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Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice
Open accessAbstract
Excessive mucin degradation by intestinal bacteria may contribute to inflammatory bowel diseases because access of luminal antigens to the intestinal immune system is facilitated. This study investigated how the presence of a mucin degrading commensal bacterium affects the severity of an intestinal Salmonella enterica Typhimurium-induced gut inflammation. Using a gnotobiotic C3H mouse model with a background microbiota of eight bacterial species (SIHUMI) the impact of the mucin-degrading commensal bacterium Akkermansia muciniphila (SIHUMI-A) on inflammatory and infectious symptoms caused by S. Typhimurium was investigated. Presence of A. muciniphila in S. Typhimurium-infected SIHUMI mice caused significantly increased histopathology scores and elevated mRNA levels of IFN-γ, IP-10, TNF-α, IL-12, IL-17 and IL-6 in cecal and colonic tissue. The increase in pro-inflammatory cytokines was accompanied by 10-fold higher S. Typhimurium cell numbers in mesenteric lymph nodes of SIHUMI mice associated with A. muciniphila and S. Typhimurium (SIHUMI-AS) compared to SIHUMI mice with S. Typhimurium only (SIHUMI-S). The number of mucin filled goblet cells was 2- to 3-fold lower in cecal tissue of SIHUMI-AS mice compared to SIHUMI-S, SIHUMI-A or SIHUMI mice. Reduced goblet cell numbers significantly correlated with increased IFN-γ mRNA levels (r(2) = -0.86, ***P<0.001) in all infected mice. In addition, loss of cecal mucin sulphation was observed in SIHUMI mice containing both A. muciniphila and S. Typhimurium compared to other mouse groups. Concomitant presence of A. muciniphila and S. Typhimurium resulted in a drastic change in microbiota composition of SIHUMI mice: the proportion of B. thetaiotaomicron in SIHUMI-AS mice was 0.02% of total bacteria compared to 78%-88% in the other mouse groups and the proportion of S. Typhimurium was 94% in SIHUMI-AS mice but only 2.2% in the SIHUMI-S mice. These results indicate that A. muciniphila exacerbates S. Typhimurium-induced intestinal inflammation by its ability to disturb host mucus homeostasis.
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“It has been reported that the abundance of g_Akkermansia has a negative correlation with the value of body mass index (BMI) [59] and that g_Akkermansia has a protective effect for the mucus layer in pro-inflammation [60].”
From Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis (2019) · cites this paper as [60]
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“The Gram-negative bacteria, Akkermansia, can degrade mucin, cause intestinal inflammation and permeability, and increase endotoxemia and systemic inflammation, eventually promoting neuropathology [53,54,55].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [55]
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“its mucin degrading activity might also damage the gut-barrier triggering inflammation and promoting gut permeability [83,84]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [84]
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Cites
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Ganesh, B. P., & Versalovic, J. A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00269 · Cited by 37
“…by: Irene Lenoir-Wijnkoop, Utrecht University, Netherlands Reviewed by: Domenico Criscuolo, Genovax, Italy Jean Fioramonti, Institut National de la Recherche Agronomique, France *Correspondence: James Versalovic jamesv@bcm.edu Specialty section: This article was submitted to…”
InfluentialSelf-citationAbbasi, A., Bazzaz, S., da Cruz, A. G., Khorshidian, N., Saadat, Y. R., Sabahi, S., Ozma, M. A., Lahouty, M., Aslani, R., & Mortazavian, A. M. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10118-x · Cited by 38
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Green Tea Encourages Growth of Akkermansia muciniphila
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“Another study indicates that Akkermansia muciniphila can exacerbate intestinal inflammation in Salmonella Typhimurium-infected mice, probably through its ability to disturb mucus layer homeostasis [104].”
Liu, J., Jin, Y., Li, H., Yu, J., Gong, T., Gao, X., & Sun, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06332 · Cited by 37
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“However, Salmonella mice infection models showed that the excessive mucin degradation by Akkermansia may contribute to inflammatory bowel diseases because mucin degradation facilitates the access of luminal antigens to the intestinal immune system (Ganesh et al., 2013).”
BackgroundHuang, Q., Holman, D. B., Alexander, T. W., Hu, T., Jin, L., Xu, Z., McAllister, T. A., Acharya, S. N., Zhao, G., & Wang, Y. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1427-5 · Cited by 35
“Akkermansia, the mucin-degrading bacteria, are closely associated with immunity (Ganesh et al. 2013), obesity, and type 2 diabetes of hosts (Shin et al.”
