The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice
Open accessAbstract
Excessive mucin degradation by intestinal bacteria may contribute to inflammatory bowel diseases because access of luminal antigens to the intestinal immune system is facilitated. This study investigated how the presence of a mucin degrading commensal bacterium affects the severity of an intestinal Salmonella enterica Typhimurium-induced gut inflammation. Using a gnotobiotic C3H mouse model with a background microbiota of eight bacterial species (SIHUMI) the impact of the mucin-degrading commensal bacterium Akkermansia muciniphila (SIHUMI-A) on inflammatory and infectious symptoms caused by S. Typhimurium was investigated. Presence of A. muciniphila in S. Typhimurium-infected SIHUMI mice caused significantly increased histopathology scores and elevated mRNA levels of IFN-γ, IP-10, TNF-α, IL-12, IL-17 and IL-6 in cecal and colonic tissue. The increase in pro-inflammatory cytokines was accompanied by 10-fold higher S. Typhimurium cell numbers in mesenteric lymph nodes of SIHUMI mice associated with A. muciniphila and S. Typhimurium (SIHUMI-AS) compared to SIHUMI mice with S. Typhimurium only (SIHUMI-S). The number of mucin filled goblet cells was 2- to 3-fold lower in cecal tissue of SIHUMI-AS mice compared to SIHUMI-S, SIHUMI-A or SIHUMI mice. Reduced goblet cell numbers significantly correlated with increased IFN-γ mRNA levels (r(2) = -0.86, ***P<0.001) in all infected mice. In addition, loss of cecal mucin sulphation was observed in SIHUMI mice containing both A. muciniphila and S. Typhimurium compared to other mouse groups. Concomitant presence of A. muciniphila and S. Typhimurium resulted in a drastic change in microbiota composition of SIHUMI mice: the proportion of B. thetaiotaomicron in SIHUMI-AS mice was 0.02% of total bacteria compared to 78%-88% in the other mouse groups and the proportion of S. Typhimurium was 94% in SIHUMI-AS mice but only 2.2% in the SIHUMI-S mice. These results indicate that A. muciniphila exacerbates S. Typhimurium-induced intestinal inflammation by its ability to disturb host mucus homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“It has been reported that the abundance of g_Akkermansia has a negative correlation with the value of body mass index (BMI) [59] and that g_Akkermansia has a protective effect for the mucus layer in pro-inflammation [60].”
From Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis (2019) · cites this paper as [60]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“The Gram-negative bacteria, Akkermansia, can degrade mucin, cause intestinal inflammation and permeability, and increase endotoxemia and systemic inflammation, eventually promoting neuropathology [53,54,55].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [55]
In the citing paper
“its mucin degrading activity might also damage the gut-barrier triggering inflammation and promoting gut permeability [83,84]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · cited 1×
“muciniphila is known for its ability to degrade mucins [16,17].”
BackgroundMechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,806
Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,531 · cited 1×
“muciniphila is the main intestinal representative of this phylum [2], suggesting that A.”
BackgroundMucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · cited 1×
“(q increased; Q decreased; grey dotted line: assumed processes including lectin-sialic acid binding [56], M-cells for pathogen transit [43,58,59]; black line: supported by data of the present study).”
ResultGut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · cited 1×
“[21,22] and therefore represents a highly suitable model for”
BackgroundStecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · cited 4×
“Typhimurium-induced gut inflammation [14,50] or in inflamed IL-10 mice [51].”
BackgroundInfluentialHost-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019 · cited 2×
“Typhimurium-induced gut inflammation [14,50] or in inflamed IL-10 mice [51].”
BackgroundHelicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T. P., Teneberg, S., Karlsson, K., et al. (2002) · Science · doi:10.1126/science.1069076 · Cited by 935 · cited 1×
“Interestingly, changes in intestinal mucin composition characterized by a lower degree of sulphation [7,46] and a higher degree of sialylation have previously been reported to occur in UC, Crohn’s Disease (CD) and gastric ulcer caused by Helicobacter pylori-induced inflammation [7,46,47].”
BackgroundCollado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 525
Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease
Chiang, H., & Lin, C. (2019) · Journal of Movement Disorders · doi:10.14802/jmd.18067 · Cited by 107
Eid, H. M., Wright, M. L., Kumar, N. V. A., Qawasmeh, A., Hassan, S. T. S., Mocan, A., Nabavi, S. M., Rastrelli, L., Atanasov, A. G., & Haddad, P. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00387 · Cited by 110
“…for example a Chinese MGWAS study stated that A . muciniphila did not improve mucous layer thickness (Tilg and Moschen, 2014), while Ganesh et al. attributed exacerbated inflammation in Salmonella typhimurium -infected mice to the mucin-degrading effect of A. muciniphila (Ganesh et al., 2013).”
