Fecal microbiome composition and stability in 4- to 8-year old children is associated with dietary patterns and nutrient intake
Abstract
How long-term dietary intake shapes microbiota composition and stability in young children is poorly understood. Herein, the temporal variability in stool microbiota composition in relation to habitual dietary patterns of 4- to 8-year-old children (n=22) was investigated. Fecal samples were collected at baseline, 6 weeks and 6 months. Bacterial composition and volatile fatty acids were assessed by 16S rRNA sequencing and gas-chromatography, respectively. Nutrient intake was assessed using 3-day food diaries and dietary patterns were empirically derived from a food frequency questionnaire. Using a factor loading of >0.45 for a food group to be a major contributor to the overall dietary pattern, two dietary patterns were found to be associated with distinct microbiome composition. Dietary Pattern 1 (DP1), characterized by intake of fish, protein foods, refined carbohydrates, vegetables, fruit, juice and sweetened beverages, kid's meals and snacks and sweets, was associated with higher relative abundance of Bacteroidetes, Bacteroides and Ruminococcus and lower abundance of Bifidobacterium, Prevotella, Blautia and Roseburia. Dietary Pattern 2 (DP2), characterized by intake of grains, dairy and legumes, nuts and seeds, was associated with higher relative abundance of Cyanobacteria and Phascolarctobacterium and lower abundance of Dorea and Eubacterium. Fruit and starchy foods were present in both patterns, but were more associated with DP1 and DP2, respectively. Temporal stability of microbiota over a 6-month period was associated with baseline dietary patterns. Understanding how dietary intake contributes to microbiota composition and stability in early life in important for dietary recommendations and designing clinical interventions for microbiota-associated diseases.
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In a population of 4 to 8-year-old children (n = 22), Berding et al. found distinct differences in microbial composition for two habitual dietary patterns.
“Likewise, in a population of 4 to 8-year-old children (n = 22), Berding et al. found distinct differences in microbial composition for two habitual dietary patterns [99].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [99]
A dietary pattern associated with grains, dairy, legumes, nuts and seeds was associated with higher relative abundance of Cyanobacteria and Phascolarctobacterium and a lower abundance of Dorea and Eubacterium.
“A dietary pattern associated with grains, dairy, legumes, nuts and seeds, however, was shown to be associated with higher relative abundance of Cyanobacteria and Phascolarctobacterium and a lower abundance of Dorea and Eubacterium [99].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [99]
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
Bokulich, N. A., Subramanian, S., Faith, J. J., Gevers, D., Gordon, J. I., Knight, R. D., Mills, D. A., & Caporaso, J. G. (2012) · Nature Methods · doi:10.1038/nmeth.2276 · Cited by 4,406 · see citing works
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works
Stool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
Bacteroides : the Good, the Bad, and the Nitty-Gritty
Wexler, H. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-07 · Cited by 2,318 · see citing works
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works
Trajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503 · see citing works
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320 · see citing works
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,234 · see citing works
Moving pictures of the human microbiome
Caporaso, J. G., Lauber, C. L., Costello, E. K., Berg-Lyons, D., Gonzalez, A., Stombaugh, J., Knights, D., Gajer, P., Ravel, J., Fierer, N., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r50 · Cited by 1,138 · see citing works
Bifidobacteria and Their Role as Members of the Human Gut Microbiota
O’Callaghan, A. A., & van Sinderen, D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00925 · Cited by 1,108 · see citing works
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055 · see citing works
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970 · see citing works
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works
Americans Do Not Meet Federal Dietary Recommendations
