Cited by 176Hormonal and reproductive studiesClinical Laboratory Practices and Quality ControlAdrenal Hormones and Disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Predictive accuracy and sources of variability in calculated free testosterone estimates

Sartorius, Gideon, Ly, Lam P, Sikaris, Ken, McLachlan, Robert, Handelsman, David J·2009·Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

DOI 10.1258/acb.2008.008171

Open this paper in CoChat — free account

Abstract

Background: Serum free testosterone (FT) concentrations are commonly requested, but because reference FT methods are too laborious various calculational algorithms for FT based on total testosterone (TT) and sex hormone-binding globulin (SHBG) are frequently used. This study provides the first large-scale evaluation of the predictive accuracy and sources of variability for different FT formulae compared with direct laboratory measurements. Methods: Using a large data-set of direct FT measurements by centrifugal ultrafiltration, the predictive accuracy of five different formulas for cFT (four existing plus a new formula) is evaluated in 3975 consecutive blood samples. In a second data-set of 124 samples from a reference panel of healthy eugonadal young men, we estimate the relative influence of the five algorithms and eight different TT and two SHBG assays including all available commercial total TT and SHBG assays together with a gas chromatography/mass spectrometry T reference method. Results: cFT formulae show wide discrepancies with equilibrium-binding algorithms showing systematic overestimation relative to direct FT measurements, whereas two empirical cFT methods were more concordant. Variations between commercially available TT immunoassays have a strong impact on calculation of FT with TT assays contributing 82.2% of overall variance compared with 13.7% for the cFT algorithms and 4.1% for the SHBG assays. Conclusions: If FT measurements are requested and direct measurement impractical, cFT formulae using TT and SHBG immunoassays provide an approximation to direct FT measurement that is strongly dependent on the TT, cFT formula used and, to a lesser extent, SHBG immunoassays.

Integrity signals

Registry

Crossref · 10.1258/acb.2008.008171

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Some suggestions for measuring predictive performance
Sheiner, L. B., & Beal, S. L. (1981) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01060893 · Cited by 1,618
Prediction error estimation: a comparison of resampling methods
Molinaro, A. M., Simon, R. M., & Pfeiffer, R. M. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti499 · Cited by 1,343
Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
DUNN, J. F., NISULA, B. C., & RODBARD, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-58 · Cited by 1,238
Utility, Limitations, and Pitfalls in Measuring Testosterone: An Endocrine Society Position Statement
Rosner, W., Auchus, R. J., Azziz, R., Sluss, P. M., & Raff, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1864 · Cited by 1,176
Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature
Södergard, R., Bäckström, T., Shanbhag, V., & Carstensen, H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90038-3 · Cited by 1,080
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961
Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography–Mass Spectrometry in Sera from 116 Men, Women, and Children
Taieb, J., Mathian, B., Millot, F., Patricot, M. C., Mathieu, E., Queyrel, N., Lacroix, I., Somma-Delpéro, C., & Boudou, P. (2003) · Clinical Chemistry · doi:10.1373/49.8.1381 · Cited by 638