BackgroundRecent advances and health implications of dietary fasting regimens on the gut microbiome
Mohr, A. E., Gumpricht, E., Sears, D. D., & Sweazea, K. L. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00475.2020 · Cited by 35
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“Along the same line, it was shown that A muciniphila also was increased in Salmonella Typhimuriuminfected gnotobiotic mice with gut inflammation.(21) Taken together, our data and those studies point to an association between A muciniphila expansion and gut inflammation, which is, at first, unexpected, given the fact t…”
ResultA Review of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models
Hansen, A. K., Krych, Ł., Nielsen, D. S., & Hansen, C. H. F. (2015) · ILAR Journal · doi:10.1093/ilar/ilv010 · Cited by 34
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“A. muciniphila exacerbates gut inflammation by disturbing host mucus homeostasis (30).”
Conesa, M. P. B., Blixt, F. W., Peesh, P., Khan, R., Korf, J. M., Lee, J., Jagadeesan, G., Andersohn, A. P., Das, T. K., Tan, C., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02887-7 · Cited by 33
“Gut inflammation can cause gut barrier break-down (GBB) which in turn leads to “leaky gut” [19–21] characterized by reduced mucus producing goblet cells Fig.”
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Yao, S., Xie, H., Wang, Y., Shen, N., Chen, Q., Zhao, Y., Gu, Q., Zhang, J., Liu, J., Sun, J., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1116065 · Cited by 33
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“muciniphila may contribute to proinflammatory processes in the gut [65,66].”
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Arvonen, M., Vänni, P., Sarangi, A. N., Tejesvi, M. V., Vähäsalo, P., Aggarwal, A., & Stoll, M. L. (2019) · Immunological Reviews · doi:10.1111/imr.12826 · Cited by 34
Cao, L., Lee, S. G., Melough, M. M., Sakaki, J. R., Maas, K. R., Koo, S. I., & Chun, O. K. (2020) · Nutrients · doi:10.3390/nu12020290 · Cited by 31
“Furthermore, members of this genus exacerbate gut inflammation in Salmonella Typhimurium-infected mice [37].”
BackgroundPutative Pathobionts in HLA-B27-Associated Spondyloarthropathy
Gill, T., & Rosenbaum, J. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.586494 · Cited by 31
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“muciniphila is observed to exacerbate the gut inflammation in Salmonella typhimurium-infected gnotobiotic mice (36) and was sufficient for promoting intestinal inflammation in germ-free Il10mice (37).”
BackgroundTung, Y., Zeng, J., Ho, S., Xu, J.-W., Lin, I., & Wu, J. (2021) · Antioxidants · doi:10.3390/antiox11010045 · Cited by 31
“In contrast, excessive mucin degradation by Akkermansia may lead to inflammatory bowel diseases (IBDs) because the access of luminal antigens to the intestinal immune system is facilitated [74].”
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“…subjected to a fibre deprived diet (Parrish et al., 2023) and its administration as a ‘probiotic’, was reported to exacerbate enteric infection (Ganesh et al., 2013), inflammatory bowel disease (Zhang et al., 2021) and even colon carcinogenesis (Wang, Cai, et al., 2022; Wang, Li, et al., 2022).”
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“[22] found that Akkermansia aggravated the intestinal inflammation induced by Salmonella typhimurium and destroyed the microbial balance of the intestinal mucosa of the host.”
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“A. muciniphila is generally thought of as a health-promoting microbe (de Vos, 2017), however with alterations to the protective mucous layer, this microbe has pathobiont characteristics (Ganesh et al., 2013).”
BackgroundLi, H., Liu, Y., Zhou, J., Liu, S., Liu, Y., Yang, Y., Wang, W. “., Che, Y., Inam, M., & Guan, L. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.256 · Cited by 31
Rise of the guardians: Gut microbial maneuvers in bacterial infections
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Crypt residing bacteria and proximal colonic carcinogenesis in a mouse model of Lynch syndrome
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“This positive association between enrichment in Akkermansia, inflammation and tumorigenesis has also been found in other models of colitisassociated carcinogenesis such as the AOM/DSS model,(7) inflammation models such as the IL10NLRP6 mice(32) and infection models.(38)”
BackgroundGraef, F. A., Celiberto, L. S., Allaire, J. M., Kuan, M. T. Y., Bosman, E. S., Crowley, S. M., Yang, H., Chan, J., Stahl, M., Yu, H., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009719 · Cited by 29
“While it is possible that the increase in Akkermansia could play a role in suppressing Salmonella invasion of epithelial cells, another study found that an increase in Akkermansia in fact rendered mice more susceptible to Salmonella and Citrobacter rodentium infections [48,49].”
