Natural and artificial feeding management before weaning promote different rumen microbial colonization but not differences in gene expression levels at the rumen epithelium of newborn goats
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The aim of this work was to evaluate the effect of feeding management during the first month of life (natural with the mother, NAT, or artificial with milk replacer, ART) on the rumen microbial colonization and the host innate immune response. Thirty pregnant goats carrying two fetuses were used. At birth one kid was taken immediately away from the doe and fed milk replacer (ART) while the other remained with the mother (NAT). Kids from groups received colostrum during first 2 days of life. Groups of four kids (from ART and NAT experimental groups) were slaughtered at 1, 3, 7, 14, 21 and 28 days of life. On the sampling day, after slaughtering, the rumen content was sampled and epithelial rumen tissue was collected. Pyrosequencing analyses of the bacterial community structure on samples collected at 3, 7, 14 and 28 days showed that both systems promoted significantly different colonization patterns (P = 0.001). Diversity indices increased with age and were higher in NAT feeding system. Lower mRNA abundance was detected in TLR2, TLR8 and TLR10 in days 3 and 5 compared to the other days (7, 14, 21 and 28). Only TLR5 showed a significantly different level of expression according to the feeding system, presenting higher mRNA abundances in ART kids. PGLYRP1 showed significantly higher abundance levels in days 3, 5 and 7, and then experienced a decline independently of the feeding system. These observations confirmed a highly diverse microbial colonisation from the first day of life in the undeveloped rumen, and show that the colonization pattern substantially differs between pre-ruminants reared under natural or artificial milk feeding systems. However, the rumen epithelial immune development does not differentially respond to distinct microbial colonization patterns.
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The presence of the dam and the associated increase in the availability of microorganisms in the environment promotes differences in rumen colonization.
“Another factor that promotes differences in rumen colonization is the presence of the dam and the associated increase in the availability of microorganisms in the environment.”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
The transitional stage of rumen microbial establishment occurs 3-15 days during the transition from colostrum to milk.
“(ii) transitional stage (3–15 days) during the transition from colostrum to milk,”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
The maturation stage of rumen microbial establishment is characterized by progressively increasing solid feed intake and a distribution of main bacterial phyla and other microbial groups comparable to that in adult animals.
“iii) maturation stage in which solid feed intake progressively increases and the distribution of main bacterial phyla and other microbial groups is comparable to that in adult animals.”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
Presence of the dam can allow earlier and different inoculation of microbes in the digestive tract of naturally raised newborns as compared to those fed milk replacer and kept in isolation.
“This can allow earlier (and different) inoculation of microbes in the digestive tract of naturally raised newborns as compared to those fed milk replacer and kept in isolation (Abecia et al., 2017).”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
Naturally reared calves have a greater number of Operational Taxonomic Units (OTUs) and bacterial diversity than artificially reared calves.
“This explains the greater number of Operational Taxonomic Units (OTUs) and bacterial diversity observed in naturally reared calves.”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
The dynamics of gut microbial community establishment in young ruminants occurs in three successive steps.
“The dynamics of the gut microbial community establishment in young ruminants occurs in three successive steps (Rey et al., 2014; Abecia et al., 2017):”
From Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future (2018) · cites this paper as Abecia et al., 2017
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- Authors
- Abecia, L., Jiménez, E., Martínez-Fernandez, G., Martín-García, A. I., Ramos-Morales, E., Pinloche, E., Denman, S. E., Newbold, C. J., & Yáñez-Ruiz, D. R.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Aberystwyth University (GB)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-08-16
- Volume
- 12
- Issue
- 8
- Pages
- e0182235
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5558975
- OpenAlex
- W2745463354
- Cited by
- 59
- References
- 65
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 16 · 2019: 7 · 2018: 5 · 2017: 1
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Keywords
- milk replacer feeding, rumen epithelium, innate immune gene expression, Toll-like receptors, PGLYRP1, colostrum, rumen bacterial diversity, weaning
- MeSH terms
- Gastrointestinal Microbiome, Animals, Animal Feed, Female, Gastric Mucosa, Goats, Immunoglobulin A, Immunoglobulin G, Pregnancy, Rumen, Weaning, Biomarkers, Gene Expression, Nutritional Support, Biodiversity, Metagenome, Metagenomics, DNA Barcoding, Taxonomic
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