Show all 39 references

Research works printed but not linked: 2

Kratzsch J, 2001, Clin Lab, 47, 73
Burke CW, 1972, J Endocrinol, 53, xxvi

Sorted by citations

Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society Clinical Practice Guideline
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00229 · Cited by 1,736
A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications
Goldman, A. L., Bhasin, S., Wu, F. C. W., Krishna, M., Matsumoto, A. M., & Jasuja, R. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00025 · Cited by 414
Requirement for mass spectrometry sex steroid assays in the journal of clinical endocrinology and metabolism
Handelsman, D. J., & Wartofsky, L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3375 · Cited by 368
Self-citation
Androgen therapy in women: a reappraisal: an Endocrine Society Clinical Practice Guideline
Wierman, M. E., Arlt, W., Basson, R., Davis, S. R., Miller, K. K., Murad, M. H., Rosner, W., & Santoro, N. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2260 · Cited by 363
Reference Ranges for Testosterone in Men Generated Using Liquid Chromatography Tandem Mass Spectrometry in a Community-Based Sample of Healthy Nonobese Young Men in the Framingham Heart Study and Applied to Three Geographically Distinct Cohorts
Bhasin, S., Pencina, M., Jasuja, G. K., Travison, T. G., Coviello, A., Orwoll, E., Wang, P. Y., Nielson, C., Wu, F., Tajar, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-3012 · Cited by 355
Male hypogonadism
Basaria, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61126-5 · Cited by 328
High Serum Testosterone Is Associated With Reduced Risk of Cardiovascular Events in Elderly Men
Ohlsson, C., Barrett-Connor, E. L., Bhasin, S., ORWOLL, E. S., Labrie, F., Karlsson, M. K., Ljunggren, Ö., Vandenput, L., Mellström, D., & Tivesten, Å. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.019 · Cited by 298
Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry
Rothman, M. S., Carlson, N. E., Xu, M., Wang, C., Swerdloff, R., Lee, P., Goh, V. H. H., Ridgway, E. C., & Wierman, M. E. (2011) · Steroids · doi:10.1016/j.steroids.2010.10.010 · Cited by 248
Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study
Sartorius, G., Spasevska, S., Idan, A., Turner, L., Forbes, E., Zamojska, A., Allan, C. A., Ly, L. P., Conway, A. J., McLachlan, R. I., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04432.x · Cited by 209
Self-citation
Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood
Whitehouse, A., Gilani, S. Z., Faisal Shafait, B., Mian, A. S., Tan, D. W., Maybery, M. T., Keelan, J. A., Hart, R. J., Handelsman, D. J., Goonawardene, M., et al. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1351 · Cited by 181
Self-citation
Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study
Hyde, Z., Norman, P. E., Flicker, L. A., Hankey, G. J., Almeida, O. P., McCaul, K. A., Chubb, S. A. P., & Yeap, B. B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1617 · Cited by 181
Serum androgen levels and their relation to performance in track and field: mass spectrometry results from 2127 observations in male and female elite athletes
Bermon, S., & Garnier, P.-Y. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097792 · Cited by 173
Androgens and obesity
Allan, C. A., & McLachlan, R. I. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283398ee2 · Cited by 168
Self-citation
Free Testosterone Levels Are Associated with Mobility Limitation and Physical Performance in Community-Dwelling Men: The Framingham Offspring Study
Krasnoff, J. B., Basaria, S., Pencina, M. J., Jasuja, G. K., Vasan, R. S., Ulloor, J., Zhang, A., Coviello, A., Kelly-Hayes, M., D'Agostino, R. B., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2680 · Cited by 152
Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone Replacement Therapy
Surampudi, P. N., Wang, C., & Swerdloff, R. S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/625434 · Cited by 154
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism
Jayasena, C. N., Anderson, R. A., Llahana, S., Barth, J. H., MacKenzie, F., Wilkes, S., Smith, N., Sooriakumaran, P., Minhas, S., Wu, F. C. W., et al. (2022) · Clinical Endocrinology · doi:10.1111/cen.14633 · Cited by 147
ORIGINAL ARTICLE: Accuracy of calculated free testosterone formulae in men
