The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
Open accessAbstract
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions. However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems. We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes. Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children. However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns. Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Cross-sectional studies comparing the gut microbiota composition between healthy and ASD individuals have revealed an altered microbiota profile in patients with ASD, with several studies reporting increased levels of Clostridium and Lactobacillus along with elevated levels of SCFAs, including propionic and butyric acid (Wang et al., 2012, 2013; De Angelis et al., 2013; Kang et al., 2013).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Kang et al., 2013
In the citing paper
“Nevertheless, reduced bacterial diversity and increased biomass were reported in individuals with ASD [228,230].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The most important may be reduced amounts of Prevotella, Corprococcus, and Veilonellaceae (participating in carbohydrate ingestion and fermentation), Bacteroidetes, Actinobacteria, Proteobacteria [228]”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“In the case of impaired BBB, which can be observed in certain (but not all) autistic subjects [37,254], LPS or SCFAs may cause brain inflammation and thus, further facilitate access to the brain for harmful substances, like heavy metals, that can accumulate there [228,246,255].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [228]
In the citing paper
“The last three studies indicated decreases; however, the studies came from one laboratory [39–41].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“Instead, these seven studies showed either a non-significant result in relative abundance [41, 48, 50, 52] or a lower relative abundance in children classified as ASD versus SIB or HC [31, 39, 42].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“No specific findings were identified in the Verrucomicrobia phylum [31, 33, 36, 39, 48] and in the Verrucomicrobiaceae family [31, 37, 39, 41, 52].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [39]
In the citing paper
“This study did not replicate previously reported differences in the relative abundances of bacterial categories, including the Bacteroidetes phylum [12–14], the Sutterella genus [7,8,10] and the Prevotella genus [11] between ASD and unrelated control children.”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Of note, previous studies [6–8,12,14], with the exception of one study [13], failed to detect differences in microbial composition between ASD and NT siblings [11].”
From Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection (2015) · cites this paper as [11]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Stool-based microbiome characterization in several cohorts identified specific genera that differed in ASD vs control subjects, but most previous studies conducted their analysis at higher taxonomic levels, with little published data at the genus or species (ie, OTU) level.22, 25, 26, 27”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [25]
In the citing paper
“Indeed, some studies have revealed significant reductions in the relative abundance of Prevotella, Coprococcus, Enterococcus, Lactobacillus, Streptococcus, Lactococcus, Staphylococcus, Ruminococcus, and Bifidobacterium species in children with ASD compared with healthy controls [36,128,143].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Several studies on ASD have showed changes in the composition of the microbiota, particularly in the relative abundance of the mains gut bacterial phyla [36,37,143,144].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“In the scientific literature, some studies highlight a higher abundance of Clostridia and Desulfovibrio bacteria and a lower ratio of Bacteroidetes to Firmicutes in ASD [37,39,143,145].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Others studies observed, in ASD children, high abundance of: Akkermansia muciniphilia, [36,143,148] Desulfovibrio, [37] and Faecalibacterium prausnitzii [36].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [143]
In the citing paper