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The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer
Kuštrimović, N. Z., Bilato, G., Mortara, L., & Baci, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031732 · Cited by 31
“…cancer [90] since they are known mucin degraders, undermining the integrity of the mucosal barrier and leading to increased inflammation [91,92]. spp. may constitute a clinically important factor for colon cancer initiation the colibactin toxin known to cause DNA double-strand breaks,…”
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“Conversely, in a gnotobiotic mouse model infected with Salmonella typhimurium , A. muciniphila fails to regulate host homeostasis in the mucosal layer, exacerbating intestinal inflammation [71].”
Jacobs, J. P., Goudarzi, M., Lagishetty, V., Li, D., Mak, T. D., Tong, M., Ruegger, P. M., Haritunians, T., Landers, C. J., Fleshner, P. R., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01099-7 · Cited by 29
“in CD, consistent with preclinical studies which have found that Akkermansia can reduce or exacerbate intestinal inflammation depending on the animal model [94, 95].”
ResultCrisol‐Martínez, E., Moreno-Moyano, L. T., Wilkinson, N., Prasai, T. P., Brown, P. H., Moore, R. J., & Stanley, D. (2016) · PeerJ · doi:10.7717/peerj.2002 · Cited by 30
“In mice, it was suggested that intestinal bacteria producing excessive mucin degradation could contribute to inflammatory bowel diseases, since of luminal antigens to the intestinal immune system was facilitated (Ganesh et al., 2013).”
BackgroundTowards an understanding ofSalmonella entericaserovar Typhimurium persistence in swine
Patterson, S. K., Kim, H. B., Borewicz, K., & Isaacson, R. E. (2016) · Animal Health Research Reviews · doi:10.1017/s1466252316000165 · Cited by 29
“While this observation was observed in a sample of colon from one pig at 22 weeks of age (Borewicz et al., 2015), it is known that Akkermansia does contribute to infection with S. enterica presumably by degrading mucin in the gut and increasing gut inflammation (Ganesh et al., 2013).”
BackgroundHoffman, J. B., Petriello, M. C., Morris, A. J., Mottaleb, M. A., Sui, Y., Zhou, C., Deng, P., Wang, C., & Hennig, B. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114183 · Cited by 27
“muciniphila can actually exacerbate intestinal inflammation in mice (Ganesh et al., 2013).”
BackgroundMinich, D. J., Madden, C. C., Evans, M. V., Ballash, G. A., Barr, D. J., Poulsen, K. P., Dennis, P. M., & Hale, V. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-89896-9 · Cited by 28
Tezé, D., Shuoker, B., Chaberski, E. K., Kunstmann, S., Fredslund, F., Nielsen, T. S., Stender, E. G. P., Peters, G. H. J., Karlsson, E. N., Welner, D. H., et al. (2020) · ACS Catalysis · doi:10.1021/acscatal.9b04474 · Cited by 25
Barnich, N., Rodrigues, M., Sauvanet, P., Chevarin, C., Denis, S., Goff, O. L., Faure-Imbert, D., Hanh, T., Roques, C. F., Chassaing, B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094336 · Cited by 27
Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout
Song, C., Kim, N., Nam, R. H., Choi, S. I., Yu, J. E., Nho, H., & Surh, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.636808 · Cited by 26
“muciniphila functions as an opportunistic pathogen to exacerbate intestinal inflammation in mice infected with Salmonella typhimurium by dysregulating host homeostasis in the mucus layer (Ganesh et al., 2013).”
BackgroundTherapies for Parkinson’s disease and the gut microbiome: evidence for bidirectional connection
Hey, G. E., Nair, N., Klann, E. M., Gurrala, A., Safarpour, D., Mai, V., Ramirez‐Zamora, A., & Vedam‐Mai, V. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1151850 · Cited by 27
“, 2011) nevertheless, it has also been linked to gut inflammation and systemic inflammatory conditions (Ganesh et al., 2013; Ley, 2016).”
BackgroundFicetola, G. F., Guerrieri, A., Cantera, I., & Bonin, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298905 · Cited by 26
Bolsega, S., Bleich, A., & Basic, M. (2021) · Nutrients · doi:10.3390/nu13114173 · Cited by 28
“enterica serovar Typhimurium was able to suppress the dominating bacterial taxa Bacteroides thetaiotaomicron [51].”