Ly, L. P., Sartorius, G., Hull, L., Leung, A., Swerdloff, R. S., Wang, C., & Handelsman, D. J. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03804.x · Cited by 172
Self-citation
Premature Decline of Serum Total Testosterone in HIV-Infected Men in the HAART-Era
Rochira, V., Zirilli, L., Orlando, G., Santi, D., Brigante, G., Diazzi, C., Carli, F., Carani, C., & Guaraldi, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028512 · Cited by 137
Complexities of androgen receptor signalling in breast cancer
McNamara, K. M., Moore, N. L. T., Hickey, T. E., Sasano, H., & Tilley, W. D. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0243 · Cited by 134
Obesity and male hypogonadism: Tales of a vicious cycle
Carrageta, D. F., Oliveira, P. F., Alves, M. G., & Monteiro, M. P. (2019) · Obesity Reviews · doi:10.1111/obr.12863 · Cited by 130
Estrogens as regulators of bone health in men
Vandenput, L., & Ohlsson, C. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.112 · Cited by 133
Estimating age-specific trends in circulating testosterone and sex hormone-binding globulin in males and females across the lifespan
Handelsman, D. J., Sikaris, K., & Ly, L. P. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563215610589 · Cited by 122
Self-citation
The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men
O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O’Neill, T. W., Pendleton, N., Bártfai, G., Boonen, S., Casanueva, F. F., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2216 · Cited by 125
The association of obesity with sex hormone‐binding globulin is stronger than the association with ageing – implications for the interpretation of total testosterone measurements
Cooper, L. A., Page, S. T., Amory, J. K., Anawalt, B. D., & Matsumoto, A. M. (2015) · Clinical Endocrinology · doi:10.1111/cen.12768 · Cited by 117
Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project
Travison, T. G., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R. G., Couteur, D. G. L., Sambrook, P. N., & Handelsman, D. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0143 · Cited by 111
Self-citation
Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men
Auyeung, T. W., Lee, J. S. W., Kwok, T. C. Y., Leung, J. C. S., Ohlsson, C., Vandenput, L., Leung, P., & Woo, J. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-0952 · Cited by 109
Evolving utility of sex hormone-binding globulin measurements in clinical medicine
Hammond, G. L., Wu, T.-S., & Simard, M. (2012) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328353732f · Cited by 104
Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Evidence for geographical and racial variation in serum sex steroid levels in older men
Orwoll, E. S., Nielson, C. M., Labrie, F., Barrett-Connor, E., Cauley, J. A., Cummings, S. R., Ensrud, K., Karlsson, M., Lau, E., Leung, P. C., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2435 · Cited by 100
Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials
Trost, L. W., & Mulhall, J. P. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.04.068 · Cited by 98
Salivary testosterone measurement by liquid chromatography tandem mass spectrometry in adult males and females
Keevil, B. G., Macdonald, P. R., Macdowall, W. G., Lee, D. M., Wu, F. C. W., & the NATSAL Team (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563213506412 · Cited by 99
Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women
Mumford, S. L., Chavarro, J. E., Zhang, C., Perkins, N. J., Sjaarda, L. A., Pollack, A. Z., Schliep, K. C., Michels, K. A., Zarek, S. M., Plowden, T. C., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119321 · Cited by 99
Androgen Misuse and Abuse
Handelsman, D. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab001 · Cited by 104
Self-citation
Investigation and management of subfertility
Thurston, L., Abbara, A., & Dhillo, W. S. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2018-205579 · Cited by 102
Sex differences in vascular aging in response to testosterone
Moreau, K. L., Babcock, M. C., & Hildreth, K. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00294-8 · Cited by 98
Associations between Testosterone Levels and Incident Prostate, Lung, and Colorectal Cancer. A Population-Based Study
