BDNF mediates improvements in executive function following a 1-year exercise intervention.
Open accessAbstract
Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which aerobic exercise may preserve executive function is through the up-regulation of brain-derived neurotropic factor (BDNF), which also declines with age. The present study examined BDNF as a mediator of the effects of a 1-year walking intervention on executive function in 90 older adults (mean age = 66.82). Participants were randomized to a stretching and toning control group or a moderate intensity walking intervention group. BDNF serum levels and performance on a task-switching paradigm were collected at baseline and follow-up. We found that age moderated the effect of intervention group on changes in BDNF levels, with those in the highest age quartile showing the greatest increase in BDNF after 1-year of moderate intensity walking exercise (p = 0.036). The mediation analyses revealed that BDNF mediated the effect of the intervention on task-switch accuracy, but did so as a function of age, such that exercise-induced changes in BDNF mediated the effect of exercise on task-switch performance only for individuals over the age of 71. These results demonstrate that both age and BDNF serum levels are important factors to consider when investigating the mechanisms by which exercise interventions influence cognitive outcomes, particularly in elderly populations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Brain-derived neurotrophic factor plays an important role in neuroplasticity and cognition.
“which play an important role in neuroplasticity (Erickson et al., 2010, 2011; Brigadski and Leßmann, 2014) and cognition (Erickson et al., 2010; Brigadski and Leßmann, 2014; Leckie et al., 2014).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Leckie et al., 2014
Serum BDNF mediates improvements in cognitive functions following a 1-year aerobic endurance training.
“serum BDNF mediates improvements in cognitive functions following a 1-year aerobic endurance training (Leckie et al., 2014)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Leckie et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Sheikh (1986) · doi:10.1300/j018v05n01_09 · Cited by 7,236 · see citing works
Introduction to mediation, moderation, and conditional process analysis :
Hayes, A. F., & names (2015) · Cited by 7,004 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Self-citationFitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782 · see citing works
Self-citationMapping cortical change across the human life span
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328 · see citing works
Aerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134 · see citing works
Self-citationExercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714 · see citing works
Neural plasticity in the ageing brain
Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,600 · see citing works
Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C., Teri, L., Crane, P., & Kukull, W. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-2-200601170-00004 · Cited by 1,463 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Ageing, fitness and neurocognitive function
Kramer, A. F., Hahn, S., Cohen, N. J., Banich, M. T., McAuley, E., Harrison, C. R., Chason, J., Vakil, E., Bardell, L., Boileau, R. A., et al. (1999) · Nature · doi:10.1038/22682 · Cited by 1,394 · see citing works
Self-citationNeural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works
Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
Sofi, F., Valecchi, D., Bacci, D., Abbate, R., Gensini, G. F., Casini, A., & Macchi, C. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02281.x · Cited by 1,210 · see citing works
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171 · cited 1× · see citing works
“However, more chronic and longer-term exercise programs have not reliably demonstrated increases in BDNF levels (Baker et al., 2010; Erickson et al., 2011; Ruscheweyh et al., 2011).”
BackgroundNagamatsu, L. S., Chan, A., Davis, J. C., Beattie, B. L., Graf, P., Voss, M. W., Sharma, D., & Liu-Ambrose, T. Y. L. (2013) · Journal of Aging Research · doi:10.1155/2013/861893 · Cited by 1,090 · see citing works
Self-citationAerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Self-citationNeeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Aging cognition: from neuromodulation to representation
Li, S., Lindenberger, U., & Sikström, S. (2001) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01769-1 · Cited by 884 · see citing works
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Inflammatory markers in population studies of aging
Singh, T., & Newman, A. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.11.002 · Cited by 866 · see citing works
The impact of age, weight and gender on BDNF levels in human platelets and plasma
Lommatzsch, M., Zingler, D., Schuhbaeck, K., Schloetcke, K., Zingler, C., Schuff‐Werner, P., & Virchow, J. C., Jr. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.03.002 · Cited by 849 · see citing works
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works
Timing of onset of cognitive decline: results from Whitehall II prospective cohort study
Singh-Manoux, A., Kivimaki, M., Glymour, M. M., Elbaz, A., Berr, C., Ebmeier, K. P., Ferrie, J. E., & Dugravot, A. (2012) · BMJ · doi:10.1136/bmj.d7622 · Cited by 836 · see citing works
Age-related alterations in white matter microstructure measured by diffusion tensor imaging
Salat, D. H., Tuch, D. S., Greve, D. N., van der Kouwe, A. J. W., Hevelone, N. D., Zaleta, A. K., Rosen, B. R., Fischl, B. R., Corkin, S., Rosas, H. D., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.017 · Cited by 832 · see citing works
Neural mechanisms of transient and sustained cognitive control during task switching.