“Of the nine studies compared α-diversity, three studies demonstrated that α-diversity has a significant reduction in ASD patients16,19,22.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Two sequencing studies reported that the abundance of Akkermansia was elevated in ASD patients22,23. Inconsistently, one qPCR study30 indicated that lower amount of Akkermansia muciniphila was found in feces of ASD patients than HCs.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Among them, three studies18,19,22 indicated the functional modules of gut microbiota in ASD patients were substantially different from that in HCs (Fig. 2).”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two studies of Kang et al. (Figs. 2b, c)19,22, the pathways of “Cell Motility”, “Cellular Processes” and “Bacterial motility proteins” had consistent significant discriminative power in HCs. In addition, “Bacterial chemotaxis” and “Flagellar assembly” were also noted.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“It should be noted that pathways of “Huntingtons disease” and “Amyotrophic lateral sclerosis (ALS)” under Neurodegenerative Diseases category as well as “Glutamatergic synapse” under Nervous System category were also increased in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In ASD patients, the functional modules of metabolism were higher than that in HCs, such as “Oxidative phosphorylation” under Energy Metabolism category and “Glycine, serine and threonine metabolism” under Amino Acid Metabolism.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Whereas, in ASD patients, the most enhanced functional module of microbiota was metabolism, including amino acid metabolism, lipid metabolism, carbohydrate metabolism, energy metabolism, cofactors and vitamins metabolism and tetracycline biosynthesis.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Akkermansia and Ruminococcus are mucin-degrading bacterium and associated with the gut permeability59,60.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [59]
In the citing paper
“Moreover, some functional modules involved in neurodegenerative diseases in human, such as Huntington disease and ALS were also raised in ASD patients.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“Functions of xenobiotics degradation such as toluene, aminobenzoate, polycyclic aromatic hydrocarbon, and bisphenol were also enhanced.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In two accordant studies19,22, functional modules of microbiota in HCs mostly involved in cell motility, cellular processes, bacterial motility proteins, bacterial chemotaxis, and flagellar assembly, which indicated the basic physiological maintenance under normal condition.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [22]
In the citing paper
“In addition, GI microbial dysbiosis, an imbalance in the organisms that make up the gut microbiota, has been documented in multiple studies of children with ASD [5, 7–14].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
In the citing paper
“However, other studies have shown that Akkermansia levels are higher in children with ASD compared to typically developing children, although species-level composition was not examined [13].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Classification and Regression by randomForest
Liaw, A. I., & Wiener, M. C. (2007) · Cited by 18,594
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 1,000
Changes in the Gut Microbiota of Children with Autism Spectrum Disorder
Zou, R., Xu, F., Wang, Y., Duan, M., Guo, M., Zhang, Q., Zhao, H., & Zheng, H. (2020) · Autism Research · doi:10.1002/aur.2358 · Cited by 216
Santocchi, E., Guiducci, L., Fulceri, F., Billeci, L., Buzzigoli, E., Apicella, F., Calderoni, S., Grossi, E., Morales, M. A., & Muratori, F. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0887-5 · Cited by 213
Gut microbial composition in patients with psoriasis
Codoñer, F. M., Ramírez-Boscá, A., Climent, E., Carrión-Gutiérrez, M. A., Guerrero, M., Pérez-Orquín, J. M., de la Parte, J. H., Genovés, S., Ramón, D., Navarro‐López, V., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22125-y · Cited by 213
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics
Kim, N., Yun, M., Oh, Y. J., & Choi, H.-J. (2018) · Journal of Microbiology · doi:10.1007/s12275-018-8032-4 · Cited by 210
Houlden, A., Hayes, K. S., Bancroft, A. J., Worthington, J. J., Wang, P., Grencis, R. K., & Roberts, I. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125945 · Cited by 208
Altered Gut Microbiota in Chinese Children With Autism Spectrum Disorders
Ma, B., Liang, J., Dai, M., Wang, J., Luo, J., Zhang, Z., & Jing, J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00040 · Cited by 202
Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders
Horn, J., Mayer, D. E., Chen, S., & Mayer, E. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01922-0 · Cited by 193
Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder
Fulceri, F., Morelli, M., Santocchi, E., Cena, H., Del Bianco, T., Narzisi, A., Calderoni, S., & Muratori, F. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.11.026 · Cited by 191
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 194
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 190
Gut microbial dysbiosis in indian children with autism spectrum disorders
Pulikkan, J., Maji, A., Dhakan, D. B., Saxena, R., Mohan, B., Anto, M. M., Agarwal, N., Grace, T., & Sharma, V. K. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1176-2 · Cited by 189
Caio, G., Lungaro, L., Segata, N., Guarino, M., Zoli, G., Volta, U., & GIORGIO, R. D. (2020) · Nutrients · doi:10.3390/nu12061832 · Cited by 189
Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 193
Gut Microbiota: The Brain Peacekeeper
Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188
Zhang, M., Ma, W., Zhang, J., He, Y., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32219-2 · Cited by 188
Autism Spectrum Disorders: Etiology and Pathology
Sauer, A. K., Stanton, J. E., Hans, S., & Grabrucker, A. M. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.autismspectrumdisorders.2021.etiology · Cited by 195
Bacterial community collapse: a meta‐analysis of the sinonasal microbiota in chronic rhinosinusitis
Mackenzie, B. W., Waite, D. W., Hoggard, M., Douglas, R. G., Taylor, M. W., & Biswas, K. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13632 · Cited by 187
Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour
Clarke, G., O'Mahony, S., Dinan, T., & Cryan, J. (2014) · Acta Paediatrica · doi:10.1111/apa.12674 · Cited by 179
Gut Microbiota Differs Between Parkinson’s Disease Patients and Healthy Controls in Northeast China
Li, C., Cui, L., Yang, Y., Miao, J., Zhao, X., Zhang, J., Cui, G., & Zhang, Y. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00171 · Cited by 178
Tye, C., Runicles, A. K., Whitehouse, A. J. O., & Alvares, G. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00751 · Cited by 177
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177
Cowan, C. S. M., Dinan, T. G., & Cryan, J. F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13156 · Cited by 176
Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175
Yang, J., Summanen, P. H., Henning, S. M., Hsu, M., Lam, H., Huang, J., Tseng, C., Dowd, S. E., Finegold, S. M., Heber, D., et al. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00216 · Cited by 175
Qiao, Y., Wu, M., Feng, Y., Zhou, Z., Chen, L., & Chen, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-19982-y · Cited by 174
The curious case of Prevotella copri
Abdelsalam, N. A., Hegazy, S. M., & Aziz, R. K. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2249152 · Cited by 174
Krajmalnik‐Brown, R., Lozupone, C., Kang, D., & Adams, J. B. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26914 · Cited by 175
Self-citationParkinson’s Disease and the Gastrointestinal Microbiome
Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172
Davis, E. C., Wang, M., & Donovan, S. M. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1278104 · Cited by 169
Frye, R. E. (2018) · CNS Drugs · doi:10.1007/s40263-018-0556-y · Cited by 169
pH-Mediated Microbial and Metabolic Interactions in Fecal Enrichment Cultures
Ilhan, Z. E., Marcus, A. K., Kang, D., Rittmann, B. E., & Krajmalnik‐Brown, R. (2017) · mSphere · doi:10.1128/msphere.00047-17 · Cited by 168
Self-citationKang, S. S., Kurti, A., Fair, D. A., & Fryer, J. D. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0156-9 · Cited by 167
Gut microbiota changes in patients with autism spectrum disorders
Ding, X., Xu, Y., Zhang, X., Zhang, L., Duan, G., Song, C., Li, Z., Yang, Y., Wang, Y., Wang, X., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.06.032 · Cited by 166
Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810028 · Cited by 166
Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions
Pantazi, A. C., Bălașa, A. L., Mihai, C. M., Chisnoiu, T., Lupu, V. V., Kassim, M. A. K., Mihai, L., Frecuș, C. E., Chirila, S. I., Lupu, A., et al. (2023) · Nutrients · doi:10.3390/nu15163647 · Cited by 166
Psychobiotics: The Next-Generation Probiotics for the Brain
Sharma, R., Gupta, D., Mehrotra, R., & Mago, P. (2021) · Current Microbiology · doi:10.1007/s00284-020-02289-5 · Cited by 164
Gut microbiota: a potential regulator of neurodevelopment
Tognini, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00025 · Cited by 163
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Forsythe, P., Kunze, W., & Bienenstock, J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0604-8 · Cited by 162
Influence of the microbiota-gut-brain axis on behavior and welfare in farm animals: A review
Kraïmi, N., Dawkins, M. S., Gebhardt‐Henrich, S. G., Velge, P., Rychlı́k, I., Volf, J., Créach, P., Smith, A. L., Colles, F. M., & Leterrier, C. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112658 · Cited by 161
Microbiota influence the development of the brain and behaviors in C57BL/6J mice
Lu, J., Synowiec, S., Lu, L., Yu, Y., Bretherick, T., Takada, S., Yarnykh, V., Caplan, J., Caplan, M., Claud, E. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201829 · Cited by 159
Nutritional interventions for autism spectrum disorder
Karhu, E., Zukerman, R. J., Eshraghi, R. S., Mittal, J., Deth, R. C., Castejon, A. M., Trivedi, M. S., Mittal, R., & Eshraghi, A. A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz092 · Cited by 159
Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder
Dhaliwal, K. K., Orsso, C. E., Richard, C., Haqq, A. M., & Zwaigenbaum, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133285 · Cited by 157
Physiology and central carbon metabolism of the gut bacterium Prevotella copri
Franke, T., & Deppenmeier, U. (2018) · Molecular Microbiology · doi:10.1111/mmi.14058 · Cited by 155
Can probiotics benefit children with autism spectrum disorders?