Hyde, Z., Flicker, L. A., McCaul, K. A., Almeida, O. P., Hankey, G. J., Chubb, S. A. P., & Yeap, B. B. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0129 · Cited by 93
Uncertainty in measurement: a review of monte carlo simulation using microsoft excel for the calculation of uncertainties through functional relationships, including uncertainties in empirically derived constants.
(2014) · Europe PMC (PubMed Central) · Cited by 91
Free Testosterone
Shea, J. L., Wong, P.-Y., & Chen, Y. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-800094-6.00002-9 · Cited by 91
Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Cumming, R. G., Waite, L. M., Blyth, F., Naganathan, V., Couteur, D. G. L., Seibel, M. J., & Handelsman, D. J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1016 · Cited by 88
Self-citation
Androgen Concentrations in Umbilical Cord Blood and Their Association with Maternal, Fetal and Obstetric Factors
Keelan, J. A., Mattes, E., Tan, H., Dinan, A., Newnham, J. P., Whitehouse, A., Jacoby, P. A., & Hickey, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042827 · Cited by 82
Principles and pitfalls of free hormone measurements
Faix, J. D. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.06.007 · Cited by 81
A multi-step, dynamic allosteric model of testosterone's binding to sex hormone binding globulin
Zakharov, M. N., Bhasin, S., Travison, T. G., Xue, R., Ulloor, J., Vasan, R. S., Carter, E., Wu, F., & Jasuja, R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.001 · Cited by 81
The Laboratory Diagnosis of Testosterone Deficiency
Paduch, D. A., Brannigan, R. E., Fuchs, E. F., Kim, E. D., Marmar, J. L., & Sandlow, J. I. (2014) · Urology · doi:10.1016/j.urology.2013.12.024 · Cited by 79
Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study
Whitehouse, A., Mattes, E., Maybery, M. T., Dissanayake, C., SAWYER, M. G., Jones, R., Pennell, C. E., Keelan, J. A., & Hickey, M. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-25 · Cited by 80
Free Testosterone: Pumping up the Tires or Ending the Free Ride?
Handelsman, D. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00171 · Cited by 78
Self-citation
Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity
Lawson, L. P., Keelan, J. A., Jamnadass, E. S. L., Maybery, M. T., Hickey, M., & Whitehouse, A. (2015) · Early Human Development · doi:10.1016/j.earlhumdev.2014.12.011 · Cited by 70
Thyroid hormones and male sexual function
Corona, G., Wu, F. C. W., Forti, G., Lee, D. M., O'Connor, D. B., O’Neill, T. W., Pendleton, N., Bártfai, G., Boonen, S., Casanueva, F. F., et al. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01266.x · Cited by 69
Relation of total and free testosterone and sex hormone-binding globulin with cardiovascular risk factors in men aged 24–45 years. The Cardiovascular Risk in Young Finns Study
Firtser, S., Juonala, M., Magnussen, C. G., Jula, A., Loo, B.-M., Marniemi, J., Viikari, J. S. A., Toppari, J., Perheentupa, A. H., Hutri‐Kähönen, N., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.020 · Cited by 69
Prospective longitudinal study of testosterone and incident depression in older men: The Health In Men Study
Ford, A. H., Yeap, B. B., Flicker, L. A., Hankey, G. J., Chubb, S. A. P., Handelsman, D. J., Golledge, J., & Almeida, O. P. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.012 · Cited by 69
Self-citation
Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study
Marriott, R. J., Murray, K., Flicker, L. A., Hankey, G. J., Matsumoto, A. M., Dwivedi, G., Antonio, L., Almeida, O. P., Bhasin, S., Dobs, A. S., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12529 · Cited by 67
Self-citation
Associations of Serum Testosterone and Sex Hormone–Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men
Yeap, B. B., Marriott, R. J., Antonio, L., Raj, S., Dwivedi, G., Reid, C. M., Anawalt, B. D., Bhasin, S., Dobs, A. S., Handelsman, D. J., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m21-0551 · Cited by 62
Self-citation
Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project
Hsu, B., Cumming, R. G., Seibel, M. J., Naganathan, V., Blyth, F., Bleicher, K., Dave, A., Couteur, D. G. L., Waite, L. M., & Handelsman, D. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2493 · Cited by 63
Self-citation
Accuracy of calculated free testosterone differs between equations and depends on gender and SHBG concentration