BackgroundTargeting the gut microbiota to alleviate chemotherapy-induced toxicity in cancer
Xu, Y., Du, H., Chen, Y., Ma, C., Zhang, Q., Li, H., Xie, Z., & Hong, Y. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2023.2233605 · Cited by 27
“…(ScFAs) production and intestinal homeostasis maintenance, and the Verrucomicrobia phylum has been discovered to exacerbate intestinal inflammation (Ganesh et al. 2013; Sougiannis et al. 2019). in addition, FMt from 5-FU-treated mice to antibiotic-pretreated mice led to a reduction in body weight…”
A history of repeated antibiotic usage leads to microbiota-dependent mucus defects
Krigul, K. L., Feeney, R. H., Wongkuna, S., Aasmets, O., Holmberg, S. M., Andreson, R., Puértolas-Balint, F., Pantiukh, K., Sootak, L., Org, T., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2377570 · Cited by 25
“Additionally, previous studies have linked A. muciniphila -mediated mucus disruption to an exacerbation of food allergy (Parrish et al., 2023) and Salmonella typhimurium infection (Ganesh et al., 2013).”
BackgroundThe Microbiome in Inflammatory Bowel Disease
Jauregui-Amezaga, A., & Smet, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164622 · Cited by 28
“Thirdly, the balance between different types of bacteria populations in the gut microbiome may determine the susceptibility to inflammation-associated colon tumorigenesis [88].”
BackgroundBiotics and bacterial function: impact on gut and host health
Kandari, A., Al-Odat, M. A., Alzaïd, F., & Scott, K. P. (2024) · The ISME Journal · doi:10.1093/ismejo/wrae226 · Cited by 29
“It plays a key role in improving metabolic disorders, such as obesity [136] and diabetes [137], as well as maintaining gut health [138], regulating immunity, and reducing inflammation [139].”
Huang, Y., Huang, L., Sheen, J., Hou, C., Yeh, Y., Chiang, C.-P., Lin, I.-C., Tiao, M., Tsai, C., Lin, Y., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108260 · Cited by 24
Becraft, A., Sturm, M., Mendez, R. L., Park, S. H., Lee, S. I., & Shay, N. F. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz267 · Cited by 24
Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
Huang, P.-Y., Yang, Y., Wang, C., Hsiao, P., Chiang, H., & Chen, T.-W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179626 · Cited by 25
“muciniphila, has the potential to induce colonic inflammation and cancer development [45].”
BackgroundMaternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring
Jama, H. A., Dona, M. S. I., Dinakis, E., Nakai, M. E., Paterson, M. R., Shihata, W., Krstevski, C., Cohen, C. D., Weeks, K. L., Farrugia, G. E., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324614 · Cited by 24
Neto, C. C., Mortzfeld, B. M., Turbitt, J. R., Bhattarai, S. K., Yeliseyev, V., DiBenedetto, N., Bry, L., & Bucci, V. (2021) · Microbial Cell · doi:10.15698/mic2021.06.752 · Cited by 24
“9 completely clear, since overabundance of Akkermansia has been reported to exacerbate the 270 inflammation caused by pathogenic bacteria Salmonella typhimurium [44, 45].”
BackgroundThe biofunction of Akkermansia muciniphila in intestinal-related diseases
Jiang, P., Ji, S., Su, D., Zhao, Y., Goncalves, V. B. E., Xu, G., & Zhang, M. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.12 · Cited by 23
Yang, W., Chou, C., & Wang, C. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101751 · Cited by 23
“AM was perceived to normalize the mucus thickness and promote intestinal barrier by enhancing goblet cell numbers, stimulating the turnover of the mucus layer, and up-regulating the expression of tight-junction proteins (Ganesh et al., 2013; Shin et al., 2014; Zhong et al., 2015; Grander et al., 2018).”