Braver, T. S., Reynolds, J. R., & Donaldson, D. I. (2003) · Neuron · doi:10.1016/s0896-6273(03)00466-5 · Cited by 826 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724 · see citing works
Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study
Schmidt, R., Schmidt, H., Curb, J. D., Masaki, K., White, L. R., & Launer, L. J. (2002) · Annals of Neurology · doi:10.1002/ana.10265 · Cited by 710 · see citing works
Adult age differences in task switching.
Kray, J., & Lindenberger, U. (2000) · Psychology and Aging · doi:10.1037//0882-7974.15.1.126 · Cited by 691 · see citing works
Adult age differences in task switching.
Kray, J., & Lindenberger, U. (2000) · Psychology and Aging · doi:10.1037/0882-7974.15.1.126 · Cited by 691 · see citing works
Podewils, L. J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi092 · Cited by 675 · see citing works
Changes in executive control across the life span: Examination of task-switching performance.
Cepeda, N. J., Kramer, A. F., & Gonzalez de Sather, J. C. M. (2001) · Developmental Psychology · doi:10.1037/0012-1649.37.5.715 · Cited by 657 · see citing works
Self-citationTrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634 · see citing works
Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume.
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Heo, S., McLaren, M., Pence, B. D., Martin, S. A., Vieira, V. J., Woods, J. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6251-09.2010 · Cited by 604 · see citing works
Self-citationRunning enhances spatial pattern separation in mice
Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H., & Bussey, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911725107 · Cited by 553 · see citing works
The role of prefrontal cortex and posterior parietal cortex in task switching
Sohn, M.-H., Ursu, S., Anderson, J. R., Stenger, V. A., & Carter, C. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240460497 · Cited by 552 · see citing works
Predictors of cognitive change in older persons: MacArthur studies of successful aging.
Albert, M., Jones, K. J., Savage, C. R., Berkman, L. F., Seeman, T. E., Blazer, D. G., & Rowe, J. W. (1995) · Psychology and Aging · doi:10.1037//0882-7974.10.4.578 · Cited by 543 · see citing works
Predictors of cognitive change in older persons: MacArthur studies of successful aging.
Albert, M. S., Jones, K., Savage, C. R., Berkman, L., Seeman, T., Blazer, D., & Rowe, J. W. (1995) · Psychology and Aging · doi:10.1037/0882-7974.10.4.578 · Cited by 543 · see citing works
Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
Driscoll, I. F., Davatzikos, C. A., An, Y., Wu, X., Shen, D. G., Kraut, M. A., & Resnick, S. M. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a82634 · Cited by 527 · see citing works
Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study
Erickson, K. I., Raji, C. A., Lopez, O. L., Becker, J. T., Rosano, C., Newman, A. B., Gach, H. M., Thompson, P. M., Ho, A. J., & Kuller, L. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88359 · Cited by 508 · see citing works
Self-citationPhysical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
Heyman, E., Gamelin, F.-X., Goekint, M., Piscitelli, F., Roelands, B., Leclair, E., Di Marzo, V., & Meeusen, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.017 · Cited by 427 · see citing works
Neurobiological markers of exercise-related brain plasticity in older adults
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.021 · Cited by 418 · see citing works
Self-citationKramer, A. F., Hahn, S., & Gopher, D. (1999) · Acta Psychologica · doi:10.1016/s0001-6918(99)00011-6 · Cited by 405 · see citing works
Self-citationAron, A. R., Monsell, S., Sahakian, B. J., & Robbins, T. W. (2004) · Brain · doi:10.1093/brain/awh169 · Cited by 372 · see citing works
Oliff, H. S., Berchtold, N. C., Isackson, P., & Cotman, C. W. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00222-8 · Cited by 361 · see citing works
Bekinschtein, P., Cammarota, M., & Medina, J. H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.024 · Cited by 351 · see citing works
Weinstein, A. M., Voss, M. W., Prakash, R. S., Chaddock, L., Szabo‐Reed, A. N., White, S. M., Wójcicki, T. R., Mailey, E. L., McAuley, E., Kramer, A. F., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.008 · Cited by 342 · see citing works
Self-citationPang, P. T., & Lu, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.07.002 · Cited by 337 · see citing works
Early diagnosis of herpes simplex encephalitis by MRI
Schroth, G., Gawehn, J., Thron, A., Vallbracht, A., & Voigt, K. (1987) · Neurology · doi:10.1212/wnl.37.2.179 · Cited by 336 · see citing works
