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A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
Open accessAbstract
Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy in Aβ production and AD progression is complex. To study whether increased basal autophagy plays a beneficial role in Aβ clearance and cognitive improvement, we developed a novel genetic model to hyperactivate autophagy in vivo. We found that knock-in of a point mutation F121A in the essential autophagy gene Beclin 1/Becn1 in mice significantly reduces the interaction of BECN1 with its inhibitor BCL2, and thus leads to constitutively active autophagy even under non-autophagy-inducing conditions in multiple tissues, including brain. Becn1F121A-mediated autophagy hyperactivation significantly decreases amyloid accumulation, prevents cognitive decline, and restores survival in AD mouse models. Using an immunoisolation method, we found biochemically that Aβ oligomers are autophagic substrates and sequestered inside autophagosomes in the brain of autophagy-hyperactive AD mice. In addition to genetic activation of autophagy by Becn1 gain-of-function, we also found that ML246, a small-molecule autophagy inducer, as well as voluntary exercise, a physiological autophagy inducer, exert similar Becn1-dependent protective effects on Aβ removal and memory in AD mice. Taken together, these results demonstrate that genetically disrupting BECN1-BCL2 binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents AD progression. The study establishes new approaches to activate autophagy in the brain, and reveals the important function of Becn1-mediated autophagy hyperactivation in the prevention of AD.
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“Evidence indicates that Aβ peptides can accumulate intracellularly while their extracellular release decreases when autophagy is impaired [85, 93].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [93]
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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Genome engineering using the CRISPR-Cas9 system
Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,728
Self-citationBcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
Self-citationOakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530
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Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
Self-citationAutophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313
The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630
Self-citationPromoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 566
Self-citationAutophagy and the cell biology of age-related disease
Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424
Self-citationAutophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
Zhang, Z., Yang, X., Song, Y., & Tu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101464 · Cited by 387
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
Menon, M., & Dhamija, S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00137 · Cited by 350
Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
Mahalakshmi, B., Maurya, N., Lee, S., & Kumar, V. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165895 · Cited by 374
Xu, H., & Qin, Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0602-4_5 · Cited by 326
Role of tau protein in Alzheimer’s disease: The prime pathological player
Muralidar, S., Ambi, S. V., Sekaran, S., Thirumalai, D., & Palaniappan, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.327 · Cited by 278
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases
Djajadikerta, A., Keshri, S., Tanasa, M. P., Prestil, R., Ryan, L., & Rubinsztein, D. C. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.035 · Cited by 244
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 243
Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation
Hill, S. M., Wróbel, L., & Rubinsztein, D. C. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0254-9 · Cited by 226
BECLIN1: Protein Structure, Function and Regulation
Tran, S. H., Fairlie, W. D., & Lee, E. F. (2021) · Cells · doi:10.3390/cells10061522 · Cited by 234
Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities
Liu, J., & Li, L. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00203 · Cited by 162
Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T., & He, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.032 · Cited by 144
Self-citationWang, S., Wang, L., Qin, X., Turdi, S., Sun, D., Culver, B., Reiter, R. J., Wang, X., Zhou, H., & Ren, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0171-5 · Cited by 135
Pignataro, P., Dicarlo, M., Zerlotin, R., Zecca, C., Dell’Abate, M. T., Buccoliero, C., Logroscino, G., Colucci, S. C., & Grano, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041605 · Cited by 137
Increased autophagy blocks HER2-mediated breast tumorigenesis
Vega-Rubín-de-Celis, S., Zou, Z., Fernández, Á. F., Ci, B., Kim, M., Xiao, G., Xie, Y., & Levine, B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717800115 · Cited by 131
Self-citationAutophagy in Age-Associated Neurodegeneration
Metaxakis, A., Ploumi, C., & Tavernarakis, N. (2018) · Cells · doi:10.3390/cells7050037 · Cited by 127
The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders
Kaur, S., & Changotra, H. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.025 · Cited by 116
β-cell autophagy: Mechanism and role in β-cell dysfunction
Lee, Y., Kim, J., Park, K., & Lee, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.014 · Cited by 106
Crosstalk between apoptosis and autophagy signaling pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2020.01.003 · Cited by 92
Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms
Zhang, X.-W., 澳门大学中华医药研究院中药质量研究国家重点实验室, 澳. 凼. 9., State Key Laboratory of Quality Research in Chinese Medicine, I. O. C. M. S., Zhu, X.-X., Tang, D.-S., Lu, J.-H., 佛山大学广东省动物分子设计与精准育种重点实验室, 广., & Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, G. E. T. C. O. G. P. (2023) · Zoological Research · doi:10.24272/j.issn.2095-8137.2023.294 · Cited by 77
Chiang, W., Wei, Y., Kuo, Y.-C., Wei, S., Zhou, A., Zou, Z., Yehl, J., Ranaghan, M. J., Skepner, A. P., Bittker, J. A., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00421 · Cited by 75
Self-citationGalizzi, G., & Carlo, M. D. (2022) · Biology · doi:10.3390/biology11060943 · Cited by 77
Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine
Zeng, Q., Siu, W. S., Li, L., Yu, J., Liang, S., Cao, M., Ma, M., & Wu, Z. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.027 · Cited by 64
Comprehensive autophagy evaluation in cardiac disease models
Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernández, Á. F., de Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz233 · Cited by 64
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles
Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58
Insulin and Autophagy in Neurodegeneration
de Mello, N. P., Orellana, A. M., Mazucanti, C. H., Lima, G. D. M., Scavone, C., & Kawamoto, E. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00491 · Cited by 57
Li, P., Shi, M., Maique, J., Shaffer, J., Yan, S. X., Moe, O. W., & Hu, M. C. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00504.2019 · Cited by 54
Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment
Popescu, A., & German, M. (2021) · Nutrients · doi:10.3390/nu13072206 · Cited by 57
Tang, Z., Cao, J., Yao, J.-L., Fan, X., Zhao, J., Zhao, M., Duan, Q., Han, B., & Duan, S. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.099 · Cited by 54
Mechanisms by which autophagy regulates memory capacity in ageing
Risi, M. D., Torromino, G., Tufano, M., Moriceau, S., Pignataro, A., Rivagorda, M., Carrano, N., Middei, S., Settembre, C., Ammassari‐Teule, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13189 · Cited by 54
Yang, J., Zhang, W., Zhang, S., Iyaswamy, A., Sun, J., Wang, J., & Yang, C. (2023) · Aging and Disease · doi:10.14336/ad.2022.0927 · Cited by 49
Self-citationGiovedı̀, S., Ravanelli, M. M., Parisi, B., Bettegazzi, B., & Guarnieri, F. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.602116 · Cited by 53
Zhao, Y., Zou, Z., Sun, D., Li, Y., Sinha, S. C., Yu, L., Bennett, L. B., & Levine, B. (2020) · Autophagy · doi:10.1080/15548627.2020.1847798 · Cited by 45
Self-citationThe plasma peptides of Alzheimer’s disease
Florentinus-Mefailoski, A., Bowden, P., Scheltens, P., Killestein, J., Teunissen, C. E., & Marshall, J. G. (2021) · Clinical Proteomics · doi:10.1186/s12014-021-09320-2 · Cited by 44
Compromised autophagy and mitophagy in brain ageing and Alzheimer’s diseases.
