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Foxp2 Regulates Gene Networks Implicated in Neurite Outgrowth in the Developing Brain
Open accessAbstract
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. Across diverse vertebrate species, this well-conserved transcription factor is highly expressed in the developing and adult central nervous system. Very little is known about the mechanisms regulated by Foxp2 during brain development. We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. Specifically, we performed genome-wide in vivo ChIP-chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targets under strict, empirically derived significance thresholds. The findings, coupled to expression profiling and in situ hybridization of brain tissue from wild-type and mutant mouse embryos, strongly highlighted gene networks linked to neurite development. We followed up our genomics data with functional experiments, showing that Foxp2 impacts on neurite outgrowth in primary neurons and in neuronal cell models. Our data indicate that Foxp2 modulates neuronal network formation, by directly and indirectly regulating mRNAs involved in the development and plasticity of neuronal connections.
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“Among the genes downstream of BAZ1B that we uncovered in this study, FOXP2, ROBO1, and ROBO2 have long been implicated in brain wiring processes critical for vocal learning in several species (50, 51), including humans”
From Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication (2019) · cites this paper as [50]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
A forkhead-domain gene is mutated in a severe speech and language disorder
Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha‐Khadem, F., & Monaco, A. P. (2001) · Nature · doi:10.1038/35097076 · Cited by 2,053
WebGestalt: an integrated system for exploring gene sets in various biological contexts
Zhang, B., Kirov, S. A., & Snoddy, J. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki475 · Cited by 1,803
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547
Use of within-array replicate spots for assessing differential expression in microarray experiments
Smyth, G. K., Michaud, J., & Scott, H. S. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti270 · Cited by 1,406
Unified nomenclature for the winged helix/forkhead transcription factorsPreprint
Kaestner, K. H., Knöchel, W., & Martínez, D. E. (2000) · Genes & Development · doi:10.1101/gad.14.2.142 · Cited by 1,162
Neural pathways underlying vocal control
Jürgens, U. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00068-9 · Cited by 871
A PCR primer bank for quantitative gene expression analysis
Wang, X. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng154 · Cited by 856
Forkhead Transcription Factors: Key Players in Development and Metabolism
Carlsson, P., & Mahlapuu, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0780 · Cited by 842
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712
A functional genetic link between distinct developmental language disorders
Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676
The evolution of Fox genes and their role in development and disease
Hannenhalli, S. S., & Kaestner, K. H. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2523 · Cited by 669
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605
Learned Birdsong and the Neurobiology of Human Language
Jarvis, E. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.038 · Cited by 549
FOXP2 as a molecular window into speech and language
Fisher, S. E., & Scharff, C. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.03.002 · Cited by 549
GenePaint.org: an atlas of gene expression patterns in the mouse embryo
Visel, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh029 · Cited by 528
FoxP2 Expression in Avian Vocal Learners and Non-Learners
Haesler, S., Wada, K., Nshdejan, A., Morrisey, E., Lints, T., Jarvis, E., & Scharff, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4369-03.2004 · Cited by 497
Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons
Gertler, T. S., Chan, C. S., & Surmeier, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2660-08.2008 · Cited by 495
Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain
Ferland, R. J., Cherry, T. J., Preware, P. O., Morrisey, E. E., & Walsh, C. A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10654 · Cited by 486
Haesler, S., Rochefort, C., Georgi, B., Licznerski, P., Osten, P., & Scharff, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050321 · Cited by 433
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
Shu, W., Cho, J. Y., Jiang, Y., Zhang, M., Weisz, D. J., Elder, G. A., Schmeidler, J., Gasperi, R. D., Sosa, M. A. G., Rabidou, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503739102 · Cited by 415
Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits
MacDermot, K. D., Bonora, E., Sykes, N., Coupe, A., Lai, C. S. L., Vernes, S. C., Vargha‐Khadem, F., McKenzie, F., Smith, R. L., Monaco, A. P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/430841 · Cited by 411
Lai, C. S. L. (2003) · Brain · doi:10.1093/brain/awg247 · Cited by 399
Human-specific transcriptional regulation of CNS development genes by FOXP2
Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A., & Geschwind, D. H. (2009) · Nature · doi:10.1038/nature08549 · Cited by 390
Shu, W., Yang, H., Zhang, L., Lu, M. M., & Morrisey, E. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100636200 · Cited by 353
Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex
Sun, T., Patoine, C., Abu‐Khalil, A., Visvader, J. E., Sum, E. Y. M., Cherry, T. J., Orkin, S. H., Geschwind, D. H., & Walsh, C. A. (2005) · Science · doi:10.1126/science.1110324 · Cited by 352
Overdier, D. G., Porcella, A., & Costa, R. H. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2755 · Cited by 351
