Ribosome biogenesis is necessary for skeletal muscle hypertrophy
Open accessAbstract
Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy.
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Ribosome biogenesis has been associated with skeletal muscle hypertrophy.
“ribosome biogenesis has been associated with skeletal muscle hypertrophy [reviewed in (Chaillou et al., 2014; Wen et al., 2016; Mcglory et al., 2017; Bamman et al., 2018; Roberts et al., 2018a; Figueiredo and Mccarthy, 2019; Kim et al., 2019)]”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Wen et al., 2016
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Cites
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752 · see citing works
A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11083 · Cited by 1,477 · see citing works
MYC as a regulator of ribosome biogenesis and protein synthesis
van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956 · see citing works
Baar, K., & Esser, K. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c120 · Cited by 726 · see citing works
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
Jefferies, H. B. J., Reinhard, C., Kozma, S. C., & Thomas, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4441 · Cited by 623 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
Self-citationRibosome assembly in eukaryotes
Fromont‐Racine, M., Senger, B., Saveanu, C., & Fasiolo, F. (2003) · Gene · doi:10.1016/s0378-1119(03)00629-2 · Cited by 592 · see citing works
Dynamics of muscle fibre growth during postnatal mouse development
White, R. B., Biérinx, A.-S., Gnocchi, V. F., & Zammit, P. S. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-21 · Cited by 512 · see citing works
Goodman, C. A., Mabrey, D. M., Frey, J. W., Miu, M. H., Schmidt, E. K., Pierre, P., & Hornberger, T. A. (2010) · The FASEB Journal · doi:10.1096/fj.10-168799 · Cited by 478 · see citing works
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy
McCarthy, J. J., & Esser, K. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00932.2006 · Cited by 423 · see citing works
Self-citationThe relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass
Millward, D. J., Garlick, P. J., Nnanyelugo, D. O., & Waterlow, J. C. (1976) · Biochemical Journal · doi:10.1042/bj1560185 · Cited by 348 · see citing works
The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth
Goodman, C. A., Frey, J. W., Mabrey, D. M., Jacobs, B. L., Lincoln, H. C., You, J., & Hornberger, T. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.218255 · Cited by 297 · see citing works
Mechanisms Modulating Skeletal Muscle Phenotype
Blaauw, B., Schiaffino, S., & Reggiani, C. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130009 · Cited by 278 · see citing works
Roberts, L. A., Raastad, T., Markworth, J. F., Figueiredo, V. C., Egner, I. M., Shield, A., Cameron‐Smith, D., Coombes, J. S., & Peake, J. M. (2015) · The Journal of Physiology · doi:10.1113/jp270570 · Cited by 218 · see citing works
Time course of changes in markers of myogenesis in overloaded rat skeletal muscles
Adams, G. R., Haddad, F., & Baldwin, K. M. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1705 · Cited by 218 · see citing works
Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise
Bickel, C. S., Slade, J. M., Mahoney, E., Haddad, F., Dudley, G. A., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00895.2004 · Cited by 200 · see citing works
Miyazaki, M., McCarthy, J. J., Fedele, M. J., & Esser, K. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.205658 · Cited by 194 · see citing works
Self-citationmTOR function in skeletal muscle hypertrophy: Increased ribosomal RNA via cell cycle regulators
Nader, G. A., McLoughlin, T. J., & Esser, K. A. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00165.2005 · Cited by 166 · see citing works
Stec, M. J., Kelly, N. A., Many, G. M., Windham, S. T., Tuggle, S. C., & Bamman, M. M. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00486.2015 · Cited by 161 · see citing works
Cardiac hypertrophy: A matter of translation
Hannan, R. D., Jenkins, A., Jenkins, A., & Brandenburger, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03873.x · Cited by 150 · see citing works
West, D. W. D., Baehr, L. M., Marcotte, G. R., Chason, C. M., Tolento, L., Gomes, A. V., Bodine, S. C., & Baar, K. (2015) · The Journal of Physiology · doi:10.1113/jp271365 · Cited by 150 · see citing works
Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy
Figueiredo, V. C., Caldow, M. K., Massie, V., Markworth, J. F., Cameron-Smith, D., & Blazevich, A. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2015 · Cited by 133 · see citing works
Nader, G. A., von Walden, F., Liu, C., Lindvall, J., Gutmann, L., Pistilli, E. E., & Gordon, P. M. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01366.2013 · Cited by 129 · see citing works
Goodman, C. A., Dietz, J. M., Jacobs, B. L., McNally, R. M., You, J.-S., & Hornberger, T. A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.047 · Cited by 121 · see citing works
Protein metabolism in rat gastrocnemius muscle after stimulated chronic concentric exercise
Wong, T., & Booth, F. W. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.5.1709 · Cited by 104 · see citing works
Figueiredo, V. C., Roberts, L. A., Markworth, J. F., Barnett, M. P. G., Coombes, J. S., Raastad, T., Peake, J. M., & Cameron-Smith, D. (2016) · Physiological Reports · doi:10.14814/phy2.12670 · Cited by 104 · see citing works
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation.
