NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo

Reversible middle cerebral artery occlusion without craniectomy in rats.

Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05396.x · Cited by 2,863

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676

Regulation of neuronal survival by the serine-threonine protein kinase Akt

Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385

Activity‐dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones

Wild, A. R., Jones, S., & Gibb, A. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267310 · Cited by 13

GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion

Huang, B., Xie, Q., Lu, X., Qian, T., Li, S., Zhu, R., Wan, Y., Chen, G., Chen, Z., Xu, X., et al. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445556 · Cited by 14

Tissue-Type Plasminogen Activator-A296–299Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor–Dependent Increase in cAMP and p38

Armstead, W. M., Riley, J., Yarovoi, S. V., Higazi, A. A., & Cines, D. B. (2016) · Stroke · doi:10.1161/strokeaha.116.012678 · Cited by 14

A peptide mimetic of tyrosine phosphatase STEP as a potential therapeutic agent for treatment of cerebral ischemic stroke

Poddar, R., Rajagopal, S., Winter, L., Allan, A. M., & Paul, S. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17747193 · Cited by 14

Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors

Balsara, R. D., Li, N. Y., Weber‐Adrian, D., Huang, L., & Castellino, F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.018 · Cited by 15

Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis

Shakova, F. M., Kirova, Y. I., Silachev, D. N., Romanova, G. A., & Morozov, S. G. (2021) · Brain Sciences · doi:10.3390/brainsci11030325 · Cited by 13

The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke

Wu, T., Chen, S., Pan, H., & Luo, Y. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1148697 · Cited by 13

Scorpion venom heat-resistant synthesized peptide ameliorates epileptic seizures and imparts neuroprotection in rats mediated by NMDA receptors

Sui, A., Piao, H. Z., Xiong, S.-T., Zhang, P., Guo, S., Kong, Y., Gao, C., Wang, Z., Yang, J., Ge, B.-Y., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176704 · Cited by 13

N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation

Li, Y., Zhang, Y., Song, Q., Liu, F., Liu, Y., Li, Y., Zhou, C., & Shen, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04291-5 · Cited by 13

Neurotransmitter and metabolic effects of interferon-alpha in association with decreased striatal dopamine in a non-human primate model of cytokine-Induced depression

Bekhbat, M., Block, A. M., Dickinson, S. Y., Tharpd, G. K., Bosinger, S. E., & Felger, J. C. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.01.010 · Cited by 13

Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures

Jung, Y. J., Suh, E. C., & Lee, K. E. (2012) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2012.16.6.423 · Cited by 12

Hyperforin alleviates the psychiatric disorders of adult rats suffered from early maternal separation via activating autophagy

Wang, S., Wang, S., Wang, Y., Yu, X., Zhang, J., Yang, Z. R., & Liu, C. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135750 · Cited by 13

Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice

Lyons, C. E., Zhou, X., Razzoli, M., Chen, M., Xia, W., Ashe, K. H., Zhang, B., & Bartolomucci, A. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15329 · Cited by 14

Enhancement of NMDA Receptor-Mediated Excitatory Postsynaptic Currents by gp120-Treated Macrophages: Implications for HIV-1-Associated Neuropathology

Yang, J., Hu, D., Xia, J., Liu, J., Zhang, G., Gendelman, H. E., Boukli, N. M., & Xiong, H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9468-2 · Cited by 13

The novel NMDA receptor antagonist, 2‐hydroxy‐5‐(2,3,5,6‐tetrafluoro‐4‐trifluoromethyl‐benzylamino)‐benzoic acid, is a gating modifier in cultured mouse cortical neurons

Noh, J., Lee, E., & Chung, J.-M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06044.x · Cited by 13

A Rho-kinase inhibitor reverses learning and memory deficits in a Rat model of chronic cerebral ischemia by altering Bcl-2/Bax-NMDAR signaling in the cerebral cortex

Ni, M., Zhang, J., Huang, L., Liu, G., & Li, Q. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.08.012 · Cited by 12

Specific role of N-methyl-D-aspartate (NMDA) receptor in elastin-derived VGVAPG peptide-dependent calcium homeostasis in mouse cortical astrocytes in vitro

Szychowski, K. A., & Gmiński, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-56781-5 · Cited by 13

Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes

Drastichová, Z., Rudajev, V., Pallag, G., & Novotný, J. (2021) · Biological Research · doi:10.1186/s40659-021-00327-5 · Cited by 12

N-methyl- d -aspartate-evoked adenosine and inosine release from neurons requires extracellular calciumThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.

