Unraveling the Genetics of Human Obesity

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,719 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Yeo, G. S. H., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., & O'Rahilly, S. (1998) · Nature Genetics · doi:10.1038/2404 · Cited by 1,159 · see citing works

Gene–environment interactions in human diseases

Hunter, D. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1578 · Cited by 1,132 · see citing works

The Human Obesity Gene Map: The 2005 Update

Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Vaisse, C., Clément, K., Guy-grand, B., & Froguel, P. (1998) · Nature Genetics · doi:10.1038/2407 · Cited by 1,091 · see citing works

Patterns of linkage disequilibrium in the human genome

Ardlie, K., Kruglyak, L., & Seielstad, M. (2002) · Nature reviews genetics · doi:10.1038/nrg777 · Cited by 1,064 · see citing works

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897 · see citing works

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896 · see citing works

Finding genes that underlie complex traits.

Glazier, A. M., Nadeau, J. H., & Aitman, T. J. (2002) · Science · doi:10.1126/science.1076641 · Cited by 855 · see citing works

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Farooqi, I. S., Yeo, G. S. H., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G. E., Cheetham, T. D., & O’Rahilly, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9397 · Cited by 811 · see citing works

BDNF regulates eating behavior and locomotor activity in mice

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806 · see citing works

Genetics of body-weight regulation

Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 775 · see citing works

A common genetic variant is associated with adult and childhood obesity.

Herbert, A., Gerry, N. P., McQueen, M. B., Heid, I. M., Pfeufer, A., Illig, T., Wichmann, H.-E., Meitinger, T., Hunter, D., Hu, F. B., et al. (2006) · Science · doi:10.1126/science.1124779 · Cited by 732 · see citing works

The genetics of human obesity

Bell, C. G., Walley, A. J., & Froguel, P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1556 · Cited by 650 · see citing works

Elevated plasma ghrelin levels in Prader–Willi syndrome

Cummings, D. E., Clément, K., Purnell, J., Vaisse, C., Foster, K. E., Frayo, R. S., Schwartz, M., Basdevant, A., & Weigle, D. (2002) · Nature Medicine · doi:10.1038/nm0702-643 · Cited by 622 · see citing works

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

Yeo, G. S. H., Hung, C.-C. C., Rochford, J. J., Keogh, J. M., Gray, J. A., Sivaramakrishnan, S., O’Rahilly, S., & Farooqi, I. S. (2004) · Nature Neuroscience · doi:10.1038/nn1336 · Cited by 608 · see citing works

Population structure, differential bias and genomic control in a large-scale, case-control association study

Clayton, D. G., Walker, N. M., Smyth, D. J., Pask, R., Cooper, J. D., Maier, L. M., Smink, L. J., Lam, A. C., Ovington, N. R., Stevens, H. E., et al. (2005) · Nature Genetics · doi:10.1038/ng1653 · Cited by 526 · see citing works

Family-based designs in the age of large-scale gene-association studies

Laird, N., & Lange, C. (2006) · Nature reviews genetics · doi:10.1038/nrg1839 · Cited by 477 · see citing works

Monogenic Obesity in Humans

Farooqi, I. S., & O’Rahilly, S. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.062904.144924 · Cited by 439 · see citing works

The nature and identification of quantitative trait loci: a community's view

Members of the Complex Trait Consortium (2003) · Nature Reviews Genetics · doi:10.1038/nrg1206 · Cited by 437 · see citing works

Homozygosity mapping with SNP arrays identifies TRIM32 , an E3 ubiquitin ligase, as a Bardet–Biedl syndrome gene ( BBS11 )

Chiang, A. P.-F., Beck, J. S., Yen, H.-J., Tayeh, M. K., Scheetz, T. E., Swiderski, R. E., Nishimura, D. Y., Braun, T. A., Kim, K. A., Huang, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600158103 · Cited by 433 · see citing works

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

L., J., Jr. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.101 · Cited by 400 · see citing works

Prader-Willi syndrome: advances in genetics, pathophysiology and treatment

Goldstone, A. P. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.11.003 · Cited by 388 · see citing works

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

de Luca, C., Kowalski, T. J., Zhang, Y., Elmquist, J. K., Lee, C., Kilimann, M. W., Ludwig, T. E., Liu, S.-M., & Chua, S. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24059 · Cited by 383 · see citing works

Nutrigenomics and nutrigenetics: the emerging faces of nutrition

Mutch, D. M., Wahli, W., & Williamson, G. (2005) · The FASEB Journal · doi:10.1096/fj.05-3911rev · Cited by 352 · see citing works

Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome

Fan, Y., Esmail, M. A., Ansley, S. J., Blacque, O. E., Boroevich, K. A., Ross, A. J., Moore, S., Badano, J. L., May‐Simera, H., Compton, D. S., et al. (2004) · Nature Genetics · doi:10.1038/ng1414 · Cited by 336 · see citing works

Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly

Mykytyn, K., Mullins, R. F., Andrews, M., Chiang, A. P.-F., Swiderski, R. E., Yang, B., Braun, T. A., Casavant, T. L., Stone, E. M., & Sheffield, V. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402354101 · Cited by 336 · see citing works

Cilia: Tuning in to the Cell's Antenna

Marshall, W. F., & Nonaka, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.07.012 · Cited by 286 · see citing works

BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus

Stoetzel, C., Laurier, V., Davis, E. E., Muller, J., Rix, S., Badano, J. L., Leitch, C. C., Salem, N., Chouery, É., Corbani, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1771 · Cited by 285 · see citing works

Nutritional Epigenomics of Metabolic Syndrome

Gallou‐Kabani, C., & Junien, C. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1899 · Cited by 273 · see citing works

Melanocortin 4 Receptor Mutations in a Large Cohort of Severely Obese Adults: Prevalence, Functional Classification, Genotype-Phenotype Relationship, and Lack of Association with Binge Eating

Lubrano-Berthelier, C., Dubern, B., Lacorte, J., Picard, F., Shapiro, A., Zhang, S., Bertrais, S., Herçberg, S., Basdevant, A., Clément, K., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1411 · Cited by 241 · see citing works

A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance

Lee, Y. S., Challis, B. G., Thompson, D. A., Yeo, G. S. H., Keogh, J. M., Madonna, M. E., Wraight, V., Sims, M., Vatin, V., Meyre, D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.006 · Cited by 235 · see citing works

Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

Coll, A. P., Farooqi, I. S., Challis, B., Yeo, G. S. H., & O’Rahilly, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0428 · Cited by 232 · see citing works

Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity

Geller, F., Reichwald, K., Dempfle, A., Illig, T., Vollmert, C., Herpertz, S., Siffert, W., Platzer, M., Hess, C., Gudermann, T. W., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/382490 · Cited by 217 · see citing works

Comparative Genomics and Gene Expression Analysis Identifies BBS9, a New Bardet-Biedl Syndrome Gene

Nishimura, D. Y., Swiderski, R. E., Searby, C. C., Berg, E. M., Ferguson, A. L., Hennekam, R. C. M., Merin, S. C., Weleber, R. G., Biesecker, L. G., Stone, E. M., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/498323 · Cited by 216 · see citing works

Prevalence, Spectrum, and Functional Characterization of Melanocortin-4 Receptor Gene Mutations in a Representative Population-Based Sample and Obese Adults from Germany

Hinney, A., Bettecken, T., Tarnow, P., Brumm, H., Reichwald, K., Lichtner, P., Scherag, A., Nguyen, T. T., Schlumberger, P., Rief, W., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2056 · Cited by 209 · see citing works

Polygenic control of Caenorhabditis elegans fat storage

Mak, H. Y., Nelson, L. S., Basson, M., Johnson, C. D., & Ruvkun, G. (2006) · Nature Genetics · doi:10.1038/ng1739 · Cited by 194 · see citing works

Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Sebhat, I. K., Martin, W. J., Ye, Z., Barakat, K., Mosley, R. T., Johnston, D. B. R., Bakshi, R. K., Palucki, B. L., Weinberg, D. H., MacNeil, T., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025539h · Cited by 194 · see citing works

Targeting melanocortin receptors as potential novel therapeutics

Getting, S. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.022 · Cited by 194 · see citing works

Statistical false positive or true disease pathway?

Todd, J. A. (2006) · Nature Genetics · doi:10.1038/ng0706-731 · Cited by 178 · see citing works

The metabolic syndrome: the crossroads of diet and genetics

Roche, H. M., Phillips, C. M., & Gibney, M. J. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005445 · Cited by 177 · see citing works

Exploring the molecular basis of Bardet-Biedl syndrome

Katsanis, N. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.20.2293 · Cited by 166 · see citing works

The case for strategic international alliances to harness nutritional genomics for public and personal health

Kaput, J., Ordovás, J. M., Ferguson, L. R., van Ommen, B., Rodriguez, R. L., Allen, L. H., Ames, B. N., Dawson, K., German, B. J., Krauss, R. M., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051585 · Cited by 156 · see citing works

Growth hormone improves mobility and body composition in infants and toddlers with Prader-Willi syndrome

Carrel, A. L., Moerchen, V. A., Myers, S. E., Bekx, M. T., Whitman, B. Y., & Allen, D. B. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.08.002 · Cited by 153 · see citing works

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

Boutin, P., Christian Dina, C., Vasseur, F., Dubois, S. G., Corset, L., Séron, K., Bekris, L. M., Cabellon, J., NEVE, B. P., Vasseur-Delannoy, V., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000068 · Cited by 149 · see citing works

The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models

Ellacott, K. L. J., & Cone, R. D. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1861 · Cited by 134 · see citing works

Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity

Gray, J. A., Yeo, G. S. H., Hung, C.-C. C., Keogh, J. M., Clayton, P., Banerjee, K., McAulay, A., O’Rahilly, S., & Farooqi, I. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803390 · Cited by 121 · see citing works

