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Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice
Open accessAbstract
Excessive mucin degradation by intestinal bacteria may contribute to inflammatory bowel diseases because access of luminal antigens to the intestinal immune system is facilitated. This study investigated how the presence of a mucin degrading commensal bacterium affects the severity of an intestinal Salmonella enterica Typhimurium-induced gut inflammation. Using a gnotobiotic C3H mouse model with a background microbiota of eight bacterial species (SIHUMI) the impact of the mucin-degrading commensal bacterium Akkermansia muciniphila (SIHUMI-A) on inflammatory and infectious symptoms caused by S. Typhimurium was investigated. Presence of A. muciniphila in S. Typhimurium-infected SIHUMI mice caused significantly increased histopathology scores and elevated mRNA levels of IFN-γ, IP-10, TNF-α, IL-12, IL-17 and IL-6 in cecal and colonic tissue. The increase in pro-inflammatory cytokines was accompanied by 10-fold higher S. Typhimurium cell numbers in mesenteric lymph nodes of SIHUMI mice associated with A. muciniphila and S. Typhimurium (SIHUMI-AS) compared to SIHUMI mice with S. Typhimurium only (SIHUMI-S). The number of mucin filled goblet cells was 2- to 3-fold lower in cecal tissue of SIHUMI-AS mice compared to SIHUMI-S, SIHUMI-A or SIHUMI mice. Reduced goblet cell numbers significantly correlated with increased IFN-γ mRNA levels (r(2) = -0.86, ***P<0.001) in all infected mice. In addition, loss of cecal mucin sulphation was observed in SIHUMI mice containing both A. muciniphila and S. Typhimurium compared to other mouse groups. Concomitant presence of A. muciniphila and S. Typhimurium resulted in a drastic change in microbiota composition of SIHUMI mice: the proportion of B. thetaiotaomicron in SIHUMI-AS mice was 0.02% of total bacteria compared to 78%-88% in the other mouse groups and the proportion of S. Typhimurium was 94% in SIHUMI-AS mice but only 2.2% in the SIHUMI-S mice. These results indicate that A. muciniphila exacerbates S. Typhimurium-induced intestinal inflammation by its ability to disturb host mucus homeostasis.
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“It has been reported that the abundance of g_Akkermansia has a negative correlation with the value of body mass index (BMI) [59] and that g_Akkermansia has a protective effect for the mucus layer in pro-inflammation [60].”
From Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis (2019) · cites this paper as [60]
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“The Gram-negative bacteria, Akkermansia, can degrade mucin, cause intestinal inflammation and permeability, and increase endotoxemia and systemic inflammation, eventually promoting neuropathology [53,54,55].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [55]
In the citing paper
“its mucin degrading activity might also damage the gut-barrier triggering inflammation and promoting gut permeability [83,84]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [84]
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Citations
Cites
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · cited 1×
“muciniphila is known for its ability to degrade mucins [16,17].”
BackgroundMechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,806
Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,531 · cited 1×
“muciniphila is the main intestinal representative of this phylum [2], suggesting that A.”
BackgroundMucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · cited 1×
“(q increased; Q decreased; grey dotted line: assumed processes including lectin-sialic acid binding [56], M-cells for pathogen transit [43,58,59]; black line: supported by data of the present study).”
ResultGut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · cited 1×
“[21,22] and therefore represents a highly suitable model for”
BackgroundStecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · cited 4×
“Typhimurium-induced gut inflammation [14,50] or in inflamed IL-10 mice [51].”
BackgroundInfluentialHost-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019 · cited 2×
“Typhimurium-induced gut inflammation [14,50] or in inflamed IL-10 mice [51].”
BackgroundHelicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T. P., Teneberg, S., Karlsson, K., et al. (2002) · Science · doi:10.1126/science.1069076 · Cited by 935 · cited 1×
“Interestingly, changes in intestinal mucin composition characterized by a lower degree of sulphation [7,46] and a higher degree of sialylation have previously been reported to occur in UC, Crohn’s Disease (CD) and gastric ulcer caused by Helicobacter pylori-induced inflammation [7,46,47].”