Caponio, D., Veverová, K., Zhang, S.-Q., Shi, L., Wong, G., Vyhnalek, M., & Fang, E. F. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100056 · Cited by 45
Wang, J., Liu, B., Xu, Y. X., Yang, M., Wang, C., Song, M., Liu, J., Wang, W., You, J., Sun, F., et al. (2021) · Aging Cell · doi:10.1111/acel.13333 · Cited by 47
The effects of treadmill exercise on autophagy in hippocampus of APP/PS1 transgenic mice
Zhao, N., Zhang, X., Song, C., Yang, Y., He, B., & Xu, B. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001038 · Cited by 45
Bonam, S. R., Bayry, J., Tschan, M. P., & Muller, S. (2020) · Cells · doi:10.3390/cells9051321 · Cited by 46
Suelves, N., Saleki, S., Ibrahim, T., Palomares, D., Moonen, S., Koper, M. J., Vrancx, C., Vadukul, D. M., Papadopoulos, N., Viceconte, N., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01578-x · Cited by 43
Wang, C., Haas, M., Yeo, S. K., Sebti, S., Fernández, Á. F., Zou, Z., Levine, B., & Guan, J. (2021) · Autophagy · doi:10.1080/15548627.2021.1936358 · Cited by 39
Self-citationMolecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease
Zhao, Y., Zhang, Y., Zhang, J., Zhang, X., & Yang, G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200114163636 · Cited by 40
Lin, X., Wen, X., Wei, Z., Guo, K., Shi, F., Huang, T., Wang, W., & Zheng, J. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001599 · Cited by 39
Companys‐Alemany, J., Turcu, A. L., Schneider, M., Müller, C. E., Vázquez, S., Griñán‐Ferré, C., & Pallàs, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04438-4 · Cited by 43
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
Bieri, G., Lucin, K. M., O’Brien, C. E., Zhang, H., Villeda, S., & Wyss‐Coray, T. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0302-4 · Cited by 36
Kuramoto, K., Kim, Y.-J., Hong, J. H., & He, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109184 · Cited by 40
Self-citationSong, L., Yao, L., Zhang, L., Piao, Z., & Lu, Y. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01792-2 · Cited by 36
Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders
Soria, L. R., Gurung, S., Sabbata, G. D., Perocheau, D. P. B., Angelis, A. D., Bruno, G., Polishchuk, E., Paris, D., Cuomo, P., Motta, A., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202013158 · Cited by 34
Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression
Kaleli, H. N., Ozer, E., Kaya, V. O., & Kutlu, Ö. (2020) · Cells · doi:10.3390/cells9030553 · Cited by 36
Xu, J., Kong, L., Oliver, B. A., Li, B., Creasey, E. A., Guzman, G., Schenone, M., Carey, K. L., Carr, S. A., Graham, D. B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112708 · Cited by 35
Gebril, H. M., Aryasomayajula, A., de Lima, M. R. N., Uhrich, K. E., & Moghe, P. V. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-023-00393-7 · Cited by 37
Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy
Chen, L., Mei, G., Jiang, C., Cheng, X., Li, D., Zhao, Y., Chen, H., Wan, C., Yao, P., Gao, C., et al. (2021) · Cell Proliferation · doi:10.1111/cpr.13052 · Cited by 33
Li, S., Poon, C. H., Zhang, Z., Yue, M., Chen, R., Zhang, Y., Hossain, M. F., Pan, Y., Zhao, J. J., Rong, L., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14143 · Cited by 34
Exercise-driven cellular autophagy: A bridge to systematic wellness
Zhou, X.-H., Luo, Y., & Yao, X. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.12.036 · Cited by 35
Griffin, E. F., Yan, X., Caldwell, K. A., & Caldwell, G. A. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy308 · Cited by 34
Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases
Suresh, S., Chakravorty, A., Giridharan, M., Garimella, L., & Manjithaya, R. R. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.02.023 · Cited by 34
Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration
Hussain, M. S., Agrawal, N., Ilma, B., Rekha, M. M., Nayak, P. P., Kaur, M., Khachi, A., Goyal, K., Rekha, A., Gupta, S., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70503 · Cited by 35
Autophagy in ageing and ageing-related neurodegenerative diseases
Karabiyik, C., Frake, R. A., Park, S. J., Tanasa, M. P., & Rubinsztein, D. C. (2021) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2021.05 · Cited by 31
Das, S., Murumulla, L., Ghosh, P., & Challa, S. (2025) · BioMetals · doi:10.1007/s10534-025-00665-x · Cited by 30
Autophagy system as a potential therapeutic target for neurodegenerative diseases
Cui, M., Yoshimori, T., & Nakamura, S. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105308 · Cited by 29
Popli, P., Tang, S., Chadchan, S. B., Talwar, C., Rucker, E. B., Guan, X., Monsivais, D., Lydon, J. P., Stallings, C. L., Moley, K. H., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2023.03.013 · Cited by 31