MRI analysis of an inherited speech and language disorder: structural brain abnormalities
Watkins, K. E., Vargha‐Khadem, F., Ashburner, J., Passingham, R. E., Connelly, A., Friston, K. J., Frackowiak, R. S. J., Mishkin, M., & Gadian, D. G. (2002) · Brain · doi:10.1093/brain/awf057 · Cited by 351
MicroRNAs Potentiate Neural Development
Fineberg, S. K., Kosik, K. S., & Davidson, B. L. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.020 · Cited by 330
Groszer, M., Keays, D. A., Deacon, R. M. J., de Bono, J. P., Prasad-Mulcare, S., Gaub, S., Baum, M. G., French, C. A., Nicod, J., Coventry, J. A., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.060 · Cited by 288
Spiteri, E., Konopka, G., Coppola, G., Bomar, J. M., Oldham, M. C., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., & Geschwind, D. H. (2007) · The American Journal of Human Genetics · doi:10.1086/522237 · Cited by 288
Estrogen Receptor Target Gene: An Evolving Concept
Carroll, J. S., & Brown, M. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0334 · Cited by 284
Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice
Valjent, E., Bertran‐Gonzalez, J., Hervé, D., Fisone, G., & Girault, J. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.005 · Cited by 269
Vernes, S. C., Spiteri, E., Nicod, J., Groszer, M., Taylor, J. M., Davies, K. E., Geschwind, D. H., & Fisher, S. E. (2007) · The American Journal of Human Genetics · doi:10.1086/522238 · Cited by 268
Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis
Naeve, G. S., Ramakrishnan, M., Kramer, R., Hevroni, D., Citri, Y., & Theill, L. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2648 · Cited by 255
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246 · cited 1×
“For example, our high-confidence shortlist of direct targets includes Pak3 – a downstream effector of the Rho family of GTPases which plays critical roles in pathways restraining neurite growth [43]; Nptn (neuroplastin) – encoding a synaptic glycoprotein involved both in development/maintenance of synaptic connections…”
BackgroundGuidance Molecules in Synapse Formation and PlasticityPreprint
Shen, K., & Cowan, C. W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001842 · Cited by 233
Wang, B., Lin, D., Li, C., & Tucker, P. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207174200 · Cited by 232
Fischer, J., & Hammerschmidt, K. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00610.x · Cited by 205
Absence of a Paternally Inherited FOXP2 Gene in Developmental Verbal Dyspraxia
Feuk, L., Kalervo, A., Lipsanen‐Nyman, M., Skaug, J., Nakabayashi, K., Finucane, B. M., Hartung, D., Innes, A. M., Kerem, B., Nowaczyk, M. J. M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/508902 · Cited by 188
Rac1 Regulates Neuronal Polarization through the WAVE Complex
Tahirović, S., Hellal, F., Neukirchen, D., Hindges, R., Garvalov, B. K., Flynn, K. C., Stradal, T. E. B., Chrostek‐Grashoff, A., Brakebusch, C., & Bradke, F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5395-09.2010 · Cited by 186
Functional genetic analysis of mutations implicated in a human speech and language disorder
Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167 · cited 5×
“This suggests that the introduction of this mutation yields a stable, but nonfunctional protein product, a conclusion that is supported by in vitro functional studies [30].”
BackgroundResultInfluentialYue, Y., Widmer, D. A. J., Halladay, A. K., Cerretti, D. P., Wagner, G. C., Dreyer, J., & Zhou, R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02090.1999 · Cited by 133
Smalla, K., Matthies, H. K., Langnäse, K., Shabir, S., Böckers, T. M., Wyneken, Ú., Staak, S., Krug, M., Beesley, P. W., & Gundelfinger, E. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080389297 · Cited by 124
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
Sung, J. Y., Engmann, O., Teylan, M. A., Nairn, A. C., Greengard, P., & Kim, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712180105 · Cited by 117
Overdier, D. G., Porcella, A., & Costa, R. H. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2755-2766.1994 · Cited by 106
The DLX1and DLX2 genes and susceptibility to autism spectrum disorders
Liu, X., Novosedlik, N., Wang, A., Hudson, M. L., Cohen, I. L., Chudley, A. E., Forster‐Gibson, C., Lewis, M. E. S., & Holden, J. J. A. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.148 · Cited by 94
Generation of mice with a conditional Foxp2 null allele
French, C. A., Groszer, M., Preece, C., Coupe, A., Rajewsky, K., & Fisher, S. E. (2007) · genesis · doi:10.1002/dvg.20305 · Cited by 94
MicroRNAs in neuronal development, function and dysfunction
Saba, R., & Schratt, G. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.107 · Cited by 84
Specific Interactions of the Wing Domains of FOXA1 Transcription Factor with DNA
Cirillo, L. A., & Zaret, K. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.087 · Cited by 83
A Mutation inAf4Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse
Isaacs, A. M., Oliver, P. L., Jones, E. L., Jeans, A. F., Potter, A. C., Hovik, B. H., Nolan, P. M., Vizor, L., Glenister, P. H., Simon, A. K., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01631.2003 · Cited by 77
A trace of silence: memory and microRNA at the synapse
Ashraf, S. I., & Kunes, S. M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.007 · Cited by 73
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
Poitras, L., Yu, M., Lesage-Pelletier, C., MacDonald, R. B., Gagné, J.-P., Hatch, G., Kelly, I., Hamilton, S. P., Rubenstein, J. L. R., Poirier, G. G., et al. (2010) · Development · doi:10.1242/dev.051052 · Cited by 69 · cited 1×
“Thus it is interesting that both the DLX1/2 and DLX5/6 loci have been implicated in autism via independent studies, including a common polymorphism in the DLX5/6 enhancer itself [51–53].”
BackgroundParallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction
Teramitsu, I., Kudo, L., London, S. E., Geschwind, D., & White, S. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5589-03.2004 · Cited by 64
Oberley, M. J., & Farnham, P. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)71043-x · Cited by 60
NELL2 promotes motor and sensory neuron differentiation and stimulates mitogenesis in DRG in vivo
Nelson, B. R., Claes, K., Todd, V. J., Chaverra, M. E., & Lefcort, F. B. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.03.004 · Cited by 58
Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
Simsek‐Duran, F., Linden, D. J., & Lónárt, G. (2004) · Nature Neuroscience · doi:10.1038/nn1348 · Cited by 53
Marzban, H., Khanzada, U., Shabir, S., Hawkes, R. B., Langnaese, K., Smalla, K., Böckers, T. M., Gundelfinger, E. D., Gordon‐Weeks, P. R., & Beesley, P. W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10719 · Cited by 50
Semaphorin4F interacts with the synapse‐associated protein SAP90/PSD‐95
Schultze, W., Eulenburg, V., Leßmann, V., Herrmann, L., Dittmar, T., Gundelfinger, E. D., Heumann, R., & Erdmann, K. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00447.x · Cited by 45
Expression analysis and mutation detection of DLX5 and DLX6 in autism
Nakashima, N., Yamagata, T., Mori, M., Kuwajima, M., Suwa, K., & Momoi, M. Y. (2009) · Brain and Development · doi:10.1016/j.braindev.2008.12.021 · Cited by 34
Choi, E. J., Kim, D. H., Kim, J. G., Kim, D. Y., Kim, J. D., Seol, O. J., Jeong, C. S., Park, J. W., Choi, M. Y., Kang, S. G., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100545 · Cited by 32
MArray: analysing single, replicated or reversed microarray experiments
Wang, J., Nygaard, V., Smith‐Sørensen, B., Hovig, E. J., & Myklebost, O. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.8.1139 · Cited by 30
Faedo, A., Quinn, J. C., Stoney, P. N., Long, J. E., Dye, C. A., Zollo, M., Rubenstein, J. L. R., Price, D. J., & Bulfone, A. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20152 · Cited by 22
Characterization of a novel member of murine semaphorin family
Taniguchi, M., & Shimizu, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.083 · Cited by 14
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Metadata
- Authors
- Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., Nicod, J., Groszer, M., Baban, D., Sahgal, N., Cazier, J.-B., Ragoussis, J., Davies, K. E., Geschwind, D. H., & Fisher, S. E.
- Affiliations
- Centre for Human Genetics (GB)
- University of Oxford (GB)
- University of California, Los Angeles (US)
- Inserm (FR)
- Corresponding author
- Fisher, Simon E.
- ORCID
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-07-07
- Volume
- 7
- Issue
- 7
- Pages
- e1002145
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC3131290
- OpenAlex
- W2010016215
- Cited by
- 276
- References
- 69
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 12 · 2020: 19 · 2019: 27 · 2018: 26 · 2017: 19 · 2016: 21 · 2015: 16 · 2014: 26 · 2013: 29 · 2012: 21
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Max Planck Digital Library (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Autism Speaks
- Simons Foundation
- Wellcome Trust (075491, 080971, 075491/Z/04,)
- Simons Foundation Autism Research Initiative
- Royal Society
- Institut National de la Santé et de la Recherche Médicale
- Max-Planck-Gesellschaft
- National Institutes of Health (080971, 075491/Z/04)
- Directorate for Biological Sciences
- National Institute of Mental Health (R21MH075028, R37MH060233)
- National Institute of General Medical Sciences (T32GM008243)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- FOXP2, transcription factors, neurite outgrowth, embryonic brain development, gene regulatory networks, ChIP-chip, neuronal network formation, synaptic plasticity, speech and language disorders, corticostriatal synapses, motor skill learning, vocal learning
- MeSH terms
- Animals, Brain, Corpus Striatum, Mice, Inbred C57BL, Models, Biological, Mutation, Repressor Proteins, RNA, Messenger, Neurites, Gene Expression Regulation, Developmental, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Cell Line, Tumor, Chromatin Immunoprecipitation, Mice, Forkhead Transcription Factors, Gene Regulatory Networks, Primary Cell Culture
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