BackgroundŠevčíková, A., Izoldova, N., Števurková, V., Kasperova, B., Chovanec, M., Čierniková, S., & Mego, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010488 · Cited by 109
“reported that Akkermansia muciniphila exacerbated intestinal inflammation due to its mucolytic activity [78], which could have a negative effect on gemcitabine-treated mice.”
BackgroundAkkermansia muciniphila plays critical roles in host health
Zhao, Q., Yu, J., Hao, Y., Zhou, H., Hu, Y., Zhang, C., Zheng, H., Wang, X., Zeng, F., Hu, J., et al. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2037506 · Cited by 102
“…Thickened mucous layer and reduced mucus sulphation qPCR, immunohistochemical (IHC), PAS/AB and high iron diamine (HID)/AB staining IBD and colitis (Ganesh et al. 2013; Seregin et al. 2017; Ring et al. 2019) Did not change thickness of mucus layer, expression of Muc2 and number of goblet…”
BackgroundInfluentialConn, K. A., Borsom, E. M., & Cope, E. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2371950 · Cited by 106
“6,7 Communication between the brain and gut microbiota is known as the gut-microbiome-brain axis and functions bidirectionally via pathways such as the vagus nerve 8–10 immune activation 11–13 and circulation of microbial metabolites.”
BackgroundIhekweazu, F. D., Fofanova, T. Y., Queliza, K., Nagy‐Szakal, D., Stewart, C. J., Engevik, M. A., Hultén, K. G., Tatevian, N., Graham, D. Y., Versalovic, J. A., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1560753 · Cited by 99
“thetaiotaomicron population.(53) This corroborates our finding that mice with the highest abundance of Akkermansia were less likely to have significant levels of Bacteroides (Figure 4C).”
BackgroundResultInfluentialThe Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut
Elzinga, J., John van der, O. O. S. T., de Vos, W. M., & Smidt, H. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00054-18 · Cited by 105
Interactions between Innate Immunity, Microbiota, and Probiotics
Giorgetti, G., Brandimarte, G., Fabiocchi, F., Ricci, S., Flamini, P., Sandri, G., Trotta, M. C., Elisei, W., Penna, A., Lecca, P. G., et al. (2015) · Journal of Immunology Research · doi:10.1155/2015/501361 · Cited by 99
“These authors have demonstrated that, in an animal model of mice with microbiota consisting essentially of eight bacterial species, the presence of a commensal bacterium (Akkermansia muciniphila) is able to degrade the mucin and exacerbate the inflammation and the severity of symptoms due to Salmonella entericaTyphimu…”
BackgroundSpace-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
Casero, D., Gill, K., Sridharan, V., Koturbash, I., Nelson, G. A., Hauer‐Jensen, M., Boerma, M., Braun, J. G., & Cheema, A. K. (2017) · Microbiome · doi:10.1186/s40168-017-0325-z · Cited by 99
Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
Lei, W., Cheng, Y., Gao, J., Liu, X., Shao, L., Kong, Q., Zheng, N., Ling, Z., & Hu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1224155 · Cited by 104
Bäuerl, C., Collado, M. C., Zúñiga, M., Blas, E., & Pérez‐Martínez, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105707 · Cited by 98
“Both play an important role in the degradation of vegetable feed components and the production of short chain fatty acids [38,39], hence controlling Bacteroidetes numbers [40], and therefore, could constitute essential components of rabbit cecal microbiota and candidates as probiotics.”
BackgroundInfluence of gemcitabine chemotherapy on the microbiota of pancreatic cancer xenografted mice
Panebianco, C., Adamberg, K., Jaagura, M., Copetti, M., Fontana, A., Adamberg, S., Kolk, K., Vilu, R., Andriulli, A., & Pazienza, V. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3549-0 · Cited by 97
“muciniphila, a mucin-degrading bacterium, strongly increased in gemcitabine-treated mice, has been found to favor gut inflammation because of its mucolytic activity [38].”
