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Analysis of the lung microbiome in the “healthy” smoker and in COPD.
Open accessAbstract
Although culture-independent techniques have shown that the lungs are not sterile, little is known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We used pyrosequencing of 16S amplicons to analyze the lung microbiome in two ways: first, using bronchoalveolar lavage (BAL) to sample the distal bronchi and air-spaces; and second, by examining multiple discrete tissue sites in the lungs of six subjects removed at the time of transplantation. We performed BAL on three never-smokers (NS) with normal spirometry, seven smokers with normal spirometry ("healthy smokers", HS), and four subjects with COPD (CS). Bacterial 16 s sequences were found in all subjects, without significant quantitative differences between groups. Both taxonomy-based and taxonomy-independent approaches disclosed heterogeneity in the bacterial communities between HS subjects that was similar to that seen in healthy NS and two mild COPD patients. The moderate and severe COPD patients had very limited community diversity, which was also noted in 28% of the healthy subjects. Both approaches revealed extensive membership overlap between the bacterial communities of the three study groups. No genera were common within a group but unique across groups. Our data suggests the existence of a core pulmonary bacterial microbiome that includes Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas. Most strikingly, there were significant micro-anatomic differences in bacterial communities within the same lung of subjects with advanced COPD. These studies are further demonstration of the pulmonary microbiome and highlight global and micro-anatomic changes in these bacterial communities in severe COPD patients.
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“Under certain conditions, Streptococcus gordonii can attack host fibronectin, and subsequent cytokine production can induce inflammatory responses (Erb-Downward et al., 2011; Liu et al., 2018).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Erb-Downward et al., 2011
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Kwon‐Chung, J. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733256399.793546187
Chronic Respiratory Disease, COPD
Huang, Y. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6418-1_698-1
Cotter, P. D., & Barton, W. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727307658.793567408
Chronic Respiratory Disease, COPD
Huang, Y. J. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7475-4_698
Nisar, A., Kathade, S. A., Aswani, M. A., Harsulkar, A., Jagtap, S., & Kunchiraman, B. N. (2022) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/2992
Vientós‐Plotts, A. I. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/91692
Metadata
- Authors
- Erb-Downward, J. R., Thompson, D. L., Han, M. K., Freeman, C. M., McCloskey, L., Schmidt, L. A., Young, V. B., Toews, G. B., Curtis, J. L., Sundaram, B., Martinez, F. J., & Huffnagle, G. B.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Huffnagle, Gary B.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-02-22
- Volume
- 6
- Issue
- 2
- Pages
- e16384
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3043049
- OpenAlex
- W2163401084
- Cited by
- 973
- References
- 42
- Citations by year
- 2026: 32 · 2025: 50 · 2024: 59 · 2023: 66 · 2022: 73 · 2021: 57 · 2020: 74 · 2019: 62 · 2018: 85 · 2017: 80 · 2016: 75 · 2015: 72 · 2014: 68 · 2013: 57 · 2012: 49
- FWCI
- 50.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Veterans Affairs (R01 HL082480)
- University of Michigan (UL1 RR024986)
- National Institutes of Health (n01hr46162-13-0-1)
- Michigan Institute for Clinical and Health Research (UL 1RR024986)
- University of Michigan Comprehensive Cancer Center (P30 CA46952, CA46952)
- National Heart, Lung, and Blood Institute (R01HL082480, N01HR046162, T32HL007749)
- National Cancer Institute (P30 CA 46952)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK070875, RR024986, R01DK070875)
- National Center for Research Resources (UL1RR024986)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- lung microbiome, chronic obstructive pulmonary disease, healthy smokers, bronchoalveolar lavage, lung tissue sampling, bacterial community diversity, core microbiome, Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, Porphyromonas, lung transplantation
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Bronchoscopy, DNA, Bacterial, Female, Health, Humans, Lung, Male, Middle Aged, RNA, Ribosomal, 16S, Smoking, Sequence Analysis, DNA, Pulmonary Disease, Chronic Obstructive, Metagenome
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