The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
Open accessAbstract
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions. However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems. We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes. Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children. However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns. Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
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In the citing paper
“Cross-sectional studies comparing the gut microbiota composition between healthy and ASD individuals have revealed an altered microbiota profile in patients with ASD, with several studies reporting increased levels of Clostridium and Lactobacillus along with elevated levels of SCFAs, including propionic and butyric acid (Wang et al., 2012, 2013; De Angelis et al., 2013; Kang et al., 2013).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Kang et al., 2013
In the citing paper
“Nevertheless, reduced bacterial diversity and increased biomass were reported in individuals with ASD [228,230].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The most important may be reduced amounts of Prevotella, Corprococcus, and Veilonellaceae (participating in carbohydrate ingestion and fermentation), Bacteroidetes, Actinobacteria, Proteobacteria [228]”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“In the case of impaired BBB, which can be observed in certain (but not all) autistic subjects [37,254], LPS or SCFAs may cause brain inflammation and thus, further facilitate access to the brain for harmful substances, like heavy metals, that can accumulate there [228,246,255].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The last three studies indicated decreases; however, the studies came from one laboratory [39–41].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“Instead, these seven studies showed either a non-significant result in relative abundance [41, 48, 50, 52] or a lower relative abundance in children classified as ASD versus SIB or HC [31, 39, 42].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“No specific findings were identified in the Verrucomicrobia phylum [31, 33, 36, 39, 48] and in the Verrucomicrobiaceae family [31, 37, 39, 41, 52].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“This study did not replicate previously reported differences in the relative abundances of bacterial categories, including the Bacteroidetes phylum [12–14], the Sutterella genus [7,8,10] and the Prevotella genus [11] between ASD and unrelated control children.”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Of note, previous studies [6–8,12,14], with the exception of one study [13], failed to detect differences in microbial composition between ASD and NT siblings [11].”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Indeed, some studies have revealed significant reductions in the relative abundance of Prevotella, Coprococcus, Enterococcus, Lactobacillus, Streptococcus, Lactococcus, Staphylococcus, Ruminococcus, and Bifidobacterium species in children with ASD compared with healthy controls [36,128,143].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Several studies on ASD have showed changes in the composition of the microbiota, particularly in the relative abundance of the mains gut bacterial phyla [36,37,143,144].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“In the scientific literature, some studies highlight a higher abundance of Clostridia and Desulfovibrio bacteria and a lower ratio of Bacteroidetes to Firmicutes in ASD [37,39,143,145].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Others studies observed, in ASD children, high abundance of: Akkermansia muciniphilia, [36,143,148] Desulfovibrio, [37] and Faecalibacterium prausnitzii [36].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Of the nine studies compared α-diversity, three studies demonstrated that α-diversity has a significant reduction in ASD patients16,19,22.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Two sequencing studies reported that the abundance of Akkermansia was elevated in ASD patients22,23. Inconsistently, one qPCR study30 indicated that lower amount of Akkermansia muciniphila was found in feces of ASD patients than HCs.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Among them, three studies18,19,22 indicated the functional modules of gut microbiota in ASD patients were substantially different from that in HCs (Fig. 2).”