BackgroundCollado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706
Heazlewood, C. K., Cook, M. C., Eri, R., Price, G. R., Tauro, S. B., Taupin, D., Thornton, D. J., Png, C. W., Crockford, T. L., Cornall, R. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050054 · Cited by 701
The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract
Derrien, M., Collado, M. C., Amor, K. B., Salminen, S., & de Vos, W. M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01226-07 · Cited by 685 · cited 1×
“muciniphila is known for its ability to degrade mucins [16,17].”
BackgroundFalk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 658 · cited 1×
“thetaiotaomicron in NMRI mice; utilization of fucose by this organism triggered the synthesis of fucosylated glycoconjugates by the host epithelium [5].”
BackgroundMunder, M., Mallo, M., Eichmann, K., & Modolell, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2103 · Cited by 601
Mucin-bacterial interactions in the human oral cavity and digestive tract
Derrien, M., van Passel, M. W. J., van de Bovenkamp, J. H. B., Schipper, R., de Vos, W., & Dekker, J. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12778 · Cited by 556
Diversity in cell surface sialic acid presentations: implications for biology and disease
Varki, N. M., & Varki, A. P. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700656 · Cited by 521
Sialic acid utilization by bacterial pathogens
Severi, E., Hood, D. W., & Thomas, G. H. (2007) · Microbiology · doi:10.1099/mic.0.2007/009480-0 · Cited by 489 · cited 1×
“Images were analyzed using an Eclipse E600 microscope and [56,57].”
MethodII. Stress and intestinal barrier function
Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424
Monack, D. M., Bouley, D. M., & Falkow, S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031319 · Cited by 396 · cited 1×
“Typhimurium involves its survival within host macrophages [23] and promotes macrophage recruitment [24,25].”
BackgroundCorfield, A. P., MYERSCOUGH, N., LONGMAN, R., SYLVESTER, P., Arul, G. S., & Pignatelli, M. N. (2000) · Gut · doi:10.1136/gut.47.4.589 · Cited by 391 · cited 1×
“Interestingly, changes in intestinal mucin composition characterized by a lower degree of sulphation [7,46] and a higher degree of sialylation have previously been reported to occur in UC, Crohn’s Disease (CD) and gastric ulcer caused by Helicobacter pylori-induced inflammation [7,46,47].”
BackgroundComparative study of the intestinal mucus barrier in normal and inflamed colon
Swidsinski, A. V., Loening-Baucke, V. A., Theissig, F., Engelhardt, H., Bengmark, S., Koch, S., Lochs, H. H., & Dörffel, Y. (2006) · Gut · doi:10.1136/gut.2006.098160 · Cited by 365
Inflammatory bowel disease is associated with changes of enterocytic junctions
Gaßler, N., Rohr, C. M., Schneider, A., Kartenbeck, J., Bach, A., Obermüller, N., Otto, H. F., & Autschbach, F. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g216 · Cited by 363
Endt, K., Stecher, B., Chaffron, S., Slack, E. M. C., Tchitchek, N., Benecke, A., Maele, L. V., Sirard, J., Müller, A. J., Heikenwälder, M. F., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001097 · Cited by 352 · cited 1×
“tissues by exploiting host inflammation [14,48,49].”
Mucosal and Invading Bacteria in Patients with Inflammatory Bowel Disease Compared with Controls
Kleessen, B., Kroesen, A. J., Buhr, H. J., & Blaut, M. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202320378220 · Cited by 351 · cited 1×
“differs from that in healthy controls [53].”
Self-citationA Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation
Chow, J., & Mazmanian, S. K. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.03.004 · Cited by 312 · cited 1×
“muciniphila into a pathobiont (a resident intestinal bacterium that under certain circumstances causes disease) [27,28].”
