Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
Open accessAbstract
Active multi-electrode arrays are used in vision prostheses, including optic nerve cuffs and cortical and retinal implants for stimulation of neural tissue. For retinal implants, arrays with up to 1500 electrodes are used in clinical trials. The ability to convey information with high spatial resolution is critical for these applications. To assess the extent to which spatial resolution is impaired by electric crosstalk, finite-element simulation of electric field distribution in a simplified passive tissue model of the retina is performed. The effects of electrode size, electrode spacing, distance to target cells, and electrode return configuration (monopolar, tripolar, hexagonal) on spatial resolution is investigated in the form of a mathematical model of electric field distribution. Results show that spatial resolution is impaired with increased distance from the electrode array to the target cells. This effect can be partly compensated by non-monopolar electrode configurations and larger electrode diameters, albeit at the expense of lower pixel densities due to larger covering areas by each stimulation electrode. In applications where multi-electrode arrays can be brought into close proximity to target cells, as presumably with epiretinal implants, smaller electrodes in monopolar configuration can provide the highest spatial resolution. However, if the implantation site is further from the target cells, as is the case in suprachoroidal approaches, hexagonally guarded electrode return configurations can convey higher spatial resolution.
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Current prosthesis users report seeing highly distorted phosphenes that vary in shape across subjects and electrodes and often fail to assemble into more complex percepts.
“In contrast, current prosthesis users report seeing highly distorted phosphenes, which vary in shape across subjects as well as electrodes and often fail to assemble into more complex percepts (Wilke et al., 2011; Beyeler et al., 2019; Beauchamp et al., 2020; Erickson-Davis and Korzybska, 2021; Fernández et al., 2021).”
From Towards a <i>Smart Bionic Eye</i> : AI-powered artificial vision for the treatment of incurable blindness (2022) · cites this paper as Wilke et al., 2011
Section 3.2 says electrode crosstalk degrades the spatial information needed for patterned perception, which supports a possible difficulty forming complex percepts. But the paper models that difficulty rather than reporting that users often experience it. The Discussion reports that subretinal implant users typically describe percepts as compact and round; it does not report highly distorted shapes varying across subjects and electrodes. The indexed passages provide no page numbers. (LLM, conf=0.84)
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- Authors
- Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Lovell, N H
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2011-06-15
- Volume
- 8
- Issue
- 4
- Pages
- 046016
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2084193319
- Cited by
- 110
- References
- 34
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- University of New South Wales
- Eberhard Karls Universität Tübingen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
- Keywords
- retinal prosthesis, microelectrode arrays, spatial resolution, electric field distribution, electrode configuration, monopolar electrodes, electrode diameter, electrode spacing, epiretinal implants, finite element analysis
- MeSH terms
- Algorithms, Electrodes, Implanted, Electromagnetic Fields, Electronics, Prosthesis Design, Retina, Models, Statistical, Prostheses and Implants, Finite Element Analysis
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