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two studies of Kang et al. (Figs. 2b, c)19,22, the pathways of “Cell Motility”, “Cellular Processes” and “Bacterial motility proteins” had consistent significant discriminative power in HCs. In addition, “Bacterial chemotaxis” and “Flagellar assembly” were also noted.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“It should be noted that pathways of “Huntingtons disease” and “Amyotrophic lateral sclerosis (ALS)” under Neurodegenerative Diseases category as well as “Glutamatergic synapse” under Nervous System category were also increased in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In ASD patients, the functional modules of metabolism were higher than that in HCs, such as “Oxidative phosphorylation” under Energy Metabolism category and “Glycine, serine and threonine metabolism” under Amino Acid Metabolism.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Whereas, in ASD patients, the most enhanced functional module of microbiota was metabolism, including amino acid metabolism, lipid metabolism, carbohydrate metabolism, energy metabolism, cofactors and vitamins metabolism and tetracycline biosynthesis.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Akkermansia and Ruminococcus are mucin-degrading bacterium and associated with the gut permeability59,60.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [59]
In the citing paper
“Moreover, some functional modules involved in neurodegenerative diseases in human, such as Huntington disease and ALS were also raised in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Functions of xenobiotics degradation such as toluene, aminobenzoate, polycyclic aromatic hydrocarbon, and bisphenol were also enhanced.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two accordant studies19,22, functional modules of microbiota in HCs mostly involved in cell motility, cellular processes, bacterial motility proteins, bacterial chemotaxis, and flagellar assembly, which indicated the basic physiological maintenance under normal condition.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In addition, GI microbial dysbiosis, an imbalance in the organisms that make up the gut microbiota, has been documented in multiple studies of children with ASD [5, 7–14].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
In the citing paper
“However, other studies have shown that Akkermansia levels are higher in children with ASD compared to typically developing children, although species-level composition was not examined [13].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
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Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Classification and Regression by randomForest
Liaw, A. I., & Wiener, M. C. (2007) · Cited by 18,594
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
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Items 301–400 of 1,000
West, K., Yin, X., Rutherford, E. M., Wee, B., Choi, J., Chrisman, B., Dunlap, K., Hannibal, R. L., Hartono, W., Lin, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21327-9 · Cited by 67
Association between gut microbiota and psychiatric disorders: a systematic review
Valle, C. G.-D., Fernández, J., Solá, E., Montoya‐Castilla, I., Morillas, C., & Bañuls, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1215674 · Cited by 66
Lasheras, I., Seral, P., Latorre, E., Barroso, E., Gracia‐García, P., & Santabárbara, J. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.101874 · Cited by 66
Jeong, D., Kim, D.-H., Kang, I.-B., Kim, H., Song, K.-Y., Kim, H.-S., & Seo, K.-H. (2017) · Food & Function · doi:10.1039/c6fo01559j · Cited by 65
Comparative study of classifiers for human microbiome data
Wang, X., & Liu, Y. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100013 · Cited by 65
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
Mohan, M., Chow, C. T., Ryan, C., Chan, L. S., Dufour, J., Aye, P. P., Blanchard, J., Moehs, C. P., & Sestak, K. (2016) · Nutrients · doi:10.3390/nu8110684 · Cited by 65
Park, M. J., Pilla, R., Panta, A., Pandey, S., Sarawichitr, B., Suchodolski, J. S., & Sohrabji, F. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00760-5 · Cited by 65
Roussin, L., Prince, N., Perez‐Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020) · Microorganisms · doi:10.3390/microorganisms8091369 · Cited by 64
A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome
Johnson, D., Letchumanan, V., Thurairajasingam, S., & Lee, L. (2020) · Nutrients · doi:10.3390/nu12071983 · Cited by 64
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 67
Gut microbiome: An intermediary to neurotoxicity
Dempsey, J. L., Little, M., & Cui, J. Y. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.005 · Cited by 63