Functional Characterization of Mutations in Melanocortin-4 Receptor Associated with Human Obesity

Ho, G., & MacKenzie, R. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35816 · Cited by 121 · see citing works

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus Neurons

Kublaoui, B. M., Holder, J. L., Gemelli, T., & Zinn, A. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0483 · Cited by 121 · see citing works

Molecular Genetics of Human Obesity‐Associated MC4R Mutations

Lubrano-Berthelier, C., Cavazos, M. M., Dubern, B., Shapiro, A., Stunff, C. L., Zhang, S., Picart, F., Govaerts, C., Froguel, P., Bougneres, P. F., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03161.x · Cited by 119 · see citing works

Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys

Heid, I. M., Vollmert, C., Hinney, A., Döring, A., Geller, F., Löwel, H., Wichmann, H. ‐., Illig, T., Hebebrand, J., & Kronenberg, F. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.027011 · Cited by 114 · see citing works

PT‐141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction

Molinoff, P. B., Shadiack, A. M., Earle, D. C., Diamond, L. E., & Quon, C. Y. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03167.x · Cited by 106 · see citing works

Perspectives: molecular genetic research in human obesity

Hebebrand, J., Friedel, S., Schäuble, N., Geller, F., & Hinney, A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00106.x · Cited by 80 · see citing works

Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets

S�rensen, T. I. A., Boutin, P., Taylor, M. A., Larsen, L. H., Verdich, C., Petersen, L. V., Holst, C., Echwald, S. M., Christian Dina, C., Toubro, S., et al. (2006) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0010012 · Cited by 78 · see citing works

Genetics of human obesity

Clément, K. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.10.009 · Cited by 76 · see citing works

Mutation analysis of the MKKS gene in McKusick-Kaufman syndrome and selected Bardet-Biedl syndrome patients

Slavotinek, A. M., Searby, C. C., Al‐Gazali, L., Hennekam, R. C. M., Schrander-Stumpel, C. T. R. M., Orcana-Losa, M., Pardo-Reoyo, S., Cantani, A., Kumar, D., Capellini, Q., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0733-3 · Cited by 68 · see citing works

Triallelic inheritance: a bridge between Mendelian and multifactorial traits

Eichers, E. R., Lewis, R. A., Katsanis, N., & Lupski, J. R. (2004) · Annals of Medicine · doi:10.1080/07853890410026214 · Cited by 67 · see citing works

Genetics of human obesity

Clément, K. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005416 · Cited by 64 · see citing works

Melanocortin-4 receptors, β-MSH and leptin: Key elements in the satiety pathway

Harrold, J. A., & Williams, G. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.030 · Cited by 60 · see citing works

Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats

Li, G., Zhang, Y., Wilsey, J. T., & Scarpace, P. J. (2005) · Diabetologia · doi:10.1007/s00125-005-1943-8 · Cited by 54 · see citing works

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity

Swarbrick, M. M., Waldenmaier, B., Pennacchio, L. A., Lind, D. L., Cavazos, M. M., Geller, F., Merriman, R. B., Ustaszewska, A., Malloy, M. J., Scherag, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030315 · Cited by 51 · see citing works

Molecular physiology of syndromic obesities in humans

Chung, W. K., & Leibel, R. L. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.06.009 · Cited by 47 · see citing works

Strategies for dissecting epigenetic mechanisms in the mouse

Mager, J., & Bartolomei, M. S. (2005) · Nature Genetics · doi:10.1038/ng1664 · Cited by 39 · see citing works

Personalized Medicine: Decades Away?

Lunshof, J. E., Pirmohamed, M., & Gurwitz, D. (2006) · Pharmacogenomics · doi:10.2217/14622416.7.2.237 · Cited by 35 · see citing works

DiOGenes: a multidisciplinary offensive focused on the obesity epidemic

Saris, W. H. M., & Harper, A. E. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00200.x · Cited by 33 · see citing works

The 103I Variant of the Melanocortin 4 Receptor Is Associated with Low Serum Triglyceride Levels

Brönner, G., Sattler, A., Hinney, A., Soufi, M., Geller, F., Schäfer, H., Maisch, B., Hebebrand, J., & Schaefer, J. R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0919 · Cited by 31 · see citing works

Emerging trends in the search for genetic variants predisposing to human obesity

Swarbrick, M. M., & Vaisse, C. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000078997.96795.03 · Cited by 28 · see citing works

MT‐II Induces Penile Erection via Brain and Spinal Mechanisms

Wessells, H., Hruby, V. J., Hackett, J. T., Han, G., Balse, P., & Vanderah, T. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03166.x · Cited by 28 · see citing works

The Effect of the Melanocortin Agonist, MT-II, on the Defended Level of Body Adiposity

Seeley, R. J., Burklow, M. L., Wilmer, K. A., Matthews, C. C., Reizes, O., McOsker, C. C., Trokhan, D. P., Gross, M. C., & Sheldon, R. J. (2005) · Endocrinology · doi:10.1210/en.2004-1663 · Cited by 26 · see citing works

Identifying regulatory hubs in obesity with nutrigenomics

Mutch, D. M. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000244224.76033.06 · Cited by 13 · see citing works

Is GAD2 on Chromosome 10p12 a Potential Candidate Gene for Morbid Obesity?

