Phospholipid Metabolism in an Industry Microalga Chlorella sorokiniana: The Impact of Inoculum Sizes
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Chlorella sorokiniana is an important industry microalga potential for biofuel production. Inoculum size is one of the important factors in algal large-scale culture, and has great effects on the growth, lipid accumulation and metabolism of microalgae. As the first barrier of cell contents, membrane plays a vital role in algal inoculum-related metabolism. The knowledge of phospholipids, the main membrane component and high accumulation of phospholipids as the major content of total lipids mass in some microalgae, is necessary to understand the role of membrane in cell growth and metabolism under different inoculum density. Profiling of C. sorokiniana phospholipids with LC-MS led to the identification of 119 phospholipid species. To discover the phospholipid molecules most related to change of inoculum sizes, Partial Least Squares Discriminant Analysis (PLS-DA) was employed and the results revealed that inoculum sizes significantly affected phospholipid profiling. Phosphatidylglycerol (PG), phosphatidyl- ethanolamine (PE) and several phosphatidylcholine (PC) species might play an important role under our experimental conditions. Further analysis of these biomarkers indicated that cell membrane status of C. sorokiniana might play an important role in the adaption to the inoculum sizes. And the culture with inoculum size of 1 × 10(6) cells mL(-1) presented the best membrane status with the highest content of PC and PG, and the lowest content of PE. We discovered that the inoculum size of 1 × 10(6) cells mL(-1) might provide the best growth condition for C. sorokiniana. Also we proposed that PG, PE and several PC may play an important role in inoculum-related metabolism in C. sorokiniana, which may work through thylakoid membrane and photosynthetic pathway. Thus this study would provide more potential targets for metabolic engineering to improve biofuel production and productivity in microalgae.
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In Chlorella sorokiniana, response to high-density cultivation and UV radiation with fatty acid profiling targeting biofuel increased lipid content and tolerance to environmental stress.
“| 3 | Chlorella sorokiniana | 58.53 | Response to high-density cultivation and UV radiation; fatty acid profiling | Biofuel | Lipid analysis, growth rate measurements | Endogenous promoters or heterologous expression constructs | Increased lipid content, tolerance to environmental stress | Sustainable biofuel production | [91] |”
From A Holistic Approach to Circular Bioeconomy Through the Sustainable Utilization of Microalgal Biomass for Biofuel and Other Value-Added Products (2024) · cites this paper as [91]
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- Authors
- Lu, S., Wang, J., Ma, Q., Yang, J., Li, X., & Yuan, Y.-J.
- Affiliations
- Tianjin University (CN)
- Corresponding author
- Yuan, Ying-Jin
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-08-05
- Volume
- 8
- Issue
- 8
- Pages
- e70827
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3733633
- OpenAlex
- W1986776773
- Cited by
- 42
- References
- 75
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 10 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Key Research and Development Program of China (2013CB733601)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- Chlorella sorokiniana, phospholipid metabolism, inoculum size, phospholipid profiling, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, thylakoid membranes, photosynthesis, microalgae growth, biofuel production, metabolic engineering
- MeSH terms
- Cell Membrane, Chlorella, Chromatography, High Pressure Liquid, Photosynthesis, Signal Transduction, Biomarkers, Glycerophospholipids, Spectrometry, Mass, Electrospray Ionization, Culture Techniques, Lipid Metabolism, Biofuels, Microalgae
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