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Cited by 359

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The C8 Health Project: Design, Methods, and Participants

Open access
Frisbee, Stephanie J., Brooks, A. Paul, Maher, Arthur, Flensborg, Patsy, Arnold, Susan, Fletcher, Tony, Steenland, Kyle, Shankar, Anoop, Knox, Sarah S., Pollard, Cecil, Halverson, Joel A., Vieira, Verónica M., Jin, Chuanfang, Leyden, Kevin M., Ducatman, Alan M.·2009·Environmental Health Perspectives
DOI 10.1289/ehp.0800379
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Abstract

BACKGROUND: The C8 Health Project was created, authorized, and funded as part of the settlement agreement reached in the case of Jack W. Leach, et al. v. E.I. du Pont de Nemours & Company (no. 01-C-608 W.Va., Wood County Circuit Court, filed 10 April 2002). The settlement stemmed from the perfluorooctanoic acid (PFOA, or C8) contamination of drinking water in six water districts in two states near the DuPont Washington Works facility near Parkersburg, West Virginia. OBJECTIVES: This study reports on the methods and results from the C8 Health Project, a population study created to gather data that would allow class members to know their own PFOA levels and permit subsequent epidemiologic investigations. METHODS: Final study participation was 69,030, enrolled over a 13-month period in 2005-2006. Extensive data were collected, including demographic data, medical diagnoses (both self-report and medical records review), clinical laboratory testing, and determination of serum concentrations of 10 perfluorocarbons (PFCs). Here we describe the processes used to collect, validate, and store these health data. We also describe survey participants and their serum PFC levels. RESULTS: The population geometric mean for serum PFOA was 32.91 ng/mL, 500% higher than previously reported for a representative American population. Serum concentrations for perfluorohexane sulfonate and perfluorononanoic acid were elevated 39% and 73% respectively, whereas perfluorooctanesulfonate was present at levels similar to those in the U.S. population. CONCLUSIONS: This largest known population study of community PFC exposure permits new evaluations of associations between PFOA, in particular, and a range of health parameters. These will contribute to understanding of the biology of PFC exposure. The C8 Health Project also represents an unprecedented effort to gather basic data on an exposed population; its achievements and limitations can inform future legal settlements for populations exposed to environmental contaminants.

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Cites

Show all 4 references

Research works printed but not linked: 15

  1. Apelberg, 2007, Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth, Environ Health Perspect, 115, 1670, 10.1289/ehp.10334 · DOI · Paper page
  2. Calafat, 2007, Serum concentrations of 11 polyfluoroalkyl compounds in the US population: data from the National Health and Nutrition Examination Survey (NHANES) 1999–2000, Environ Sci Technol, 41, 2237, 10.1021/es062686m · DOI · Paper page
  3. Emmett, 2006, Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources, J Occup Environ Med, 48, 759, 10.1097/01.jom.0000232486.07658.74 · DOI · Paper page
  4. Flaherty, 2005, Quantitative determination of perfluorooctanoic acid in serum and plasma by liquid chromatography tandem mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 819, 329, 10.1016/j.jchromb.2005.03.002 · DOI
  5. Jensen, 2008, Emerging endocrine disrupters: perfluoroalkylated substances, Int J Androl, 31, 161, 10.1111/j.1365-2605.2008.00870.x · DOI · Paper page
  6. Kudo, 2003, Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals, Toxicol Sci, 28, 49, 10.2131/jts.28.49 · DOI · Paper page
  7. Kuklenyik, 2004, Automated solid phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk, Environ Sci Technol, 38, 3698, 10.1021/es040332u · DOI · Paper page
  8. Nolan, 2008, The relationship between birth weight, gestational age, and perfluorooctanoic acid (PFOA)-contaminated public drinking water, Reprod Toxicol, 27, 231
  9. Olsen, 2003, Epidemiologic assessment of worker serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations, J Occup Environ Med, 45, 260, 10.1097/01.jom.0000052958.59271.10 · DOI · Paper page
  10. Steenland, 2009, Predictors of PFOA levels in a community surrounding a chemical plant, Environ Health Perspect, 117, 1083, 10.1289/ehp.0800294 · DOI
  11. Taniyasu, 2005, Analysis of flurotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota, J Chromatogr A, 1093, 89, 10.1016/j.chroma.2005.07.053 · DOI · Paper page
  12. Tao, 2006, Perfluorooctane sulfonate and related chemicals in albatrosses, elephant seals, penguins, and polar skuas from the Southern Ocean, Environ Sci Technol, 40, 7642, 10.1021/es061513u · DOI
  13. van Leeuwen, 2006, Struggle for quality in determination of perfluorinated contaminants in environmental and human samples, Environ Sci Technol, 40, 7854, 10.1021/es061052c · DOI
  14. Washino, 2009, Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth, Environ Health Perspect, 117, 660, 10.1289/ehp.11681 · DOI · Paper page
  15. Yamashita, 2008, Perfluorinated acids as novel chemical tracers of global circulation of ocean waters, Chemosphere, 70, 1247, 10.1016/j.chemosphere.2007.07.079 · DOI · Paper page

Cited by

Metadata

Authors
Frisbee, S. J., Brooks, A. P., Maher, A., Flensborg, P., Arnold, S., Fletcher, T., Steenland, K., Shankar, A., Knox, S. S., Pollard, C., Halverson, J. A., Vieira, V. M., Jin, C., Leyden, K. M., & Ducatman, A. M.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2009-12
Volume
117
Issue
12
Pages
1873-1882
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.0800379
OpenAlex
W2068337533
Cited by
359
References
4
FWCI
11.15
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor, 3091 d)

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