Tiwari, H. K., Bouchard, L., Përusse, L., & Allison, D. B. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00147.x · Cited by 9 · see citing works

Growth hormone therapy in children with Prader-Willi syndrome

Franzese, A., Romano, A., Spagnuolo, M. I., Ruju, F., & Valerio, G. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.10.022 · Cited by 7 · see citing works

Does my diet fit my genes? The new science of nutrigenomics has some answers. It explains why fat and caffeine are worse for some than others.

Gorman, C. (2006) · PubMed · Cited by 3 · see citing works

Dietary intervention impact on gut microbial gene richness

Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375 · see citing works

Childhood and Adolescent Obesity: A Review

Kansra, A. R., Lakkunarajah, S., & Jay, M. S. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2020.581461 · Cited by 584 · see citing works

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

Pallejá, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, T., Liang, S., Feng, Q., Jørgensen, N. B., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0312-1 · Cited by 312 · see citing works

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

Yang, X., Deignan, J. L., Qi, H., Zhu, J., Qian, S., Zhong, J., Torosyan, G., Majid, S., Falkard, B., Kleinhanz, R. R., et al. (2009) · Nature Genetics · doi:10.1038/ng.325 · Cited by 288 · see citing works

Genetic influence on appetite in children

Carnell, S., Haworth, C. M. A., Plomin, R. J., & Wardle, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.127 · Cited by 234 · see citing works

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

Albuquerque, D., Stice, E. M., Rodríguez‐López, R., Manco, L., & Nóbrega, C. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1015-9 · Cited by 223 · see citing works

Genetic and Epigenetic Causes of Obesity

Thaker, V. (2017) · American Academy of Pediatrics eBooks · doi:10.1542/9781581109405-genetic · Cited by 221 · see citing works

Obesity and vascular dysfunction

Stapleton, P. A., James, M. E., Goodwill, A. G., & Frisbee, J. C. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2008.04.007 · Cited by 221 · see citing works

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

Bauer, F., Elbers, C. C., Adan, R. A. H., Loos, R. J. F., Onland‐Moret, N. C., Grobbee, D. E., van Vliet‐Ostaptchouk, J. V., Wijmenga, C., & van der Schouw, Y. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27781 · Cited by 201 · see citing works

Evidence for defective mesolimbic dopamine exocytosis in obesity‐prone rats

Geiger, B. M., Behr, G. G., Frank, L. E., Caldera-Siu, A. D., Beinfeld, M. C., Kokkotou, E. G., & Pothos, E. N. (2008) · The FASEB Journal · doi:10.1096/fj.08-110759 · Cited by 194 · see citing works

Life‐threatening infectious diseases of childhood: single‐gene inborn errors of immunity?

Alcaïs, A., Quintana‐Murci, L., Thaler, D. S., Schurr, E., Abel, L., & Casanova, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05834.x · Cited by 180 · see citing works

Vitamin D deficiency is the cause of common obesity

Foss, Y. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.10.005 · Cited by 179 · see citing works

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

Schwer, B., Schumacher, B., Lombard, D. B., Xiao, C., Kurtev, M. V., Gao, J., Schneider, J. I., Chai, H., Bronson, R. T., Tsai, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016306107 · Cited by 176 · see citing works

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

Madsen, A. N., Hansen, G., Paulsen, S. J., Lykkegaard, K., Tang‐Christensen, M., Hansen, H. S., Levin, B. E., Larsen, P. J., Knudsen, L. B., Fosgerau, K., et al. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0004 · Cited by 151 · see citing works

Lessons from Extreme Human Obesity: Monogenic Disorders

Ranadive, S. A., & Vaisse, C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.07.003 · Cited by 135 · see citing works

Genetics of fat tissue accumulation in pigs: a comparative approach

Switonski, M., Stachowiak, M., Cieślak, J., Bartz, M., & Grzes, M. (2010) · Journal of Applied Genetics · doi:10.1007/bf03195724 · Cited by 116 · see citing works

Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

Kaska, Ł., Śledziński, T., Chomiczewska, A., Dettlaff‐Pokora, A., & Świerczyński, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i39.8698 · Cited by 111 · see citing works

The utility of animal models to evaluate novel anti‐obesity agents

Vickers, S. P., Jackson, H. C., & Cheetham, S. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01245.x · Cited by 107 · see citing works

Unexpected Endocrine Features and Normal Pigmentation in a Young Adult Patient Carrying a Novel Homozygous Mutation in the POMC Gene

Clément, K., Dubern, B., Mencarelli, M., Czernichow, P., Ito, S., Wakamatsu, K., Barsh, G. S., Vaisse, C., & Léger, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1164 · Cited by 94 · see citing works

Mechanisms of obesity in Prader–Willi syndrome

Khan, M. J., Gerasimidis, K., Edwards, C. A., & Shaikh, M. G. (2016) · Pediatric Obesity · doi:10.1111/ijpo.12177 · Cited by 95 · see citing works

A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake

Azevedo, E. P., Pomeranz, L. E., Cheng, J., Schneeberger, M., VAUGHAN, R. D., Stern, S. A., Tan, B., Doerig, K. R., Greengard, P., & Friedman, J. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.011 · Cited by 89 · see citing works

The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?