Imbalance in the Gut Microbiota of Children With Autism Spectrum Disorders
Ding, H., Yi, X., Zhang, X., Wang, H., Liu, H., & Mou, W.-W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.572752 · Cited by 63
Feng, P., Zhao, S., Zhang, Y., & Li, E. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123462 · Cited by 62
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62
Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota
Ericsson, A. C., Akter, S., Hanson, M. M., Busi, S. B., Parker, T. W., Schehr, R., Hankins, M. A., Ahner, C. E., Davis, J. W., Franklin, C. L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5604 · Cited by 62
van der Eijk, J. A. J., de Vries, H., Kjær, J. B., Naguib, M., Kemp, B., Smidt, H., Rodenburg, T. B., & Lammers, A. (2019) · Poultry Science · doi:10.3382/ps/pez336 · Cited by 62
Berding, K., Holscher, H. D., Arthur, A. E., & Donovan, S. M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.002 · Cited by 61
Davies, C., Mishra, D., Eshraghi, R. S., Mittal, J., Sinha, R., Bulut, E., Mittal, R., & Eshraghi, A. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.001 · Cited by 61
The Gut-Brain-Immune Axis in Autism Spectrum Disorders: A State-of-Art Report
Puricelli, C., Rolla, R., Gigliotti, C. L., Boggio, E. M., Beltrami, E., Dianzani, U., & Keller, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.755171 · Cited by 64
Cao, X., Lin, P., Jiang, P. X., & Li, C. (2013) · PubMed Central · doi:10.3969/j.issn.1002-0829.2013.06.003 · Cited by 61
Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system
Guo, Y., Yang, X., Qi, Y., Shu, W., Liu, Y., Tang, S., Huang, R., & Tang, L. (2017) · Scientific Reports · doi:10.1038/srep43035 · Cited by 61
Cristiano, C., Lama, A., Lembo, F., Mollica, M. P., Calignano, A., & Raso, G. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00184 · Cited by 60
Needham, B. D., Tang, W., & Wu, W. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22581 · Cited by 60
Relationship between diet, the gut microbiota, and brain function
Tengeler, A. C., Kozicz, T., & Kiliaan, A. J. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy016 · Cited by 61
van de Wouw, M., Walsh, C. J., Vigano, G. M. D., Lyte, J. M., Boehme, M., Gual‐Grau, A., Crispie, F., Walsh, A. M., Clarke, G. A., Dinan, T. G., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.004 · Cited by 59
Zheng, Y., Bek, M. K., Prince, N., Marzal, L. N. P., Garssen, J., Perez‐Pardo, P., & Kraneveld, A. D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.738220 · Cited by 59
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats
Liu, R., Liu, B., Tian, L., Jiang, X., Li, X., Cai, D., Sun, J., Bai, W., & Jin, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148042 · Cited by 59
Gut microbiota impact on stroke outcome: Fad or fact?
Winek, K., Meisel, A., & Dirnagl, U. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16636890 · Cited by 59
Laue, H. E., Korrick, S., Baker, E., Karagas, M. R., & Madan, J. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-72386-9 · Cited by 59
The Brain–Gut–Microbiome Axis in Psychiatry
Jang, S.-H., Woo, Y. S., Lee, S.-Y., & Bahk, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197122 · Cited by 59
Hu, J., Lesseur, C., Yu, M., Manservisi, F., Panzacchi, S., Mandrioli, D., Belpoggi, F., Chen, J., & Petrick, L. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-82552-2 · Cited by 59
Gut Microbiota and Neuroplasticity
Murciano-Brea, J., García-Montes, M. E., Geuna, S., & Herrera‐Rincon, C. (2021) · Cells · doi:10.3390/cells10082084 · Cited by 59
Characterization of the fecal microbiome in different swine groups by high-throughput sequencing
Park, S.-J., Kim, J., Lee, J., Rhee, S., & Kim, H. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.06.002 · Cited by 58
Eshraghi, R. S., Deth, R. C., Mittal, R., Aranke, M., Kay, S.-I. S., Moshiree, B., & Eshraghi, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00256 · Cited by 58
The Gut Microbiome in Autism: Study-Site Effects and Longitudinal Analysis of Behavior Change
Fouquier, J., Huizar, N. M., Donnelly, J., Glickman, C. M., Kang, D., Maldonado, J., Jones, R. A., Johnson, K. A., Adams, J. B., Krajmalnik‐Brown, R., et al. (2021) · mSystems · doi:10.1128/msystems.00848-20 · Cited by 59
Self-citationMelatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
Bonmatí‐Carrión, M., & Rol, M. A. (2023) · Antioxidants · doi:10.3390/antiox13010034 · Cited by 57
Beneficial Impact and Molecular Mechanism of Bacillus coagulans on Piglets’ Intestine
Wu, T., Lyu, Y., Xueni, L., Zhang, L., Shi, Y., Du, L., Yi, D., Chen, H., Guo, S., Wang, L., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072084 · Cited by 56