BackgroundShkoda, A., Ruiz, P. A., Daniel, H., Kim, S. C., Rogler, G., Sartor, R. B., & Haller, D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.030 · Cited by 278
Mucin Dynamics in Intestinal Bacterial Infection
Lindén, S. K., Florin, T. H., & McGuckin, M. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003952 · Cited by 242 · cited 1×
“Recent studies propose that excessive mucin degradation facilitates the access of pathogen to the mucosa [12,35].”
BackgroundA Mouse Model of Salmonella Typhi Infection
Mathur, R., Oh, H.-J., Zhang, D., Park, S., Seo, J., Koblansky, A. A., Hayden, M. S., & Ghosh, S. (2012) · Cell · doi:10.1016/j.cell.2012.08.042 · Cited by 215 · cited 1×
“[21,22] and therefore represents a highly suitable model for”
BackgroundBacteria as the cause of ulcerative colitis
Campieri, M., & Gionchetti, P. (2001) · Gut · doi:10.1136/gut.48.1.132 · Cited by 215
Ayres, J. S., Trinidad, N. J., & Vance, R. E. (2012) · Nature Medicine · doi:10.1038/nm.2729 · Cited by 213 · cited 1×
“muciniphila into a pathobiont (a resident intestinal bacterium that under certain circumstances causes disease) [27,28].”
BackgroundBruno, V. M., Hannemann, S., Lara-Tejero, M., Flavell, R. A., Kleinstein, S. H., & Galán, J. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000538 · Cited by 203 · cited 1×
“murine pathogen [19] that triggers acute inflammatory responses [20] in TLR11 knock-out mice or streptomycin-treated mice”
BackgroundSmith, W. E., Kane, A. V., Campbell, S. T., Acheson, D. W. K., Cochran, B., & Thorpe, C. M. (2003) · Infection and Immunity · doi:10.1128/iai.71.3.1497-1504.2003 · Cited by 191
Kaiser, P., Diard, M., Stecher, B., & Hardt, W. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01070.x · Cited by 184 · cited 1×
“This may be explained by the fact that it takes several days for the inflammation to spread from cecum to colon [34].”
BackgroundMoulin-Schouleur, M., Schouler, C., Tailliez, P., Kao, M., Brée, A., Germon, P., Oswald, É., Mainil, J. G., Blanco, M., & Blanco, J. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00548-06 · Cited by 177 · cited 1×
“coli which lacks fitness genes [52] and might therefore be more”
Backgroundvan der Velden, A. W. M., Lindgren, S. W., Worley, M. J., & Heffron, F. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5702-5709.2000 · Cited by 172
Human intestinal microbiota: Characterization of a simplified and stable gnotobiotic rat model
Becker, N., Kunath, J., Loh, G., & Blaut, M. (2011) · Gut Microbes · doi:10.4161/gmic.2.1.14651 · Cited by 170 · cited 3×
“To test this hypothesis we took advantage of a well-defined gnotobiotic mouse model associated with a defined simplified human intestinal microbiota (SIHUMI) of eight bacterial species [18], complemented with A.”
BackgroundMethodInfluentialSelf-citationEndoplasmic reticulum stress and intestinal inflammation
Kaser, A., & Blumberg, R. S. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.122 · Cited by 151
Wiggins, R. D. (2001) · Sexually Transmitted Infections · doi:10.1136/sti.77.6.402 · Cited by 148 · cited 1×
“Recent studies propose that excessive mucin degradation facilitates the access of pathogen to the mucosa [12,35].”
BackgroundBerclaz, P., Shibata, Y., Whitsett, J. A., & Trapnell, B. C. (2002) · Blood · doi:10.1182/blood-2002-04-1102 · Cited by 128
Salmonella, the host and its microbiota
Thiennimitr, P., Winter, S., & Bäumler, A. J. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.10.002 · Cited by 126 · cited 3×
“Typhimurium infection and in turn to induce the production of IFN-c which enhances the ability of macrophages to kill intracellular pathogens [25,29].”