Stranahan, A. M., Lee, K. M., Martin, B., Maudsley, S. R., Golden, E. J., Cutler, R. G., & Mattson, M. P. (2009) · Hippocampus · doi:10.1002/hipo.20577 · Cited by 333 · see citing works
Coelho, F. G. D. M., Gobbi, S., Andreatto, C. A. A., Corazza, D. I., Pedroso, R. V., & Santos-Galduróz, R. F. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.06.003 · Cited by 327 · see citing works
Schulz, K., Gold, S. M., Witte, J. A., Bartsch, K., Lang, U. E., Hellweg, R., Reer, R., Braumann, K.-M., & Heesen, C. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.06.009 · Cited by 313 · see citing works
Evaluation of heart rate as a method for assessing moderate intensity physical activity
Strath, S. J., Swartz, A. M., Bassett, D. R., BRIEN, W. L. O., King, G. A., & Ainsworth, B. E. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00005 · Cited by 302 · see citing works
Serum neurotrophins—A study on the time course and influencing factors in a large old age sample
Ziegenhorn, A. A., Schulte‐Herbrüggen, O., Danker‐Hopfe, H., Malbranc, M., Hartung, H.-D., Anders, D., Lang, U. E., Steinhagen‐Thiessen, E., Schaub, R., & Hellweg, R. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.011 · Cited by 277 · see citing works
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 268 · see citing works
Aguiar, A. S., de Castro, A. A., Moreira, E. L. G., Glaser, V., Santos, A. R. S., Tasca, C. I., Latini, A., & Prediger, R. D. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.09.005 · Cited by 266 · see citing works
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Malkowski, E., Alves, H., Kim, J., Morris, K. S., White, S. M., Wójcicki, T. R., et al. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.005 · Cited by 261 · see citing works
Self-citationThe exercise-induced expression of BDNF within the hippocampus varies across life-span
Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.006 · Cited by 260 · see citing works
Relation of task switching to speed, age, and fluid intelligence.
Salthouse, T. A., Fristoe, N. M., McGuthry, K. E., & Hambrick, D. Z. (1998) · Psychology and Aging · doi:10.1037/0882-7974.13.3.445 · Cited by 251 · see citing works
Flöel, A., Ruscheweyh, R., Krüger, K., Willemer, C., Winter, B., Völker, K., Lohmann, H., Zitzmann, M., Mooren, F. C., Breitenstein, C., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.043 · Cited by 243 · see citing works
Self-Regulatory Processes and Exercise Adherence in Older Adults
McAuley, E., Mullen, S. P., Szabo‐Reed, A. N., White, S. M., Wójcicki, T. R., Mailey, E. L., Gothe, N. P., Olson, E. A., Voss, M. W., Erickson, K. I., et al. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.04.014 · Cited by 237 · see citing works
Self-citationRelation of task switching to speed, age, and fluid intelligence.
Salthouse, T. A., Fristoe, N. M., McGuthry, K. E., & Hambrick, D. Z. (1998) · Psychology and Aging · doi:10.1037//0882-7974.13.3.445 · Cited by 207 · see citing works
Marais, L., Stein, D. J., & Daniels, W. M. U. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9157-2 · Cited by 190 · see citing works
Neuroprotective lifestyles and the aging brain
Gow, A. J., Bastin, M. E., Maniega, S. M., Hernández, M. C. V., Morris, Z., Murray, C. L., Royle, N. A., Starr, J. M., Deary, I. J., & Wardlaw, J. M. (2012) · Neurology · doi:10.1212/wnl.0b013e3182703fd2 · Cited by 188 · see citing works
High-Throughput SNP Genotyping by Single-Tube PCR with T m -Shift Primers
Wang, J., Chuang, K., Ahluwalia, M. K., Patel, S., Umblas, N., Mirel, D. B., Higuchi, R., & Germer, S. (2005) · BioTechniques · doi:10.2144/000112028 · Cited by 167 · see citing works
Gold, B. T., Powell, D. K., Xuan, L., Jicha, G. A., & Smith, C. D. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.005 · Cited by 163 · see citing works
Yang, J.-L., Lin, Y.-T., Chuang, P.-C., Bohr, V. A., & Mattson, M. P. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8270-x · Cited by 159 · see citing works
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
Smith, J. C., Nielson, K. A., Woodard, J. L., Seidenberg, M., Durgerian, S., Hazlett, K. E., Figueroa, C. M., Kandah, C. C., Kay, C. D., Matthews, M. A., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00061 · Cited by 156 · see citing works
Gunstad, J., Benitez, A. M., Smith, J. L., Glickman, E., Spitznagel, M. B., Alexander, T. S., Juvancic-Heltzel, J. A., & Murray, L. K. (2008) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988708316860 · Cited by 144 · see citing works
Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF
Diógenes, M., Costenla, A. R., Lopes, L. V., Jerónimo-Santos, A., Sousa, V., Fontinha, B., Ribeiro, J., & Sebastião, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.64 · Cited by 144 · see citing works
Lang, U. E., Hellweg, R., Sander, T., & Gallinat, J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.80 · Cited by 142 · see citing works
Hopkins, M. E., & Bucci, D. J. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.06.006 · Cited by 139 · see citing works
Association between physical activity and brain health in older adults
Benedict, C., Brooks, S. J., Kullberg, J., Nordenskjöld, R., Burgos, J., Grevès, M. L., Kilander, L., Larsson, E., Johansson, L. O. M., Ahlström, H. K., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.013 · Cited by 139 · see citing works
Age-Related Shifts in Brain Activity Dynamics during Task Switching
Jimura, K., & Braver, T. S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp206 · Cited by 138 · see citing works
Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
Ströhle, A., Stoy, M., Graetz, B., Scheel, M., Wittmann, A., Gallinat, J., Lang, U. E., Dimeo, F., & Hellweg, R. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.013 · Cited by 135 · cited 1× · see citing works
“Acute bouts of exercise increase serum BDNF levels, which, in turn, are associated with improvements in cognitive performance (Knaepen et al., 2010; Ströhle et al., 2010; Heyman et al., 2012; Coelho et al., 2013).”
BackgroundHughes, M. M., Linck, J. A., Bowles, A. R., Koeth, J. T., & Bunting, M. F. (2013) · Behavior Research Methods · doi:10.3758/s13428-013-0411-5 · Cited by 134 · see citing works
Schiffer, T., Schulte, S., Hollmann, W., Bloch, W., & Strüder, H. K. (2008) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093322 · Cited by 132 · see citing works
Bechara, R. G., & Kelly, A. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.018 · Cited by 132 · see citing works
Erickson, K. I. (2008) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.011.2008 · Cited by 124 · see citing works
Self-citationCognitive Performance in Older Women Relative to ApoE-ε4 Genotype and Aerobic Fitness
ETNIER, J. L., CASELLI, R. J., REIMAN, E. M., ALEXANDER, G. E., SIBLEY, B. A., TESSIER, D., & MCLEMORE, E. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000239399.85955.5e · Cited by 124 · see citing works
Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory.
Erickson, K. I., Weinstein, A. M., Sutton, B. P., Prakash, R. S., Voss, M. W., Chaddock, L., Szabo, A. N., Mailey, E. L., White, S. M., Wojcicki, T. R., et al. (2012) · Brain and Behavior · doi:10.1002/brb3.30 · Cited by 110 · see citing works
Self-citationPhillips, J. M., Vinck, M. A., Everling, S., & Womelsdorf, T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht050 · Cited by 107 · see citing works
Verstynen, T., Lynch, B., Miller, D. L., Voss, M. W., Prakash, R. S., Chaddock, L., Basak, C., Szabo‐Reed, A. N., Olson, E. A., Wójcicki, T. R., et al. (2012) · Journal of Aging Research · doi:10.1155/2012/939285 · Cited by 106 · see citing works
Self-citationHoomissen, J. D. V., Holmes, P. V., Zellner, A. S., Poudevigne, A., & Dishman, R. K. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1378 · Cited by 105 · see citing works
Driscoll, I. F., Martin, B., An, Y., Maudsley, S. R., Ferrucci, L., Mattson, M. P., & Resnick, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035217 · Cited by 99 · see citing works
Woodard, J. L., Sugarman, M. A., Nielson, K. A., Smith, J. C., Seidenberg, M., Durgerian, S., Butts, A. M., Hantke, N. C., Lancaster, M. A., & Matthews, M. A. (2012) · Current Alzheimer Research · doi:10.2174/156720512800492477 · Cited by 88 · see citing works
Physical activity is related to the structural integrity of cerebral white matter
Gons, R. A. R., Tuladhar, A. M., de Laat, K. F., van Norden, A. G. W., van Dijk, E. J., Norris, D. G., Zwiers, M. P., & de Leeuw, F. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e33 · Cited by 85 · see citing works
Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults
Tian, Q., Erickson, K. I., Simonsick, E. M., Aizenstein, H. J., Glynn, N. W., Boudreau, R. M., Newman, A. B., Kritchevsky, S. B., Yaffe, K. S., Harris, T. B., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt287 · Cited by 70 · see citing works
Self-citationThe Methodology of the Social Sciences
(1951) · The Journal of Philosophy · doi:10.5840/jphil19514812 · Cited by 55 · see citing works
The neural basis of task switching changes with skill acquisition
Jimura, K., Cazalis, F., Stover, E. R. S., & Poldrack, R. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00339 · Cited by 38 · see citing works
Does White Matter Matter? Spatio-temporal Dynamics of Task Switching in Aging