Zamzow, C. R., Bose, R., & Parkinson, F. E. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-075 · Cited by 13

Role of the NR2A/2B subunits of the N-methyl-d-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro

Monnerie, H., Hsu, F.-C., Coulter, D. A., & Roux, P. D. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.050 · Cited by 12

Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions

Hanuska, A., Szénási, G., Albert, M., Köles, L., Varga, A., Szabó, A., Mátyus, P., & Hársing, L. G. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1713-z · Cited by 12

Development of NMDAR Antagonists with Reduced Neurotoxic Side Effects: a Study on GK11

Vandame, D., Ulmann, L., Teigell, M., Prieto-Cappellini, M., Vignon, J., Privat, A., Perez‐Polo, R. J., Nešić, O., & Hirbec, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081004 · Cited by 12

Voluntary exercise rescues sevoflurane-induced memory impairment in aged male mice

Tian, D., Tian, M., Ma, Z., Zhang, L., Cui, Y., & Li, J. (2016) · Experimental Brain Research · doi:10.1007/s00221-016-4756-8 · Cited by 12

Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors

Song, Z., Yang, W., Cheng, G., Zhou, X., Yang, L., & Zhao, D. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0576-z · Cited by 12

Sprouty1 regulates neuritogenesis and survival of cortical neurons

Gu, X., Su, X., Jia, C., Lin, L., Liu, S., Zhang, P., Wang, X., & Jiang, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27949 · Cited by 10

Purinergic–Glycinergic Interaction in Neurodegenerative and Neuroinflammatory Disorders of the Retina

Hársing, L. G., Szénási, G., Zelles, T., & Köles, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126209 · Cited by 12

Perspective of synaptic protection after post-infarction treatment with statins

Vargas, J. A. G., Céspedes-Rubio, Á. E., & Cardona‐Gómez, G. P. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0472-6 · Cited by 12

Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population

Apland, J. P., Aroniadou‐Anderjaska, V., Figueiredo, T. H., Pidoplichko, V. I., Rossetti, K., & Braga, M. F. M. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245969 · Cited by 12

Potential of D‐cycloserine in the treatment of behavioral and neuroinflammatory disorders in Parkinson's disease and studies that need to be performed before clinical trials

Pawlak, C. R., Chen, F., Wu, F.-Y., & Ho, Y. (2012) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2012.02.010 · Cited by 11

Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation

Roig, M. N. B., Leduc, T., Areal, C. C., & Mongrain, V. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3020020 · Cited by 12

Neuroprotection of Kaji-Ichigoside F1 via the BDNF/Akt/mTOR Signaling Pathways against NMDA-Induced Neurotoxicity

Chen, F., Wang, L., Jin, F., Li, L., Wang, T., Gao, M., Li, L., Wang, Y., Lou, Z., Yang, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416150 · Cited by 11

Excitatory amino acids in neurological and neurodegenerative disorders.