Navarro, F., Liu, Y., & Rhoads, J. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10093 · Cited by 154
Connection between gut microbiome and brain development in preterm infants
Lu, J. N., & Claud, E. C. (2018) · Developmental Psychobiology · doi:10.1002/dev.21806 · Cited by 152
Kong, X., Liu, J., Çetinbaş, M., Sadreyev, R. I., Koh, M., Huang, H. Y., Adeseye, A., He, P., Zhu, J., Russell, H., et al. (2019) · Nutrients · doi:10.3390/nu11092128 · Cited by 155
Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 153
Moré, M. I., & Swidsinski, A. V. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s85574 · Cited by 151
Kong, X.-J., Liu, J., Liu, K., Koh, M., Sherman, H., Liu, S., Tian, R., Sukijthamapan, P., Wang, J., Fong, M., et al. (2021) · Nutrients · doi:10.3390/nu13051552 · Cited by 150
Kang, D., Adams, J. B., Vargason, T., Santiago, M., Hahn, J., & Krajmalnik‐Brown, R. (2020) · mSphere · doi:10.1128/msphere.00314-20 · Cited by 154
Self-citationEicher, T. P., & Mohajeri, M. H. (2022) · Nutrients · doi:10.3390/nu14132661 · Cited by 151
Gut microbiota changes in children with autism spectrum disorder: a systematic review
Ho, L. K. H., Tong, V. J. W., Syn, N., Nagarajan, N., Tham, E. H., Tay, S. K., Shorey, S., Tambyah, P. A., & Law, E. C. N. (2020) · Gut Pathogens · doi:10.1186/s13099-020-0346-1 · Cited by 149
Mandal, S., Godfrey, K. M., McDonald, D. T., Treuren, W. V., Bjørnholt, J. V., Midtvedt, T., Moen, B., Rudi, K., Knight, R. D., Brantsæter, A. L., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0200-3 · Cited by 149
Inoue, R., Sakaue, Y., Sawai, C., Sawai, T., Ozeki, M., Romero-Pérez, G. A., & Tsukahara, T. (2016) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2016.1222267 · Cited by 148
Gut microbiota composition is associated with temperament traits in infants
Aatsinki, A.-K., Lahti, L., Uusitupa, H.-M., Munukka, E., Keskitalo, A., Nolvi, S., O'Mahony, S., Pietilä, S., Elo, L. L., Eerola, E., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.035 · Cited by 148
Altered gut microbiota in Rett syndrome
Strati, F., Cavalieri, D., Albanese, D., Felice, C. D., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Pindo, M., Renzi, D., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0185-y · Cited by 149
Microbiota and neurologic diseases: potential effects of probiotics
Umbrello, G., & Esposito, S. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1058-7 · Cited by 147
Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs
Berding, K., & Donovan, S. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw048 · Cited by 146
Diet can impact microbiota composition in children with autism spectrum disorder
Berding, K., & Donovan, S. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00515 · Cited by 144
Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder
Saurman, V. E., Margolis, K. G., & Luna, R. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06133-5 · Cited by 144
Zhou, Y., Chen, Y., He, H., Peng, M., Zeng, M., & Sun, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109690 · Cited by 147
Human Microbiota-Associated Swine: Current Progress and Future Opportunities
Wang, M., & Donovan, S. M. (2015) · ILAR Journal · doi:10.1093/ilar/ilv006 · Cited by 143
Kim, Y. S., Kim, J., & Park, S.-J. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.01.004 · Cited by 145
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142
Li, R. W., Li, W., Sun, J., Yu, P., Baldwin, R. L., & Urban, J. F. (2016) · Scientific Reports · doi:10.1038/srep20606 · Cited by 142
The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?