BackgroundFunctional mucous layer and healing of proximal colonic anastomoses in an experimental model
Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nyström, E. E. L., Gijbels, M. J., Derikx, J. P. M., Bouvy, N. D., & Hansson, G. C. (2017) · British journal of surgery · doi:10.1002/bjs.10456 · Cited by 23
Satô, K., Hara‐Chikuma, M., Yasui, M., Inoue, J., & Kim, Y. (2024) · iScience · doi:10.1016/j.isci.2024.109903 · Cited by 31
Su, R., Wen, W., Jin, Y., Cao, Z., Feng, Z., Chen, J., Yu, L., Zhou, G., Dong, C., Gao, S., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334516 · Cited by 25
“43 Our study discovered a gut commensal phage that can lyse A. muciniphila to maintain mucus integrity, and moreover, this phage-bacteria dynamics can downstream lead to a blossom of the symbiotic bacterium S. thermophilus to further protect the intestine, highlighting the significance of gut…”
Defined gut microbial communities: promising tools to understand and combat disease
Bayer, G., Ganobis, C. M., Allen‐Vercoe, E., & Philpott, D. J. (2021) · Microbes and Infection · doi:10.1016/j.micinf.2021.104816 · Cited by 27
Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il‐10 Deficient Mice
Geng, Y., Yue, Y., Guan, Q., Ren, Y., Guo, L., Fan, Y., Lu, Z., Shi, J., & Xu, Z. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001227 · Cited by 23
High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome
Zhang, M., Liang, Y., Liu, Y., Li, Y., Shen, L., & Shi, G. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.916089 · Cited by 23
Yuan, Z., Kang, Y., Mo, C., Huang, S., Qin, F., Zhang, J., Wang, F., Jiang, J., Yang, X., Liang, H., et al. (2024) · Respiratory Research · doi:10.1186/s12931-023-02652-7 · Cited by 23
“For example, A.muciniphila is capable of degrading mucin and promoting gut inflammation [46].”
BackgroundBottoms up: the role of gut microbiota in brain health
Radisavljevic, N., Cirstea, M. S., & Finlay, B. B. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14506 · Cited by 24
Immunological and safety profile of bacteriophage therapy: A pre-clinical study
Gangwar, M., Rastogi, S., Singh, D., Shukla, A., Dhameja, N., Kumar, D., Kumar, R., & Nath, G. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15642 · Cited by 22
“Sensitized cells result in the production and release of proinflammatory cytokines, which helps the immune system to repel incoming pathogens such as pathogenic bacteria and viruses (Ganesh et al., 2013; McCarthy et al., 2013).”
BackgroundThe Role of Akkermansia muciniphila in Disease Regulation
Ding, Y., Hou, Y., & Lao, X. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10642-y · Cited by 21
“Bhanu Priya Ganesh et al. [91] using a gnotobiotic C3H mouse model with a background microbiota of eight bacterial species (SIHUMI) found A. muciniphila worsened inflammation caused by S. typhimurium .”
Composition of fecal microbiota in low-set rectal cancer patients treated with FOLFOX
Li, J., Li, J., Lyu, N., Ma, Y., Liu, F., Feng, Y., Li, Y., Hou, Z., Song, X., Zhao, H.-C., et al. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320904293 · Cited by 23
Changes to the Gut Microbiome in Young Children Showing Early Behavioral Signs of Autism
Jones, J. C., Reinke, S. N., Mousavi‐Derazmahalleh, M., Palmer, D. J., & Christophersen, C. T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.905901 · Cited by 24
Emu, Q., Guan, H., Zhu, J., Zhang, L., JinSheng, F., Ji, Y., Lin, Y., Li, C., Dan, X., Aguo, Y., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.666837 · Cited by 21
Characterization of Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review
Todberg, T., Kaiser, H., Zachariae, C. O. C., Egeberg, A., Halling, A., & Skov, L. (2021) · Acta Dermato Venereologica · doi:10.2340/00015555-3882 · Cited by 21
“In murine studies Akkermansia has been linked with mucus degradation (46, 47), which may, in turn, facilitate increased permeability of the intestinal wall.”
BackgroundLu, C.-L., Lee, B. H., Ren, Y., Ji, D., Rao, S., Li, H., & Yang, Z.-Q. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102116 · Cited by 20
Impact of grape polyphenols on Akkermansia muciniphila and the gut barrier
Mezhibovsky, E., Wu, Y., Bawagan, F. G., Tveter, K. M., Szeto, S., & Roopchand, D. E. (2022) · AIMS Microbiology · doi:10.3934/microbiol.2022035 · Cited by 21
“Special interest has been placed on A. muciniphila , a mucin-metabolizing species of phylum Verrucomicrobiota [8], due to its frequent association with improved cardiometabolic outcomes and gut barrier integrity [26–37], with some exceptions [38,39].”
