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Cited by 283Exercise and Physiological ResponsesCardiovascular and exercise physiologyPhysical Activity and Health

The Influence of Exercise Training on Inflammatory Cytokines and C-Reactive Protein

STEWART, LAURA K., FLYNN, MICHAEL G., CAMPBELL, WAYNE W., CRAIG, BRUCE A., ROBINSON, J. PAUL, TIMMERMAN, KYLE L., MCFARLIN, BRIAN K., COEN, PAUL M. +1 more·2007·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0b013e31811ece1c
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Abstract

PURPOSE: The purpose of this study was to examine the influence of a 12-wk exercise training program on inflammatory cytokine and C-reactive protein (CRP) concentrations. A secondary purpose was to determine whether training-induced changes in cytokines and CRP were influenced by age. METHODS: Twenty-nine younger (18-35 yr) and 31 older (65-85 yr) subjects were assigned to young physically active (YPA, N = 15; 25 +/- 5 yr), young physically inactive (YPI, N= 14; 25 +/- 4.7 yr), old physically active (OPA, N = 14; 71 +/- 4 yr), or old physically inactive (OPI, N = 17; 71 +/- 4 yr) groups. The inactive groups completed 12 wk (3 d.wk) of aerobic and resistance exercises, and the physically active control groups continued their normal exercise programs. Blood samples were collected before and after the 12-wk period, and the concentrations of serum CRP, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) were determined using separate ELISA. RESULTS: Control (YPA and OPA) estimated VO2max was unchanged. Exercise training increased estimated VO2max an average of 10.4% and increased strength by an average of 38.1% in both PI groups. Serum CRP decreased with training (YPI and OPI) groups and was not different from the YPA and OPA groups after training. Plasma IL-6 and IL-1beta did not change, whereas TNF-alpha was higher than YPI and YPA at baseline and after the intervention period. CONCLUSION: These results support the use of combined aerobic/resistance training as a modality to reduce the risk of cardiovascular disease development as defined by a decrease in serum CRP concentration in healthy humans.

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  • Longitudinal studies show that regular training induces a reduction in CRP level, suggesting that physical activity as such may suppress systemic low-grade inflammation.

    “Moreover, the finding in longitudinal studies that regular training induces a reduction in CRP level suggests that the physical activity as such may suppress systemic low-grade inflammation [74, 75, 79, 80].”

    From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [79]

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Authors
STEWART, L. K., FLYNN, M. G., CAMPBELL, W. W., CRAIG, B. A., ROBINSON, J. P., TIMMERMAN, K. L., MCFARLIN, B. K., COEN, P. M., & TALBERT, E.
Affiliations
  • Louisiana State University (US)
  • Purdue University West Lafayette (US)
  • University of Houston (US)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-10
Volume
39
Issue
10
Pages
1714-1719
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/mss.0b013e31811ece1c
OpenAlex
W2042930302
Semantic Scholar
0a7d8889584dc62c829b06e52dce3aefa4fea613
Cited by
283
References
45
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 13 · 2022: 10 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 16 · 2017: 18 · 2016: 22 · 2015: 21 · 2014: 27 · 2013: 18 · 2012: 16
FWCI
16.75
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
exercise training, inflammatory cytokines, C-reactive protein, interleukin-6, TNF-α, IL-1β, aerobic exercise, resistance training, physical activity, aging, cardiovascular risk, VO2max, muscle strength
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, C-Reactive Protein, Exercise Test, Female, Humans, Inflammation, Male, Oxygen Consumption, United States, Exercise, Cytokines

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