Paoli, A., Bianco, A., Moro, T., Mota, J. F., & Coelho‐Ravagnani, C. D. F. (2023) · Nutrients · doi:10.3390/nu15143120 · Cited by 88 · see citing works

Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles

Mutch, D. M., Tordjman, J., Pelloux, V., Hanczar, B., Hénégar, C., Poitou, C., Veyrie, N., Zucker, J., & Clément, K. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26802 · Cited by 82 · see citing works

Genetics of human obesity

Mutch, D. M., & Clément, K. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.006 · Cited by 78 · see citing works

1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet

Kim, S., Yang, S.-O., Kim, H.-S., Kim, Y., Park, T., & Choi, H.-K. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3054-8 · Cited by 78 · see citing works

The Effects of Gastrointestinal Surgery on Gut Microbiota: Potential Contribution to Improved Insulin Sensitivity

Aron‐Wisnewsky, J., & Clément, K. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0454-9 · Cited by 78 · see citing works

Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

Roca-Rivada, A., Alonso, J., Al–Massadi, O., Castelao, C., Peinado, J. R., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.010 · Cited by 75 · see citing works

The genetics of childhood obesity and interaction with dietary macronutrients

Garver, W. S., Newman, S. B., Gonzales‐Pacheco, D., Castillo, J., Jelínek, D., Heidenreich, R. A., & Orlando, R. A. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0339-5 · Cited by 71 · see citing works

Obesity Gene Atlas in Mammals

Kunej, T., Skok, D. J., Zorc, M., Ogrinc, A., Michal, J. J., Kovač, M., & Jiang, Z. (2013) · Journal of Genomics · doi:10.7150/jgen.3996 · Cited by 71 · see citing works

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice

Heydet, D., Chen, L. X., Larter, C. Z., Inglis, C. D., Silverman, M. A., Farrell, G. C., & Leroux, M. R. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22031 · Cited by 67 · see citing works

Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions

Fenwick, P. H., Jeejeebhoy, K. N., Dhaliwal, R., Royall, D., Brauer, P. M., Tremblay, A., Klein, D., & Mutch, D. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1437022 · Cited by 64 · see citing works

Architecture of energy balance traits in emerging lines of the Collaborative Cross

Mathes, W. F., Aylor, D. L., Miller, D. R., Churchill, G. A., Chesler, E. J., de Villena, F. P., Threadgill, D. W., & Pomp, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00707.2010 · Cited by 62 · see citing works

Homozygous Leptin Receptor Mutation Due to Uniparental Disomy of Chromosome 1: Response to Bariatric Surgery

Beyec, J. L., Cugnet‐Anceau, C., Pépin, D., Alili, R., Cotillard, A., Lacorte, J., Basdevant, A., Laville, M., & Clément, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2779 · Cited by 61 · see citing works

Obesidomics: contribution of adipose tissue secretome analysis to obesity research

Pardo, M., Roca-Rivada, A., Seoane, L. M., & Casanueva, F. F. (2012) · Endocrine · doi:10.1007/s12020-012-9617-z · Cited by 61 · see citing works

Selection Signature Analysis Implicates the PC1/PCSK1 Region for Chicken Abdominal Fat Content

Zhang, H., Hu, X., Wang, Z., Zhang, Y., Wang, S., Wang, N., Ma, L., Leng, L., Wang, S., Wang, Q., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040736 · Cited by 57 · see citing works

Clinical, molecular genetics and therapeutic aspects of syndromic obesity

Geets, E., Meuwissen, M. E. C., & Hul, W. V. (2018) · Clinical Genetics · doi:10.1111/cge.13367 · Cited by 55 · see citing works

Physical Therapists’ Attitudes, Knowledge, and Practice Approaches Regarding People Who Are Obese

Sack, S., Radler, D. R., Mairella, K. K., Touger-Decker, R. E., & Khan, H. M. R. (2009) · Physical Therapy · doi:10.2522/ptj.20080280 · Cited by 52 · see citing works

Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders

Vos, N., Oussaada, S. M., Cooiman, M. I., Kleinendorst, L., ter Horst, K. W., Hazebroek, E. J., Romijn, J. A., Serlie, M. J. M., Mannens, M. M. A. M., & van Haelst, M. M. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01327-7 · Cited by 50 · see citing works

Adipose Gene Expression Prior to Weight Loss Can Differentiate and Weakly Predict Dietary Responders

Mutch, D. M., Temanni, R., Hénégar, C., Combes, F., Pelloux, V., Holst, C., Sørensen, T. I. A., Astrup, A. V., Martínez, J. A., Saris, W. H. M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001344 · Cited by 50 · see citing works