Krebs-Smith, S. M., Guenther, P. M., Subar, A. F., Kirkpatrick, S. I., & Dodd, K. W. (2010) · The Journal of Nutrition · doi:10.3945/jn.110.124826 · Cited by 711 · see citing works
Validation of a Youth/Adolescent Food Frequency Questionnaire
Rockett, H. R. H., Breitenbach, M., Frazier, A. L., Witschi, J. C., Wolf, A., Field, A. E., & Colditz, G. A. (1997) · Preventive Medicine · doi:10.1006/pmed.1997.0200 · Cited by 692 · see citing works
Food Selectivity in Children with Autism Spectrum Disorders and Typically Developing Children
Bandini, L. G., Anderson, S. E., Curtin, C., Cermak, S., Evans, E. W., Scampini, R., Maslin, M., & Must, A. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.02.013 · Cited by 664 · see citing works
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · see citing works
Genomic approaches to studying the human microbiota
Weinstock, G. M. (2012) · Nature · doi:10.1038/nature11553 · Cited by 539 · see citing works
Bergström, A., Skov, T. H., Bahl, M. I., Roager, H. M., Christensen, L. B., Ejlerskov, K. T., Mølgaard, C., Michaelsen, K. F., & Licht, T. R. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00342-14 · Cited by 532 · see citing works
Sex, body mass index, and dietary fiber intake influence the human gut microbiome
Dominianni, C., Sinha, R., Goedert, J. J., Pei, Z., Yang, L., Hayes, R. B., & Ahn, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124599 · Cited by 468 · see citing works
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412 · see citing works
Structure and function of the healthy pre-adolescent pediatric gut microbiome
Hollister, E. B., Riehle, K., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Mistretta, T.-A., Raza, S., Doddapaneni, H. V., Metcalf, G. A., Muzny, D. M., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0101-x · Cited by 406 · see citing works
Kirkpatrick, S. I., Dodd, K. W., Reedy, J., & Krebs‐Smith, S. M. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2011.11.012 · Cited by 395 · see citing works
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works
Agans, R., Rigsbee, L., Kenche, H., Michail, S., Khamis, H. J., & Paliy, O. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01120.x · Cited by 343 · see citing works
Sardesai, V. (2011) · CRC Press eBooks · doi:10.1201/b16601-28 · Cited by 339 · see citing works
Banfield, E. C., Liu, Y., Davis, J. S., Chang, S., & Wood, A. C. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.08.010 · Cited by 324 · see citing works
Modulation of immune development and function by intestinal microbiota
Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 312 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
Vanegas, S. M., Meydani, M., Barnett, J. B., Goldin, B., Kane, A., Rasmussen, H., Brown, C., Vangay, P., Knights, D., Jonnalagadda, S., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.146928 · Cited by 277 · see citing works
Long‐term monitoring of the human intestinal microbiota composition
Rajilić-Stojanović, M. D., Heilig, H. G. H. J., Tims, S., Zoetendal, E. G., & de Vos, W. M. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12023 · Cited by 268 · see citing works
Son, J. S., Zheng, L. J., Rowehl, L. M., Tian, X., Zhang, Y., Zhu, W., Litcher-Kelly, L., Gadow, K. D., Gathungu, G., Robertson, C. E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0137725 · Cited by 229 · see citing works
McGill, C., III, V., & Devareddy, L. (2015) · Nutrients · doi:10.3390/nu7021119 · Cited by 222 · see citing works
Clausen, M. R., & Mortensen, P. B. (1995) · Gut · doi:10.1136/gut.37.5.684 · Cited by 217 · see citing works
Vanhoutte, T., Huys, G. R. B., Brandt, E. D., & Swings, J. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.03.001 · Cited by 215 · see citing works
Dietary Patterns and Body Mass Index in Children with Autism and Typically Developing Children
Evans, E. W., Must, A., Anderson, S. E., Curtin, C., Scampini, R., Maslin, M., & Bandini, L. (2012) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2011.06.014 · Cited by 201 · see citing works
Kaczmarek, J. L., Musaad, S. M., & Holscher, H. D. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156380 · Cited by 200 · see citing works
Self-citationMartínez, I., Muller, C. E., & Walter, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069621 · Cited by 181 · see citing works
Haro, C., García‐Carpintero, S., Rangel‐Zúñiga, O. A., Alcalá‐Díaz, J. F., Landa, B. B., Clemente, J. C., Pérez‐Martínez, P., López‐Miranda, J., Pérez‐Jiménez, F., & Camargo, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700300 · Cited by 149 · see citing works
Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs
Berding, K., & Donovan, S. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw048 · Cited by 146 · see citing works
Self-citationMudd, A. T., Berding, K., Wang, M., Donovan, S. M., & Dilger, R. N. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1353849 · Cited by 134 · see citing works
Self-citationDietary resistant starch and chronic inflammatory bowel diseases
Jacobasch, G., Schmiedl, D., Kruschewski, M., & Schmehl, K. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050212 · Cited by 130 · see citing works
Beneficial Microbes: The pharmacy in the gut
Linares, D. M., Ross, R. P., & Stanton, C. (2015) · Bioengineered · doi:10.1080/21655979.2015.1126015 · Cited by 118 · see citing works
Aguirre, M., de Souza, C. B., & Venema, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159236 · Cited by 100 · see citing works
Composition of human faecal microbiota in resistance to Campylobacter infection
Kampmann, C., Dicksved, J., Engstrand, L., & Rautelin, H. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.09.004 · Cited by 94 · see citing works
Li, M., Bauer, L. L., Chen, X., Wang, M., Kuhlenschmidt, T. B., Kuhlenschmidt, M. S., Fahey, G. C., Jr., & Donovan, S. M. (2012) · Journal of Nutrition · doi:10.3945/jn.111.154427 · Cited by 92 · see citing works
Self-citationMonk, J. M., Lepp, D., Wu, W., Pauls, K. P., Robinson, L. E., & Power, K. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.002 · Cited by 85 · see citing works
Dicksved, J., Ellström, P., Engstrand, L. G., & Rautelin, H. I. K. (2014) · mBio · doi:10.1128/mbio.01212-14 · Cited by 77 · see citing works
Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosis
Arthur, A. E., Peterson, K. E., Rozek, L. S., Taylor, J. M. G., Light, E., Chepeha, D. B., Hébert, J. R., Terrell, J. E., Wolf, G. T., & Duffy, S. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044859 · Cited by 69 · see citing works
Self-citationRode, L. M., Genthner, B. R. S., & Bryant, M. P. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.42.1.20-22.1981 · Cited by 68 · see citing works
5-A-DAY: dietary behavior and the fruit and vegetable intake of Latino children.
Basch, C. E., ZYBERT, P. A., & Shea, S. A. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.5.814 · Cited by 67 · see citing works
Nutritional Status Outcomes for Children
Bronner, Y. L. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00242-8 · Cited by 59 · see citing works
Carbohydrate Staple Food Modulates Gut Microbiota of Mongolians in China
Li, J., Hou, Q., Zhang, J., Xu, H., Sun, Z., Menghe, B., & Zhang, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00484 · Cited by 58 · see citing works
Michels, N., Van de Wiele, T., & De Henauw, S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000413 · Cited by 47 · see citing works
Durbán, A., Abellan, J. J., Jiménez‐Hernández, N., Latorre, A., & Moyá, A. (2012) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2012.01368.x · Cited by 27 · see citing works
Claassen-Weitz, S., Wiysonge, C. S., Machingaidze, S., Thabane, L., Horsnell, W. G. C., Zar, H. J., Nicol, M. P., & Kaba, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00838 · Cited by 6 · see citing works
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- Authors
- Berding, K., Holscher, H. D., Arthur, A. E., & Donovan, S. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Carle Foundation Hospital (US)
- Corresponding author
- Donovan, Sharon M.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 56
- Pages
- 165-174
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2790174111
- Cited by
- 61
- References
- 69
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 3
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- fecal microbiota, gut microbiota composition, microbiome stability, dietary habits, children, nutrient intake, volatile fatty acids, Bacteroidetes, Bifidobacterium, Phascolarctobacterium, cyanobacteria, temporal variation, early life nutrition
- MeSH terms
- Gastrointestinal Microbiome, Nutrients, Cyanobacteria, Bifidobacterium, Energy Intake, Child, Child, Preschool, Chromatography, Gas, Dairy Products, Diet, Dietary Fats, Dietary Fiber, Dietary Proteins, Fatty Acids, Volatile, Feces, Female, Fish Products, Fruit, Humans, Male, Nuts, Surveys and Questionnaires, RNA, Ribosomal, 16S, Seeds, Vegetables
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