Flores, G., Negrete-Díaz, J. V., Carrión, M., Andrade‐Talavera, Y., Bello, S. A., Sihra, T. S., & Rodríguez-Moreno, A. (2011) · CABI eBooks · doi:10.1079/9781845937980.0427 · Cited by 11

Cloning, expression, and purification of a recombinant Tat-HA-NR2B9c peptide

Zhou, H.-H., Zhang, A., Zhang, Y., & Zhu, D. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.08.011 · Cited by 11

Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways

Rittase, W. B., Dong, Y., Barksdale, D., Galdzicki, Z., & Bausch, S. B. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.04.002 · Cited by 11

Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes

Sarnico, I., Boroni, F., Benarese, M., Alghisi, M., Valerio, A., Battistin, L., Spano, P., & Pizzi, M. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0016-1 · Cited by 11

The Good and Bad Sides of NAAG

Khacho, P., Wang, B., & Bergeron, R. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.01.003 · Cited by 10

Regional-specific effects of cerebral ischemia/reperfusion and dehydroepiandrosterone on synaptic NMDAR/PSD-95 complex in male Wistar rats

Kontić, M. Z., Drakulić, D., Stojanović, I. G., Mitrović, N., Grković, I., & Martinović, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.023 · Cited by 11

Non‐canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis

Feldmann, K. G., Chowdhury, A., Becker, J. L., McAlpin, N., Ahmed, T., Haider, S., Xia, J. X. R., Diaz, K., Mehta, M., & Mano, I. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14629 · Cited by 11

The Levels of Circulating MicroRNAs at 6-Hour Cardiac Arrest Can Predict 6-Month Poor Neurological Outcome

Oh, S. H., Kim, H., Park, K. N., Ji, S., Park, J.-Y., Choi, S. P., Lim, J. Y., Lim, J. Y., & on behalf of CROWN Investigators (2021) · Diagnostics · doi:10.3390/diagnostics11101905 · Cited by 10

Inhibition of NR2B-Containing N-methyl-D-Aspartate Receptors (NMDARs) in Experimental Autoimmune Encephalomyelitis, a Model of Multiple Sclerosis.

Farjam, M., Zarandi, F. B. B., Farjadian, S., Geramizadeh, B., Nikseresht, A. R., & Panjehshahin, M. R. (2014) · PubMed Central · Cited by 11

Hsp70 promotes synaptic transmission in brain slices damaged by contact with blood clot

Mokrushin, A. A., & Pavlinova, L. I. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.12.004 · Cited by 11

TRPC6 expression in neurons is differentially regulated by NR2A‐ and NR2B‐containing NMDA receptors

Qu, Z., Wang, Y., Li, X., Wu, L., & Wang, Y. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14215 · Cited by 11

Tex261 modulates the excitotoxic cell death induced by N-methyl-d-aspartate (NMDA) receptor activation

Taniura, H., Iijima, S., Kambe, Y., Georgiev, D. D., & Yoneda, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.126 · Cited by 11

Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer's disease: A narrative review

Behroozi, Z., Askarpour, H., & Baghcheghi, Y. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261415807 · Cited by 10

Piceatannol-3′-O-β-D-glucopyranoside inhibits neuroexcitotoxicity and ferroptosis through NMDAR/NRF2/BACH1/ACSL4 pathway in acute ischemic stroke

Fan, G., Liu, J., Liu, M., & Huang, Y. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.029 · Cited by 10

Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis

Jara, C., Torres, A. K., Park-Kang, H. S., Sandoval, L., Retamal, C., González, A., Ricca, M., Valenzuela, S., Murphy, M. P., Inestrosa, N. C., et al. (2025) · Neurotoxicity Research · doi:10.1007/s12640-024-00726-y · Cited by 12

Future Perspectives of NMDAR in CNS Disorders

Capó, T., Rebassa, J. B., Raïch, I., Lillo, J., Badia, P., Navarro, G., & Reyes‐Resina, I. (2025) · Molecules · doi:10.3390/molecules30040877 · Cited by 12

Neuroinflammation to neurodegeneration: Boulevard of broken nerves

Attiq, A., Afzal, S., Raman, H., & Ahmad, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115015 · Cited by 12

DCMQA, a caffeoylquinic acid derivative alleviates NMDA-induced neurotoxicity via modulating GluN2A and GluN2B-containing NMDA receptors in vitro