Gratton, G., Wee, E., Rykhlevskaia, E. I., Leaver, E. E., & Fabiani, M. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21093 · Cited by 37 · see citing works
Gazes, Y., Rakitin, B. C., Habeck, C. G., Steffener, J., & Stern, Y. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.09.039 · Cited by 28 · see citing works
Silver, H., Goodman, C., Gur, R. C., Gur, R. E., & Bilker, W. B. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000322568 · Cited by 20 · see citing works
Relationship between source monitoring in episodic memory and executive function in normal aging
Haj, M. E., & Allain, P. (2012) · Gériatrie et Psychologie Neuropsychiatrie du Viellissement · doi:10.1684/pnv.2012.0342 · Cited by 19 · see citing works
Gómez‐Pinilla, F., & Feng, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_2 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432 · see citing works
Herold, F., Törpel, A., Schega, L., & Müller, N. G. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0217-2 · Cited by 349 · see citing works
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337 · see citing works
Neuroprotective strategies for retinal disease
Pardue, M. T., & Allen, R. S. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.02.002 · Cited by 237 · see citing works
Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research
Herold, F., Müller, P., Gronwald, T., & Müller, N. G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02338 · Cited by 196 · see citing works
Mavros, Y., Gates, N., Wilson, G. C., Jain, N., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B. T., Suo, C., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14542 · Cited by 162 · see citing works
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160 · see citing works
Sanders, L. M. J., Hortobágyi, T., Karssemeijer, E. G. A., Van der Zee, E. A., Scherder, E. J. A., & van Heuvelen, M. J. G. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00597-3 · Cited by 154 · see citing works
Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
Stimpson, N. J., Davison, G., & Javadi, A.-H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.018 · Cited by 134 · see citing works
Hwang, J., Brothers, R. M., Castelli, D. M., Glowacki, E. M., Chen, Y. T., Salinas, M. M., Kim, J., Jung, Y., & Calvert, H. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.033 · Cited by 126 · see citing works
Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults
Baniqued, P. L., Gallen, C. L., Voss, M. W., Burzynska, A. Z., Wong, C. N., Cooke, G. E., Duffy, K., Fanning, J., Ehlers, D. K., Salerno, E. A., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00426 · Cited by 112 · see citing works
Self-citationMulti-domain interventions for the prevention of dementia and cognitive decline
Hafdi, M., Hoevenaar-Blom, M. P., & Richard, E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013572.pub2 · Cited by 124 · see citing works
Brown, B. M., Castalanelli, N., Rainey-Smith, S. R., Doecke, J., Weinborn, M., Sohrabi, H. R., Laws, S. M., Martins, R. N., & Peiffer, J. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.013 · Cited by 16 · see citing works
- Authors
- Leckie, R. L., Oberlin, L. E., Voss, M. W., Prakash, R. S., Szabo-Reed, A., Chaddock-Heyman, L., Phillips, S. M., Gothe, N. P., Mailey, E., Vieira-Potter, V. J., Martin, S. A., Pence, B. D., Lin, M., Parasuraman, R., Greenwood, P. M., Fryxell, K. J., Woods, J. A., McAuley, E., Kramer, A. F., & Erickson, K. I.
- Affiliations
- University of Pittsburgh (US)
- University of Iowa (US)
- The Ohio State University (US)
- Northwestern University (US)
- Wayne State University (US)
- Kansas State University (US)
- University of Illinois Urbana-Champaign (US)
- George Mason University (US)
- Corresponding author
- Leckie, Regina L.
- ORCID
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-12-11
- Volume
- 8
- Pages
- 985-985
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC4263078
- OpenAlex
- W2143246362
- Cited by
- 307
- References
- 99
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 27 · 2023: 25 · 2022: 25 · 2021: 30 · 2020: 40 · 2019: 33 · 2018: 31 · 2017: 27 · 2016: 18 · 2015: 13
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of General Medical Sciences (T32GM081760)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095172, F32DK103493)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, executive function, aerobic exercise, walking intervention, older adults, aging, task switching, mediation analysis, age as moderator, serum BDNF, cognitive decline
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review