Ruminococcaceae_UCG-013 Promotes Obesity Resistance in Mice

Feng, J., Ma, H., Huang, Y., Li, J., & Li, W. (2022) · Biomedicines · doi:10.3390/biomedicines10123272 · Cited by 49 · see citing works

Circannual Transitions in Gene Expression

Schwartz, C. P., & Andrews, M. T. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-396968-2.00009-9 · Cited by 48 · see citing works

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants

Celis-Morales, C. A., Lyall, D. M., Gray, S. R., Steell, L., Anderson, J. J., Iliodromiti, S., Welsh, P. I., Guo, Y., Petermann-Rocha, F. E., Mackay, D., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.169 · Cited by 48 · see citing works

Short-Term Effects of Sleeve Gastrectomy and Caloric Restriction on Blood Pressure in Diet-Induced Obese Rats

Rodrı́guez, A., Becerril, S., Valentí, V., Moncada, R., Méndez-Giménez, L., Ramírez, B., Lancha, A., Martín, M., Burrell, M. A., Catalán, V., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0702-4 · Cited by 45 · see citing works

Precision Medicine in Weight Loss and Healthy Living

Severin, R. S., Sabbahi, A., Mahmoud, A. M., Arena, R. A., & Phillips, S. A. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.12.012 · Cited by 43 · see citing works

Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2 diabetes mellitus

Namekawa, J., Takagi, Y., WAKABAYASHI, K., Nakamura, Y., Watanabe, A., Nagakubo, D., Shirai, M., & Fumitoshi, A. S. A. I. (2017) · Journal of Veterinary Medical Science · doi:10.1292/jvms.17-0136 · Cited by 42 · see citing works

A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity

Dao, M. C., Sokolovska, N., Brazeilles, R., Affeldt, S., Pelloux, V., Prifti, E., Chilloux, J., Verger, E. O., Kayser, B. D., Aron‐Wisnewsky, J., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01958 · Cited by 41 · see citing works

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

Roubert, P., Dubern, B., Plas, P., Lubrano-Berthelier, C., Alihi, R., Auger, F., DeOliveira, D. B., Dong, J. Z., Basdevant, A., Thurieau, C., et al. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0336 · Cited by 40 · see citing works

The Increase in Childhood Obesity and Its Association with Hypertension during Pandemics

Vasile, C. M., Padovani, P., Dumitrache‐Rujinski, S., Nicolosu, D., Toma, C., Turcu, A. A., & Cioboată, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185909 · Cited by 39 · see citing works

Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons

Zhang, Z., Hao, C., Li, C., Zang, D., Zhao, J. C., Li, X., Wei, A., Wei, Z., Yang, L., He, X., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004124 · Cited by 36 · see citing works

Influence of Age on Clock Gene Expression in Peripheral Blood Cells of Healthy Women

Ando, H., Ushijima, K., Kumazaki, M., Takamura, T., Yokota, N., Saito, T., Irie, S., Kaneko, S., & Fujimura, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp160 · Cited by 36 · see citing works

Implications of Gene–Behavior Interactions: Prevention and Intervention for Obesity

Bray, M. S. (2008) · Obesity · doi:10.1038/oby.2008.522 · Cited by 35 · see citing works

Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries

Martins, I. J. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.44011 · Cited by 35 · see citing works

Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia

Zhang, G., Karns, R. A., Narančić, N. S., Sun, G., Cheng, H., Missoni, S., Duraković, Z., Rudan, P., Chakraborty, R., & Deka, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010375 · Cited by 34 · see citing works

Primary cilia in energy balance signaling and metabolic disorder

Lee, H., Song, J., Jung, J. H., & Ko, H. W. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.12.229 · Cited by 34 · see citing works

Associations between green area in school neighbourhoods and overweight and obesity among Norwegian adolescents

Wilhelmsen, C. K., Skalleberg, K., Raanaas, R. K., Tveite, H., & Aamodt, G. (2017) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2017.05.020 · Cited by 35 · see citing works

Genetic resistance to diet-induced obesity in chromosome substitution strains of mice

Burrage, L. C., Hill‐Baskin, A. E., Sinasac, D. S., Singer, J. B., Croniger, C. M., Kirby, A. W., Kulbokas, E. J., Daly, M. J., Lander, E. S., Broman, K. W., et al. (2010) · Mammalian Genome · doi:10.1007/s00335-010-9247-9 · Cited by 34 · see citing works

Dietary diversity and adiposity in Chinese men and women: an analysis of four waves of cross-sectional survey data

Tian, X., Wu, M., Zang, J., Zhu, Y., & Wang, H. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.212 · Cited by 34 · see citing works

Bariatric surgery, adipose tissue and gut microbiota

Clément, K. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.141 · Cited by 32 · see citing works

Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity?