BackgroundAkkermansia muciniphila: a potential candidate for ameliorating metabolic diseases
Niu, H., Zhou, M., Zogona, D., Xing, Z., Wu, T., Chen, R., Cui, D., Liang, F., & Xu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370658 · Cited by 112
Chen, H., Ma, X., Liu, Y., Ma, L., Chen, Z., Lin, X., Si, L., Ma, X., & Chen, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01662 · Cited by 96
“And Akkermansia also plays a reverse role in degrading the mucus layer in proinflammation function (44, 45).”
BackgroundRole of Akkermansia in Human Diseases: From Causation to Therapeutic Properties
Pellegrino, A., Coppola, G., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Nutrients · doi:10.3390/nu15081815 · Cited by 107
“muciniphila administration also exacerbated the symptoms of Salmonella-typhimurium-induced gut inflammation in a mouse model with a background microbiota of eight bacterial species [66], and it was possibly implicated in the worsening of colitis in IL10 −/− mice.”
BackgroundGandy, K. A. O., Zhang, J., Nagarkatti, P. S., & Nagarkatti, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-43356-7 · Cited by 97
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
Wang, Y., Yang, G., You, L., Yang, J., Feng, M., Qiu, J., Zhao, F., Liu, Y., Cao, Z., Zheng, L., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1103-2 · Cited by 97
Zhuang, P., Shou, Q., Lu, Y., Wang, G., Qiu, J., Wang, J., He, L., Chen, J., Jiao, J., & Zhang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.003 · Cited by 94
Therapeutic effect of baicalin on inflammatory bowel disease: A review
Wang, X., Xie, L., Long, J., Liu, K., Lu, J., Liang, Y., Cao, Y., Dai, X., & Li, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114749 · Cited by 94
Belluz, L. D. B., Guidi, R., Pateras, I. S., Levi, L., Mihaljević, B., Rouf, S. F., Wrande, M., Candela, M., Turroni, S., Nastasi, C., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005528 · Cited by 98
Xu, R., Zhang, Y., Chen, S., Zeng, Y., Fu, X., Chen, T., Luo, S., & Zhang, X. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2044286 · Cited by 96
“This indicates the complex interactions within the microbial ecosystem (Ganesh et al. 2013).”
BackgroundZhu, W., Yan, J., Zhi, C., Zhou, Q., & Yuan, X. (2019) · Gut Pathogens · doi:10.1186/s13099-019-0291-z · Cited by 90
Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904204116 · Cited by 89
Zádori, Z., Király, K. P., Al‐Khrasani, M., & Gyires, K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108327 · Cited by 92
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 136
Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88
“flammation and promoting gut permeability [83,84].”
Zhu, L., Lu, X., Liu, L., Voglmeir, J., Zhong, X., & Yu, Q. (2020) · Veterinary Research · doi:10.1186/s13567-020-00755-3 · Cited by 90
The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis
Vamanu, E., & Nand, S. (2021) · Diseases · doi:10.3390/diseases9030045 · Cited by 91
Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology
Engevik, M. A., & Versalovic, J. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0012-2016 · Cited by 87
Badran, M., Khalyfa, A., Ericsson, A. C., & Gozal, D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113439 · Cited by 86
“Bacterial degradation of mucin, which is protective to the host intestinal lumen, could initiate a variety of intestinal disorders, starting with increased intestinal permeability, but potentially also progressing to inflammatory bowel disease (IBD), as access of luminal antigens to the intestinal immune system is fac…”
BackgroundSun, Y., Zhang, Z., Cheng, L., Zhang, X., Liu, Y., Zhang, R., Weng, P., & Wu, Z. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110675 · Cited by 85
Impact of the gut microbiota on rodent models of human disease
Hansen, A. K., Hansen, C. H. F., Krych, Ł., & Nielsen, D. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17727 · Cited by 85
Pierantonelli, I., Rychlicki, C., Agostinelli, L., Giordano, D. M., Gaggini, M., Fraumene, C., Saponaro, C., Manghina, V., Sartini, L., Mingarelli, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11744-6 · Cited by 82
Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis
Chen, K., Xie, K., Liu, Z., Nakasone, Y., Sakao, K., Hossain, M. A., & Hou, D.-X. (2019) · Nutrients · doi:10.3390/nu11061225 · Cited by 79
“It has been reported that the abundance of g_Akkermansia has a negative correlation with the value of body mass index (BMI) [59] and that g_Akkermansia has a protective effect for the mucus layer in pro-inflammation [60].”