Ochoa‐Repáraz, J., & Kasper, L. H. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0191-1 · Cited by 141
Li, N., Yang, J., Zhang, J., Liang, C., Wang, Y., Chen, B., Zhao, C., Wang, J., Zhang, G., Zhao, D., et al. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.01.002 · Cited by 141
Virk, M. S., Virk, M. A., He, Y., Tufail, T., Gul, M., Qayum, A., Rehman, A., Rashid, A., Ekumah, J., Han, X., et al. (2024) · Nutrients · doi:10.3390/nu16040546 · Cited by 144
Targeting gut microbiome: a novel and potential therapy for autism
Yang, Y., Tian, J., & Yang, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.027 · Cited by 140
Aljumaah, M. R., Bhatia, U., Roach, J., Gunstad, J., & Peril, M. A. A. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.09.012 · Cited by 140
Structure and Function of the Fecal Microbiota in Diarrheic Neonatal Piglets
Yang, Q., Huang, X., Zhao, S., Sun, W., Yan, Z., Wang, P., Li, S., Huang, W., Zhang, S., Liu, L., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00502 · Cited by 138
Role of the gut microbiome in three major psychiatric disorders
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. (2022) · Psychological Medicine · doi:10.1017/s0033291722000897 · Cited by 139
Swanson, N. L., Leu, A. F., Abrahamson, J., & Wallet, B. C. (2014) · Cited by 136
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135
Zhai, Q., Cen, S., Jiang, J., Zhao, J., Zhang, H., & Chen, W. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.060 · Cited by 135
Notting, F., Pirovano, W., Sybesma, W., & Kort, R. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.14 · Cited by 135
Association Study of Gut Flora in Coronary Heart Disease through High-Throughput Sequencing
Cui, L., Zhao, T., Hu, H., Zhang, W., & Hua, X. (2017) · BioMed Research International · doi:10.1155/2017/3796359 · Cited by 133
Plaza‐Díaz, J., Gómez-Fernández, A., Chueca, N., de la Torre‐Aguilar, M. J., Gil, Á., Pérez-Navero, J. L., Flores‐Rojas, K., Martín-Borreguero, P., Solis‐Urra, P., Ruiz‐Ojeda, F. J., et al. (2019) · Nutrients · doi:10.3390/nu11020337 · Cited by 131
Defining Dysbiosis in Patients with Urolithiasis
Zampini, A. M., Nguyen, A. H., Rose, E., Monga, M., & Miller, A. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-41977-6 · Cited by 131
Human Microbiome and its Association With Health and Diseases
Thani, A. A. A., Marei, H. E. S., Hamdi, W. S., Nasrallah, G. K., Zowalaty, M. E. E., Khodor, S. A., Al‐Asmakh, M., Aziz, H. A., & Cenciarelli, C. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25284 · Cited by 130
Impact of early gut microbiota on immune and metabolic development and function
Wang, M., Monaco, M. H., & Donovan, S. M. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.004 · Cited by 130
The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 130
Heat-killed lactobacilli alter both microbiota composition and behaviour
Warda, A. K., Rea, K., Fitzgerald, P., Hueston, C. M., González-Tortuero, E., Dinan, T. G., & Hill, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.047 · Cited by 129
Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes
Sordillo, J. E., Korrick, S., Laranjo, N., Carey, V. J., Weinstock, G. M., Gold, D. R., O’Connor, G. T., Sandel, M. T., Bacharier, L. B., Beigelman, A., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.0905 · Cited by 128
The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder
Alharthi, A., Alhazmi, S., Alburae, N. A., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031363 · Cited by 126
Microbial colonization is required for normal neurobehavioral development in zebrafish
Phelps, D. W., Brinkman, N. E., Keely, S. P., Anneken, E. M., Catron, T. R., Betancourt, D. A., Wood, C. E., Espenschied, S. T., Rawls, J. F., & Tal, T. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-10517-5 · Cited by 127