Ye, F., Gao, X., Wang, Z., Cao, S., Liang, G., He, D., Lv, Z., Wang, L., Xu, P., & Zhang, Q. (2021) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.03.003 · Cited by 56
Gut Microbiota in Psychiatric Disorders: A Systematic Review
Chen, L. L., Abbaspour, A., Mkoma, G. F., Bulik, C. M., Rück, C., & Djurfeldt, D. R. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000959 · Cited by 57
Potential etiologic factors of microbiome disruption in autism
Buie, T. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.001 · Cited by 55
Kang, D.-W., DiBaise, J. K., Ilhan, Z. E., Crowell, M. D., Rideout, J. R., Caporaso, J. G., Rittmann, B. E., & Krajmalnik-Brown, R. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.01.005 · Cited by 55
Self-citationPietrucci, D., Teofani, A., Milanesi, M., Fosso, B., Putignani, L., Messina, F., Pesole, G., Desideri, A., & Chillemi, G. (2022) · Biomedicines · doi:10.3390/biomedicines10082028 · Cited by 55
Nazeen, S., Palmer, N., Berger, B., & Kohane, I. S. (2016) · Genome biology · doi:10.1186/s13059-016-1084-z · Cited by 55
Ou, Y., Belzer, C., Smidt, H., & de Weerth, C. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2038853 · Cited by 54
Guidetti, C., Salvini, E., Viri, M., Deidda, F., Amoruso, A., Visciglia, A., Drago, L., Calgaro, M., Vitulo, N., Pane, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185263 · Cited by 54
Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier
Wynendaele, E., Verbeke, F., Stalmans, S., Gevaert, B., Janssens, Y., de Wiele, C. V., Peremans, K. Y., Burvenich, C., & Spiegeleer, B. M. J. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142071 · Cited by 53
Chen, K., Fu, Y., Wang, Y., Liao, L., Xu, H., Zhang, A., Zhang, J., Fan, L., Ren, J., & Fang, B. (2020) · Microbial Ecology · doi:10.1007/s00248-020-01494-w · Cited by 53
Lu, J. N., Lu, L., Yu, Y., Baranowski, J. R., & Claud, E. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-65180-0 · Cited by 53
Alteration of Gut Microbiota in Autism Spectrum Disorder: An Overview
Oh, D., & Cheon, K.-A. A. (2020) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.190039 · Cited by 53
A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder
Azhari, A., Azizan, F., & Esposito, G. (2018) · Developmental Psychobiology · doi:10.1002/dev.21803 · Cited by 52
Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders
Wu, W., Kong, Q., Tian, P., Zhai, Q., Wang, G., Liu, X., Zhao, J., Zhang, H., Lee, Y. K., & Chen, W. (2020) · Engineering · doi:10.1016/j.eng.2019.07.026 · Cited by 52
Gut–brain link grabs neuroscientists
Reardon, S. (2014) · Nature · doi:10.1038/515175a · Cited by 52
Implications of Gut Microbiota in Complex Human Diseases
Yu, D., Meng, X., de Vos, W. M., Wu, H., Fang, X., & Maiti, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312661 · Cited by 51
Nature Connection: Providing a Pathway from Personal to Planetary Health
Zelenski, J. M., Warber, S. L., Robinson, J. M., Logan, A. C., & Prescott, S. L. (2023) · Challenges · doi:10.3390/challe14010016 · Cited by 51
Lagod, P. P., & Naser, S. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417432 · Cited by 54
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Sizemore, N., Oliphant, K., Zheng, R., Martin, C. R., Claud, E. C., & Chattopadhyay, I. (2024) · Science Advances · doi:10.1126/sciadv.adj0400 · Cited by 51
Shiadeh, S. M. J., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S. R. L., Westberg, L., Elfvin, A., Mallard, C. E., & Ardalan, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03504-2 · Cited by 52
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Ameringen, M. V., Turna, J., Patterson, B. A., Pipe, A., Mao, R. Q., Anglin, R., & Surette, M. G. (2019) · Depression and Anxiety · doi:10.1002/da.22936 · Cited by 51
Zhang, Z., Li, N., Chen, R., Lee, T., Gao, Y.-X., Yuan, Z., Nie, Y., & Sun, T. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100333 · Cited by 51
Li, Z., Wright, A. G., Liu, H., Fan, Z., Yang, F., Zhang, Z., & Li, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123481 · Cited by 50
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Qin, C., Gong, L., Zhang, X., Wang, Y., Wang, Y., Wang, B., Li, Y., & Li, W. (2018) · Animal nutrition · doi:10.1016/j.aninu.2018.03.004 · Cited by 50
Pistollato, F., Forbes-Hernández, T. Y., Iglesias, R. C., Ruíz, R., Elexpuru-Zabaleta, M., Cianciosi, D., Giampieri, F., & Battino, M. A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104579 · Cited by 49
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Liu, Z., Wang, J., Xu, Q., Hong, Q., Zhu, J., & Chi, X. (2021) · Behavioural Neurology · doi:10.1155/2021/5417497 · Cited by 49