BackgroundRaouf, A. H., Tsai, H. H., Parker, N., Hoffman, J., Walker, R. J., & Rhodes, J. M. (1992) · Clinical Science · doi:10.1042/cs0830623 · Cited by 125 · cited 1×
“Interestingly, changes in intestinal mucin composition characterized by a lower degree of sulphation [7,46] and a higher degree of sialylation have previously been reported to occur in UC, Crohn’s Disease (CD) and gastric ulcer caused by Helicobacter pylori-induced inflammation [7,46,47].”
BackgroundKeeping Bacteria at a Distance
Johansson, M., & Hansson, G. C. (2011) · Science · doi:10.1126/science.1213909 · Cited by 124 · cited 1×
“The inner layer serves as a barrier that prevents bacterial access to the epithelium [45].”
BackgroundRole of interferon-gamma in interleukin 12-induced pathology in mice.
Car, B. D., Eng, V. M., Schnyder, B., LeHir, M., Shakhov, A. N., Woerly, G., Huang, S., Aguet, M., Anderson, T. D., & Ryffel, B. (1995) · Europe PMC (PubMed Central) · Cited by 123
Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response
Kallis, Y. N., Robson, A. J., Fallowfield, J. A., Thomas, H. C., Alison, M. R., Wright, N. A., Goldin, R. D., Iredale, J. P., & Forbes, S. J. (2010) · Gut · doi:10.1136/gut.2010.224436 · Cited by 111 · cited 1×
“muciniphila enhanced this process, we scored macrophage infiltration in cecal tissue by immunohistochemical detection of the F4/80 receptor present on mouse macrophages [26].”
BackgroundInteractions between Human NK Cells and Macrophages in Response to Salmonella Infection
Lapaque, N., Walzer, T., Méresse, S., Vivier, É., & Trowsdale, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803329 · Cited by 110
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection
Nix, R. N., Altschuler, S. E., Henson, P. M., & Detweiler, C. S. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030193 · Cited by 104 · cited 1×
“Typhimurium involves its survival within host macrophages [23] and promotes macrophage recruitment [24,25].”
BackgroundStress and intestinal barrier function
Wang, H. (2002) · Parenteral & Enteral Nutrition · Cited by 97
Adherence of Salmonella typhimurium to Caco-2 cells: identification of a glycoconjugate receptor
Giannasca, K. T., Giannasca, P. J., & Neutra, M. R. (1996) · Infection and Immunity · doi:10.1128/iai.64.1.135-145.1996 · Cited by 95 · cited 2×
“Images were analyzed using an Eclipse E600 microscope and [56,57].”
MethodResultStromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection
Songhet, P., Barthel, M., Stecher, B., Müller, A. J., Kremer, M., Hansson, G. C., & Hardt, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022459 · Cited by 86
Bogaert, S., Vos, M. D., Olievier, K., Peeters, H., Elewaut, D. S., Lambrecht, B. N., Pouliot, P., & Laukens, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025589 · Cited by 85
Clark, M. A., Reed, K. A., Lodge, J., Stephen, J., Hirst, B. H., & Jepson, M. A. (1996) · Infection and Immunity · doi:10.1128/iai.64.10.4363-4368.1996 · Cited by 79 · cited 1×
“(q increased; Q decreased; grey dotted line: assumed processes including lectin-sialic acid binding [56], M-cells for pathogen transit [43,58,59]; black line: supported by data of the present study).”
ResultSalmonella Transiently Reside in Luminal Neutrophils in the Inflamed Gut
Loetscher, Y., Wieser, A., Lengefeld, J., Kaiser, P., Schubert, S., Heikenwälder, M. F., Hardt, W., & Stecher, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034812 · Cited by 66 · cited 1×
“tissues by exploiting host inflammation [14,48,49].”