BackgroundGuo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82
Borewicz, K., Kim, H. B., Singer, R. S., Gebhart, C. J., Sreevatsan, S., Johnson, T. J., & Isaacson, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139106 · Cited by 79
Age-dependent remodeling of gut microbiome and host serum metabolome in mice
Wu, C., Muthyala, S. D. V., Klemashevich, C. L., Ufondu, A., Menon, R., Chen, Z., Devaraj, S., Jayaraman, A., & Sun, Y. (2021) · Aging · doi:10.18632/aging.202525 · Cited by 88
“Akkermansia are typically linked to health beneficial and antiinflammatory effects [33], such as improving glucose homeostasis in diet-induced obesity [34], and slowing progression of dextran sulfate sodium-induced colitis [35], although the mucin degradation properties of the members of this genus may also exacerbate…”
BackgroundA Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms
Chiàntera, V., Laganà, A. S., Basciani, S., Nordio, M., & Bizzarri, M. (2023) · Life · doi:10.3390/life13061247 · Cited by 91
“Indeed, a study by Dingemanse and colleagues demonstrated that in the case of Salmonella typhimurium infection, the procolonization of Akkermansia makes Salmonella a dominant bacterium of microbiota [13,15].”
BackgroundThe mouse gut microbiome revisited: From complex diversity to model ecosystems
Clavel, T., Lagkouvardos, I., Blaut, M., & Stecher, B. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.002 · Cited by 84
Self-citationXie, S., Zhang, C., Zhao, J., Li, D., & Chen, J. (2022) · Environment International · doi:10.1016/j.envint.2022.107138 · Cited by 77
Zhai, Q., Qu, D., Feng, S., Yu, Y., Yu, L., Tian, F., Zhao, J., Zhang, H., & Chen, W. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03161 · Cited by 78
Shenghua, P., Zhu, Z., Shuyu, T., Zhan, H., Xianglu, R., & Jiao, G. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109421 · Cited by 76
Lu, L., Dong, J., Liu, Y., Qian, Y., Zhang, G., Zhou, W., Zhao, A., Ji, G., & Xu, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.964793 · Cited by 73
“Both are known to degrade mucin, and the expression of several genes associated with mucin degradation is positively correlated with intestinal inflammation (Bloom et al., 2011; Ganesh et al., 2013; Ng et al., 2013) and tumour incidence (Baxter et al.”
BackgroundMayers, M., Moon, C., Stupp, G. S., Su, A. I., & Wolan, D. W. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00938 · Cited by 72
Salmonella Typhimurium and Multidirectional Communication in the Gut
Gart, E. V., Suchodolski, J. S., Welsh, T. H., Alaniz, R. C., Randel, R. D., & Lawhon, S. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01827 · Cited by 73
“Thus, during S. Typhimurium infection commensal A. muciphila turns into a pathobiont and contributes to disease symptoms (Ganesh et al., 2013).”
BackgroundChen, D., Chen, G., Chen, C., Zeng, X., & Ye, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.248 · Cited by 72
Hussain, A., Yadav, M., Bose, S., Wang, J., Lim, D., Song, Y.-K., Ko, S., & Kim, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165483 · Cited by 73
Kaczmarczyk, M., Löber, U., Adamek, K., Węgrzyn, D., Skonieczna‐Żydecka, K., Malinowski, D., Łoniewski, I., Markó, L., Ulas, T., Forslund, S. K., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02839-w · Cited by 72
“[53, 57, 58] Consequently, increased mucin degradation makes luminal antigens cross the gut barrier and stimulate the immune system, leading to intestinal disorders.[59] Of note, in this study, the abundance of these above bacteria positively correlated with the concentration zonulin and the dynamics of calprotectin c…”
BackgroundFunction of Akkermansia muciniphila in type 2 diabetes and related diseases
Li, J., Yang, G., Zhang, Q., Liu, Z., Jiang, X. M., & Xin, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1172400 · Cited by 73
“Several lines of evidence have shown that A. muciniphila administration can ameliorate inflammatory bowel diseases (IBD) or delay colitis-associated tumorigenesis in mice (Wang et al., 2020; Wade and Su, 2021), whereas certain oral treatments for colitis have enriched the abundance of A. muciniphila (Ke et al., 2021).”
InfluentialYvon, S., Olier, M., Leveque, M., Jard, G., Tormo, H., Haimoud-Lekhal, D. A., Peter, M., & Eutamène, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1304-z · Cited by 71
“typhimurium-induced intestinal inflammation [65].”