Bundgaard‐Nielsen, C., Knudsen, J. K., Leutscher, P. D. C., Lauritsen, M. B., Nyegaard, M., Hagstrøm, S., & Sørensen, S. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1748258 · Cited by 125
Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders
Gilbert, J. A., Krajmalnik‐Brown, R., Porazinska, D. L., Weiss, S. J., & Knight, R. D. (2013) · Cell · doi:10.1016/j.cell.2013.11.035 · Cited by 124
Self-citationLefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120
Gut microbiota composition during infancy and subsequent behavioural outcomes
Loughman, A., Ponsonby, A.-L., O'Hely, M., Symeonides, C., Collier, F., Tang, M. L. K., Carlin, J., Ranganathan, S., Allen, K., Pezic, A., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102640 · Cited by 120
Metabolic tinkering by the gut microbiome
Selkrig, J., Wong, P., Zhang, X., & Pettersson, S. (2014) · Gut Microbes · doi:10.4161/gmic.28681 · Cited by 120
Ly, V., Bottelier, M. A., Hoekstra, P. J., Vásquez, A. A., Buitelaar, J. K., & Rommelse, N. N. J. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0959-1 · Cited by 120
Navarro‐López, V., Martínez‐Andrés, A., Ramírez-Boscá, A., Ruzafa-Costas, B., Núñez-Delegido, E., Carrión-Gutiérrez, M. A., Prieto‐Merino, D., Codoñer-Cortés, F. M., Ramón, D., Genovés, S., et al. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3305 · Cited by 120
Gut Vibes in Parkinson's Disease: The Microbiota‐Gut‐Brain Axis
Bullich‐Vilarrubias, C., Keshavarzian, A., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12840 · Cited by 120
Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases
Hirschberg, S., Gisevius, B., Duscha, A., & Haghikia, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123109 · Cited by 120
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 118
Ishaq, H. M., Mohammad, I. S., Guo, H., Shahzad, M., Hou, Y. J., Ma, C., Naseem, Z., Wu, X., Shi, P., & Xu, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.101 · Cited by 116
Liu, J., Liu, X., Xiong, X.-Q., Yang, T., Cui, T., Hou, N.-L., Lai, X., Liu, S., Guo, M., Liang, X.-H., et al. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1096-1 · Cited by 115
Assal, K. A., Martínez, A. C. U., Torrinhas, R. S., Cardinelli, C. D. S., & Waitzberg, D. L. (2018) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2018.03.001 · Cited by 114
Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives
Mehra, A., Arora, G., Sahni, G., Kaur, M., Singh, H. B., Singh, B., & Kaur, S. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.03.001 · Cited by 116
Metadata
- Authors
- Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R.
- Affiliations
- Arizona State University (US)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-07-03
- Volume
- 8
- Issue
- 7
- Pages
- e68322
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3700858
- OpenAlex
- W2149756110
- Cited by
- 976
- References
- 71
- Citations by year
- 2026: 36 · 2025: 75 · 2024: 65 · 2023: 94 · 2022: 83 · 2021: 114 · 2020: 85 · 2019: 100 · 2018: 94 · 2017: 53 · 2016: 74 · 2015: 49 · 2014: 39 · 2013: 14
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Arizona State University Library Digital Repository (Arizona State University) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Autism Research Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autism spectrum disorder, gut microbiota, gastrointestinal symptoms, Prevotella, Coprococcus, Veillonellaceae, microbial diversity, autism severity, diet patterns, fecal microbiota, children
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Female, Gastrointestinal Diseases, Humans, Male, Phylogeny, ROC Curve, Incidence, Cluster Analysis, Bacteroidaceae Infections, Prevotella, Gastrointestinal Tract, Biodiversity, Metagenome, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
