The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development
Open accessAbstract
Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and hair abnormalities in humans and rodents may be caused by selenium deficiency, which are overcome by dietary selenium supplementation. Most important biological functions of selenium are attributed to selenoproteins, proteins containing selenium in the form of the amino acid, selenocysteine (Sec). Sec insertion into proteins depends on Sec tRNA; thus, knocking out the Sec tRNA gene (Trsp) ablates selenoprotein expression. We generated mice with targeted removal of selenoproteins in keratin 14 (K14) expressing cells and their differentiated descendents. The knockout progeny had a runt phenotype, developed skin abnormalities and experienced premature death. Lack of selenoproteins in epidermal cells led to the development of hyperplastic epidermis and aberrant hair follicle morphogenesis, accompanied by progressive alopecia after birth. Further analyses revealed that selenoproteins are essential antioxidants in skin and unveiled their role in keratinocyte growth and viability. This study links severe selenoprotein deficiency to abnormalities in skin and hair and provides genetic evidence for the role of these proteins in keratinocyte function and cutaneous development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Se-enriched proteins are also essential in keratinocyte development and function [67].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,385
Self-citationThe human keratins: biology and pathology
Moll, R., Divo, M., & Langbein, L. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0435-6 · Cited by 1,465
Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,044
Getting under the skin of epidermal morphogenesis
Fuchs, E., & Raghavan, S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg758 · Cited by 753
How Selenium Has Altered Our Understanding of the Genetic Code
Hatfield, D. L., & Gladyshev, V. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3565-3576.2002 · Cited by 681
Self-citationRole of integrins in regulating epidermal adhesion, growth and differentiation
Watt, F. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf399 · Cited by 647
Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin
Shindo, Y., Witt, E., Han, D., Epstein, W., & Packer, L. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371744 · Cited by 546
Oxidative mechanisms in carcinogenesis
Guyton, K. Z., & Kensler, T. W. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072628 · Cited by 465
Lichti, U. F., Anders, J., & Yuspa, S. H. (2008) · Nature Protocols · doi:10.1038/nprot.2008.50 · Cited by 444
Self-citationPatterned acquisition of skin barrier function during development
Hardman, M. J., Sisi, P., Banbury, D. N., & Byrne, C. (1998) · Development · doi:10.1242/dev.125.8.1541 · Cited by 385
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- HPM Gollnick, 1996, Systemic b carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the Berlin-Eilath study., Eur J Dermatol, 6, 200
Cited by
Sorted by citations
Items 101–107 of 107
O′Connor, K., & Goldberg, L. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82921-2.00013-5
Kalasariya, H. S., & Pereira, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98819-3.00004-3
Prospects of using mineral-containing preparations in cosmetology
Bakuridze, A., Berashvili, D., Bakuridze, L., Tsurtsumia, I., & Ebralidze, L. (2025) · GEORGIAN SCIENTISTS · doi:10.52340/gs.2025.07.02.12
Zhang, C., & 许发明 (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115148
Is the World Getting Smaller? Network‐Driven Heterogeneity in Gravity‐Model Elasticities
Kosztyán, Z. T., Mátrai, R., & Kiss, D. (2026) · World Economy · doi:10.1111/twec.70148
Thukral, S., Singh, S., & Salvi, A. (2026) · International Journal of Research in Dermatology · doi:10.18203/issn.2455-4529.intjresdermatol20263696
Metadata
- Authors
- Sengupta, A., Lichti, U. F., Carlson, B. A., Ryscavage, A. O., Gladyshev, V. N., Yuspa, S. H., & Hatfield, D. L.
- Affiliations
- National Institutes of Health (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Yuspa, Stuart H.
- Hatfield, Dolph L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-18
- Volume
- 5
- Issue
- 8
- Pages
- e12249
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2923614
- OpenAlex
- W2140893882
- Cited by
- 109
- References
- 41
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences (R01GM061603)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Keywords
- selenoproteins, selenocysteine, keratinocytes, skin development, hair follicle morphogenesis, hair loss, selenium deficiency, keratin 14, epidermal hyperplasia, antioxidant enzymes, keratinocyte viability, knockout mice
- MeSH terms
- Epidermal Cells, Animals, Animals, Newborn, Antioxidants, Cell Adhesion, Cell Differentiation, Epidermis, Female, Gene Expression Regulation, Macrophages, Male, Organ Specificity, Recombination, Genetic, RNA, Messenger, RNA, Transfer, Amino Acid-Specific, Selenium, Skin, Lipid Peroxidation, Biomarkers, Keratinocytes, Gene Deletion, Reactive Oxygen Species, Hair Follicle, Cell Proliferation, Selenoproteins, Mice, Keratin-14, Gene Knockout Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
