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Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress
Open accessAbstract
OBJECTIVES: Accumulating evidence indicates that the gut microbiota communicates with the central nervous system, possibly through neural, endocrine, and immune pathways, and influences brain function. B. longum 1714™ has previously been shown to attenuate cortisol output and stress responses in healthy subjects exposed to an acute stressor. However, the ability of B. longum 1714™ to modulate brain function in humans is unclear. METHODS: In a randomized, double-blinded, placebo-controlled trial, the effects of B. longum 1714™ on neural responses to social stress, induced by the "Cyberball game," a standardized social stress paradigm, were studied. Forty healthy volunteers received either B. longum 1714™ or placebo for 4 weeks at a dose of 1 × 10 cfu/d. Brain activity was measured using magnetoencephalography and health status using the 36-item short-form health survey. RESULTS: B. longum 1714™ altered resting-state neural oscillations, with an increase in theta band power in the frontal and cingulate cortex (P < 0.05) and a decrease in beta-3 band in the hippocampus, fusiform, and temporal cortex (P < 0.05), both of which were associated with subjective vitality changes. All groups showed increased social stress after a 4-week intervention without an effect at behavioral level due to small sample numbers. However, only B. longum 1714™ altered neural oscillation after social stress, with increased theta and alpha band power in the frontal and cingulate cortex (P < 0.05) and supramarginal gyrus (P < 0.05). DISCUSSION: B. longum 1714™ modulated resting neural activity that correlated with enhanced vitality and reduced mental fatigue. Furthermore, B. longum 1714™ modulated neural responses during social stress, which may be involved in the activation of brain coping centers to counter-regulate negative emotions.
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“Most human intervention studies have focused on probiotic and prebiotic supplementation to manipulate the microbiota and investigate the effect on brain function and mental health (327, 328).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [328]
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Cites
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371
Oostenveld, R., Fries, P., Maris, E., & Schoffelen, J.-M. (2011) · Computational Intelligence and Neuroscience · doi:10.1155/2011/156869 · Cited by 10,323
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
Schulz, K. F., Altman, D. G., Moher, D., & for the CONSORT Group (2010) · BMJ · doi:10.1136/bmj.c332 · Cited by 9,329
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Kroenke, K., Spitzer, R. L., Williams, J. B. W., & Löwe, B. (2010) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2010.03.006 · Cited by 4,057
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Theories for social epidemiology in the 21st century: An ecosocial perspective
Krieger, N. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.4.668 · Cited by 2,155 · cited 1×
“Social stress was induced by social exclusion/rejection (11) through a standardized paradigm, called “Cyberball Game” (CBG) (12).”
MethodStress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760
Why Does Social Exclusion Hurt? The Relationship Between Social and Physical Pain.
MacDonald, G., & Leary, M. R. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.2.202 · Cited by 1,712
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192
Social Bonds of Female Baboons Enhance Infant Survival
Silk, J. B., Alberts, S. C., & Altmann, J. (2003) · Science · doi:10.1126/science.1088580 · Cited by 1,157
Cyberball: A program for use in research on interpersonal ostracism and acceptance
Williams, K. D., & Jarvis, B. (2006) · Behavior Research Methods · doi:10.3758/bf03192765 · Cited by 1,088
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513
Self-citationSocial brain development and the affective consequences of ostracism in adolescence
Sebastian, C., Viding, E., Williams, K. D., & Blakemore, S.-J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.008 · Cited by 497
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365
Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355
Self-citationEffect of probiotics on central nervous system functions in animals and humans: a systematic review
Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334
Self-citationPsychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice
Liu, Y.-W., Liu, W., Wu, C.-C., Juan, Y.-C., Wu, Y.-C., Tsai, H.-P., Wang, S. Z., & Tsai, Y.-C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.018 · Cited by 290
Xu, D., Gao, J., Gillilland, M., Wu, X., Song, I., Kao, J. Y., & Owyang, C. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.10.026 · Cited by 271
Liu, W.-H., Chuang, H.-L., Huang, Y.-T., Wu, C.-C., Chou, G.-T., Wang, S., & Tsai, Y.-C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.046 · Cited by 269
Probiotics drive gut microbiome triggering emotional brain signatures
Bagga, D., Reichert, J. L., Koschutnig, K., Aigner, C. S., Holzer, P. D., Koskinen, K., Moissl‐Eichinger, C., & Schöpf, V. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1460015 · Cited by 234
Massage Therapy Reduces Anxiety and Enhances Eeg Pattern of Alertness and Math Computations
Field, T. M., Ironson, G. H., SCAFIDI, F. A., Nawrocki, T., Goncalves, A., Burman, I., Pickens, J., Fox, N. A., Schanberg, S. M., & Kuhn, C. M. (1996) · International Journal of Neuroscience · doi:10.3109/00207459608986710 · Cited by 200
MASSAGE THERAPY OF MODERATE AND LIGHT PRESSURE AND VIBRATOR EFFECTS ON EEG AND HEART RATE