Wall, M., Poortinga, G., Hannan, K., Pearson, R., Hannan, R., & McArthur, G. (2008) · Blood · doi:10.1182/blood-2007-09-111856 · Cited by 103 · see citing works
von Walden, F., Figueiredo, V. C., Farrants, A. Ö., & Nader, G. A. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00460.2011 · Cited by 100 · see citing works
Time course of gene expression during mouse skeletal muscle hypertrophy
Chaillou, T., Lee, J. D., England, J. H., Esser, K. A., & McCarthy, J. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00611.2013 · Cited by 97 · see citing works
Self-citationRegulation of rDNA transcription in response to growth factors, nutrients and energy
Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B., & Kang, J. (2014) · Gene · doi:10.1016/j.gene.2014.11.010 · Cited by 95 · see citing works
Kirby, T. J., Lee, J. D., England, J. H., Chaillou, T., Esser, K. A., & McCarthy, J. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00296.2015 · Cited by 89 · see citing works
Self-citationThe effects of age and resistance loading on skeletal muscle ribosome biogenesis
Stec, M. J., Mayhew, D. L., & Bamman, M. M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00489.2015 · Cited by 80 · see citing works
Nakada, S., Ogasawara, R., Kawada, S., Maekawa, T., & Ishii, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147284 · Cited by 64 · see citing works
Brandenburger, Y., Jenkins, A., Autelitano, D. J., & Hannan, R. D. (2001) · The FASEB Journal · doi:10.1096/fj.00-0853fje · Cited by 62 · see citing works
Polyribosome concentration of mouse skeletal muscle as a function of age
Srivastava, U. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90018-6 · Cited by 60 · see citing works
Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise
Bickel, C. S., Slade, J. M., Mahoney, E. T., Haddad, F., Dudley, G. A., & Adams, G. (2005) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2005.453_2.x · Cited by 50 · see citing works
Mechanisms Modulating Skeletal Muscle Phenotype
Blaauw, B., Schiaffino, S., & Reggiani, C. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00534.x · Cited by 38 · see citing works
Regulation of Protein Synthesis and Skeletal Muscle Growth
Young, V. R. (1974) · Journal of Animal Science · doi:10.2527/jas1974.3851054x · Cited by 34 · see citing works
Ribonucleic Acids Associated with Myofibrils*
Zak, R., Rabinowitz, M., & Platt, C. (1967) · Biochemistry · doi:10.1021/bi00860a028 · Cited by 34 · see citing works
Chaillou, T., Jackson, J. R., England, J. H., Kirby, T. J., White, J., Esser, K. A., Dupont‐Versteegden, E. E., & McCarthy, J. J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00351.2014 · Cited by 33 · see citing works
Self-citationFiorotto, M. L., Davis, T. A., Sosa, H. A., Villegas‐Montoya, C., Estrada, I. J., & Fleischmann, R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279067 · Cited by 32 · see citing works
Brandenburger, Y. (2001) · The FASEB Journal · doi:10.1096/fj.01-0853fje · Cited by 16 · see citing works
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Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Self-citationRegulation of ribosome biogenesis in skeletal muscle hypertrophy
Figueiredo, V. C., & McCarthy, J. J. (2019) · Physiology · doi:10.1152/physiol.00034.2018 · Cited by 140 · see citing works
Self-citationMcGlory, C., Devries, M. C., & Phillips, S. M. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00613.2016 · Cited by 135 · see citing works
Mobley, C. B., Haun, C. T., Roberson, P. A., Mumford, P. W., Kephart, W. C., Romero, M. A., Osburn, S. C., Vann, C. G., Young, K. C., Beck, D. T., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195203 · Cited by 112 · see citing works
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
Figueiredo, V. C., Wen, Y., Alkner, B., Fernandez‐Gonzalo, R., Norrbom, J., Vechetti, I. J., Valentino, T., Mobley, C. B., Zentner, G. E., Peterson, C. A., et al. (2021) · The Journal of Physiology · doi:10.1113/jp281244 · Cited by 64 · see citing works
Self-citationMesquita, P. H. C., Vann, C. G., Phillips, S. M., McKendry, J., Young, K. C., Kavazis, A. N., & Roberts, M. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725866 · Cited by 62 · see citing works
- Authors
- Wen, Y., Alimov, A. P., & McCarthy, J. J.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- McCarthy, John J.
- Venue
- Exercise and Sport Sciences Reviews
- Published
- 2016-07
- Volume
- 44
- Issue
- 3
- Pages
- 110-115
- ISSN
- 0091-6331 (ISSN-L)
- 1538-3008
- PMC
- PMC4911282
- OpenAlex
- W2342507851
- Cited by
- 82
- References
- 42
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Exercise and Sport Sciences Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR064896, R01AR061939)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- ribosome biogenesis, skeletal muscle hypertrophy, translational capacity, protein synthesis, protein degradation, ribosome abundance
- MeSH terms
- Animals, Humans, Hypertrophy, Ribosomes, Protein Biosynthesis, Muscle, Skeletal, Mice
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