Yue, Y., Gao, H., Liu, W., Jiang, X., Shen, Z., Li, X., Ren, T., Xu, Z., Cheng, G., & Zhao, Q. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104888 · Cited by 10

Prevention of glutamate excitotoxicity in lateral habenula alleviates ethanol withdrawal-induced somatic and behavioral effects in ethanol dependent mice

Gakare, S. G., Varghese, S. S., Patni, P., Wagh, S. A., & Ugale, R. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113557 · Cited by 10

3-Mercaptopropionic Acid-Induced Repetitive Seizures Increase GluN2A Expression in Rat Hippocampus: A Potential Neuroprotective Role of Cyclopentyladenosine

Gori, B., & Girardi, E. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9947-2 · Cited by 10

Allopregnanolone Prevents Dieldrin-Induced NMDA Receptor Internalization and Neurotoxicity by Preserving GABAA Receptor Function

Briz, V., Parkash, J., Sánchez‐Redondo, S., Prévot, V., & Sunol, C. E. (2011) · Endocrinology · doi:10.1210/en.2011-1333 · Cited by 10

A novel translocator protein 18 kDa ligand, ZBD‐2, exerts neuroprotective effects against acute spinal cord injury

Cheng, Q., Sun, G., Liu, S., Yang, Q., Li, X., Li, X., Liu, G., Zhao, J., & Zhao, M. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12606 · Cited by 10

Role of GluN2A NMDA receptor in homocysteine-induced prostaglandin E2 release from neurons

Rajagopal, S., Fitzgerald, A., Deep, S., Paul, S., & Poddar, R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14775 · Cited by 12

Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks

Djemil, S., Chen, X., Zhang, Z., Lee, J., Rauf, M., Pak, D. T. S., & Dzakpasu, R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14938 · Cited by 13

N-Methyl-D-Aspartate Receptors Mediate Synaptic Plasticity Impairment of Hippocampal Neurons Due to Arsenic Exposure

Liu, X., & Wang, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.017 · Cited by 10

Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons

Baldassari, S., Cervetto, C., Amato, S., Fruscione, F., Balagura, G., Pelassa, S., Musante, I., Iacomino, M., Traverso, M., Corradi, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810545 · Cited by 10

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice

Zheng, C., Qiao, Z., Hou, M. Z., Liu, N. N., Fu, B., Ding, R., Li, Y. Y., Wei, L. P., Liu, A. L., & Shen, H. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00186 · Cited by 10

U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors

Li, J., Yan, D., Liu, X., Wang, Y., Zhao, X., Zhang, Y., & Zhang, C. (2018) · Neurological Research · doi:10.1080/01616412.2018.1441693 · Cited by 10

Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke

Salaudeen, M. A., Allan, S. M., & Pinteaux, E. (2023) · Human Cell · doi:10.1007/s13577-023-00997-1 · Cited by 9

Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices

Ai, H., Lu, W., Ye, M., & Yang, W. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1337-8 · Cited by 9

Robust Expression of Functional NMDA Receptors in Human Induced Pluripotent Stem Cell-Derived Neuronal Cultures Using an Accelerated Protocol

Ruden, J. B., Dixit, M., Zepeda, J. C., Grueter, B. A., & Dugan, L. L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.777049 · Cited by 10

Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents

Chen, X., Zhu, H., liu, X., Li, Q., & Dong, M. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117236 · Cited by 9

Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light

Geoffroy, C., Berraud-Pache, R., Chéron, N., McCort-Tranchepain, I., Doria, J., Paoletti, P., & Mony, L. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00247 · Cited by 9

Differential stimulus-dependent synaptic recruitment of CaMKIIα by intracellular determinants of GluN2B

She, K., Rose, J. K., & Craig, A. M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.08.001 · Cited by 9

Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s Disease

Girling, K., & Wang, Y. T. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1425-z · Cited by 9

Endothelin-1-Induced Ischemic Damage and Functional Impairment Is Mediated Primarily by NR2B-Containing NMDA Receptors