Diego, M., Field, T. M., SANDERS, C., & Hernandez‐Reif, M. (2003) · International Journal of Neuroscience · doi:10.1080/00207450490249446 · Cited by 178
Effects of serotonin 2A/1A receptor stimulation on social exclusion processing
Preller, K. H., Pokorny, T., Hock, A., Kraehenmann, R., Stämpfli, P., Seifritz, E., Scheidegger, M., & Vollenweider, F. X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524187113 · Cited by 169
Dynamic changes and spatial correlation of EEG activities during cold pressor test in man
Chang, P. F., Arendt‐Nielsen, L., & Chen, A. C. N. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00763-8 · Cited by 154
How the brain reacts to social stress (exclusion) – A scoping review
Wang, H., Braun, C., & Enck, P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.012 · Cited by 141
Self-citationThe Role of Antibiotics in Gut Microbiota Modulation: The Eubiotic Effects of Rifaximin
Ponziani, F. R., Scaldaferri, F., Petito, V., Sterbini, F. P., Pecere, S., Lopetuso, L. R., Palladini, A., Gerardi, V., Masucci, L., Pompili, M., et al. (2016) · Digestive Diseases · doi:10.1159/000443361 · Cited by 138
Topographic brain measures of human pain and pain responsivity
Chen, A. C. N., Dworkin, S. F., Haug, J., & Gehrig, J. D. (1989) · Pain · doi:10.1016/0304-3959(89)90125-5 · Cited by 132
Neural effects of mental fatigue caused by continuous attention load: A magnetoencephalography study
Tanaka, M., Ishii, A., & Watanabe, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.009 · Cited by 130
Reis, D. J., Ilardi, S. S., & Punt, S. E. W. (2018) · PLOS ONE · doi:10.1371/journal.pone.0199041 · Cited by 123
Theta Signal as the Neural Signature of Social Exclusion
Cristofori, I., Moretti, L., Harquel, S., Posada, A., Deiana, G., Isnard, J., Mauguı̀ere, F., & Sirigu, A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs236 · Cited by 101
Bagga, D., Aigner, C. S., Reichert, J. L., Cecchetto, C., Fischmeister, F. P. S., Holzer, P. D., Moissl‐Eichinger, C., & Schöpf, V. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1732-z · Cited by 98
Amygdalectomy in the free-ranging vervet (Cercopithecus Aethiops)
Kling, A. S., Lancaster, J. B., & Benitone, J. (1970) · Journal of Psychiatric Research · doi:10.1016/0022-3956(70)90006-3 · Cited by 71
Kawamoto, T., Nittono, H., & Ura, M. (2013) · Neuroscience Journal · doi:10.1155/2013/304674 · Cited by 68
Social exclusion modulates event-related frontal theta and tracks ostracism distress in children
van Noordt, S. J. R., White, L. O., Wu, J., Mayes, L. C., & Crowley, M. J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.05.085 · Cited by 63
The Influence of Perceived Stress on Cortical Reactivity: A Proof-Of-Principle Study
Luijcks, R., Vossen, C. J., Hermens, H. J., van Os, J., & Lousberg, R. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129220 · Cited by 37
Monetary reward suppresses anterior insula activity during social pain
Cristofori, I., Harquel, S., Isnard, J., Mauguı̀ere, F., & Sirigu, A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv054 · Cited by 31
Effects of Blood Glucose Levels on Resting-State EEG and Attention in Healthy Volunteers
An, Y. J., Jung, K.-Y., Kim, S., Lee, C., & Kim, D. W. (2015) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000119 · Cited by 25
Effects of Rifaximin on Central Responses to Social Stress—a Pilot Experiment
Wang, H., Braun, C., & Enck, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0627-2 · Cited by 24
Self-citationBolling, D. Z., Pelphrey, K. A., & Vander Wyk, B. C. (2016) · Social Neuroscience · doi:10.1080/17470919.2015.1117019 · Cited by 21
Genetic and neural correlates of romantic relationship satisfaction
Luo, S., Yu, D. L., & Han, S. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv117 · Cited by 21
Effects of a carbohydrate supplement upon resting brain activity
Wang, C., Szabo, J. S., & Dykman, R. A. (2004) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02734278 · Cited by 17
Ishii, A., Tanaka, M., & Watanabe, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109740 · Cited by 16
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The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis
Schneider, E., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01108-6 · Cited by 317
Recent Development of Probiotic Bifidobacteria for Treating Human Diseases
Chen, J., Chen, X., & Ho, C. L. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.770248 · Cited by 259
Metadata
- Authors
- Wang, H., Braun, C., Murphy, E. F., & Enck, P.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- University of Trento (IT)
- Alimentary Health (Ireland) (IE)
- University of Tübingen (DE)
- Corresponding author
- Enck, Paul
- Venue
- American Journal of Gastroenterology
- Published
- 2019-04-17
- Volume
- 114
- Issue
- 7
- Pages
- 1152-1162
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- PMC
- PMC6615936
- OpenAlex
- W2942132156
- Cited by
- 159
- References
- 50
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 23 · 2023: 20 · 2022: 26 · 2021: 23 · 2020: 15 · 2019: 9
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The American Journal of Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University College Cork
- Alimentary Health
- APC Microbiome Institute
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, social stress, gut-brain axis, theta power, beta power, alpha power, Cyberball game, subjective vitality, mental fatigue, cingulate cortex, hippocampus, magnetoencephalography
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium longum, Analysis of Variance, Brain, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Stress, Psychological, Statistics, Nonparametric, Probiotics, Young Adult, Healthy Volunteers
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