-tenth of those in the serum. Next, to investigate the effects on brain function, the cognitive function alterations of PFOA, PFDA, and PFDoA were estimated by the novel object recognition test 5-6 days after dosing. A significant decrease in the discrimination index was observed in PFDoA-treated rats while no significant alteration was observed in PFDA- and PFOA-treated rats. The effects of PFDoA were further assessed by other behavioral tests. PFDoA-associated alteration was observed in the elevated-plus maze test, but not in the Y-maze test, open-field test, and forced swim test. A decrease in the discrimination index of the novel object recognition test was dependent on the PFDoA dose and the PFDoA concentration in the brain. PFDoA concentration in the brain was 28.6 ± 2.6 µg/g 30 days after dosing, and a decrease in discrimination index was observed. Taken together, these results suggest that PFDoA distributes in the brain easier than PFOA and PFDA and causes cognitive deficit.
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In Kawabata et al. (2017), rats exposed to the same dosage of PFOA or PFDA did not exhibit memory deficits in the novel object recognition task, and animals in all treatment groups exhibited intact working memory.
“However, rats exposed to the same dosage of PFOA or perfluorodecanoic acid (PFDA) did not exhibit memory deficits in the novel object recognition task, and animals in all treatment groups exhibited intact working memory (Kawabata et al., 2017).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Kawabata et al., 2017
The Animals and treatments and Effects of PFCA on memory function sections report that PFOA and PFDA were tested at the same 50 mg/kg dose as PFDoA and showed no significant novel-object-recognition deficit. The Y-maze result supports intact working memory only for the vehicle and PFDoA groups; the Experimental protocols section says PFOA and PFDA groups were not given that test. Page numbers are unavailable in the supplied copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredRats exposed to PFDoA showed evidence of decreased anxiety by spending more time than control rats in the open arm of an elevated plus maze, and exhibited no changes in anxiety-related behavior when tested in the open field.
“In contrast, rats exposed to PFDoA showed evidence of decreased anxiety, by spending more time than control rats in the open arm of an elevated plus maze, and exhibited no changes in anxiety-related behavior when tested in the open field (Kawabata et al., 2017).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Kawabata et al., 2017
Kawabata et al. (2017) found that adult male rats exposed to a single oral dose of 50 mg/kg PFDoA experienced decreased memory and attention in a dose-dependent fashion.
“Similarly, in a novel object recognition test conducted by Kawabata et al. (2017), adult male rats exposed to a single oral dose of 50 mg/kg perfluorododecanoic acid (PFDoA) experienced decreased memory and attention in a dose dependent fashion.”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Kawabata et al., 2017
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“In contrast, rats exposed to PFDoA showed evidence of decreased anxiety, by spending more time than control rats in the open arm of an elevated plus maze, and exhibited no changes in anxietyrelated behavior when tested in the open field (Kawabata et al., 2017).”
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- Authors
- Kawabata, K., Matsuzaki, H., Nukui, S., Okazaki, M., Sakai, A., Kawashima, Y., & Kudo, N.
- Affiliations
- Josai University (JP)
- Corresponding author
- Kudo, Naomi
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-11
- Volume
- 157
- Issue
- 2
- Pages
- 421-428
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2605989708
- Cited by
- 37
- References
- 57
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (acceptedVersion)
- Josai University Repository of Academia (Josai University) (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- perfluorododecanoic acid, perfluorooctanoic acid, perfluorodecanoic acid, perfluorinated compounds, brain distribution, cognitive impairment, novel object recognition, discrimination index, neurotoxicity, dose-dependent effects
- MeSH terms
- Animals, Behavior, Animal, Brain, Environmental Pollutants, Fluorocarbons, Lauric Acids, Male, Tissue Distribution, Rats, Wistar, Maze Learning, Cognitive Dysfunction
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