Alteration of Gut Microbiota in Alzheimer’s Disease and Their Relation to the Cognitive Impairment
Khedr, E. M., Omeran, N., Ramadan, H. K., Ahmed, G. K., & Abdelwarith, A. M. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220176 · Cited by 73
Yang, S., Qiao, J., Zhang, M., Kwok, L., Matijašić, B. B., Zhang, H., & Zhang, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.006 · Cited by 73
Cheng, W., Ho, J. Y. S., & Chang, R. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101620 · Cited by 71
Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection
Hu, X., Zhao, Y., Yang, Y. P., Gong, W., Sun, X., Yang, L., Zhang, Q., & Jin, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.586476 · Cited by 72
“typhimurium-induced intestinal inflammation by disturbing the host mucus homeostasis (Ganesh et al., 2013).”
BackgroundLiu, J., Liu, H., Liu, H., Teng, Y., Qin, N., Ren, X., & Xia, X. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.03.008 · Cited by 66
Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation
Blasco, M. P., Chauhan, A., Honarpisheh, P., Ahnstedt, H. W., d’Aigle, J., Ganesan, A., Ayyaswamy, S., Blixt, F. W., Venable, S. F., Major, A. M., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01833-1 · Cited by 67
Self-citationGarcía-Mazcorro, J. F., Lage, N. N., Mertens‐Talcott, S. U., Talcott, S. T., Chew, B. P., Dowd, S. E., Kawas, J. R., & Noratto, G. D. (2018) · PeerJ · doi:10.7717/peerj.4195 · Cited by 66
“…shown to be increased in mouse studies of dextran sodium 572 sulfate (DSS)-induced colitis (Berry et al., 2012; Kang et al., 2013; Hakansson et al., 2015) and 573 can seemingly aggravate Salmonella enterica Typhimurium-induced gut inflammation in a 574 gnotobiotic mouse model (Ganesh et al., 2013).”
BackgroundChang, J. P., & Su, K. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.4.469 · Cited by 74
“tio and improved the stress-associated inflammatory conditions by increasing the abundance of butyrate-producing bacteria and decreasing the levels of pro-inflammatory bacterial genera, such as Akkermansia and Flexibacter [31,32].”
BackgroundColonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection
Deng, L., & Wang, S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2424914 · Cited by 76
Zhang, H., Pan, Y., Jiang, Y., Chen, M., Ma, X., Yu, X., Ren, D., & Jiang, B. (2024) · npj Science of Food · doi:10.1038/s41538-024-00339-x · Cited by 65
“However, there is also evidence suggesting that this strain may intensify intestinal in fl ammationinmiceinfectedwith Salmonellatyphimurium 35 .”
Ganesh, B. P., Hall, A., Ayyaswamy, S., Nelson, J. W., Fultz, R., Major, A. M., Haag, A. M., Esparza, M., Lugo, M., Venable, S. F., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.58 · Cited by 65
“Mucus serves as the primary contact between the intestinal epithelial layer and luminal antigens.(39,40) As GF mice were colonized with Lr, it was of interest to evaluate mucus maturation after probiotic colonization using lectin staining.”
MethodSelf-citationZeng, S.-Y., Liu, Y., Liu, J., Zeng, Z., Xie, H., & Liu, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0325 · Cited by 67
“Despite the lack of large-scale supporting data, evidence suggests that over-colonization by A. muciniphila is associated with thinning of the mucus layer and deterioration of the intestinal barrier [71-73].”
BackgroundObservation of inflammatory responses in mice orally fed with bacteriophage T7
Park, K., Cha, K., & Myung, H. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12565 · Cited by 64
“Prominent inflammatory responses are readily induced by infection with pathogenic viruses (McCarthy et al. 2013) and bacteria (Ganesh et al. 2013).”
BackgroundPalmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, P., Loviselli, A., Velluzzi, F., & Manzin, A. (2022) · Nutrients · doi:10.3390/nu14122436 · Cited by 68
“Akkermansia muciniphila is a mucin degrading bacterium that resides in the human intestinal mucous layer and is able of promoting intestinal integrity due to its capacity for restoring mucous thickness and thus stimulating the mucous turnover rate [67,68].”
