Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults
Open accessAbstract
To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [V̇O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, V̇O2peak, and body composition. The increase in V̇O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = -0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults.
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After 8-week endurance training in healthy adults, increased circulating irisin levels were positively correlated with the amount of visceral fat loss measured by DEXA.
“After an 8-week endurance training in healthy adults, increased circulating irisin levels were positively correlated with the amount of visceral fat loss measured by DEXA scan [121].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [121]
The Discussion reports that, after eight weeks of endurance training, increased irisin was associated with reduced visceral fat in healthy middle-aged and older adults; it was not increased in the young adults studied. The Materials and Methods (Body composition) specify that visceral adipose tissue area was measured by MRI, not DEXA; DEXA was used for other body-composition measures. (LLM, conf=0.92)
Experimental — accuracy not yet measuredIn 25 healthy young and elderly individuals who practiced 8 weeks of cycloergometer training, serum irisin levels increased in the elderly group compared to the young group.
“The main results indicated an increase in serum irisin levels in the elderly group compared to the young group (age 21 ± 1 years)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
The Results (Comparison of serum irisin concentrations; page not specified) report an increase after training in the middle-aged/older group but not in the young group, and Methods (Endurance training intervention; page not specified) confirms eight weeks of cycling. However, Methods (Subjects; page not specified) lists 25 young and 28 middle-aged/older participants, with only 14 in each training group—not 25 young and elderly individuals who all trained. The paper also reports lower absolute irisin levels in the older cohort, so the comparison applies to the training response, not serum levels overall. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn the same study, the increase in serum irisin in the elderly group was accompanied by a reduction in visceral adiposity, which was negatively correlated with irisin levels (r = −0.54, P < 0.05).
“accompanied by a reduction in visceral adiposity which was negatively correlated with irisin levels (r = −0.54, P < 0.05; Miyamoto-Mikami et al., 2015).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
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- Authors
- Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., & Iemitsu, M.
- Affiliations
- Ritsumeikan University (JP)
- Corresponding author
- Iemitsu, Motoyuki
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-20
- Volume
- 10
- Issue
- 3
- Pages
- e0120354
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4368602
- OpenAlex
- W1969017622
- Cited by
- 143
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 13 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 3
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (25560378)
- Japan Society for the Promotion of Science (26282199, 25560378, 26350825, 24300235, 24300239)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- irisin, endurance training, visceral fat, middle-aged and older adults, peak oxygen uptake, body composition, aging, cycling training
- MeSH terms
- Aged, Body Composition, Body Weight, Female, Fibronectins, Humans, Male, Middle Aged, Physical Endurance, Case-Control Studies, Intra-Abdominal Fat, Young Adult
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