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Cited by 129Muscle Physiology and DisordersMuscle metabolism and nutritionCardiovascular and exercise physiology

Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy

Nader, G. A., von Walden, F., Liu, C., Lindvall, J., Gutmann, L., Pistilli, E. E., Gordon, P. M.·2014·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01366.2013
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Abstract

We sought to determine whether acute resistance exercise (RE)-induced gene expression is modified by RE training. We studied the expression patterns of a select group of genes following an acute bout of RE in naïve and hypertrophying muscle. Thirteen untrained subjects underwent supervised RE training for 12 wk of the nondominant arm and performed an acute bout of RE 1 wk after the last bout of the training program (training+acute). The dominant arm was either unexercised (control) or subjected to the same acute exercise bout as the trained arm (acute RE). Following training, men (14.8 ± 2.8%; P < 0.05) and women (12.6 ± 2.4%; P < 0.05) underwent muscle hypertrophy with increases in dynamic strength in the trained arm (48.2 ± 5.4% and 72.1 ± 9.1%, respectively; P < 0.01). RE training resulted in attenuated anabolic signaling as reflected by a reduction in rpS6 phosphorylation following acute RE. Changes in mRNA levels of genes involved in hypertrophic growth, protein degradation, angiogenesis, and metabolism commonly expressed in both men and women was determined 4 h following acute RE. We show that RE training can modify acute RE-induced gene expression in a divergent and gene-specific manner even in genes belonging to the same ontology. Changes in gene expression following acute RE are multidimensional, and may not necessarily reflect the actual adaptive response taking place during the training process. Thus RE training can selectively modify the acute response to RE, ther…

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  • Compared to trained athletes, untrained individuals have a greater capacity to activate the molecular machinery in muscle in response to contractile activity because any overload stimulus induces large perturbations to cellular homeostasis regardless of the mode of exercise.

    “Compared to trained athletes, untrained individuals have a greater capacity to activate the molecular machinery in muscle in response to contractile activity because any overload stimulus induces large perturbations to cellular homeostasis regardless of the mode of exercise (Benziane et al., 2008b;Perry et al., 2010;Nader et al., 2014).”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Nader et al., 2014

  • PGC-1α4 expression was not induced in the muscle of untrained subjects in response to an acute bout of resistance exercise undertaken at the beginning of a 12 week training programme, but was selectively up-regulated by the same exercise session at the end of the intervention period.

    “Of note, Nader et al. (Nader et al., 2014) showed PGC-1α4 expression was not induced in the muscle of untrained subjects in response to an acute bout of resistance exercise undertaken at the beginning of a 12 week training programme, but was selectively up-regulated by the same exercise session at the end of the intervention period.”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Nader et al., 2014

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Authors
Nader, G. A., von Walden, F., Liu, C., Lindvall, J., Gutmann, L., Pistilli, E. E., & Gordon, P. M.
Affiliations
  • Karolinska Institutet (SE)
  • Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden;
  • University of Iowa (US)
  • West Virginia University (US)
  • Baylor University (US)
Corresponding author
Nader, G. A.
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2014-03-15
Volume
116
Issue
6
Pages
693-702
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01366.2013
OpenAlex
W1996232933
Cited by
129
References
7
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 11 · 2017: 9 · 2016: 17 · 2015: 17 · 2014: 4
FWCI
6.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
resistance training, skeletal muscle hypertrophy, training effects, anabolic signaling, S6 phosphorylation, mRNA expression, protein degradation, angiogenesis, muscle metabolism, sex differences, exercise-induced adaptations
MeSH terms
Adaptation, Physiological, Adult, Female, Gene Expression Regulation, Humans, Hypertrophy, Male, Muscle Contraction, Muscle Proteins, RNA, Messenger, Time Factors, Muscle, Skeletal, Upper Extremity, Muscle Strength, Resistance Training, Young Adult

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