BackgroundMohammed, A. K., Alghetaa, H., Zhou, J., Chatterjee, S., Nagarkatti, P. S., & Nagarkatti, M. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15226 · Cited by 63
Salmonellain Swine: Microbiota Interactions
Kim, H. B., & Isaacson, R. E. (2016) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022516-022834 · Cited by 68
Song, C., Kim, N., Nam, R. H., Choi, S. I., Lee, H., & Surh, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-69112-w · Cited by 66
Fekete, E. R., & Buret, A. G. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00261.2022 · Cited by 60
Yu, J., Liu, T., Guo, Q., Wang, Z., Chen, Y., & Dong, Y. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04698-22 · Cited by 62
The underlying microbial mechanism of epizootic rabbit enteropathy triggered by a low fiber diet
Jin, D. X., Zou, H. W., Liu, S. Q., Wang, L. Z., Xue, B., Wu, D., Tian, G., Cai, J., Yan, T. H., Wang, Z. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30178-2 · Cited by 56
Kosciow, K., & Deppenmeier, U. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.246 · Cited by 59
Machiels, K., Pozuelo, M., la Torre, A. M.-D., Xie, Z., Andreu, V., Sabino, J., Santiago, A., Campos, D., Wolthuis, A. M., D’Hoore, A., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa081 · Cited by 59
The impact of maternal and early life malnutrition on health: a diet-microbe perspective
Forgie, A. J., Drall, K. M., Bourque, S. L., Field, C. J., Kozyrskyj, A. L., & Willing, B. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01584-z · Cited by 59
“For example, Akkermansia muciniphila has been shown to improve glucose control [31, 32], but has also been shown to exacerbate infections and colitis [33, 34].”
BackgroundRing, C., Klopfleisch, R., Dahlke, K., Basic, M., Bleich, A., & Blaut, M. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1511663 · Cited by 52
“muciniphila was due to the weakening of the intestinal barrier.(17) In the present study, A.”
BackgroundMethodInfluentialLakshmanan, A. P., Murugesan, S., Khodor, S. A., & Terranegra, A. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03631-0 · Cited by 64
Demehri, F. R., Barrett, M., & Teitelbaum, D. H. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609904 · Cited by 53
Rosa, G. L., Lonardo, M. S., Cacciapuoti, N., Muscariello, E., Guida, B., Faraonio, R., Santillo, M., & Damiano, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087247 · Cited by 56
“Furthermore, these bacteria may have a proinflammatory action related to their ability to degrade mucus, causing damage to the intestinal barrier, and increasing the exposure of intestinal immune cells to microbial antigens [54].”
BackgroundNative and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases
Shen, H., Zhao, Z., Zhao, Z., Chen, Y., & Zhang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020594 · Cited by 55
Implications of Gut Microbiota in Complex Human Diseases
Yu, D., Meng, X., de Vos, W. M., Wu, H., Fang, X., & Maiti, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312661 · Cited by 51
Faghfuri, E., & Gholizadeh, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116416 · Cited by 53
Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure
Nakanishi, M., Chen, Y., Qendro, V., Miyamoto, S., Weinstock, E., Weinstock, G. M., & Rosenberg, D. W. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0026 · Cited by 52
Song, L., Li, Y., Qu, D. C., Ouyang, P.-L., Ding, X., Wu, P., Guan, Q., & Yang, L. (2019) · Food & Function · doi:10.1039/c9fo01570a · Cited by 53
Breaking down the gut microbiome composition in multiple sclerosis
Budhram, A., Parvathy, S., Kremenchutzky, M., & Silverman, M. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458516682105 · Cited by 51
Xu, Y., Yang, Y., Li, B., Xie, Y., Shi, Y., & Le, G. (2022) · Food & Function · doi:10.1039/d2fo03366f · Cited by 52
Gaulke, C. A., Rolshoven, J., Wong, C. P., Hudson, L. G., Ho, E., & Sharpton, T. J. (2018) · mSphere · doi:10.1128/msphere.00521-18 · Cited by 51
“Akkermansia has also been shown to exacerbate inflammation during infection with intestinal pathogens (59).”
BackgroundAlterations of the Gut Microbiota in Multiple System Atrophy Patients
Wan, L., Zhou, X. M., Wang, C., Chen, Z., Peng, H., Hou, X., Peng, Y., Wang, P., Li, T., Yuan, H., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01102 · Cited by 49
Biagioli, M., Giorgio, C. D., Massa, C., Marchianò, S., Bellini, R., Bordoni, M., Urbani, G., Roselli, R., Lachi, G., Morretta, E., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117731 · Cited by 54
Gill, T., Brooks, S. R., Rosenbaum, J. T., Asquith, M. J., & Colbert, R. A. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41018 · Cited by 48
“On the other hand, Akkermansia muciniphila exacerbates inflammation directly by degrading the mucous layer over epithelial cells, thereby weakening the epithelial barrier (10).”