Raghavan, K., Dedeepiya, V. D., Yamamoto, N., Ikewaki, N., Sonoda, T., Iwasaki, M., Kandaswamy, R. S., Senthilkumar, R., Preethy, S., & Abraham, S. J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220388 · Cited by 49
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Mussap, M., Noto, A., & Fanos, V. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2016.1202765 · Cited by 49
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Flannery, J., Callaghan, B. L., Sharpton, T. J., Fisher, P. A., & Pfeifer, J. H. (2019) · Developmental Psychobiology · doi:10.1002/dev.21821 · Cited by 48
Yan, R., Ho, C., & Zhang, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000187 · Cited by 49
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Domènech, L., Willis, J. R., Alemany-Navarro, M., Morell, M., Real, E., Escaramís, G., Bertolín, S., Chinchilla, D. S., Balcells, S., Segalàs, C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05480-9 · Cited by 49
Aw, W., & Fukuda, S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0456-2 · Cited by 48
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Delgado, A. G., Kang, D., Nelson, K. G., Fajardo-Williams, D., Miceli, J. F., Done, H. Y., Popat, S. C., & Krajmalnik‐Brown, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100654 · Cited by 47
Self-citationValcheva, R. S., Hotte, N., Gillevet, P. M., Sikaroodi, M., Thiesen, A., & Madsen, K. L. (2015) · Journal of Nutrition · doi:10.3945/jn.114.207738 · Cited by 47
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Jia, Z., Chen, A., Bao, F., He, M., Gao, S., Xu, J., Zhang, X., Niu, P., & Wang, C. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.04.005 · Cited by 46
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Yousefi, B., Kokhaei, P., Mehranfar, F., Bahar, A., Abdolshahi, A., Emadi, A., & Eslami, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.046 · Cited by 45
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An, E., Delgadillo, D. R., Yang, J., Agarwal, R., Labus, J. S., Pawar, S., Leitman, M., Kilpatrick, L. A., Bhatt, R. R., Vora, P. P., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00266-6 · Cited by 45
Naudé, P. J. W., Claassen-Weitz, S., Gardner‐Lubbe, S., Botha, G., Kaba, M., Zar, H. J., Nicol, M. P., & Stein, D. J. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.43 · Cited by 45
Berding, K., & Donovan, S. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00193 · Cited by 45
Wan, J., Zhou, S., Mea, H. J., Guo, Y., Ku, H., & Urbina, B. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00480 · Cited by 45
Abujamel, T. S., Al-Otaibi, N. M., Abuaish, S., Alharbi, R. H., Assas, M. B., Alzahrani, S. A., Alotaibi, S. M., El-Ansary, A. K., & Aabed, K. (2022) · Nutrients · doi:10.3390/nu14030608 · Cited by 45
Quan, L., Yi, J., Zhao, Y., Zhang, F., Shi, X.-T., Feng, Z., & Miller, H. L. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2019.10.012 · Cited by 44
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Yang, C.-J., Xiao, H., Zhu, H., Du, Y., & Wang, L. (2024) · BioScience Trends · doi:10.5582/bst.2024.01123 · Cited by 43
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Self-citationNirmalkar, K., Qureshi, F. A., Kang, D., Hahn, J., Adams, J. B., & Krajmalnik‐Brown, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113481 · Cited by 43
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Metadata
- Authors
- Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R.
- Affiliations
- Arizona State University (US)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-07-03
- Volume
- 8
- Issue
- 7
- Pages
- e68322
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3700858
- OpenAlex
- W2149756110
- Cited by
- 976
- References
- 71
- Citations by year
- 2026: 36 · 2025: 75 · 2024: 65 · 2023: 94 · 2022: 83 · 2021: 114 · 2020: 85 · 2019: 100 · 2018: 94 · 2017: 53 · 2016: 74 · 2015: 49 · 2014: 39 · 2013: 14
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Arizona State University Library Digital Repository (Arizona State University) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Autism Research Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autism spectrum disorder, gut microbiota, gastrointestinal symptoms, Prevotella, Coprococcus, Veillonellaceae, microbial diversity, autism severity, diet patterns, fecal microbiota, children
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Female, Gastrointestinal Diseases, Humans, Male, Phylogeny, ROC Curve, Incidence, Cluster Analysis, Bacteroidaceae Infections, Prevotella, Gastrointestinal Tract, Biodiversity, Metagenome, Microbiota
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