Antioxidant and Angiostatic Effect of Spirulina platensis Suspension in Complete Freund’s Adjuvant-Induced Arthritis in Rats
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BACKGROUND: Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested. RESULTS: We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group. CONCLUSIONS: The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.
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In rat models of experimental colitis and arthritis, the antioxidant activity of Spirulina was associated with anti-inflammatory effects.
“In rat models of experimental colitis (acetic-acid induced) [48] and arthritis (Freund's adjuvant-induced [49] and collagen-induced [50]) the antioxidant activity of Spirulina was associated with anti-inflammatory effects.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [49]
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- Authors
- Ali, E. A. I., Barakat, B. M., & Hassan, R.
- Affiliations
- Suez Canal University (EG)
- Al-Azhar University (EG)
- Corresponding author
- Hassan, Ranya
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-08
- Volume
- 10
- Issue
- 4
- Pages
- e0121523
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4390336
- OpenAlex
- W1970903730
- Cited by
- 73
- References
- 42
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 4
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- Spirulina platensis, adjuvant-induced arthritis, rheumatoid arthritis, antioxidant activity, angiogenesis inhibition, anti-inflammatory activity, immunomodulation, cyclooxygenase-2, TNF-α, interleukin-6, vascular endothelial growth factor, lipid peroxidation, glutathione, cyanobacteria, natural products
- MeSH terms
- Animals, Antioxidants, Arthritis, Experimental, Biological Availability, Freund's Adjuvant, Male, Suspensions, Tumor Necrosis Factor-alpha, Interleukin-6, Rats, Wistar, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Rats, Spirulina, Immunomodulation
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