BackgroundTingler, A. M., & Engevik, M. A. (2025) · Infection and Immunity · doi:10.1128/iai.00503-24 · Cited by 58
“In terms of detrimental effects, using a simplified gut microbiota (SIHUMI) in gnotobiotic mice, one study found that A. muciniphila was specifically responsible for exacerbating S. Typhimurium infection in mice (256).”
Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
Tveter, K. M., Mezhibovsky, E., Wu, Y., & Roopchand, D. E. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108457 · Cited by 52
Rawski, M., Kierończyk, B., Długosz, J., Świątkiewicz, S., & Józefiak, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147859 · Cited by 49
“municiphila exacerbates gut inflammation and supports the development of Salmonella Typhimurium infection [53].”
BackgroundMetabolic Fate of Orally Ingested Proanthocyanidins through the Digestive Tract
Niwano, Y., Kohzaki, H., Shirato, M., Shishido, S., & Nakamura, K. (2022) · Antioxidants · doi:10.3390/antiox12010017 · Cited by 47
“muciniphila is a mucinolytic bacterium found in the mucus layer of the human gut [90], and it has the potential to restore mucus thickness and intestinal barrier integrity [91,92].”
BackgroundHashemi, B., Abdollahi, M., Abbaspour‐Aghdam, S., Hazrati, A., Malekpour, K., Meshgi, S., Kafil, H. S., Ghazi, F., Yousefi, M., Roshangar, L., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114195 · Cited by 49
Piewngam, P., Quiñones, M., Thirakittiwatthana, W., Yungyuen, T., Otto, M. J., & Kiratisin, P. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.12.006 · Cited by 46
Raising the ‘Good’ Oxidants for Immune Protection
Dumas, A., & Knaus, U. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698042 · Cited by 44
Zhang, Y., Song, F., Yang, M., Chen, C., Cui, J., Xing, M., Dai, Y., Li, M., Cao, Y., Lu, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202306297 · Cited by 43
Yan, X., Li, H.-L., Zhang, Y., Wu, S., Lu, H., Yu, X., Meng, F., Sun, J., & Gong, L. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0295-8 · Cited by 44
Dubinsky, V., Reshef, L., Rabinowitz, K. M., Yadgar, K., Godny, L., Zonensain, K., Wasserberg, N., Dotan, I., & Gophna, U. (2021) · mSystems · doi:10.1128/msystems.00984-20 · Cited by 45
Akkermansia muciniphila, an important link between dietary fiber and host health
Zhang, Y., Hu, J., Tan, H., Zhong, Y., & Nie, S. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100905 · Cited by 46
Li, L., Li, M., Chen, Y., Yu, Z., Chen, P., Yu, Z., Cheng, W., Zhang, W., Wang, Z., Gao, X., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1354447 · Cited by 42
Metadata
- Authors
- Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Freie Universität Berlin (DE)
- Corresponding author
- Loh, Gunnar
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-10
- Volume
- 8
- Issue
- 9
- Pages
- e74963
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3769299
- OpenAlex
- W2085991415
- Cited by
- 522
- References
- 60
- Citations by year
- 2026: 27 · 2025: 47 · 2024: 69 · 2023: 56 · 2022: 59 · 2021: 50 · 2020: 46 · 2019: 41 · 2018: 37 · 2017: 27 · 2016: 36 · 2015: 13 · 2014: 11 · 2013: 2
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Akkermansia muciniphila, Salmonella typhimurium, intestinal inflammation, mucin degradation, commensal bacteria, gnotobiotic mice, goblet cells, Bacteroides thetaiotaomicron, inflammatory cytokines, interferon-gamma, gut microbiota, Salmonella enteritis
- MeSH terms
- Animals, Germ-Free Life, Inflammation, Interferon-gamma, Interleukin-1, Intestines, Lymph Nodes, Macrophages, Mice, Inbred C3H, RNA, Messenger, Salmonella Infections, Salmonella typhimurium, Symbiosis, Tumor Necrosis Factor-alpha, Interleukin-6, Interleukin-12, Mice, Chemokine CXCL10, Mucin-2, Verrucomicrobia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