Baig, U. I., Belsare, P. V., Watve, M., & Jog, M. M. (2011) · Journal of Obesity · doi:10.1155/2011/861049 · Cited by 31 · see citing works

Genetic aspects of human obesity

Larder, R., Lim, C. T., & Coll, A. P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00006-x · Cited by 31 · see citing works

A Novel Rat Model with Obesity-Associated Retinal Degeneration

Reddy, G. B., Vasireddy, V., Mandal, M. N. A., Mrudula, T., Wang, X. F., Jablonski, M. M., Nappanveettil, G., & Ayyagari, R. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2498 · Cited by 31 · see citing works

Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity

Apalasamy, Y. D., & Mohamed, Z. (2015) · Human Genetics · doi:10.1007/s00439-015-1533-x · Cited by 30 · see citing works

Cultural Influences on the Regulation of Energy Intake and Obesity: A Qualitative Study Comparing Food Customs and Attitudes to Eating in Adults from France and the United States

Dao, M. C., Thiron, S., Messer, E., Sergeant, C., Sévigné, A., Huart, C., Rossi, M., Silverman, I. H., Sakaida, K., Lassen, P. B., et al. (2020) · Nutrients · doi:10.3390/nu13010063 · Cited by 29 · see citing works

Genetics of Human Obesity

Fisler, J. S., & Warden, C. H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00023-8 · Cited by 29 · see citing works

Personalized Medicine

Dedov, I. I. (2019) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn1108 · Cited by 27 · see citing works

Proteomics in obesity research

Barceló-Batllori, S., & Gomis, R. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800178 · Cited by 27 · see citing works

Candidate Molecular Pathway Genes Related to Appetite Regulatory Neural Network, Adipocyte Homeostasis and Obesity: Results from the CARDIA Study

Friedlander, Y., Guo, L., Fornage, M., Williams, O. D., Lewis, C. E., Schreiner, P. J., Pletcher, M. J., Enquobahrie, D. A., Williams, M. A., & Siscovick, D. S. (2010) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2010.00596.x · Cited by 27 · see citing works

Parental and early childhood influences on adolescent obesity: a longitudinal study

Chivers, P., PARKER, H. E., Bulsara, M. K., Beilin, L. J., & Hands, B. P. (2012) · Early Child Development and Care · doi:10.1080/03004430.2012.678590 · Cited by 25 · see citing works

Heritability of body weight: Moving beyond genetics

Russo, P., Lauria, F., & Siani, A. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.09.007 · Cited by 25 · see citing works

Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity

Perrone, L., Marzuillo, P., Grandone, A., & del Giudice, E. M. (2010) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-36-43 · Cited by 23 · see citing works

Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program

Roberts, K. J., Ariza, A. J., Selvaraj, K., Quadri, M., Mangarelli, C., Neault, S. H., Davis, E. E., & Binns, H. J. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01139-7 · Cited by 23 · see citing works

Divergent Physical Activity and Novel Alternative Responses to High Fat Feeding in Polygenic Fat and Lean Mice

Simončič, M., Horvat, S., Stevenson, P. L., Bünger, L., Holmes, M. C., Kenyon, C. J., Speakman, J. R., & Morton, N. M. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9199-y · Cited by 23 · see citing works

Energy In, Energy Out, and the Effects of Obesity-Related Genes

Leibel, R. L. (2008) · New England Journal of Medicine · doi:10.1056/nejme0808660 · Cited by 23 · see citing works

Chromosomal localization of 13 candidate genes for human obesity in the pig genome

Nowacka‐Woszuk, J., Szczerbal, I., Fijak-Nowak, H., & Switonski, M. (2008) · Journal of Applied Genetics · doi:10.1007/bf03195636 · Cited by 22 · see citing works

Lesser Investigated Natural Ingredients for the Management of Obesity

Majeed, M. A., Majeed, S., Nagabhushanam, K., Muthuraman, G., & Mundkur, L. (2021) · Nutrients · doi:10.3390/nu13020510 · Cited by 20 · see citing works

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice

Mutch, D. M., O’Maille, G., Wikoff, W. R., Wiedmer, T., Sims, P. J., & Siuzdak, G. E. (2007) · Genome biology · doi:10.1186/gb-2007-8-3-r38 · Cited by 20 · see citing works

Macrophages and Lymphocytes

(1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-8914-9 · Cited by 19 · see citing works

The combined influence of genetic factors and sedentary activity on body mass changes from adolescence to young adulthood: the National Longitudinal Adolescent Health Study

Graff, M., North, K. E., Monda, K. L., Lange, E. M., Lange, L. A., Guo, G., & Gordon‐Larsen, P. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1147 · Cited by 18 · see citing works

Review: Genetics of the cardiometabolic syndrome: new insights and therapeutic implications

Sookoian, S. C., & Pirola, C. J. (2007) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944707082702 · Cited by 17 · see citing works

Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study

Celis-Morales, C. A., Lyall, D. M., Petermann-Rocha, F. E., Anderson, J. J., Ward, J., Iliodromiti, S., Mackay, D., Welsh, P. I., Bailey, M. E. S., Pell, J. P., et al. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0381-5 · Cited by 16 · see citing works

Pathophysiology and genetics of obesity.