Neto, J., Jantsch, J., Rodrigues, F. D. S., Squizani, S., Eller, S. C. W. D. S., de Oliveira, T. F., Silveira, A. K., Moreira, J. C. F., Giovenardi, M., Porawski, M., et al. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114068 · Cited by 21
Akkermansia and its metabolites play key roles in the treatment of campylobacteriosis in mice
Jiang, L., Yuan, C., Ye, W., Huang, Q., Chen, Z., Wu, W., & Qian, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1061627 · Cited by 19
“In the absence of Akkermansia , intestinal inflammation caused by a single Salmonella typhimurium infection was reduced with the action of IL-18 (involved in phagocytosis of intracellular pathogens), but in mice colonized by both Akkermansia and Salmonella typhimurium, levels of IL18 were significantly reduced, thereb…”
BackgroundBerries in Microbiome-Mediated Gastrointestinal, Metabolic, and Immune Health
Komarnytsky, S., Wagner, C., Gutierrez, J., & Shaw, O. M. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00449-0 · Cited by 22
Therapeutic Approach Targeting Gut Microbiome in Gastrointestinal Infectious Diseases
Han, Z., Min, Y., Pang, K., & Wu, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115654 · Cited by 19
“Typhimurium to dominate the bacterial community [150].”
Amuc Prevents Liver Inflammation and Oxidative Stress in Mice Challenged with Salmonella Typhimurium
Song, Z., Si, X., Zhang, X., Chen, J., Jia, H., He, Y., Liu, H., Kou, Z., Dai, Z., & Wu, Z. (2022) · Journal of Nutrition · doi:10.1016/j.tjnut.2022.12.004 · Cited by 18
Meijer, S., Pasquinelli, E., Renzi, S., Lavasani, S., Nouri, M., Erlandsson, L., Cavalieri, D., & Hansson, S. R. (2023) · Biomolecules · doi:10.3390/biom13020346 · Cited by 18
“involved in gut permeability homeostasis, based on its mucin-degrading ability [56,57], and Akkermansia muciniphila is associated with a low risk of diabetes [58], obesity [59], and high levels of inflammation [60].”
BackgroundDuodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
Kim, T., Holleman, C. L., Ptacek, T., Morrow, C. D., & Habegger, K. M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.224 · Cited by 17
“Its abundance is elevated by RYGB(6) and Metformin(7) therapies alike, yet it has also been linked to exacerbated gut inflammation (33).”
BackgroundKwak, M. S., Cha, J. M., Shin, H. P., Jeon, J. W., & Yoon, J. Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01162 · Cited by 18
Microbiota, IgA and Multiple Sclerosis
Boussamet, L., Rajoka, M. S. R., & Berthelot, L. (2022) · Microorganisms · doi:10.3390/microorganisms10030617 · Cited by 20
“While Methanobrevibacter activates dendritic cells [80] and is associated with shorter time to relapse in a pediatric study [46]; Akkermansia is involved in the degradation process of the mucus layer, resulting in increased exposure of the resident immune cells to microbial antigens [81].”
BackgroundZebrafish Axenic Larvae Colonization with Human Intestinal Microbiota
Arias-Jayo, N., Alonso-Sáez, L., Ramírez-García, A., & Pardo, M. (2017) · Zebrafish · doi:10.1089/zeb.2017.1460 · Cited by 12
“37 From bacteria domain, six out of nine phyla were found in HCONV samples; Firmicutes, Bacteroidetes, Verrucomi-crobia, Proteobacteria, Actinobacteria, and Cyanobacteria .”
Influential
Metadata
- Authors
- Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Freie Universität Berlin (DE)
- Corresponding author
- Loh, Gunnar
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-10
- Volume
- 8
- Issue
- 9
- Pages
- e74963
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3769299
- OpenAlex
- W2085991415
- Cited by
- 522
- References
- 60
- Citations by year
- 2026: 27 · 2025: 47 · 2024: 69 · 2023: 56 · 2022: 59 · 2021: 50 · 2020: 46 · 2019: 41 · 2018: 37 · 2017: 27 · 2016: 36 · 2015: 13 · 2014: 11 · 2013: 2
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Akkermansia muciniphila, Salmonella typhimurium, intestinal inflammation, mucin degradation, commensal bacteria, gnotobiotic mice, goblet cells, Bacteroides thetaiotaomicron, inflammatory cytokines, interferon-gamma, gut microbiota, Salmonella enteritis
- MeSH terms
- Animals, Germ-Free Life, Inflammation, Interferon-gamma, Interleukin-1, Intestines, Lymph Nodes, Macrophages, Mice, Inbred C3H, RNA, Messenger, Salmonella Infections, Salmonella typhimurium, Symbiosis, Tumor Necrosis Factor-alpha, Interleukin-6, Interleukin-12, Mice, Chemokine CXCL10, Mucin-2, Verrucomicrobia
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