Wohlgemuth, S., Haller, D., Blaut, M., & Loh, G. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01883.x · Cited by 54 · cited 1×
“Typhimurium-induced gut inflammation [14,50] or in inflamed IL-10 mice [51].”
BackgroundSelf-citationZirk, N. M., Hashmi, S., & Ziegler, H. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.319-326.1999 · Cited by 33 · cited 1×
“murine pathogen [19] that triggers acute inflammatory responses [20] in TLR11 knock-out mice or streptomycin-treated mice”
BackgroundMicrobial–Host Interactions in Inflammatory Bowel Diseases and Experimental Colitis
Sartor, R. B. (2009) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000235787 · Cited by 31
Ganesh, B. P., Richter, J. F., Blaut, M., & Loh, G. (2012) · Beneficial Microbes · doi:10.3920/bm2011.0050 · Cited by 24 · cited 3×
“The forward and reverse primers used for IFN-c, IP-10, IL12, IL-17, TNF-a, IL-6, IL-23, IL-18 and IL-4 quantification were described previously [13].”
BackgroundMethodInfluentialSelf-citationMurine Cecal Patch M Cells Transport Infectious Prions In Vivo
Foster, N. M., & MacPherson, G. G. (2010) · The Journal of Infectious Diseases · doi:10.1086/657415 · Cited by 23 · cited 1×
“(q increased; Q decreased; grey dotted line: assumed processes including lectin-sialic acid binding [56], M-cells for pathogen transit [43,58,59]; black line: supported by data of the present study).”
ResultSlezak, K., Hanske, L., Loh, G., & Blaut, M. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0047 · Cited by 15 · cited 1×
“Typhimurium, as described previously [54] and the HSP-60 gene for each member of the SIHUMI consortium [55].”
BackgroundSelf-citationSalmonella real-time PCR-Nachweis
Malorny, B., Anderson, A., & Huber, I. (2007) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-007-0167-x · Cited by 8 · cited 1×
“Typhimurium, as described previously [54] and the HSP-60 gene for each member of the SIHUMI consortium [55].”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755
“The normal intestinal microbiota triggers the epithelium for synthesizing mucus sugars, while selected commensal bacteria such as Akkermansia muciniphila regulate mucus layers by utilizing mucins as an energy source [67,68].”
BackgroundAlterations of the human gut microbiome in multiple sclerosis
Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044
Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711235114 · Cited by 1,040
“muciniphila has been reported to exacerbate inflammation during infection (23).”
Metadata
- Authors
- Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Freie Universität Berlin (DE)
- Corresponding author
- Loh, Gunnar
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-10
- Volume
- 8
- Issue
- 9
- Pages
- e74963
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3769299
- OpenAlex
- W2085991415
- Cited by
- 522
- References
- 60
- Citations by year
- 2026: 27 · 2025: 47 · 2024: 69 · 2023: 56 · 2022: 59 · 2021: 50 · 2020: 46 · 2019: 41 · 2018: 37 · 2017: 27 · 2016: 36 · 2015: 13 · 2014: 11 · 2013: 2
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Akkermansia muciniphila, Salmonella typhimurium, intestinal inflammation, mucin degradation, commensal bacteria, gnotobiotic mice, goblet cells, Bacteroides thetaiotaomicron, inflammatory cytokines, interferon-gamma, gut microbiota, Salmonella enteritis
- MeSH terms
- Animals, Germ-Free Life, Inflammation, Interferon-gamma, Interleukin-1, Intestines, Lymph Nodes, Macrophages, Mice, Inbred C3H, RNA, Messenger, Salmonella Infections, Salmonella typhimurium, Symbiosis, Tumor Necrosis Factor-alpha, Interleukin-6, Interleukin-12, Mice, Chemokine CXCL10, Mucin-2, Verrucomicrobia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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