Hume, A. W., & Tasker, R. A. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00138-3 · Cited by 9

Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP

Rajagopal, S., Yang, C., DeMars, K. M., Poddar, R., Candelario‐Jalil, E., & Paul, S. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.034 · Cited by 9

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice

Hunsberger, H. C., Setti, S. E., Rudy, C. C., Weitzner, D. S., Pfitzer, J. C., McDonald, K. L., Hong, H., Bhattacharya, S., Suppiramaniam, V. D., & Reed, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111637 · Cited by 10

Endocytosis of AMPA receptors: Role in neurological conditions

Bencsik, N., Morales, C. O. O., Haußer, A., & Schlett, K. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.09.007 · Cited by 9

Hypoxic Conditioning as a Stimulus for the Formation of Hypoxic Tolerance of the Brain

Semenov, D. G., & Belyakov, A. V. (2023) · Успехи физиологических наук · doi:10.31857/s0301179823020066 · Cited by 8

The ERK signaling pathway in cerebral ischemic stroke: Mechanism and therapeutic significance

Yin, X., Chang, J., Yang, L., Jia, L.-Y., Han, J., Chen, L., Cao, J., Chen, X., Xie, N., Lin, Y., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119058 · Cited by 8

Proline-Loaded Chitosan Nanoparticles Penetrate the Blood–Brain Barrier to Confer Neuroprotection in Mice Cerebral Ischemia Injury

Gao, J., Wang, X., Kong, X., Yao, X., Ren, J., Chen, S., Shen, N., Li, Z., Wang, Y., Ye, W., et al. (2023) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c02034 · Cited by 8

The GluN2B-Containing NMDA Receptor Alleviates Neuronal Apoptosis in Neonatal Hypoxic-Ischemic Encephalopathy by Activating PI3K-Akt-CREB Signaling Pathway

ZHANG, X.-T. Z., Peng, K.-Z., Xu, S.-L., WU, M.-X., Sun, H.-J., ZHAO, J., Yang, S., LIU, S.-J., LIAO, C.-Y., & ZHANG, X.-M. (2023) · Physiological Research · doi:10.33549/physiolres.935044 · Cited by 8

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Mottarlini, F., Targa, G., Rizzi, B., Fumagalli, F., & Caffino, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111065 · Cited by 8

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Mesfin, M. N., von Reyn, C. R., Mott, R., Putt, M., & Meaney, D. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.2253 · Cited by 8

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McCool, B. A., & McGinnis, M. M. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_296 · Cited by 9

Glycine attenuates cerebrovascular remodeling via glycine receptor alpha 2 and vascular endothelial growth factor receptor 2 after stroke.

Chen, Z., Wang, X., Liao, H., Sheng, T., Chen, P., Zhou, H., Pan, Y., Liu, W., & Yao, H. (2020) · PubMed Central · Cited by 8

A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

Chen, J., Zhuang, Y., Zhang, Y., Liao, H., Liu, R., Cheng, J., Zhang, Z., Sun, J., Gao, J., Wang, X., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.950376 · Cited by 8

Expression of N-methyl-d-aspartate receptor 1 and its phosphorylated state in basal ganglia of a neonatal piglet hypoxic-ischemic brain injury model: A controlled study of 1H MRS

Wang, X.-Y., Wang, H., Fu, X.-H., Zhang, W., Wu, X., Guo, Q., & Wang, X. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2012.01.005 · Cited by 8

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MacDonald, J. F., Belrose, J. C., Xie, Y., & Jackson, M. F. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4756-6_37 · Cited by 8

Differences in gene expression between high and low tolerance rainbow trout (Oncorhynchus mykiss) to acute thermal stress

Turner, L. A., Easton, A. A., Ferguson, M. M., & Danzmann, R. G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0312694 · Cited by 9

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Li, P., Wang, J., Wang, M., Chen, X., Zhu, H., & Dong, M. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118194 · Cited by 7