Srivastava, N., Lakhan, R., & Mittal, B. (2007) · PubMed · Cited by 15 · see citing works

What to expect from an evolutionary hypothesis for a human disease: The case of type 2 diabetes

Watve, M., & Diwekar-Joshi, M. (2016) · HOMO · doi:10.1016/j.jchb.2016.07.001 · Cited by 14 · see citing works

Gene–Diet Interactions in Childhood Obesity: Paucity of Evidence as the Epidemic of Childhood Obesity Continues to Rise

Papoutsakis, C., & Dedoussis, G. V. (2007) · Personalized Medicine · doi:10.2217/17410541.4.2.133 · Cited by 14 · see citing works

Association of Obesity with Proteasomal Gene Polymorphisms in Children

Kupča, S., Sjakste, T., Paramonova, N., Sugoka, O., Rinkuža, I., Ilva, T., Daugule, I., Sipols, A. J., & Rumba-Rozenfelde, I. (2013) · Journal of Obesity · doi:10.1155/2013/638154 · Cited by 13 · see citing works

Falling asleep after a big meal

Gallagher, T. F., & You, Y. (2014) · Worm · doi:10.4161/worm.27938 · Cited by 12 · see citing works

Potential associations between alterations in gut microbiome and obesity‐related traits after the bariatric surgery

Özdemir, A., Yozgat, A., Işgın‐Atıcı, K., Avcı, E., Yıldız, B. D., Gündoğdu, A., Nalbantoğlu, U., Turhan, T., Al, F. D., & Büyüktuncer, Z. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13087 · Cited by 12 · see citing works

Introduction to Genetics and Childhood Obesity: Relevance to Nursing Practice

Seal, N. (2010) · Biological Research For Nursing · doi:10.1177/1099800410381424 · Cited by 12 · see citing works

The Effects of Different High-Protein Low-Carbohydrates Proprietary Foods on Blood Sugar in Healthy Subjects

Lodi, A., Karsten, B., Bosco, G., López, M. G., Brandão, P. P., Bianco, A., & Paoli, A. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.0072 · Cited by 11 · see citing works

Proximate causes for diet-induced obesity in laboratory mice: a case study

Kless, C., Rink, N., Rozman, J., & Klingenspor, M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.243 · Cited by 11 · see citing works

Appetite control: worm's-eye-view

You, Y., & Avery, L. (2012) · Animal Cells and Systems · doi:10.1080/19768354.2012.716791 · Cited by 10 · see citing works

Education and BMI: a genetic informed analysis

Bella, S. D., & Lucchini, M. (2014) · Quality & Quantity · doi:10.1007/s11135-014-0129-1 · Cited by 10 · see citing works

Drug therapy for obesity with anti-aging genes modification

Martins, I. J. (2016) · UWA Profiles and Research Repository (University of Western Australia) · Cited by 9 · see citing works

Neurobiology of food choices—between energy homeostasis, reward system, and neuroeconomics

Enax, L., & Weber, B. (2016) · e-Neuroforum · doi:10.1007/s13295-015-0020-0 · Cited by 9 · see citing works

New Thoughts on Pediatric Genetic Obesity: Pathogenesis, Clinical Characteristics and Treatment Approach

Stagi, S., Bianconi, M., Sammarco, M. A., Artuso, R., Giglio, S., & de Martino, M. (2017) · InTech eBooks · doi:10.5772/66128 · Cited by 7 · see citing works

Obesity Is a Disease

Martin, W. P., & le Roux, C. W. (2022) · In clinical practice · doi:10.1007/978-3-030-83399-2_4 · Cited by 7 · see citing works

Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake

Karunakaran, S., Manji, A., Yan, C.-H., Wu, Z.-J. J., & Clee, S. M. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00159.2012 · Cited by 7 · see citing works

Genetic Factors That Act As An Effect Modifier for Environmental Risk Factors of Obesity

Al-Domi, H. A. (2014) · Cited by 5 · see citing works

Identification of target sequences for association studies - analysis of the pig FABP3 and FABP4 loci using comparative genomics methods

Chmurzyńska, A., Cieślak, J., Jankowski, T., Szydłowski, M., & Switonski, M. (2008) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/66599/2008 · Cited by 5 · see citing works

Review Unraveling the Genetics of Human Obesity

Mutch, D. M., & Clément, K. (2013)

Genetics of obesity.

Cuestas, E. (2008) · PubMed · Cited by 1 · see citing works

Genetic of obesity

Cuestas, E. (2019) · Revista de la Facultad de Ciencias Médicas de Córdoba · doi:10.31053/1853.0605.v65.n4.23569 · Cited by 1 · see citing works

Genetics of human obesity

Clément, K. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.10.009 · Cited by 76 · see citing works

Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016

Huvenne, H., Dubern, B., Clément, K., & Poitou, C. (2016) · Obesity Facts · doi:10.1159/000445061 · Cited by 279 · see citing works