Circulating Androgens in Women: Exercise-Induced Changes
Abstract
Physical exercise is known to strongly stimulate the endocrine system in both sexes. Among these hormones, androgens (e.g. testosterone, androstenedione, dehydroepiandrosterone) play key roles in the reproductive system, muscle growth and the prevention of bone loss. In female athletes, excessive physical exercise may lead to disorders, including delay in the onset of puberty, amenorrhoea and premature osteoporosis. The free and total fractions of circulating androgens vary in response to acute and chronic exercise/training (depending on the type), but the physiological role of these changes is not completely understood. Although it is commonly accepted that only the free fraction of steroids has a biological action, this hypothesis has recently been challenged. Indeed, a change in the total fraction of androgen concentration may have a significant impact on cells (inducing genomic or non-genomic signalling). The purpose of this review, therefore, is to visit the exercise-induced changes in androgen concentrations and emphasize their potential effects on female physiology. Despite some discrepancies in the published studies (generally due to differences in the types and intensities of the exercises studied, in the hormonal status of the group of women investigated and in the methods for androgen determination), exercise is globally able to induce an increase in circulating androgens. This can be observed after both resistance and endurance acute exercises. For chronic exercise/training, the picture is definitely less clear and there are even circumstances where exercise leads to a decrease of circulating androgens. We suggest that those changes have significant impact on female physiology and physical performance.
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A review of exercise-induced changes on the androgenic profile of healthy premenopausal women found that exercise acutely increases circulating androgens, but the chronic effects are less clear.
“A review of exercise-induced changes on the androgenic profile of healthy women who were premenopausal [153] found that exercise acutely increases circulating androgens, but the chronic effects are less clear.”
From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [153]
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Key Properties of Expert Movement Systems in Sport: An Ecological Dynamics Perspective
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Resistance exercise impacts lean muscle mass in women with polycystic ovary syndrome
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- Authors
- Enea, C., Boisseau, N., Fargeas-Gluck, M. A., Diaz, V., & Dugué, B.
- Affiliations
- Université de Poitiers (FR)
- ORCID
- Boisseau, Nathalie
- Venue
- Sports Medicine
- Published
- 2011-01
- Volume
- 41
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0112-1642 (ISSN-L)
- OpenAlex
- W2211436418
- Cited by
- 103
- References
- 118
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 7
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- circulating androgens, female athletes, exercise-induced hormonal changes, testosterone, androstenedione, dehydroepiandrosterone, exercise training, resistance training, endurance exercise, amenorrhea, puberty onset, female reproductive physiology, physical performance
- MeSH terms
- Amenorrhea, Androgens, Female, Humans, Osteoporosis, Physical Endurance, Puberty, Delayed, Exercise, Resistance Training
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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