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Tauskela, J. S., & Blondeau, N. (2025) · Life · doi:10.3390/life15060883 · Cited by 7

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Khan, S. A., Khan, M. M., Badruddeen, B., Ahmad, U., Akhtar, W., & Islam, A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04357-8 · Cited by 8

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Zeng, Y., Qu, Z.-Y., Zhu, Q., Wang, H., Zhou, Y., & Gao, Z.-B. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01675-8 · Cited by 8

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Carlsen, J., Fossati, S., Østergaard, L., Gutiérrez‐Jiménez, E., & Palmfeldt, J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70122 · Cited by 7

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Harris, K., Won, S. J., Uruk, G., Mai, N., Ogut, D., Zhao, Y., Xie, L., Baxter, P. S., Everaerts, K., Sah, R., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw0424 · Cited by 7

N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice

Sun, T., Liu, J., Ding, J., Zhang, C., Zhang, Y.-W., Ma, Q., & Liu, Y. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.262597 · Cited by 7

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Achzet, L. M., Astruc‐Diaz, F., Beske, P. H., Natale, N. R., Denton, T. T., & Jackson, D. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050636 · Cited by 7

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Dou, Y., Wu, X., Fei, X., & Fei, Z. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.020 · Cited by 7

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Chen, H., Dong, Y., Wu, Y. J., & Yi, F. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0096 · Cited by 7

Differential effect of transient global ischaemia on the levels of γ‐aminobutyric acid type A (GABAA) receptor subunit mRNAs in young and older rats

Montori, S., Dos-Anjos, S., Poole, A. V., Regueiro-Purriños, M. M., Llorente, I. L., Darlison, M. G., Fernández‐López, A., & Martínez‐Villayandre, B. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01254.x · Cited by 7

Glycine regulates proliferation and differentiation of salivary-gland-derived progenitor cells

Nakamura, Y., Matsumoto, S., Mochida, T., Nakamura, K., Takehana, K., & Endo, F. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0767-0 · Cited by 7

Hypoxia associated NMDA receptor 2 subunit composition: developmental comparison between the hypoxia-tolerant subterranean mole-rat, Spalax, and the hypoxia-sensitive rat

Band, M., Malik, A., Joel, A., & Avivi, A. (2012) · Journal of Comparative Physiology B · doi:10.1007/s00360-012-0669-4 · Cited by 7

Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions

Kikuchi, T., Fukuta, T., Agato, Y., Yanagida, Y., Ishii, T., Koide, H., Shimizu, K., Oku, N., & Asai, T. (2019) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2019.09.006 · Cited by 7

The international ENIGMA-II substudy on postoperative cognitive disorders (ISEP)

Haller, G., Chan, M. T. V., Combescure, C., Lopez, U., Pichon, I., Licker, M. J., Fournier, R., & Myles, P. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-91014-8 · Cited by 7

The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat

Alva-Sánchez, C., Rodríguez-Rodríguez, A., Villanueva, I., Anguiano, B., Aceves, C., & Pacheco-Rosado, J. (2014) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2014-1978 · Cited by 7

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Caffino, L., Targa, G., Mallien, A. S., Mottarlini, F., Rizzi, B., Homberg, J. R., Gass, P., & Fumagalli, F. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230913144420 · Cited by 6

Subunit-specific effects of NMDA receptor signaling: Implications for stroke

Liu, Y., Wong, T. P., Aarts, M. M., Liu, L., Wu, D., Lu, J., Tymianski, M., & Wang, Y.-T. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9591524.0431

Opposing roles of NMDA receptor subtypes in neuronal fate and novel treatments for ischemic brain injury

Liu, Y. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0092964

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von Engelhardt, J., Coserea, I., Pawlak, V., Fuchs, E. C., Köhr, G., Seeburg, P. H., & Monyer, H. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.015 · Cited by 151

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Wang, Y., & Li, V. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.194713 · Cited by 55

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

Vizi, E. S., Kisfali, M., & Lőrincz, T. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.10.005 · Cited by 125