Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder
Open accessAbstract
BACKGROUND: Convergent evidence suggests dysfunction within the prefrontal cortex (PFC) and amygdala, important components of a neural system that subserves emotional processing, in individuals with major depressive disorder (MDD). Abnormalities in this system in the left hemisphere and during processing of negative emotional stimuli are especially implicated. In this study, we used functional magnetic resonance imaging (fMRI) to investigate amygdala-PFC functional connectivity during emotional face processing in medication-naive individuals with MDD. METHODS: Individuals with MDD and healthy controls underwent fMRI scanning while processing 3 types of emotional face stimuli. We compared the strength of functional connectivity from the amygdala between the MDD and control groups. RESULTS: Our study included 28 individuals with MDD and 30 controls. Decreased amygdala-left rostral PFC (rPFC) functional connectivity was observed in the MDD group compared with controls for the fear condition (p < 0.05, corrected). No significant differences were found in amygdala connectivity to any cerebral regions between the MDD and control groups for the happy or neutral conditions. LIMITATIONS: All participants with MDD were experiencing acute episodes, therefore the findings could not be generalized to the entire MDD population. CONCLUSION: Medication-naive individuals with MDD showed decreased amygdala-left rPFC functional connectivity in response to negative emotional stimuli, suggesting that abnormalities in amygdala-left rPFC neural circuitry responses to negative emotional stimuli might play an important role in the pathophysiology of MDD.
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MDD is linked to reduced cortico-limbic functional connectivity (e.g., mPFC↔amygdala) when presented with negative cues.
“MDD has been linked to reduced cortico-limbic functional connectivity (e.g., mPFC↔amygdala) when presented with negative cues [175-178].”
From Prefrontal cortex and depression (2022) · cites this paper as [177]
The Results report reduced amygdala–left rostral PFC connectivity in participants with MDD during fearful-face processing, supporting the claim about negative cues. The paper identifies the region as rostral PFC, not explicitly as mPFC, so the example is more anatomically specific than the source states. (LLM, conf=0.83)
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- Authors
- Kong, L., Chen, K., Tang, Y., Wu, F., Driesen, N., Womer, F., Fan, G., Ren, L., Jiang, W., Cao, Y., Blumberg, H., Xu, K., & Wang, F.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Venue
- Journal of Psychiatry & Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2013-11-01
- Volume
- 38
- Issue
- 6
- Pages
- 417-422
- ISSN
- 1180-4882 (ISSN-L)
- PMC
- PMC3819156
- OpenAlex
- W2127127037
- Cited by
- 93
- References
- 59
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 12
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Natural Science Foundation of China (81101012, 81271499, 81071099)
- National Institute of Mental Health (K01MH086621, 01MH086621)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, amygdala, prefrontal cortex, functional connectivity, rostral prefrontal cortex, emotional face processing, negative emotional stimuli, fear, drug-naive patients, neural circuits, emotional processing
- MeSH terms
- Adult, Amygdala, Brain Mapping, Major Depressive Disorder, Emotions, Facial Expression, Female, Humans, Male, Middle Aged, Neural Pathways, Photic Stimulation, Case-Control Studies, Prefrontal Cortex
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