Chernyaeva, L., Ratti, G., Teirilä, L., Fudo, S., Rankka, U., Pelkonen, A., Korhonen, P., Leskinen, K., Keskitalo, S., Salokas, K., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256467 · Cited by 29
Fu, Y., Zhang, J., Qin, R., Ren, Y., Zhou, T., Han, B., & Liu, B. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100053 · Cited by 29
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Wu, R., Park, J., Qian, Y., Shi, Z., Hu, R., Yuan, Y., Xiong, S., Wang, Z., Yan, G., Ong, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38471-z · Cited by 28
Self-citationO’Keefe, L. V., & Denton, D. (2018) · BioMed Research International · doi:10.1155/2018/5195416 · Cited by 25
Hadi, F., Mortaja, M., & Hadi, Z. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4085 · Cited by 23
Current Status of Autophagy Enhancers in Metabolic Disorders and Other Diseases
Park, K., & Lee, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.811701 · Cited by 24
Chen, M., Wu, Q., Zhu, Z., Huang, A., Zhang, J., Bekhit, A. E. A., Wang, J., & Ding, Y. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2172547 · Cited by 24
Kamaruzzaman, M. A., Romli, M. H., Abas, R., Vidyadaran, S., Baharuldin, M. T. H., Nasaruddin, M. L., Vishnumukkala, T., Sura, S., Warsito, K., Nor, N. H. M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1053680 · Cited by 25
Programmable DNA Nanodevices for Applications in Neuroscience
Hivare, P., Panda, C., Gupta, S. K., & Bhatia, D. D. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00723 · Cited by 21
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control
Cai, Z., Wang, S., Cao, S. “., Chen, Y., Penati, S., Peng, V., Yuede, C. M., Beatty, W. L., Lin, K., Zhu, Y., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20230173 · Cited by 23
Long, T., Chen, X., Zhang, Y., Zhou, Y., He, Y.-N., Zhu, Y., Fu, H., Yu, L., Yu, C., Law, B. Y. K., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115261 · Cited by 21
Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases
Ejlerskov, P., Ashkenazi, A., & Rubinsztein, D. C. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.04.001 · Cited by 20
The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance
Shi, M., Maique, J., Shaffer, J., Davidson, T. L., Sebti, S., Fernández, Á. F., Zou, Z., Yan, S. X., Levine, B., Moe, O. W., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902127r · Cited by 20
Self-citationAutophagy and autophagy‐related molecules in neurodegenerative diseases
Dou, C., Zhang, Y., Zhang, L., & Qin, C. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12229 · Cited by 19
Dong, X., Liang, Q., Pan, Y.-Z., Wang, X., Kuo, Y.-C., Chiang, W., Zhang, X., Williams, N. S., Rizo, J., Levine, B., et al. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00309 · Cited by 20
Self-citationModulation of microRNAs through Lifestyle Changes in Alzheimer’s Disease
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Self-citation
Metadata
- Authors
- Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R., & He, C.
- Affiliations
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- He, Congcong
- ORCID
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-08-14
- Volume
- 13
- Issue
- 8
- Pages
- e1006962
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC5570506
- OpenAlex
- W2749882665
- Cited by
- 166
- References
- 65
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 12 · 2023: 21 · 2022: 24 · 2021: 29 · 2020: 19 · 2019: 10 · 2018: 16
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Update notices
- new_version (2017-08-24)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Cancer Prevention and Research Institute of Texas (RP120718)
- Northwestern University (AG13854)
- Northeast Normal University
- National Institutes of Health (U19AI199725, 5r01gm078555-08, AG13854, RO1 CA109618)
- University of North Carolina at Chapel Hill
- Fundamental Research Funds for the Central Universities (2412017FZ018)
- National Institute on Aging (AG13854, R01AG030142, R01AG022560, P30AG013854)
- National Cancer Institute (R01CA109618)
- National Institute of General Medical Sciences (R01 GM-078555)
- National Institute of Allergy and Infectious Diseases (U19AI109725, T32AI007163)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, autophagy, Beclin-1, Bcl-2, amyloid-beta oligomers, autophagosomes, cognitive decline, voluntary exercise, autophagy inducers, genetic mouse models
- MeSH terms
- Beclin-1, Alzheimer Disease, Animals, Autophagy, Cognition, Disease Models, Animal, HeLa Cells, Humans, Male, Memory, Mice, Inbred C57BL, Neurons, Amyloid beta-Peptides, Point Mutation, Sequence Analysis, DNA, Proto-Oncogene Proteins c-bcl-2, In Situ Nick-End Labeling, Mice, Gene Knock-In Techniques, HEK293 Cells
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