Hackbarth, J. S., Hoyne, J. B., Grebe, S. K. G., & Singh, R. (2010) · Steroids · doi:10.1016/j.steroids.2010.08.008 · Cited by 62
Performance of Total Testosterone Measurement to Predict Free Testosterone for the Biochemical Evaluation of Male Hypogonadism
Anawalt, B. D., Hotaling, J. M., Walsh, T. J., & Matsumoto, A. M. (2012) · Journal of Urology · doi:10.1016/j.juro.2011.11.095 · Cited by 55
Do low testosterone levels contribute to ill-health during male ageing?
Yeap, B. B., de Araújo, A. B., & Wittert, G. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.725461 · Cited by 53
Plasma Testosterone and the Course of Major Depressive Disorder in Older Men and Women
Giltay, E. J., van der Mast, R. C., Lauwen, E., Heijboer, A. C., de Waal, M. W. M., & Comijs, H. C. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.12.014 · Cited by 54
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00138-4 · Cited by 54
Self-citation
Characteristics of Compensated Hypogonadism in Patients with Sexual Dysfunction
Corona, G., Maseroli, E., Rastrelli, G., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12549 · Cited by 51
Testosterone, cognitive decline and dementia in ageing men
Yeap, B. B., & Flicker, L. A. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09728-7 · Cited by 51
Progressive Temporal Change in Serum SHBG, But Not in Serum Testosterone or Estradiol, Is Associated With Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Seibel, M. J., Cumming, R. G., Blyth, F., Naganathan, V., Bleicher, K., Couteur, D. G. L., Waite, L. M., & Handelsman, D. J. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2904 · Cited by 49
Self-citation
Temporal Changes in Androgens and Estrogens Are Associated With All-Cause and Cause-Specific Mortality in Older Men
Hsu, B., Cumming, R. G., Naganathan, V., Blyth, F., Couteur, D. G. L., Hirani, V., Waite, L. M., Seibel, M. J., & Handelsman, D. J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1025 · Cited by 48
Self-citation
The Longitudinal Relationship of Sexual Function and Androgen Status in Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Cumming, R. G., Blyth, F., Naganathan, V., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4104 · Cited by 48
Self-citation
Performance of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome
Handelsman, D. J., Teede, H. J., Desai, R., Norman, R. J., & Moran, L. J. (2017) · Human Reproduction · doi:10.1093/humrep/dew328 · Cited by 47
Self-citation
Association Between Peyronie Disease and Low Serum Testosterone Levels: Detection and Therapeutic Considerations
Cavallini, G., Biagiotti, G., & Giudice, C. L. (2012) · Journal of Andrology · doi:10.2164/jandrol.111.012948 · Cited by 47
Standardization of Hormonal Assays for the 21st Century
Wartofsky, L., & Handelsman, D. J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2369 · Cited by 45
Self-citation
An update on male hypogonadism therapy
Surampudi, P. N., Swerdloff, R. S., & Wang, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.913022 · Cited by 46
Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study
Schliep, K. C., Zarek, S. M., Schisterman, E. F., Wactawski‐Wende, J., Trevisan, M., Sjaarda, L. A., Perkins, N. J., & Mumford, S. L. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.102160 · Cited by 45
Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life
Yeap, B. B., Manning, L. A., Chubb, S. A. P., Handelsman, D. J., Almeida, O. P., Hankey, G. J., & Flicker, L. A. (2017) · Clinical Endocrinology · doi:10.1111/cen.13484 · Cited by 45
Self-citation
Sex hormones and incident dementia in older men: The health in men study
Ford, A. H., Yeap, B. B., Flicker, L. A., Hankey, G. J., Chubb, S. A. P., Golledge, J., & Almeida, O. P. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.013 · Cited by 47
Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men
Hsu, B., Cumming, R. G., Hirani, V., Blyth, F., Naganathan, V., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3810 · Cited by 45
Self-citation
Associations between blood cadmium and endocrine features related to PCOS-phenotypes in healthy women of reproductive age: a prospective cohort study
Kim, K., Pollack, A. Z., Nobles, C. J., Sjaarda, L. A., Zolton, J. R., Radoc, J. G., Schisterman, E. F., & Mumford, S. L. (2021) · Environmental Health · doi:10.1186/s12940-021-00749-4 · Cited by 44
Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study
Canoy, D., Barber, T. M., Pouta, A., Hartikainen, A. L., McCarthy, M. I., Franks, S., Järvelin, M., Tapanainen, J. S., Ruokonen, A., Huhtaniemi, I. T., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1046 · Cited by 40
Cannabis use while trying to conceive: a prospective cohort study evaluating associations with fecundability, live birth and pregnancy loss
Mumford, S. L., Flannagan, K. S. J., Radoc, J. G., Sjaarda, L. A., Zolton, J. R., Metz, T. D., Plowden, T. C., Perkins, N. J., DeVilbiss, E. A., Andriessen, V. C., et al. (2020) · Human Reproduction · doi:10.1093/humrep/deaa355 · Cited by 36
Sex hormone‐binding globulin is associated with androgen deficiency features independently of total testosterone
Rastrelli, G., Corona, G., Cipriani, S., Mannucci, E., & Maggi, M. (2017) · Clinical Endocrinology · doi:10.1111/cen.13530 · Cited by 35
Androgens and osteoporosis
Ebeling, P. R. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328339658c · Cited by 35
The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study
Jamnadass, E. S. L., Keelan, J. A., Lawson, L. P., Hickey, M., Maybery, M. T., & Whitehouse, A. (2015) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-015-9114-9 · Cited by 38
The Significance of Biological Variation in the Diagnosis of Testosterone Deficiency, and Consideration of the Relevance of Total, Free and Bioavailable Testosterone Determinations
Collier, C. P., Morales, Á., CLARK, A. F., Lam, M., Wynne‐Edwards, K. E., & Black, A. M. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.02.011 · Cited by 34
Increased Androgen, Anti-Müllerian Hormone, and Sporadic Anovulation in Healthy, Eumenorrheic Women: A Mild PCOS-Like Phenotype?
Sjaarda, L. A., Mumford, S. L., Kissell, K., Schliep, K. C., Hammoud, A. O., Perkins, N. J., Weck, J., Wactawski‐Wende, J., & Schisterman, E. F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3781 · Cited by 34
Longitudinal and Cross-Sectional Relationships of Circulating Reproductive Hormone Levels to Self-Rated Health and Health-Related Quality of Life in Community-Dwelling Older Men
Hsu, B., Cumming, R. G., Blyth, F., Naganathan, V., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3984 · Cited by 33
Self-citation
Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women
Kim, K., Wactawski‐Wende, J., Michels, K. A., Plowden, T. C., Chaljub, E. N., Sjaarda, L. A., & Mumford, S. L. (2016) · Journal of Nutrition · doi:10.3945/jn.116.241521 · Cited by 33
Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study
Svartberg, J., Schirmer, H., Wilsgaard, T., Mathiesen, E. B., Njølstad, I., Løchen, M.-L., & Jorde, R. (2014) · Andrology · doi:10.1111/j.2047-2927.2013.00174.x · Cited by 32
Associations Between Circulating Reproductive Hormones and SHBG and Prevalent and Incident Metabolic Syndrome in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Cumming, R. G., Naganathan, V., Blyth, F., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2464 · Cited by 30
Self-citation
Importance of hypogonadism and testosterone replacement therapy in current urologic practice: a review
Hellstrom, W. J. G., Paduch, D. A., & Donatucci, C. F. (2010) · International Urology and Nephrology · doi:10.1007/s11255-010-9879-4 · Cited by 29
Androgens and male aging: current evidence of safety and efficacy
Gooren, L. J. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.4 · Cited by 29
Early Life Events Predict Adult Testicular Function; Data Derived From the Western Australian (Raine) Birth Cohort
Hart, R. J., Doherty, D. A., Keelan, J. A., McLachlan, R. I., Skakkebæk, N. E., Norman, R. J., Dickinson, J. E., Pennell, C. E., Newnham, J. P., Hickey, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1646 · Cited by 26
Self-citation
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00137-4 · Cited by 26
Self-citation
Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Cumming, R. G., Blyth, F., Naganathan, V., Waite, L. M., Couteur, D. G. L., Seibel, M. J., & Handelsman, D. J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx170 · Cited by 24
Self-citation
An old emperor finds new clothing: rejuvenation in our time
Handelsman, D. J. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.154 · Cited by 23
Self-citation
Longitudinal Relationships of Circulating Reproductive Hormone With Functional Disability, Muscle Mass, and Strength in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project
Hsu, B., Cumming, R. G., Naganathan, V., Blyth, F., Couteur, D. G. L., Seibel, M. J., Waite, L. M., & Handelsman, D. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1124 · Cited by 22
Self-citation
Dietary Carbohydrate Intake Does Not Impact Insulin Resistance or Androgens in Healthy, Eumenorrheic Women
Sjaarda, L. A., Schisterman, E. F., Schliep, K. C., Plowden, T. C., Zarek, S. M., Yeung, E. H., Wactawski‐Wende, J., & Mumford, S. L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1957 · Cited by 28
Testosterone, frailty and physical function in older men
Hsu, B., Cumming, R. G., & Handelsman, D. J. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1475227 · Cited by 22
Self-citation
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study
Schliep, K. C., Schisterman, E. F., Wactawski‐Wende, J., Perkins, N. J., Radin, R. G., Zarek, S. M., Mitchell, E. M., Sjaarda, L. A., & Mumford, S. L. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118430 · Cited by 21
MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis
PUGEAT, M. M., Plotton, I., de la Perrière, A. B., Raverot, G., Déchaud, H., & Raverot, V. (2018) · European Journal of Endocrinology · doi:10.1530/eje-17-0776 · Cited by 20
Changes in inflammatory markers correlated with increased testosterone after laparoscopic sleeve gastrectomy in obese Chinese men with acanthosis nigricans
Zhu, C., Mei, F., Gao, J., Zhou, D., Lu, L., & Qu, S. (2019) · The Journal of Dermatology · doi:10.1111/1346-8138.14783 · Cited by 19
Certainly More Guidelines than Rules
McLachlan, R. I. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0838 · Cited by 18
Self-citation
Longitudinal changes in serum testosterone and sex hormone‐binding globulin in men aged 40–69 years from the UK Biobank
Marriott, R. J., Murray, K., Hankey, G. J., Manning, L. A., Dwivedi, G., Wu, F. C. W., & Yeap, B. B. (2021) · Clinical Endocrinology · doi:10.1111/cen.14648 · Cited by 18
The Effect of Steroid Hormones on the Physical Performance of Boys and Girls During an Olympic Weightlifting Competition
Crewther, B. T., Obmiński, Z., & Cook, C. J. (2016) · Pediatric Exercise Science · doi:10.1123/pes.2016-0070 · Cited by 18
Dietary Intakes of Vitamin B-2 (Riboflavin), Vitamin B-6, and Vitamin B-12 and Ovarian Cycle Function among Premenopausal Women
Kim, K., Mills, J. L., Michels, K. A., Chaljub, E. N., Wactawski‐Wende, J., Plowden, T. C., & Mumford, S. L. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.10.013 · Cited by 17
Ramifications of variability in sex hormone-binding globulin measurement by different immunoassays on the calculation of free testosterone
Adaway, J., Keevil, B. G., Miller, A. M., Monaghan, P. J., Merrett, N., & Owen, L. J. (2019) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563219888549 · Cited by 16

Authors: Sartorius, G., Ly, L. P., Sikaris, K., McLachlan, R., & Handelsman, D. J.
Affiliations: The University of Sydney (AU)
The University of Melbourne (AU)
Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
Corresponding author: Handelsman, David J
ORCID: Sartorius, Gideon
Sikaris, Ken
McLachlan, Robert
Handelsman, David J
Venue: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
Publisher: SAGE Publications
Published: 2009-01-22
Volume: 46
Issue: 2
Pages: 137-143
ISSN: 0004-5632 (ISSN-L)
1758-1001
DOI: 10.1258/acb.2008.008171
OpenAlex: W2042309501
Cited by: 175
References: 39
Citations by year: 2025: 8 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 16 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 12 · 2013: 9 · 2012: 16
FWCI: 11.61
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation
Johnson and Johnson
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: free testosterone, total testosterone, sex hormone-binding globulin, prediction accuracy, assay variability, centrifugal ultrafiltration, eugonadal men
MeSH terms: Humans, Male, Middle Aged, Testosterone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Predictive accuracy and sources of variability in calculated free testosterone estimates

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks